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http://dx.doi.org/10.3831/KPI.2013.16.020

Antihyperlipidemic Activity of the Ethyl-acetate Fraction of Stereospermum Suaveolens in Streptozotocin-induced Diabetic Rats  

Thirumalaisamy, Balasubramanian (Department of Pharmacology, Al Shifa College of Pharmacy)
Prabhakaran, Senthilkumar Gnanavadevel (Department of Pharmaceutical Chemistry, Bharathi College of Pharmacy)
Marimuthu, Karthikeyan (Department of Pharmacology, Al Shifa College of Pharmacy)
Chatterjee, Tapan Kumar (Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University)
Publication Information
Journal of Pharmacopuncture / v.16, no.3, 2013 , pp. 23-29 More about this Journal
Abstract
Objectives: Dyslipidemia in diabetes mellitus is a significant risk factor for the development of cardiovascular complications. The aim of this study was to evaluate the effect of the ethyl-acetate fraction of an ethanolic extract from Streospermum suaveolens on lipid metabolism in streptozotocin (STZ)-induced diabetic rats. Methods: Diabetes was induced by intraperitonial injection of STZ (50 mg/kg). Diabetic rats were treated with an ethyl-acetate fraction orally at doses of 200 and 400 mg/kg daily for 14 days. On the $15^{th}$ day, serum lipid profiles, such as total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL), were estimated in experimental rats. The atherogenic (AI) and the coronary risk (CRI) indices were also evaluated. Results: The ethyl-acetate fraction at doses of 200 and 400 mg/kg significantly (P < 0.001) and dose-dependently reduced serum cholesterol, triglycerides and LDL, but increased HDL towards near normal levels as compared to diabetic control rats. The fraction also significantly (P < 0.001) lowered the atherogenic index (AI) and coronary risk index (CAI) in a dose-dependent manner. Conclusion: The present study demonstrated that the ethyl-acetate fraction of Stereospermum suaveolens exhibits a potent antihyperlipidemic activity in hyperglycemic rats and suggests that the plant may have therapeutic value in treating the diabetic complication of hyperlipidemia.
Keywords
antihyperlipidemic; atherogenic index; coronary risk index; Stereospermum suaveolens; ethyl acetate fraction; STZ-diabetic rats;
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