• Proceedings of the Korea Concrete Institute Conference
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• 1995.10a
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• pp.69-74
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• 1995

The primary purpose of this study is to investigate reusal techniques of fly ash of combined heat power plant in the construction field, which may contribute to the saving of construction materials and conservating environment. Firstly chemical and physical characteristics of fly ash is analysed. And then, the usability of the concrete is tested by investigating the flowablility and stength development through parameters of various replacement ratios with respect to different mixing conditions. Finally, the durability and mechanical properties(elastic modulus) of the concrete is tested. As the result of the study, the following conclusions are derived : (1) the quantity of the CaO in the fly ash is relatively high based on the chemical analysis, (2)the compressive strength ratio of the mortar is satisfied with the specification, but the unit water ratio increased, (3)high strength concrete of more than 400kg/$\textrm{cm}^2$ can be developed in the ranges of FA 30%, W/B 40%, (5)the slump loss with the elapsed time due to the delivery is decreased as the replacement ratio of the fly ash is increased, (6)the modulus of the elasticity is matched withn the specification of the Architectural Institute of Korea.

• The Journal of Korean Medicine
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• v.26 no.2 s.62
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• pp.32-51
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• 2005

Objectives: To study the effect of Artemisiae Capillaris Herba extracts, that have been used as oriental medicine to treat liver disease, on the perinatal and lactational n;)productive toxicity of SD rats when administered by oral lavage. Methods: Female SD rats were dosed from 6 days of gestation to 3 weeks postpartum. This was conducted in accordance with the recommendations of the KFDA Guidelines for Detection of Toxicity to Reproduction for Medicinal Products. Results: No Artemisiae Capillaris Herba extracts treatment-related changes in clinical signs, mortalities, implantation number, dead fetus number, loss rate of fetus, number of live young, survival rate of fetus, sex ratio of live young, external anomalies, pregnancy periods, viability index, lactational index, survival rate of litters at 4 days after birth or delivery index were demonstrated in any dosed levels in this study. However, the body weight and gains, food consumption and absolute organ weights of brain, adrenal glands, liver, spleen, kidney, ovaries and heart were significantly increased in 2000 or 1000mg/kg-dosing groups and the relative organ Weights of adrenal glands were significantly increased in 2,000mg/kg-dosing groups. Therefore, it was concluded that this increase was natural according to growth. Also, no changes of gross findings, clinical signs, mortalities, body weight and gains, physical development results, necropsy findings, organ weight, faculty test, open filed test and water-filled simple T-maze test, copulation, fertility, pregnancy indices, body weight and gains during gestation periods, necropsy findings, corpora lutea number, implantation number, implantation rate, dead fetus number, post-implantation loss rate, live young, post-implantation survival rate, sex ratio of live young, external anomalies and individual body weights of live young were demonstrated in any dosed levels in this study. Conclusions: It is considered that the NOAEL (No-Observed-Adverse-Effect Level) for perinatal and lactational reproductive toxicity of Artemisiae Capillaris Herba extracts was up to 2000mg/kg/day because no changes of other perinatal and lactational reproductive indices were demonstrated.

• Nuclear Engineering and Technology
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• v.32 no.4
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• pp.395-409
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• 2000

Parametric studies were performed to assess the sensitivity in determining the maximum in-vessel heat removal capability from the core material relocated into the lower plenum of the reactor pressure vessel (RPV）during a core melt accident. A fraction of the sensible heat can be removed during the molten jet delivery from the core to the lower plenum, while the remaining sensible heat and the decay heat can be transported by rather complex mechanisms of the counter-current flow limitation (CCFL) and the critical heat flux (CHF）through the irregular, hemispherical gap that may be formed between the freezing oxidic debris and the overheated metallic RPV wall. It is shown that under the pressurized condition of 10MPa with the sensible heat loss being 50% for the reactors considered in this study, i.e. TMI-2, KORI-2 like, YGN-3&4 like and KNGR like reactors, the heat removal through the gap cooling mechanism was capable of ensuring the RPV integrity as much as 30% to 40% of the total core mass was relocated to the lower plenum. The sensitivity analysis indicated that the cooling rate of debris coupled with the sensible heat loss was a significant factor The newly proposed heat removal capability map (HRCM) clearly displays the critical factors in estimating the maximum heat removal from the debris in the lower plenum. This map can be used as a first-principle engineering tool to assess the RPV thermal integrity during a core melt accident. The predictive model also provided ith a reasonable explanation for the non-failure of the test vessel in the LAVA experiments performed at the Korea Atomic Energy Research Institute (KAERI), which apparently indicated a cooling effect of water ingression through the debris-to-vessel gap and the intra-debris pores and crevices.

• Korean Journal of Soil Science and Fertilizer
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• v.44 no.6
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• pp.983-990
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• 2011

Universal Soil Loss Equation (USLE) has been used to estimate potential long-term soil erosion in the fields. However, the USLE does not estimate sediment yield due to lack of module considering sediment delivery ratio (SDR) for watershed application. For that reason, the Sediment Assessment Tool for Effective Erosion Control (SATEEC) system was developed and applied to compute the sediment yield at watershed scale. However, the R factor of current SATEEC Ver. 2.1 was estimated based on 5-day antecedent rainfall, it is not related with fundamental concept of R factor. To compute R factor accurately, the energy of rainfall strikes should be considered. In this study, the R module in the SATEEC system was enhanced using formulas of Williams, Foster, Cooley, CREAMS which could consider the energy of rainfall strikes. The enhanced SATEEC system ver. 2.2 was applied to the Imha watershed and monthly sediment yield was estimated. As a result of this study, the $R^2$ and NSE values are 0.591 and 0.573 for calibration period, and 0.927 and 0.911 for validation period, respectively. The results demonstrate the enhanced SATEEC System estimates the sediment yield suitably, and it could be used to establish the detailed environmental policy standard using USLE input dataset at watershed scale.

• Korean Journal of Exercise Nutrition
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• v.16 no.2
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• pp.73-84
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• 2012

Thyroid hormones are important for the development of the brain including the cerebellum. In the present study, we investigated the effect of treadmill exercise on the survival of Purkinje neurons and the activation of astrocytes in the cerebellar vermis of hypothyroidism-induced rat pups. On the day of perinatal 14, pregnant rats were divided into two groups (n = 5 in each group): the pregnant control group and the pregnantmethimazole (MMI)-treated group. For the induction of hypothyroidism in the rat pups, MMI was added to the drinking water (0.02% wt/vol), from the day of perinatal 14 to postnatal 49. After delivery, male rat pups born from the pregnant control group were assigned to the control group. Male rat pups born from the MMI-treated group were divided into the hypothyroidism-induction group, the hypothyroidism-induction with treadmill exercise group, and the hypothyroidism-induction with thyroxine (T4) treatment group (n = 10 in each group). The rat pups in the exercise group were forced to run on a treadmill for 30 min once a day for 4 weeks, starting on postnatal day 22. In the hypothyroidism-induced rat pups, motor coordination was reduced and Purkinje cell death and reactive astrocytes in the cerebellar vermis were increased. Treadmill exercise enhanced motor coordination, increased the survival of Purkinje neurons, down-regulated reactive astrocytes, and enhanced brain-derived neurotrophic factor (BDNF) and receptor tyrosine kinase B (TrkB) expressions in the hypothyroidism-induced rat pups. These results suggest that treadmill exercise has beneficial effects in terms of protecting against thyroid dysfunction by increasing T3 and T4 and the related protein, BDNF, as well as TrkB, inhibition on astrocyte activation and the reduction of Purkinje cell loss regarding the cerebellum in hypothyroidism rat pups.

• Proceedings of the Korea Water Resources Association Conference
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• 2011.05a
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• pp.335-335
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• 2011

토양유실은 농업환경지표를 비롯한 국제 규범에서 농업에 의한 환경오염의 핵심문제로 제기되고 있다. 이러한 토양유실의 문제점을 해결하기 위해 USLE를 기반으로 한 SATEEC모형을 사용하여 토양유실량 및 유사량을 산정하였다. SATEEC모형은 USLE입력자료와 DEM을 이용하여 산정된 토양유실량 과 GA-SDR모듈을 통해 산정된 유달률(Sediment Delivery Ratio, SDR)을 통하여 최종유출구에서의 유사량을 산정한다. 많은 연구자들은 최종유출구에서의 유사량을 실측유사량과 비교하여 비슷하게 모의되면 유역의 특성을 잘 반영한다고 판단하므로 SATEEC모형의 단점인 토양유실량이 과하게 산정되는 문제점을 중요하게 생각하지 않는다. 하지만 SATEEC 모형의 결과값인 유사량의 신뢰도를 향상시키기 위해서는 토양유실량 검증을 통한 정확한 입력자료 구축이 필요하다. 따라서 본 연구에서는 여러개의 토양유실량 시나리오를 만들어 이에 따른 SATEEC 모형의 유사량을 비교/평가하고, 이를 이용하여 토양유실량의 검증이 필요함을 제시하고자 한다. 본 연구에서 사용한 토양유실량 시나리오는 총 4개로써, 시나리오 1은 SATEEC모형을 이용하여 산정된 토양유실량이며, 시나리오2~4는 ArcGIS를 사용하여 기존의 토양유실량 값에 ${\pm}0.25$의 범위를 주어 새롭게 산정된 토양유실량으로 SATEEC모형을 이용한 유사량 산정시 입력자료로 활용하였다. 그 결과 SATEEC모형을 이용하여 산정된 토양유실량은 시나리오별로 차이를 보였다. 또한 SATEEC GA-SDR모듈을 통해 예측된 토양유실량 값과 실측유사량을 이용하여 유달률을 산정하였으며 유달률도 토양유실량 시나리오별로 차이를 보였다. 따라서 SATEEC모형을 이용하여 최종유출구에서의 유사량 산정 결과 토양유실량의 차이에도 불구하고 유사량은 거의 비슷한 값을 나타내고 있으며, 최종유출구에서의 모의된 예측 유사량이 실측유사량과 비교 시 R2=0.688, EI=0.643 정도로 실측유사량과 비슷한 경향을 나타냈다. 따라서 SATEEC모형을 이용하여 유사량 산정시 먼저 문헌을 통한 토양유실량 검증이 필요하리라 판단되며, 문헌을 통해 토양유실량 검증 후 정확한 입력자료를 구축하여 유역에서의 유사량 저감을 위한 최적관리 기법 분석에 사용할 수 있도록 프로세서를 구축해야 할 것이라 판단된다.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.41 no.4
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• pp.315-324
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• 2015

In this study, we prepared liquid crystal emulsion composed of amphiphilic substance $C_{14-22}$ alcohol, $C_{12-20}$ alkyl glucoside, behenyl alcohol and studied liquid crystal emulsion of properties and in vitro skin permeation. The results of formulation experiments, the clear liquid crystalline structure was observed in the ratio of $C_{14-22}$ alcohol 0.8%, $C_{12-20}$ alkyl glucoside 3.2%, behenyl alcohol 4% in the formulation. The results of physical property measurements, the viscosity of liquid crystal emulsion and O/W emulsion applied as a control group was respectively $1871.26{\sim}1.15Pa{\cdot}s$, $1768.69{\sim}1.14Pa{\cdot}s$ and the shear stress of O/W emulsion was 178.68 ~ 909.18 Pa, that of liquid crystal emulsion was 190.45 ~ 919.38 Pa. The storage modulus of O/W emulsion was 3428.53 ~ 9157.45 Pa, that of liquid crystal emulsion was 4487.82 ~ 8195.59 Pa. The tan (delta) value of O/W emulsion which means a ratio of viscosity to elasticity was 0.43 ~ 0.19, and that of liquid crystal emulsion was 0.23 ~ 0.25. The water content value on the skin for liquid crystal emulsion was significantly higher from 1 h to 6 h compared with that of O/W emulsion and the transepidermal water loss on the skin was significantly superior in skin moisture loss suppression from 30 min to 4 h compared with that of O/W emulsion. The results of skin permeation using glycyrrhizic acid, the result of skin permeation amount of liquid crystal emulsion for 24 h was $64.58{\mu}g/cm^2$, that of O/W emulsion was $37.07{\mu}g/cm^2$, that of butylene glycol solution was $41.05{\mu}g/cm^2$. Hourly permeability results, it is showed that skin penetration effect of the liquid crystal emulsion increases after 8 h. These results suggest that liquid crystal emulsions are effective for skin moisturizing effect and function as potential efficacy ingredient delivery system for the transdermal delivery.

• Journal of The Korean Society of Agricultural Engineers
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• v.49 no.3
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• pp.79-88
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• 2007

This paper suggests a hierarchial method to select the target sites for the nonpoint source pollution management considering factors which reflect the interrelationships of significant outflow characteristics of nonpoint source pollution at given sites. The factors consist of land slope, delivery distance to the outlet, effective rainfall, impervious area ratio and soil loss. The weight of each factor was calculated by an analytic hierarchy process(AHP) algorithm and the resulting influencing index was defined from the sum of the product of each factor and its computed weight value. The higher index reflect the proposed target sites for nonpoint source pollution management. The proposed method was applied to the Baran HP#6 watershed, located southwest from Suwon city. The Agricultural Nonpoint Pollution Source(AGNPS) model was also applied to identify sites contributing significantly to the nonpoint source pollution loads from the watershed. The spatial correlation between the two results for sites was analyzed using Moran's I values. The I values were $0.38{\sim}0.45$ for total nitrogen(T-N), and $0.15{\sim}0.22$ for total phosphorus(T-P), respectively. The results showed that two independent estimates for sites within the test water-shed were highly correlated, and that the proposed hierarchial method may be applied to select the target sites for nonpoint source pollution management.

• Biomolecules & Therapeutics
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• v.25 no.4
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• pp.411-416
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• 2017

Paclitaxel (PTX) is a effectively chemotherapeutic agent which is extensively able to treat the non-small cell lung, pancreatic, breast and other cancers. But it is a practically insoluble drug with water solubility less than $1{\mu}g/mL$, which restricts its therapeutic application. To overcome the problem, hyaluronic acid-complexed paclitaxel nanoemulsions (HPNs) were prepared by ionic complexation of paclitaxel (PTX) nanoemulsions and hyaluronic acid (HA) to specifically target non-small cell lung cancer. HPNs were composed of ${\small{DL}}-{\alpha}$-tocopheryl acetate, soybean oil, polysorbate 80, ferric chloride, and HA and fabricated by high-pressure homogenization. The HPNs were $85.2{\pm}7.55nm$ in diameter and had a zeta potential of $-35.7{\pm}0.25mV$. The encapsulation efficiency was almost 100%, and the PTX content was 3.0 mg/mL. We assessed the in vivo antitumor efficacy of the HPNs by measuring changes in tumor volume and body weight in nude mice transplanted with CD44-overexpressing NCI-H460 xenografts and treated with a bolus dose of saline, $Taxol^{(R)}$, PTX nanoemulsions (PNs), or HPNs at a dose of 25 mg/kg. Suppression of cancer cell growth was higher in the PN- and HPN-treated groups than in the $Taxol^{(R)}$ group. In particular, HPN treatment dramatically inhibited tumor growth, likely because of the specific tumor-targeting affinity of HA for CD44-overexpressed cancer cells. The loss of body weight and organ weight did not vary significantly between the groups. It is suggest that HPNs should be used to effective nanocarrier system for targeting delivery of non-small cell lung cancer overexpressing CD44 and high solubilization of poorly soluble drug.

• Spatial Information Research
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• v.3 no.1
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• pp.1-18
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• 1995

Despite the widespread use of GIS over the past ten years, it has been limited application for regional modeling of pollutant loadings such as sediment, nitrogen, and phosphorus(non-point source pollution), The goals of this study were to: select important processes and parameters of watersheds that contribute to non-point source pollution degradation, develop a ranking model to use the environmental geologic data and verify the model by comparing results with existing water quality data(Chung-ju Lake) for specific watersheds, The GIS database consisted of topography, geology, soils, precipitation, rainfall erosivity, land use, and watershed boundaries. The index(NPSP) for assessing non-point source pollution was comprised in the following three seperate components: soil loss index(SLI) assesses the potential soil erosion and sedim-ent delivery from field to stream; run-off potential ratio(R.P.R) predicts the potential production of surface runoff; chloropgyll-a index ranks the potential manure(animal or human) production within a watershed. The GIS model was a valuable tool to assess the impact of environmental pollation in watersheds.