• Journal of Korean Clinical Health Science
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• v.10 no.2
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• pp.1600-1606
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• 2022

Objective: This study was to compares and analyzes programs applied to improve cognitive function in patients with mild cognitive impairment and early dementia in the community to find out their effectiveness. Methods: In this study, 12 papers were finalized by searching for "elderly", "cognitive", "community", and "program" using the database of the Research Information System (RISS), National Assembly Library, and Korean Studies Information (KISS). Results: Programs for cognitive function were in the order of cognitive stimulation program, arts and crafts, and exercise program. In the program, rather than applying the cognitive stimulation program alone, the program was operated by combining leisure or exercise, music, art, and handicraft. The time was shown to be 30 minutes. The most frequently used evaluation tool was MMSE, followed by GDS and BBS. By cognitive domain, cognitive stimulation program and memory, satisfaction in psychology, and balance ability in exercise were evaluated the most. In the cognitive area, various cognitive stimulation areas were included, and in the exercise area, basic exercise, muscle strength exercise, joint exercise, and balance exercise were applied. Conclusion: Therefore, developing a program to improve cognitive function for mild cognitive impairment, it will be possible to prepare guidelines to establish and development.

• Journal of Oriental Neuropsychiatry
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• v.34 no.4
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• pp.473-485
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• 2023

Objectives: The purpose of this study was to report the effectiveness of the combination of Korean medicine therapy on elderly patients with delirium due to overdose of sedative-hypnotics. Methods: The patient was diagnosed with delirium, which occurred after an overdose of sedative-hypnotics. The patient received Korean Medicine treatment, including herbal medicine, acupuncture, moxibustion and psychotherapy, and other treatments. The evaluation variables to check the effectiveness of the interventions were the Korean Version of the Delirium Rating Scale-Revised-98 (K-DRS-R-98) Mini-Mental State Examination-Korean (MMSE-K) Clinical Dementia Rating (CDR) and Manual Muscle Test (MMT). Results: During the hospitalization period, the K-DRS-R-98 score decreased from 31 to 4, MMSE-K score increased from 18 to 26. CDR score decreased from 2 to 0. MMT in the Right lower extremity was improved. Normal daily activities were possible. Conclusions: Combining Korean Medicine treatments, including herbal medicine, acupuncture, moxibustion, psychotherapy, and other treatments, may help alleviate delirium.

• Korean Journal of Psychosomatic Medicine
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• v.22 no.2
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• pp.87-92
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• 2014

Objectives : Delirium of hospitalized patients is common and it is significantly associated with increased mortality rate. Misdiagnosis rates of delirium are reported in a range of 36.7 to 63% in clinical setting. We aimed to identify the clinical features and symptomatic characteristics associated with misdiagnosis of delirium. Methods : Subjects were 256 inpatients who were referred for psychiatric consultation and diagnosed with delirium by a psychiatrist at a university hospital between January 1 and June 30, 2012. Clinical data were obtained with retrospective chart review. Patients were divided into misdiagnosed group and correct diagnosed group, after reviewing the reason which were described in the consultation request form. Results : Sixty nine(27%) subjects of the 256 patients were referred for other reasons(mood, substance, anxiety, dementia etc.) than "delirium/confusion" by clinician(misdiagnosed group). In misdiagnosed group, use of antipsychotics was more common. There were no differences between the two groups in age, gender, and department of referring clinician. Fluctuation score of DRS-R-98 was higher in the correct diagnosed group. Conclusions : In this study, the risk of misdiagnosis was higher when the patients have taken antipsychotics or less symptom fluctuation. Careful clinical attention is needed for diagnosis for delirium in these patients.

• The Journal of Internal Korean Medicine
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• v.28 no.4
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• pp.838-849
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• 2007

Backgrounds & Objectives : The aim of study was to evaluate post stroke cognitive deficit. We applied CERAD-K for post-stroke cognitive deficit, and revalued after treatment for 4 weeks. Methods : We applied CERAD-K test to 25 patients with post stroke cognitive deficit and compared with previous literature. After acupuncture treatment, moxa treatment, herb medicines, physical and occupational therapy for 4 weeks, we revalued changes by CERAD-K to 13 people that received treatment. Results : The stroke group's points were lower than the normal group in general cognition. Verbal fluency, MMSE-KC, and constructional praxis scores was lower than the AD group. Boston Naming Test, word list immediate recall, word list delayed recall, wordlist recognition, and praxis delayed recall scores were higher than the AD group. Verbal fluency (p=0.017), MMSE-KC (p=0.026), and word list immediate recall (p=0.005) scores of 13 patients participating in this study showed a statistically significant increase after treatment. Conculsions : Acupuncture treatment, moxa treatment, herb medicines, physical and occupational therapy are effective for improvement of post-stroke cognitive deficit, but this study could not demonstrate whether some treatments influenced cognition and there was a limitation in lacking a control group.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.6
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• pp.447-456
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• 2014

Until now, a disease-modifying therapy (DMT) that has an ability to slow or arrest Alzheimer's disease (AD) progression has not been developed, and all clinical trials involving AD patients enrolled by clinical assessment alone also have not been successful. Given the growing consensus that the DMT is likely to require treatment initiation well before full-blown dementia emerges, the early detection of AD will provide opportunities to successfully identify new drugs that slow the course of AD pathology. Recent advances in early detection of AD and prediction of progression of the disease using various biomarkers, including cerebrospinal fluid (CSF) $A{\beta}_{1-42}$, total tau and p-tau181 levels, and imagining biomarkers, are now being actively integrated into the designs of AD clinical trials. In terms of therapeutic mechanisms, monitoring these markers may be helpful for go/no-go decision making as well as surrogate markers for disease severity or progression. Furthermore, CSF biomarkers can be used as a tool to enrich patients for clinical trials with prospect of increasing statistical power and reducing costs in drug development. However, the standardization of technical aspects of analysis of these biomarkers is an essential prerequisite to the clinical uses. To accomplish this, global efforts are underway to standardize CSF biomarker measurements and a quality control program supported by the Alzheimer's Association. The current review summarizes therapeutic targets of developing drugs in AD pathophysiology, and provides the most recent advances in the clinical utility of CSF biomarkers and the integration of CSF biomarkers in current clinical trials.

• Journal of the Korean Data and Information Science Society
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• v.27 no.3
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• pp.773-789
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• 2016

This study was conducted to identify the sleep patterns and influencing factors of hospitalized elderly in a long-term care hospital. The sleep patterns of 142 subjects were recorded using Sleep Charts. The average sleep time of subjects was 10.7 hours a day (3.9 hours in daytime and 6.8 hours in nighttime). Sleep regularity among participants were 71.7% in all day (58.1% in day time and 80.5% in night time). The presence of dementia patients in the room (PDPR) has been identified to be a statistically significant predictor of all day sleep, and pain, PDPR, and physical function have been found to be a significant predictors of sleep regularity in all day among subjects. It suggested that elderly patients in a long-term care hospital do not slept well during night, which leads to increase in daytime sleep and decrease the quality of their sleep. Therefore, an intervention program should be developed to promote the quality of sleep among hospitalized elderly.

• Korean Journal of Clinical Pharmacy
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• v.28 no.1
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• pp.1-9
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• 2018

Polypharmacy is increasing owing to an increase in the elderly population and multimorbidities associated with the increased risk of administration of potentially inappropriate medications (PIMs). The negative effects of polypharmacy on various health conditions and aspects, such as fall, fracture, mortality, cognitive function, and dementia, have been reported. The management of excess and inappropriate polypharmacy through proper interventions and local or national guidelines has been highlighted. The purpose of polypharmacy management is to appropriately prescribe medicines that are essential to treat diseases in patients and to avoid inappropriate polypharmacy, such as interactive or duplicate medicines under prescription and PIMs for specific diseases. Community pharmacists in Australia, the EU, USA, and Japan are collaborating with prescribers to review medications to ensure that the patients can be prescribed appropriate medications. The service cost is reimbursed by public or private insurers. A study in the United States has shown that even with medication review costs, the overall medication cost has reduced. In Korea, various projects such as Drug Utilization Review service and safe use of medicines have been conducted; however, no national guidelines or management measures have been established. It is necessary to implement a national long-term plan on polypharmacy management. Furthermore, a phased implementation plan is required. Shortly, active medication review services and education programs for healthcare professionals with the support of the government should be considered in Korea with reference to other countries in order to raise awareness of seriousness and risks of inappropriate polypharmacy.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.10 no.3
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• pp.392-398
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• 2003

Purpose: The purpose of this study was to analyze trends in complementary and alternative therapy in nursing research in Korea. Method: The researchers examined academic theses and dissertations published from 1990 to 2002, and 151 articles were used for the analysis. Result: Nursing research on CAT increased rapidly from 1995 Articles with quantitative research designs made up 93.9% of the total and there were more experimental studies than non-experimental studies. Patients who had surgery, mental disorders, renal failure, hypertension, arthritis, dementia & cancer were the most frequently participants in studies on CAT. The type of CAT used in nursing research were mind-body therapy (65.8%), manual healing therapy (28.7%), phamacologic & biological therapy (3.7%), bioelectromagnetics (0.9%) and herbal therapy (0.9%). In 44 articles both psychological and physiological parameters were used as dependent variables. In 34 articles only physiological parameters were used and in 13 only psychological parameters. The most frequently used physiological parameters in CAT were pain, physiological function and vital signs, while the most used psychological parameters were anxiety, depression and stress. Conclusion: More studies about CAT are needed to extend the role and fields for professional nursing. There is a need to conduct qualitative studies in nursing about the experiences of patients who receive CAT and nurses who use CAT.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.6
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• pp.402-409
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• 2019

Patients with dementia or elderly patients who can not move at all by themselves are at a high risk of falls and bedsore due to lack of caregivers. In this paper, to solve this problem, we propose an algorithm to determine the patient's lying postures by discriminating the main body parts such as head, shoulders, and hips based on the pressure intensity sensed at regular intervals. A smart mat with a lattice structure in which a pressure sensor is arranged so that the body part can be discriminated irrespective of the physical characteristics has been implemented. It consists of two modules of $7{\times}7$ array size. Each module consists of 49 FSR-406 sensors and independently senses pressure. For each module, the body part corresponding to the upper body or the lower body is sequentially discriminated by using a pressure distribution such as a cumulative pressure sum using a filter. The proposed algorithm can identify five lying positions by examining the inclusion relationship between body parts belonging to layer-1 such as head, shoulder, and hip area.

• Journal of Convergence for Information Technology
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• v.11 no.2
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• pp.229-237
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• 2021

Among the elderly and patients with mild brain diseases (such as dementia and stroke), when there is a certain degree of self-acting ability and cognitive ability, exercise and cognitive rehabilitation are often required. However, since most of the existing rehabilitation systems are separated or specialized in exercise or cognitive rehabilitation, there is a need for a form linking both. In this paper, we propose a game-type rehabilitation system that enables both exercise and cognitive rehabilitation using CAN communication protocol, one of ICT technologies. This system uses the CAN BUS structure to separate and combine each individual module constituting the rehabilitation system in various forms. A prototype of the proposed system was actually produced to show that various types of rehabilitation environments can be implemented according to the degree of cognitive ability and motor ability of the patient (or the elderly). In addition, through several experiments using this system, it is possible to implement exercise/cognitive parallel rehabilitation applicable to various environments.