• Korean Journal of Biological Psychiatry
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• v.23 no.3
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• pp.69-79
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• 2016

Frontotemporal dementia (FTD) is a degenerative disease characterized by the selective frontal and temporal lobe atrophy, and progressive deficits in behavior, executive function, or language. The prevalence and incidence of FTD are 15-22/100000 and 2.7-4.1/100000, respectively, in midlife. Hereditary is an important risk factor for FTD. Although there is some controversy regarding the further syndromatic subdivision of the different types of FTD, FTD is clinically classified into behavioral variant of frontotemporal dementia, semantic dementia and progressive nonfluent aphasia. FTD can be misdiagnosed as many psychiatric disorders because of similarity of the prominent behavioral features. Advances in clinical, imaging, and molecular characterization have increased the accuracy of FTD diagnosis, thus developing for the accurate differentiation of these syndromes from psychiatric disorders. We also discuss about therapeutic strategies for symptom management of FTD. Medications such as serotonin reuptake inhibitors, antipsychotics, and other novel treatments have been used in FTD with various rates of success. Further advanced research should be directed at understanding and developing new diagnostic and therapeutic modalities to improve the FTD patients' prognosis and quality of life.

• Journal of Korean Academy of Nursing
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• v.48 no.2
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• pp.143-153
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• 2018

Purpose: The purpose of this study was to identify factors predicting behavioral and psychological symptoms of dementia (BPSD) in persons with dementia. Factors including the patient, caregiver, and environment based on the multi-dimensional behavioral model were tested. Methods: The subjects of the study were 139 pairs of persons with dementia and their caregivers selected from four geriatric long-term care facilities located in S city, G province, Korea. Data analysis included descriptive statistics, inverse normal transformations, Pearson correlation coefficients, Spearman's correlation coefficients and hierarchical multiple regression with the SPSS Statistics 22.0 for Windows program. Results: Mean score for BPSD was 40.16. Depression (${\beta}=.42$, p<.001), exposure to noise in the evening noise (${\beta}=-.20$, p=.014), and gender (${\beta}=.17$, p=.042) were factors predicting BPSD in long-term care facilities, which explained 25.2% of the variance in the model. Conclusion: To decrease BPSD in persons with dementia, integrated nursing interventions should consider factors of the patient, caregiver, and environment.

• Korean Journal of Psychosomatic Medicine
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• v.20 no.2
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• pp.105-111
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• 2012

Objectives : We investigated the prevalence and composite score of the neuropsychiatric symptoms in patients with mild cognitive impairment(MCI), and dementia of Alzheimer's type(AD). The aim of this study is to analyze the correlation between the result of Korean Neuropsychiatric Inventory(K-NPI) and cognitive function. Methods : A total of 163 patients diagnosed with MCI or AD was divided into three groups(55 MCI patients, 56 dementia patients with mild stage, and 52 dementia patients with moderate, severe stage). We examined neuro-psychiatric symptoms by K-NPI and compared the prevalence and composite score of each subdomain in K-NPI among three groups. Results : The most common symptoms in the MCI group were depression/dysphoria, sleep/night-time behavior, anxiety, and irritability/lability. In mild AD group, the most frequent disturbance was agitation/aggression, depression/dysphoria, anxiety, apathy/indifference, and sleep/night-time behavior. In moderate to severe AD group, the most frequent disturbance was apathy/indifference, depression/dysphoria, agitation/aggression, and delusion. The frequencies of delusion, hallucination, agitation/aggression, apathy/indifference, aberrant motor behavior, appetite/eating change were statistically significant. The total NPI score showed a negative correlation with MMSE-KC and a positive correlation with GDS. Conclusions : Neuropsychiatric symptoms are common features of MCI and AD. These symptoms observed in MCI are similar to those of mild AD. Psychosis is most common in moderate to severe AD, leading to a faster rate of cognitive decline. Therefore, proper management according to the neuropsychiatric symptoms of MCI and three stages of dementia is needed.

• Therapeutic Science for Rehabilitation
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• v.9 no.1
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• pp.56-68
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• 2020

Objective : This study introduces domestic and overseas systematic assessment tools that can identify eating problems of dementia patients based on abnormal behavior observations and turns them into Korean through the verification of content placement by expert groups. Methods : Three types of assessment tools were selected for final development in Korean version through several meetings based on a wide range of relevant literature searches. The 3 selected assessment tools were first translated by the researchers, and a 9-person expert team was used to verify the Content Validity Index. Results : The EBS content equivalence calculation shows that all 6 questions and 1 response item had a CVI value 0.9, and all items were included in Korean EBS without modification. The EdFED content equivalence calculation showed that all 11 questions had CVI value 0.9, which was included in the Korean edition of EdFED without modification. The content equivalence calculation of the FDI showed that all 19 questions had a CVI of 0.8 or higher, and all items were included in the Korean version of the FDI without modification of the item. Conclusion : Korean versions of the EBS, EdFED and FDI, which are based on behavioral observation and diet tools for people with dementia, have been developed. Early determination of problems related to diet in dementia patients and providing proper intervention through observational Korean version assessment tools is vital in terms of strengthening patient nutrition and reducing caregivers' burden.

• Journal of Society of Occupational Therapy for the Aged and Dementia
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• v.12 no.2
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• pp.13-18
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• 2018

Objective : The purpose of this study is to confirm the basis for the effectiveness of sleep intervention for dementia progression. Method : PsycINFO, CINAHL, MEDLINE, PubMed, Science Direct, PEDro, Cochrane library was used to search for published papers from 2000 to 2017 using dementia, sleep, and randomized controlled trials (RCTs). Based on the results, author analyzed the papers that met the selection criteria. Result : Finally, five papers were selected. Among them, there were four papers showing that the effectiveness of the sleep intervention was not proven to be one. Conclusion : The results of this study can provide a basis for the sleep intervention effect of dementia patients. A program to actively intervene to prevent patients' behavior control and disease progression through solving sleep problems of dementia patients is needed.

• Journal of Korean Clinical Nursing Research
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• v.14 no.2
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• pp.115-126
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• 2008

Purpose: This study was aimed to develop an aromatherapy hand massage program, and evaluate the effects of aromatherapy hand massage on cognitive function, sleep disturbance and problematic behaviors of elderly with dementia. Method: The research design was a nonequivalent control group non-synchronized quasiexperimental study. Aromatherapy hand massage was administrated to experimental groupI for 2 weeks, jojoba oil massage were administrated to experimental groupII for 2 weeks, and no treatment for control group for 2 weeks. Data were analyzed using the $x^2-test$, ANOVA, ANCOVA and $Scheff{\acute{e}}$ test in the SPSS 12.0 program. Results: Experimental group I showed significant changes in sleep disturbance and problematic behaviors compared to those in experimental groupII or control group. Conclusion: Aromatherapy hand massage program is found effective on sleep disturbance and problematic behaviors of elderly with dementia.

• The Journal of Internal Korean Medicine
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• v.19 no.1
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• pp.291-300
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• 1998

Dementia is the neurodegenerative process that affects cognition, behavior and function and one of the most prominent diseases of dementia is Alzheimer's disease(AD). AD is a dementing illness characterized clinically by the progressive and irreversible deafferentation of the limbic system, association neocortex and basal forebrain. A number of conditions are known to be predisposing risk factors for AD. In several of these, initiation of glial-mediated inflammatory pathways as a mechanism of AD is getting a lot of attention. On the other hand, a biochemical marker for monitoring the onset and progression of the disease would be a valuable tool for disease management. Also such a marker might be used as an end point in clinical intervention protocols. This biochemical marker will have the potential for identifying subjects afflicted with the disease and possibly for monitoring the onset and longitudinal progression of the disease. Here we have reviewed the latest papers of different approaches to AD. Of course, there is a section of PET which is very useful clinically nowadays.

• Journal of Digital Convergence
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• v.11 no.12
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• pp.495-505
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• 2013

This study aims to evaluate the effects of aromatherapy and a foot reflex massage program on the cognition, anxiety, aggressive behavior, and wandering behavior of elderly with dementia. The research design was a non-equivalent control group, quasi-experimental study where 43 subjects were divided into two groups. Aromatherapy and foot reflex massage was administered to the experimental group (N=21), and no treatment was administered to the control group (N=22). The data was analyzed using the ${\chi}^2$-test, t-test, while the repeated measures of ANOVA were utilized with the SPSS/Win 18.0 program. The experimental group did not show significant differences in cognitive function; however, it showed significant differences in anxiety, aggressive behavior, and wandering behavior in relation to the control group. Thus this research suggests aromatherapy and a foot reflex massage program as nursing intervention to improve the quality of life of elderly with dementia.

• Journal of the Korea Convergence Society
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• v.11 no.5
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• pp.327-333
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• 2020

The aims of this study was to verify the validity using group comparison method and test/retest reliability of the Communication Behavior Scale for Nurses Caring for People with Dementia(CBS-D). The subjects were nurses who have worked at elderly care facilities in D, U and Y cities(n = 67), and nurses who have worked at general hospitals in D and U cities. The scores of the communication behaviors of nurses working in elderly care facilities were significantly higher than those of nurses working in general hospitals(t=2.49, p=.014). The Intraclass Correlation Coefficients for the test-retest reliability test was .813. Therefore, it was confirmed that CBS-D is an appropriate evaluation tool for evaluating the level of the nurse's communication behavior through various logical analyzes, and it is expected that it can be used in various ways for nursing care for people with dementia.

• Journal of Industrial Convergence
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• v.19 no.5
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• pp.61-67
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• 2021

This study is a one group pretest-posttest design study to confirm the effect of geriatric nursing practice on elderly care attitude and dementia communication behavior of student nurses. The study was conducted from September to December, 2018. Data were collected through self-report questionnaires of 59 student nurses. The data were analyzed by frequencies and paired t-test using SPSS 21.0 program. As a result, elderly care attitude and dementia communication behavior were significantly increased after the geriatric nursing practice compaired to before the geriatric nursing practice. The results of this study can be used as basic data for the composition of the practice curriculum for student nurses to improve their competence as nurses in the future.