• 대한치과의사협회지
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• 제45권8호통권459호
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• pp.491-499
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• 2007

Deproteinized bovine bone mineral has been widely used as graft material in sinus augmentation procedure. The efficacy of OCS-B(r)(Nibec Inc., Seoul, Korea) as a graft material for sinus augmentaion was evaluated in 10 patients. A total of 13 sinus augmentation procedures were performed, and an average of 6.3 months later 27 implants were placed into the augmentation sinuses. The biopsy specimens were examined histologically and hitomorphometrically. Radiographical evaluation was done also. The average distance form grafted sinus to implant apex at the final evaluation period was $5.7\pm3.1$mm. The average percentage of newly formed bone at an average of 6.3 months was $20.0\pm8.4%$. The degree of bone to graft material contact was $18.7\pm6.4%$. It was shown from both radiographic evaluation and histologic results that sinus augmentation can successfully be performed with $\OCS-B^textcircledR$.

• 한국재료학회지
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• 제12권7호
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• pp.560-567
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• 2002

Titanium (Ti) is a bioinert material and has lower elastic coefficient and better strength/volume property than other metals. Ferroelectric materials show alignment of positive and negative charges by poling treatment. This study was purposed to develop a new implant system by combining the advantages of Ti and ferroelectric property of $BaTiO_3$ (BTO). It was performed with the assumption that the $Ca^{2+ }$ ions would be easily attracted on negatively charged surface and the attracted cation might behave as nuclei for bone-like crystal growth in biological solutions. A ferroelectric BTO thin film on Ti was fabricated and the effect of poling treatment on the improvement of calcium phosphate (Ca-P) formation in biological solutions was evaluated. After immersion in Eagle’s minimum essential media (MEM) solution, NaCl was formed on Ti, and Ca-P layer containing NaCl was formed on Ti-O. Weak and sparse Ca-P layers were formed on BTO, while thick, homogeneous, and dense Ca-P layer was formed on negatively polarized BTO (N-BTO), which was confirmed by FE-SEM and EDX. In summary, these results demonstrate that poling the ferroelectric BTO surface negatively is effective for the formation of Ca-P layer in MEM solution, and that N-BTO coating on Ti could be used as a possible alternative method for enhancing the osseointegration of the implants.

• Journal of Periodontal and Implant Science
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• 제52권4호
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• pp.312-324
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• 2022

Purpose: The role of hard-type crosslinked hyaluronic acid (HA) with particulate bone substitutes in bone regeneration for combined inlay-onlay grafts has not been fully investigated. We aimed to evaluate the effect of hard-type crosslinked HA used with bone substitute in terms of new bone formation and space maintenance. Methods: A 15-mm-diameter round defect was formed in the calvaria of 30 New Zealand White rabbits. All animals were randomly assigned to 1 of 3 groups: the control group (spontaneous healing without material, n=10), the biphasic calcium phosphate (BCP) graft group (BCP, n=10), and the BCP graft with HA group (BCP/HA, n=10). The animals were evaluated 4 and 12 weeks after surgery. Half of the animals from each group were sacrificed at 4 and 12 weeks after surgery. Samples were evaluated using micro-computed tomography, histology, and histomorphometry. Results: The BCP group showed higher bone volume/tissue volume (BV/TV) values than the control and BCP/HA groups at both 4 and 12 weeks. The BCP and BCP/HA groups showed higher bone surface/tissue volume (BS/TV) values than the control group at both 4 and 12 weeks. The BCP group showed higher BS/TV values than the control and BCP/HA groups at both 4 and 12 weeks. No statistically significant difference in newly formed bone was found among the 3 groups at 4 weeks. The BCP group showed significantly higher new bone formation than the BCP/HA group at 12 weeks. Conclusions: Hard-type crosslinked HA did not show a positive effect on new bone formation and space maintenance. The negative effect of hard-type crosslinked HA may be due to the physical properties of HA that impede osteogenic potential.

• 대한치과의사협회지
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• 제50권12호
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• pp.743-754
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• 2012

urpose : The purpose of this study was to evaluate the US II plus/GS II Osstem$^{(R)}$ implants through the study for the clinical success rate during the installation of the Osstem¢Á implants after bone graft. Materials and Methods : This study was researched in the 4 medical institutions: Chonnam National University, Chosun University, Bundang Seoul National University Hospital, and FM dental clinic from May, 2002 to September, 2009. Based on the total number of 60 patients whose treatment was the installation of the US II plus/GS II Osstem¢Á implants after bone graft, we evaluated success rate of implants. We analysis the distribution of patient's age and gender, edentulous area, bone type, fixture length and diameter, installation and loading time, donor site, bone graft material and method, antagonistic teeth, and survival and success rate. From these analyses we got the following results. Results : 1. In this study, the total number of patients who have been installed with US II plus implant was 27, and total of 52 implants were installed. The average age was 38.9, with 16 male, and 11 female patients. 2. The total number of patients who have been installed with GS II implant was 33, and total of 54 implants were installed. The average age was 49.7, with 24 male, and 9 female patients. 3. As for bone graft method, either autogenous bone or a mix of autogenous and heterogenous bone was used(88.4%) for US II plus. Chin, iliac, and Maxillary tuberosity were the donor sites for autogenous bone graft, and onlay method of bone graft was performed. 4. Allogenic bone or a mix of autogenous and heterogenous bone was used(77.8%) for GS II. Chin, ramus, and tibia were the donor sites for autogenous bone graft, and GBR method of bone graft was performed. 5. The duration from the installation of implants to setting of final prosthesis was average of 16 months and 10 months for US II plus and GS II respectively. Also, the final follow up period was average of 31 months and 28 months respectively. During this period, one GS II implant was removed from 1 patient due to failure of early osteointegration. 6. The survival rates were 100% and 98.1%, and success rates were 94.2% and 94.4% for US II plus and GS II implant respectively. Conclusion : On the evaluation of our clinical study, both US II plus and GS II Osstem¢Á implants showed the excellent clinical results after bone graft.

• 대한치과보철학회지
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• 제48권2호
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• pp.128-134
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• 2010

연구목적: 본 연구에서는 건강기능식품인 $PostPlant^{TM}$ Calcium을 임플란트 식립 환자에게 투여하고, 투여하지 않은 군과 비교하여 그 유효성과 안정성을 평가하여 투여 후 골밀도의 변화 및 골유착 기간의 단축 여부를 평가하고자 하였다. 연구 재료 및 방법 임플란트 식립 후에Post$PostPlant^{TM}$ Calcium을 투여한 실험군은 18명의 환자를 대상으로 25개의 임플란트를 식립하였고, 투여하지 않은 대조군에서는 7명의 환자에게 9개의 임플란트를 식립하여 관찰하였다. 일차수술 후, 이차수술 후, 6개월 후에 $Osstell^{TM}$ Mentor, $Periotest^{(R)}$를 이용하여 임플란트 안정성을 비교 분석하였고, 일차수술후, 1, 3, 6개월 후에 방사선 사진 촬영을 시행하여 임플란트 주위 골밀도를 측정하여 비교 분석하였다. 결과:1. $Osstell^{TM}$ Mentor의해 측정된 ISQ 값은 측정 결과 시간이 경과함에 따라 실험군, 대조군 모두 수치가 높아지는 경향을 보였다. 실험군의 측정값이 대조군에 비해 더 높은 수치를 보였으며, 식립 6개월 후에 실험군과 대조군 간에 통계적으로 유의한 차이가 관찰되었다 (P< .05); 2. $Periotest^{(R)}$ 측정 결과 시간이 경과함에 따라 실험군, 대조군 모두 수치가 낮아지는 경향을 보였으며, 실험군이 대조군에 비해 더 낮은 수치를 나타내었으나 각 군간에 통계적인 유의성은 없었다. 3. 골밀도 측정 결과 시간이 경과함에 따라 실험군, 대조군 모두 골밀도 수치가 증가하는 경향을 보였으며, 실험군이 대조군에 비해 더 높은 수치를 나타내었으나 각 군간에 통계적인 유의성은 없었다. 결론:임상적으로 임플란트 식립 후 환자가 $PostPlant^{TM}$ Calcium을 장기간 복용하는 것이 임플란트 안정성을 높이고, 골유착을 성공적으로 이루는데 도움을 줄 수 있다고 사료된다.

• 대한치과보철학회지
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• 제47권2호
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• pp.215-221
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• 2009

연구목적: 임플란트 시술을 받는 환자가 크게 증가하는 시점에 임플란트 시술환자를 시술 전후로 추적 조사하여 시술 전후의 저작능력을 평가하고, 시술 전후의 환자 만족도와 삶의 질의 변화를 비교하기 위하여 연구를 수행하였다. 연구 재료 및 방법: 대구광역시와 울산광역시에 있는 6개의 치과 의원에서 2006년 12월부터 2007년 10월까지 임플란트 시술을 받은 20세 이상의 성인 환자 109명을 대상으로 임플란트 시술 전후에 설문조사를 실시하여 임플란트 치료선택동기, 저작능력, 환자만족도, 권유의향, 삶의 질을 비교분석하였다. 결과: 임플란트 선택 동기는 '치아기능의 회복을 위하여'가 45.9%로 가장 많았고, 치료 시 가장 걱정되는 것은 '치료실패와 부작용'이 38.5%로 가장 많았다. 임플란트 시술에 대한 만족도는 시술 전 30.37점에서 시술 후 45.01점으로 시술 전후의 만족도 점수가 유의한 차이가 있었으며(P<.001), 치료에 대한 만족도는 '만족한다'라고 답한 사람이 91.8%였으며, 연구대상자의 89%가 가족이나 주위에 임플란트를 '권유할 의향이 있다'라고 응답했다. 섭취가능 식품에 대한 설문을 이용하여 측정한 저작능력 점수는 임플란트 시술 전 15.24점에서 임플란트 시술 후 19.11점으로 시술 전후의 저작능력 점수가 유의한 차이가 있었으며(P<.001), 삶의 질 점수도 임플란트 시술 전 9.99점에서 시술 후 11.17점으로 시술 전후 유의한 차이가 있었다(P<.001). 결론: 이 연구 결과를 통해 치아 질환, 치아상실로 인하여 저하된 저작 능력이 임플란트를 통하여 유의하게 개선됨을 확인할 수 있었다. 향후 임플란트를 시술한 상실치아 수나 상실 부위에 따른 임플란트 시술환자의 만족도에 대한 연구가 필요하며, 시술 후 장기간의 경과 후 평가 및 연구대상자 확대를 통한 연구를 시행할 필요가 있다고 생각한다.

• Journal of Periodontal and Implant Science
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• 제50권5호
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• pp.327-339
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• 2020

Purpose: The purpose of this study was to examine the local tissue reactions associated with 3 different poly(lactic-co-glycolic acid) (PLGA) prototype membranes and to compare them to the reactions associated with commercially available resorbable membranes in rats. Methods: Seven different membranes-3 synthetic PLGA prototypes (T1, T2, and T3) and 4 commercially available membranes (a PLGA membrane, a poly[lactic acid] membrane, a native collagen membrane, and a cross-linked collagen membrane)-were randomly inserted into 6 unconnected subcutaneous pouches in the backs of 42 rats. The animals were sacrificed at 4, 13, and 26 weeks. Descriptive histologic and histomorphometric assessments were performed to evaluate membrane degradation, visibility, tissue integration, tissue ingrowth, neovascularization, encapsulation, and inflammation. Means and standard deviations were calculated. Results: The histological analysis revealed complete integration and tissue ingrowth of PLGA prototype T1 at 26 weeks. In contrast, the T2 and T3 prototypes displayed slight to moderate integration and tissue ingrowth regardless of time point. The degradation patterns of the 3 synthetic prototypes were similar at 4 and 13 weeks, but differed at 26 weeks. T1 showed marked degradation at 26 weeks, whereas T2 and T3 displayed moderate degradation. Inflammatory cells were present in all 3 prototype membranes at all time points, and these membranes did not meaningfully differ from commercially available membranes with regard to the extent of inflammatory cell infiltration. Conclusions: The 3 PLGA prototypes, particularly T1, induced favorable tissue integration, exhibited a similar degradation rate to native collagen membranes, and elicited a similar inflammatory response to commercially available non-cross-linked resorbable membranes. The intensity of inflammation associated with degradable dental membranes appears to relate to their degradation kinetics, irrespective of their material composition.

• Imaging Science in Dentistry
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• 제45권1호
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• pp.41-47
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• 2015

Purpose: This study was performed to evaluate the linear distance accuracy and reliability of stitched small field of view (FOV) cone-beam computed tomography (CBCT) reconstructed images for the fabrication of implant surgical guides. Material and Methods: Three gutta percha points were fixed on the inferior border of a cadaveric mandible to serve as control reference points. Ten additional gutta percha points, representing fiduciary markers, were scattered on the buccal and lingual cortices at the level of the proposed complete denture flange. A digital caliper was used to measure the distance between the reference points and fiduciary markers, which represented the anatomic linear dimension. The mandible was scanned using small FOV CBCT, and the images were then reconstructed and stitched using the manufacturer's imaging software. The same measurements were then taken with the CBCT software. Results: The anatomic linear dimension measurements and stitched small FOV CBCT measurements were statistically evaluated for linear accuracy. The mean difference between the anatomic linear dimension measurements and the stitched small FOV CBCT measurements was found to be 0.34 mm with a 95% confidence interval of +0.24 - +0.44 mm and a mean standard deviation of 0.30 mm. The difference between the control and the stitched small FOV CBCT measurements was insignificant within the parameters defined by this study. Conclusion: The proven accuracy of stitched small FOV CBCT data sets may allow image-guided fabrication of implant surgical stents from such data sets.

• Imaging Science in Dentistry
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• 제48권1호
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• pp.31-39
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• 2018

Purpose: This study aimed to evaluate the effect of field-of-view (FOV) size on the gray values derived from cone-beam computed tomography (CBCT) compared with the Hounsfield unit values from multidetector computed tomography (MDCT) scans as the gold standard. Materials and Methods: A radiographic phantom was designed with 4 acrylic cylinders. One cylinder was filled with distilled water, and the other 3 were filled with 3 types of bone substitute: namely, Nanobone, Cenobone, and Cerabone. The phantom was scanned with 2 CBCT systems using 2 different FOV sizes, and 1 MDCT system was used as the gold standard. The mean gray values(MGVs) of each cylinder were calculated in each imaging protocol. Results: In both CBCT systems, significant differences were noted in the MGVs of all materials between the 2 FOV sizes(P<.05) except for Cerabone in the Cranex3D system. Significant differences were found in the MGVs of each material compared with the others in both FOV sizes for each CBCT system. No significant difference was seen between the Cranex3D CBCT system and the MDCT system in the MGVs of bone substitutes on images obtained with a small FOV. Conclusion: The size of the FOV significantly changed the MGVs of all bone substitutes, except for Cerabone in the Cranex3D system. Both CBCT systems had the ability to distinguish the 3 types of bone substitutes based on a comparison of their MGVs. The Cranex3D CBCT system used with a small FOV had a significant correlation with MDCT results.

• Journal of Periodontal and Implant Science
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• 제43권3호
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• pp.130-135
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• 2013

Purpose: The purpose of this study was to evaluate the tensile strength of surgical synthetic absorbable sutures over a period of 14 days under simulated oral conditions. Methods: Three suture materials (polyglycolic acid [PGA], polyglactin [PG] 910, and poly (glycolide-co-${\epsilon}$-caprolactone) [PGC]) were used in 4-0 and 5-0 gauges. 210 suture samples (35 of each material and gauge) were used. All of the samples were tested preimmersion and 1 hour and 1, 3, 7, 10, and 14 days postimmersion. The tensile strength of each suture material and gauge was assessed. The point of breakage and the resorption pattern of the sutures were also assessed. Results: During the first 24 hours of immersion, all 4-0 and 5-0 samples of PGA, PG 910, and PGC maintained their initial tensile strength. At baseline (preimmersion), there was a statistically significant (P<0.001) difference in the tensile strengths between the 4-0 and 5-0 gauge of PGA, PG 910, and PGC. PGA 4-0 showed the highest tensile strength until day 10. At 7 days, all the 4-0 sutures of the three materials had maintained their tensile strength with PGA 4-0 having significantly greater (P=0.003) tensile strength compared to PG. Conclusions: 4-0 sutures are stronger and have greater tensile strength than 5-0 sutures. The PGA 4-0 suture showed the highest tensile strength at the end of day 10.