• Current Optics and Photonics
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• 제3권1호
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• pp.54-65
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• 2019

To develop a biomarker predicting tumor treatment efficacy is helpful to reduce time, medical expenditure, and efforts in oncology therapy. In clinics, microvessel density using immunohistochemistry has been proposed as an indicator that correlates with both tumor size and metastasis of cancer. In the preclinical study, we hypothesized that vascular morphometrics using optical coherence tomography angiography (OCTA) could be potential indicators to estimate the treatment efficacy of breast cancer. To verify this hypothesis, a 13762-MAT-B-III rat breast tumor was grown in a dorsal skinfold window chamber which was applied to a nude mouse, and the change in vascular morphology was longitudinally monitored during tumor growth and metronomic cyclophosphamide treatment. Based on the daily OCTA maximum intensity projection map, multiple vessel parameters (vessel skeleton density, vessel diameter index, fractal dimension, and lacunarity) were compared with the tumor size in no tumor, treated tumor, and untreated tumor cases. Although each case has only one animal, we found that the vessel skeleton density (VSD), vessel diameter index and fractal dimension (FD) tended to be positively correlated with tumor size while lacunarity showed a partially negative correlation. Moreover, we observed that the changes in the VSD and FD are prior to the morphological change of the tumor. This feasibility study would be helpful in evaluating the tumor vascular response to treatment in preclinical settings.

• 대한예방한의학회지
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• 제19권1호
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• pp.131-144
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• 2015

Objective : This study was conducted to investigate anti-obesity effects of mixed-Powder(Raphani Semen, Coicis Semen, Poria, Plantaginis Testa & Theae folium)(HP) & mixed water extract(Citri Pericarpium, Crataegi Fructus, Maydis Stigma, Allium Skin) (HE) in mice fed a high-fat diet. Method : 50 Female ICR mice were divided into six groups; Normal group (Ve), high-fat diet group (Po), Po+HP(0.6g/kg) group(HP), Po+HE(1g/kg) group(HE), Po+(HP+HE) group(HPE), Po+(HP+HE)*2 group(DHPE). For 8 weeks, these groups were fed their respective diets. Body weight, liver weight and weights of adipose tissues, GOT/GPT index changes & Blood Glucose index changes were measured respectively. Lipid profiles in serum were analyzed by kit of blood. Results : Groups HP, HE, HPE, DHPE had significantly reduced body weight, liver weight, adipose tissue weights and GOT/GPT index, blood glucose index compared to the Po group. Also, serum triglyceride and total cholesterol, low density lipoprotein, were significantly reduced when compared to the Po group. Group G1 had significantly increased high density lipoprotein levels. Conclusion : Mixed powder (HP) & mixed water extract (HE) show anti-obesity effects in mice fed a high-fat diet.

• 한국레이저가공학회지
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• 제17권2호
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• pp.19-25
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• 2014

Optical embedded diffraction gratings with the bulk modification in BK-7 glass plates excited by tightly focused high-intensity femtosecond (130fs) Ti: sapphire laser (peak wavelength = 790nm) were demonstrated. The structural modifications with diameters ranging from 400nm to $4{\mu}m$ were photo-induced after plasma formation occurred upon irradiation with peak intensities of more than $1{\times}1013W/cm^2$. The graded refractive index profile was fabricated to be a symmetric around from the center of the point at which low-density plasma occurred. The maximum refractive index change was estimated to be $1.5{\times}10^{-2}$. The two optical embedded gratings in BK-7 glass plate were demonstrated with refractive index modification induced by the scanning of low-density plasma formation.

• 대한약침학회지
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• 제16권3호
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• pp.23-29
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• 2013

Objectives: Dyslipidemia in diabetes mellitus is a significant risk factor for the development of cardiovascular complications. The aim of this study was to evaluate the effect of the ethyl-acetate fraction of an ethanolic extract from Streospermum suaveolens on lipid metabolism in streptozotocin (STZ)-induced diabetic rats. Methods: Diabetes was induced by intraperitonial injection of STZ (50 mg/kg). Diabetic rats were treated with an ethyl-acetate fraction orally at doses of 200 and 400 mg/kg daily for 14 days. On the $15^{th}$ day, serum lipid profiles, such as total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL), were estimated in experimental rats. The atherogenic (AI) and the coronary risk (CRI) indices were also evaluated. Results: The ethyl-acetate fraction at doses of 200 and 400 mg/kg significantly (P < 0.001) and dose-dependently reduced serum cholesterol, triglycerides and LDL, but increased HDL towards near normal levels as compared to diabetic control rats. The fraction also significantly (P < 0.001) lowered the atherogenic index (AI) and coronary risk index (CAI) in a dose-dependent manner. Conclusion: The present study demonstrated that the ethyl-acetate fraction of Stereospermum suaveolens exhibits a potent antihyperlipidemic activity in hyperglycemic rats and suggests that the plant may have therapeutic value in treating the diabetic complication of hyperlipidemia.

• Imaging Science in Dentistry
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• 제41권3호
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• pp.101-106
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• 2011

Purpose : This study evaluated the potential use of the computed tomography indices (CTI) on cone beam CT (CBCT) images for an assessment of the bone mineral density (BMD) in postmenopausal osteoporotic women. Materials and Methods : Twenty-one postmenopausal osteoporotic women and 21 postmenopausal healthy women were enrolled as the subjects. The BMD of the lumbar vertebrae and femur were calculated by dual energy X-ray absorptiometry (DXA) using a DXA scanner. The CBCT images were obtained from the unilateral mental foramen region using a PSR-$9000N^{TM}$ Dental CT system. The axial, sagittal, and coronal images were reconstructed from the block images using $OnDemend3D^{TM}$. The new term "CTI" on CBCT images was proposed. The relationship between the CT measurements and BMDs were assessed and the intra-observer agreement was determined. Results : There were significant differences between the normal and osteoporotic groups in the computed tomography mandibular index superior (CTI(S)), computed tomography mandibular index inferior (CTI(I)), and computed tomography cortical index (CTCI). On the other hand, there was no difference between the groups in the computed tomography mental index (CTMI: inferior cortical width). Conclusion : CTI(S), CTI(I), and CTCI on the CBCT images can be used to assess the osteoporotic women.

• 국토계획
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• 제54권2호
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• pp.76-83
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• 2019

This study aims to empirically identify the effect of spatial accessibility, based on travel, on housing prices in the Korean capital region. More specifically, it has two research purposes: First, investigating the effect of comprehensive spatial accessibility, based on road network and actual trips from origin to destination, on average apartment price (Korean Won per square meter) at the level of Eup, Myeon and Dong; Second, identifying better accessibility index between Hansen's and Kalogirou and Foley's ones. The former represents a road-based travel time decay function with destination trips, while the latter is a function with origin trips as well as destination ones. The study employs spatial economic models considering spatial auto-correlative relationship as an appropriate methodology with such control independent indicators as population density, road density, educational environment and distances from CBDs. Analysis results demonstrate that spatial accessibility, based on road network and actual trips from origin to destination, has a statistically significant impacts on housing price in the region. Our empirical evidence proves that the Hansen index is more appropriate than the other in estimating housing price impacts.

• 대한방사선기술학회지:방사선기술과학
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• 제30권4호
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• pp.365-371
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• 2007

최근 연구들은 골다공증과 동맥경화증의 병인 간의 연관성을 제시한다. 이 연구에서는 건강한 중년 여성에서 high-sensitivity C-reactive protein(hs-CRP), 지질 농도 등을 포함한 심혈관 위험인자들과 요추 골밀도의 상관관계를 분석하였다. 총 300명의 성인여성을 대상으로 하여 신체계측을 시행하였고, 공복혈당, 지질, hs-CRP를 포함한 심혈관질환 위험인자들을 측정하였다. 동맥경화지수는 총콜레스테롤 농도를 고밀도지단백 콜레스테롤 농도로 나누어서 계산하였다. Dual X-ray abosorptiometry를 이용하여 요추 골밀도를 측정하였다. 연구결과 연령, 수축기 및 이완기 혈압, 총 콜레스테롤, 고밀도지단백 콜레스테롤은 요추 골밀도와 음의 상관관계를 보였다. 통계적으로는 연령과 체질량지수, 고밀도지단백 콜레스테롤이 요추 골밀도와 의미 있는 상관관계를 보였다. 요추 골밀도에 영향을 미치는 심혈관 인자들은 연령과 고밀도지단백 콜레스테롤이 요추 골밀도($R^2=0.272$)의 독립적 위험인자로 나타났다.

• Journal of Community Nutrition
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• 제7권1호
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• pp.49-57
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• 2005

Nutrition factors play an important role in the pathogenesis of osteoporosis. The purpose of this study is to investigate the relationship between nutritional status and bone mineral density of elderly women. Three hundred thirty five elderly women (over 65 years) in Asan were divided into three age groups (group 1, less than 70 y ; group 2, from 70 to 75 y ; group 3, 75 y or more). Total alkaline phosphatase and serum calcium (Ca) were analyzed using spectrophotometric procedure. Data for food and nutrient intakes were obtained by a 24-hour recall method. Bone density was measured by broadband ultrasound attenuation (BUA) using QUS-2. Age differences were tested with the X 2 test for categorical variables and with ANOVA and Tukey's test for continuous variables. Correlation was conducted to test the association between bone density and nutrient intake. The subjects in age groups 1,2 and 3 were $36.7\%$, $32.8\%$ and $30.4\%$, respectively. Height and body weight of the subjects were significantly decreased with age. Average bone density of the subjects in group 3 was lower than the other age groups. Osteoporosis determined by t-score is $17.9\%$ for group 1, $24.5\%$ for group 2 and $55.9\%$ for group 3 (p < 0.001). The serum Ca level of the subjects in group 2 was significantly lower than that of group 1 although mean values in all age groups are within the normal range. Dietary Ca intake, nutrient adequacy ratio (NAR) and index of nutrient quality (INQ) were decreased with age. Bone density was negatively correlated with age (p < 0.001), while body mass index (p < 0.01) was positively related with bone density. Although partial correlation did not reveal the significant correlation of BMD and dietary calcium after controlling for age, since calcium intake was very poor compared to sodium and phosphorous intakes, recommendation of more calcium intake for elderly women especially those over 75 years must be continuously emphasized.

• Geomechanics and Engineering
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• 제14권5호
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• pp.491-498
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• 2018

The Earth Mechanics Institute (EMI) was established at the Colorado School of Mines (CSM) in 1974 to develop innovations in rock mechanics research and education. During the last four decades, extensive rock mechanics research has been conducted at the EMI. Results from uniaxial compressive strength (UCS), Brazilian tensile strength (BTS), point load index (PLI), punch penetration (PP), and many other types of tests have been recorded in a database that has been unexamined for research purposes. The EMI database includes over 20,000 tests from over 1,000 different projects including mining and underground construction, and analysis of this database to identify relationships has been started with preliminary results reported here. Overall, statistically significant correlations are identified between bulk density and mechanical strength properties through UCS, BTS, PLI, and PP testing of sedimentary, igneous, and metamorphic rocks. In this paper, bulk density is considered as a surrogate metric that reflects both mineralogy and porosity. From this analysis, sedimentary rocks show the strongest correlation between the UCS and bulk density, whereas metamorphic rocks exhibit the strongest correlation between UCS and PP. Data trends in the EMI database also reveal a linear relationship between UCS and BTS tests. For the singular case of rock coral, the database permits correlations between bulk density of the core versus the deposition depth and porosity. The EMI database will continue under analysis, and will provide additional insightful and comprehensive understanding of the variation and predictability of rock mechanical strength properties and density. This knowledge will contribute significantly toward the increasingly safe and cost-effective geostructures and construction.

• 한국농공학회지
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• 제34권3호
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• pp.33-42
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• 1992

The shear strength of cohesionless Soils results from particle-to-particle friction and structural resistance by interlocking. And, the shear strength of soils is subjected to vary depending on the internal states and external condtions. If the volume change occurring in the soils and stress-strain relationships under the internal and external changes can accrurately he described, it is possible to predict the behaviors of soils. To accomplish these objectives a series of drained triaxial compression tests and isotropic compression test was performed on the Banwol sand at different relative densities ranging from 20% to 80% and different confining pressures ranging from 0.4kgf/cm$^2$ to l2kgf/cm$^2$. The results and main conclusions of the study are summarized as follows; 1.When the relative density or the confining pressure is increased, the maximum deviator stress is increased. The ratio of the maximum deviator stress and the confining pressure is linearly proportional to the relative density. 2.It is observed that the dilatancy depends not only upon its relative density but also the confining stress, and that the maximum deviator stress is obtained after the diatancy occurs. 3.The volume of sands undergoes initial contraction prior to the dilatancy occurred by strain softening. The dilatancy rate eventually approaches the critical state or a constant volume. 4.At lower strains, Poisson's ratio approaches a certain minimum value regadless of the state of materials. At larger strains, however, the ratio is increased as the relative density is increased. 5.It is observed that the modulus of elasticity is linearly proportional to the relative density and the pressure. 6.When the relative density is increased, the friction angle of sands is linearly increased. 7.When the relative density is increased, the expansion index and the compression index are linearly decreased, and the ratio of the two is about 1/3.