• 생명과학회지
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• 제6권2호
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• pp.142-148
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• 1996

Aloe(Aloe arborescens M$_{ILL}$) has been used as a home medicine for the past several thousand in the world, and has been studied on anti-bacterial and anti-fungal activities, hypotension, atherosclerosis, myocardiac infartion, apoplexy, diabetes as a chronic digenerative disease, tumors, gastrointestinal tract, liver and pancreas' diseases, and genitourinary tract etc. SAMP8 as a learing and memory impairment animal model were fed basic and/or experimental diets with 1.0% freezing dried(FD)-aloe for 8 months. The passive avoidance tests such as acqusition trial and retention test were significantly higher in aloe group than in control group. Grading score of senescence resulted in a marked decreases in aloe group compared with control group. Acetylcholinesterase(AChE) activity was remarkably increased in aloe group compared with control group. Neurotransmitters such as dopamine(DA) and serotonin(5-HT) almost did not change by the feeding of aloe-added diet, but their metabolites such as homovanillic acid(HVA) and 5-hydroxy-indole acetic acid(5-HIAA) in aloe group were significantly increased compared with control group. Therefore, the ratios of HVA/DA and 5-HIAA/5-HT as a ratio of metabolite on neurotransmitter were significantly increased by the feeding of aloe-added diet. These results suggest that aloe vara may be activated acetylcholinesterase, the metabolite of neurotransmitter, and ratios of metabolite on neurotransmitter, resulting ina greater prevention of learning and memory impairments such as Alzheimertype dementia.

• 인간식물환경학회지
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• 제24권1호
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• pp.107-117
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• 2021

Background and objective: The purpose of this study is to investigate the effect of a forest healing program in terms of depression, neuropsychological and physiological benefits for the elderly. Methods: For this purpose, we developed a forest therapy program for the elderly who are vulnerable to dementia and conducted a total of 11 sessions of forest therapy activities in a forest once a week. We measured the changes in depression, resting-state Electroencephalography(EEG) and heart rate variability (HRV) before and after the program. There were 60 subjects aged over 65 yesrs old. 30 subjects participated in the forest therapy program, and the other were in the control group. The Geriatric Depression Scale was used to measure the level of depression, neuroNicle FX2 (Laxtha, Korea) was used to measure the resting-state EEG, and photoplethymogram (ubpulse T1, Laxtha, Korea) was used to measure the HRV. Results: The results showed that the depression index of the experimental group improved with statistical significance after the program (experiment group = 3.267 decrease of the mean). In the EEG measurement, the alpha-peak frequency at rest (experimental group = 0.227 Hz increase of the mean) was improved (mean increase = 0.23 in the experimental group, p < .05). The high frequency of HRV, which represents the parasympathetic nerve activity of the body's autonomous response, was also significantly improved (mean increase = 0.396 in the experimental group, p < .05). Conclusion: The results suggest that the forest therapy program can reduce the cognitive, psychological and physical risk factors of dementia for the elderly at risk of cognitive decline. Therefore, forest therapy activities may be suitable for the prevention of dementia in the elderly.

• 한국인터넷방송통신학회논문지
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• 제10권6호
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• pp.209-214
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• 2010

본 논문은 이미지 분석 플랫폼(Open Eye)을 통하여서 치매노인 예방 또는 뇌졸중 환자 등을 위한 인지재활 시스템을 제안하고 한다. 본 방법은 카메라를 통하여서 사용자의 움직임에 따른 영상을 얻고 이를 OpenCV 영상처리 라이브러리를 기반으로 모션을 분석하여 이를 인지재활 시스템에 적용하였다. 제안하는 이미지 분석 시스템에서는 모션인지를 위해서 CAMshift 알고리즘을 적용하여 이미지 영역과 동작을 검출한다. 이를 통해 치매에 노출된 노인 또는 뇌졸중 환자들의 손동작 이미지를 검출하고, 검출된 이미지의 특징점을 추출한다. 추출된 결과 이미지를 다양하게 형상화하였으며, 지속적인 동작을 유도하여 운동성과 인지능력을 부여할 수 있는 게임형 인지 재활 시스템을 구현하였다.

• 동의생리병리학회지
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• 제18권6호
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• pp.1881-1891
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• 2004

Daejowhan-gamibang(DJG) is used to prevention and treatment of cerebrovascular disease, heart disease, dementia, hyperlipdemia circulatory disturbance. Korean traditional herbal prescriptions and herb medicines in neuronal cells, which have been used for the treatment of stroke and brain diseases in Korean traditional medicine were screened to study the antioxidant effects and its mechanism. Daejowhan-gamibang water extract(DJGWE) was tested on their antioxidant activity using radical scavenging effects against ABTS. It showed significant antioxidant capacities at 50㎍ concentration. The antioxidant activity of DJGWE was determined in the different concentration (10㎍, 50 ㎍, and 100㎍). At the same time, the antiperoxidation effects was determined. Lipid peroxidation in brain homogenates induced by NADPH and ADP-Fe/sup 2+/ was significantly inhibited by DJGWE in vitro. DJGWE showed a potent antioxidant and antiperoxidative activity, further investigation, in vitro and in vivo, will be needed for the confirm of possibility as an antioxidant therapeutic agents and their optimal treatment of brain diseases in human. In searching the mechanism of antioxidant effects of DJGWE, it showed the inhibition of activity of JNK, p38, ERK and caspase 3 induced by hypoxia. So, DJGWE should be surveyed for the use of the potential therapeutic prescription for stroke and brain degenerative diseases such as pakinson's disease, dementia.

• International Journal of Contents
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• 제6권3호
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• pp.30-37
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• 2010

This paper aims to propose a cognitive evaluation model to be utilized in designing game devices and developing relevant software with the purpose of the prevention of dementia of the elderly among various types of serious games for the elderly intending to improve their physical, mental or social capability. Firstly, a serious game for the elderly has been developed based on the guidelines of the areas pertaining to existing hardware, software and contents. Secondly, a pre-experiment of the game targeting specialists has been conducted in order to re-establish a cognitive evaluation model for the developed result. Thirdly, the cognitive evaluation model for the serious game for the elderly that intends to improve their cognitive capacity has been materialized based on the experiment results. Given the fact that the scope of game contents, most of which used to be focused on teenagers, have been gradually expanding to cover wider range of social classes than ever before, it is expected that the results of this study could be utilized as a model that can verify the games and their contents with special purposes based on the cognitive evaluation of the users.

• 대한통합의학회지
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• 제8권4호
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• pp.49-58
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• 2020

Purpose : This study examined the effect of a home visit cognitive training program that uses a tablet-based digital recognition rehabilitation application, Brain Doctor, on local elderly people's cognitive function and depression. Methods : This study featured 20 elderly people living in Busan Metropolitan City, South Korea, who received a voucher for a home visit service to prevent dementia. The subjects were evenly divided into an intervention group provided with Brain Doctor and a control group provided with a conventional cognitive training program. Korean version of Mini Mental State Examination (MMSE-K) and Korean version of Montreal Cognitive Assessment (K-MoCA) were used to assess cognitive function in each group. Patient Health Questionnaire-9 (PHQ-9) was used to evaluate the depression levels. Results : The intervention group showed a significant change in cognitive function and depression after the intervention (p<.05). There was a statistically significant change in cognitive function and depression between the intervention and control groups (p<.05). Conclusion : This study confirmed that Brain Doctor had a positive effect on the cognitive function and depression of elderly people in the local community. It is expected to become a useful home visit program for dementia prevention in the future.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2016년도 추계학술대회
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• pp.749-751
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• 2016

가상현실의 등장으로 인해 과거의 이미지와 영상을 통한 커뮤니케이션 방법이 3차원 공간 속으로 확장되면서 보다 사실적이고 원활한 상호작용 환경을 제공하게 되었다. 가상현실은 현실과는 달리 인간의 완벽한 통제 하에 있다는 점을 통해 현실의 대체재로 활용이 가능하며 이 같은 장점으로 인해 의학과 헬스 케어 분야에서도 가상현실을 활용한 치매 예방 및 치료가 주목받고 있다. 본 논문에서는 치매 전조 현상인 경도인지장애에 초점을 맞추어 가상현실 기반의 경도인지장애 예방훈련 시스템을 설계하고자 한다.

• 한국환경생태학회지
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• 제33권1호
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• pp.107-115
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• 2019

본 연구의 목적은 숲 환경을 이용한 산림치유 6대 요법 중 걷기, 경관 감상, 숲속 향기를 이용한 산림치유프로그램 체험활동이 독거노인의 인지기능, 우울, 삶의 질에 미치는 영향을 검증하기 위한 것이다. 연구대상은 삼척시에 거주하며 우울증과 건망이 심하다고 호소하는 독거노인 17명이 연구에 참여하였다. 이들은 각 두 집단으로 나뉘어 각 집단은 매 주 1회(총 6회기) 산림치유프로그램에 참여하여 설문조사를 하였다. 이들은 모두 인지기능, 우울, 삶의 질에서의 변화를 관찰하기 위해 한국형 간이 정신상태 검사(MMSE-K), BDI(Beck Depression Inventory 한국판), SF-36(Short Form 36 health survey questionnaire)에 대한 사전-사후(one-group pre-post test design) 설문지 검사를 받았다. 연구결과 치유 프로그램 참여 후 응답자의 정신상태와 우울 수준 그리고 삶의 질이 모두 유의미하게 높아진 것으로 나타났다. 이 결과를 통해서 산림환경을 이용한 치유프로그램 활동 참여가 은둔형 독거노인에게 인지기능 향상과 우울 해소 그리고 삶의 질 개선에 도움이 됨을 알 수 있었다. 따라서 홀로 남겨져 외부활동을 기피하는 은둔형 독거노인을 대상으로 정기적인 산림치유 프로그램에 참여토록 유도할 경우 나이와 환경으로 인한 치매 예방에 기여할 것으로 생각한다.

• 한국노년학
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• 제39권2호
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• pp.231-240
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• 2019

본 연구의 목적은 2012년부터 2015년까지의 질병관리본부의 퇴원손상심층조사 자료를 바탕으로 병원에 입원한 치매환자 중 낙상과 관련된 특성과 낙상 영향 요인을 파악하는 것이다. 한국표준질병사인분류의 질병 코드를 사용하여 치매로 진단 받은 60세 이상 환자를 선정하여, 낙상(W00-W19) 유무에 따라 낙상군과 비낙상군으로 구분한 총 1,732건을 최종분석에 사용하였다. 수집된 자료는 통계 프로그램 STATA를 이용하여 빈도분석, 교차분석(chi-square test)과 로지스틱 회귀분석을 실시하였다. 연구결과 전체 치매 입원환자 중 낙상은 8.0%에서 발생하였다. 낙상군과 비낙상군의 범주별 분석에서 통계적으로 유의한 차이는 연령에서 있었다. 질환 특성에서는 CCI(Charlson Comorbidity Index) 및 골밀도장애가 통계적으로 유의한 차이가 있었다. 낙상에 영향을 미치는 요인의 로지스틱 회귀분석 결과 60-69세 대상자를 기준으로 했을 때, 80세 이상의 노인은 낙상위험이 2.386배 높고, CCI가 0점인 대상자를 기준으로 했을 때, 3점 이상인 대상자의 낙상 위험이 0.421배로 낮으며, 골밀도장애가 없는 대상자를 기준으로 했을 때, 골밀도장애가 있는 대상자의 낙상위험이 3.581배 높았다. 본 연구의 결과 치매 입원환자는 연령이 80세 이상인 경우 약 2.3배, 골밀도장애가 있는 경우 약 3.5배 이상 낙상이 높을 수 있으며, 반면에 CCI가 3점인 경우 약 0.4배로 낙상이 낮을 수 있다. 따라서 본 연구 결과를 바탕으로 입원한 치매환자의 낙상 관련 영향 요인은 입원한 치매환자 및 돌봄자들에 대한 낙상 예방 교육에 도움이 되고 의료진의 치매환자 낙상 관리를 위한 의사결정에 기초자료로 사용되길 기대한다.

• 지역사회간호학회지
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• 제27권1호
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• pp.1-8
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• 2016

Purpose: The purpose of this study was to examine the depression and cognitive function of community-dwelling older adults. Methods: 243 aged over 65 in Won-Ju in South Korea participated in this study. Data were collected from April to June 2013 through interviews. This study utilized the Geriatric Depression Scale Short Form, the Korean version of MMSE-DS (MMSE for Dementia Screening), and infirmity testing for basic health status. Descriptive statistics, ${\chi}^2$, t-test, ANOVA, $Scheff{\acute{e}}^{\prime}s$ test, and Pearson's correlation coefficient were used. Results: 75.3% of the participants belonged to the depression group, and the prevalence of cognitive impairment was 17.3%. There were significant differences in depression and cognitive function according to gender, educational level, type of insurance, subjective health, frailty, and whether to be a client of home care service. The level of depression was significantly higher and the level of cognitive functions was significantly lower in older adults in home care services than in community-dwelling older adults. Conclusion: This study is meaningful in that it included older adults in home care services to provide information to develop effective prevention programs for improving cognitive functions. The results of this study can be used to develop future community prevention and intervention.