• 한국건설관리학회논문집
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• 제12권5호
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• pp.81-92
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• 2011

위험형 CM(CM at Risk) 제도의 시행과 함께 토목시설물에도 CM계약사례가 증가할 것으로 예상되어, 국토해양부 등에서는 CM 업무지침을 공표하고 있다. 현재 공표된 CM 업무지침은 CM 계약 이후의 업무지침이지만, CM 발주사례가 부족한 토목사설을 포함한 공공사업에서는 CM 발주 자체에 필요한 CM발주의 가획단계부터 CM 업자 (Construction Manager, CMr) 선정까지의 업무지침이 필요한 실정이다. 따라서 본 연구에서는 발주처의 건설사업관리 발주업무를 발주 기획단계부터 CMr 선정단계까지 표준화된 프로세스 모형으로 구축하였으며, 이를 위해 CM발주 업무분류체계를 구성하였다. 또한 연구에서는 구축된 모형에 근거한 CM 발주지원 시스템을 개발하여 시스템의 실무 운영성을 검증하였다. 이러한 연구는 CM 발주사례가 부족한 발주처의 CM 발주업무 지원체계로 활용성을 가질 수 있다.

• 로봇학회논문지
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• 제18권1호
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• pp.29-36
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• 2023

This paper shows a design of a gripper with an adjustable working area to depalletize a delivery cardboard box of various sizes. The gripper should pick the box with only one flat surface to lift the boxes stacked close to each other. The lift force of the gripper is the vacuum suction force. To handle boxes of various sizes, the gripper adjusts the working area. The gripper operates four vacuum generators independently. The simultaneous rotation on different axes of four gripper-arms with suction cups moves the position of suction force. The six operation modes of the gripper are divided into the size of the working area. The operation mode is determined according to the size of the top side of the box. Experiments are conducted by lifting the box of various sizes. The gripper can pick the box of various sizes without vacuum leaks from unused cups. Also, the experiments verify the improvement of stability of the box by adjusting the working area of the gripper. The gripper can lift the box without deformation of the box by adjusting the working area.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2005년도 추계종합학술대회
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• pp.189-192
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• 2005

홈 네트워크 서비스의 활성화와 더불어 홈 네트워크 제어를 포함하는 다양한 서비스가 홈 게이트웨이를 중심으로 제공되고 있는데, 이러한 다양한 서비스의 지속적인 제공과 업그레이드 등을 위해서는 개방성 및 확장성을 갖춘 서비스 분배관리 플랫폼 (Service Delivery & Management Platform)이 필수 요소가 된다. 서비스 분배관리 플랫폼은 홈 게이트웨이를 관리하는 기능 뿐아니라. 홈 게이트웨이상에 다운로드된 서비스의 라이프 사이클을 관리하는 방법을 제공한다. 서비스 제공자는 개발한 서비스 응용을 서비스 플랫폼에 등록하고, 서비스 분배라는 행위를 거쳐 홈게이트웨이의 프레임워크상에 다운로드되며, 해당 서비스 응용은 설치와 동시에 구동되면서 서비스 사용자에게 서비스를 제공하게 된다. 본 고에서는 홈네트워크 서비스 분배관리를 제공하는데 있어서, 서비스 사용자의 요구에 의한 pull 방식의 서비스 제공 방법과 시스템 관리자에 의한 push 방식의 서비스 제공 방법을 지원하는 서비스 분배관리 시스템의 구조 및 시나리오에 대해 제시하고자 한다.

• Natural Product Sciences
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• 제28권3호
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• pp.93-104
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• 2022

Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to the global healthcare system. Ineffective and resistance to antibiotic treatments have increased morbidity and mortality rates worldwide. New and effective antibiotics are needed to combat against bacterial resistance. Endophytic fungi are crucial reservoirs of novel bioactive metabolites. In particular, the secondary metabolites show promising therapeutic potential, notably, antibacterial. This review discussed the emerging potential of endophytic fungi as anti-MRSA agents. The ecological sources of endophytic fungi were discussed with the synthesis of bioactive metabolites. The mode of antibacterial actions was elucidated to give a better understanding of the mechanisms involved. This review may serve as an important reference for future discovery and developments of anti-MRSA agents from endophytic fungi.

• Journal of Yeungnam Medical Science
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• 제21권1호
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• pp.60-66
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• 2004

2001년 5월에서 11월까지 영남대학교 병원 산부인과 외래를 방문한 20세 이상의 환자 중 무작위로 선택한 412명을 대상으로 설문 조사를 하였고 이를 분석하여 다음과 같은 결과를 얻었다. 1. 대구지역 여성들의 요실금 유병률 조사대상자의 평균 연령은 45.5세이었으며 유병률은 46.84%로 조사되었다. 2. 대상환자의 연령이 증가할수록 요실금의 유병률이 높게 나타났다(p=0.00001). 3. 분만횟수가 증가할수록 요실금의 유병률이 증가하였다(p=0.007). 4. 제왕절개술에 비하여 질식분만시 요실금의 유병률이 높게 나타났다(p=0.001). 5. BMI, 유산, 폐경, 호르몬 요법, 당뇨병, 갑상선 질환, 만성 호흡기 질환은 요실금과 유의한 관계가 없는 것으로 나타났다(p=0.117, p=0.145, p=0.546, p=0.256, p=0.241, p=0.343, p=0.185).

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2003년도 학술발표대회 발표논문초록집
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• pp.98-98
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• 2003

Direct gene transfer to mammalian tissues has significant potential for gene therapy and transgenesis. Liposome-mediated in vivo transfection has begun to gain attention as an alternative to viral vectors, and may also be a good mode of transfection in gene transfer. Interestingly, polymerized cationic liposomes are reported to be very stable in the bloods and efficient for in vivo gene transfer. To examine a possible gene delivery in vivo, we investigated the efficacy and safety of the liposome-mediated gene transfer using vein injection in chick or mouse as model animals. The number of injected pGFP-LacZ using either a commercial or home-made liposomes was 8 and 19 at 16 and 7 day of hatch, respectively. One of injected chick of each experiments was analyzed and the rest is being bred. In mouse, 4/22 showed expression of pGFP-LacZ but 8/22 showed no expression and the remaining animals are also being bred. After injection of liposome/pGFP-LacZ complex into wing vein of 7 or 16 day-old chick, pGFP-LacZ was detected in various tissues isolated from not only young chick but also old chick were turned out to possess. exogenous DNA. Transcripts and proteins of the transgene were also detected by RT-PCR or histochemical analysis, respectively. These results suggest that injected DNA were inserted to genome and produced mRNA and proteins in various tissues and may give an important tools for effective gene delivery in gene therapy or transgenesis.

• Journal of Ginseng Research
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• 제41권1호
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• pp.78-84
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• 2017

Background: In the present study, metabolite profiles of ginsenosides Rk1 and Rg5 from red ginseng or red notoginseng in zebrafish were qualitatively analyzed with ultraperformance liquid chromatography/quadrupole-time-of-flight MS, and the possible metabolic were pathways proposed. Methods: After exposing to zebrafish for 24 h, we determined the metabolites of ginsenosides Rk1 and Rg5. The chromatography was accomplished on UPLC BEH C18 column using a binary gradient elution of 0.1% formic acetonitrile-0.1% formic acid water. The quasimolecular ions of compounds were analyzed in the negative mode. With reference to quasimolecular ions and MS2 spectra, by comparing with reference standards and matching the empirical molecular formula with that of known published compounds, and then the potential structures of metabolites of ginsenosides Rk1 and Rg5 were acquired. Results: Four and seven metabolites of ginsenoside Rk1 and ginsenoside Rg5, respectively, were identified in zebrafish. The mechanisms involved were further deduced to be desugarization, glucuronidation, sulfation, and dehydroxymethylation pathways. Dehydroxylation and loss of C-17 residue were also metabolic pathways of ginsenoside Rg5 in zebrafish. Conclusion: Loss of glucose at position C-3 and glucuronidation at position C-12 in zebrafish were regarded as the primary physiological processes of ginsenosides Rk1 and Rg5.

• Journal of Power Electronics
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• 제18권1호
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• pp.234-250
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• 2018

This paper presents a new load sharing control for use between paralleled three-phase inverters in an islanded microgrid based on the online line impedance estimation by the use of a Kalman filter. In this study, the mismatch of power sharing when the line impedance changes due to temperature, frequency, significant differences in line parameters and the requirements of the Plug-and-Play mode for inverters connected to a microgrid has been solved. In addition, this paper also presents a new droop control method working with the line impedance that is different from the traditional droop algorithm when the line impedance is assumed to be pure resistance or pure inductance. In this paper, the line impedance estimation for parallel inverters uses the minimum square method combined with a Kalman filter. In addition, the secondary control loops are designed to restore the voltage amplitude and frequency of a microgrid by using a combined nominal value SOGI-PLL with a generalized integral block and phase lock loop to monitor the exact voltage magnitude and frequency phase at the PCC. A control model has been simulated in Matlab/Simulink with three voltage source inverters connected in parallel for different ratios of power sharing. The simulation results demonstrate the accuracy of the proposed control method.

• 대한산업공학회지
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• 제33권1호
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• pp.164-165
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• 2007

• Journal of Pharmaceutical Investigation
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• 제37권3호
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• pp.149-158
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• 2007

To investigate the permeability of lidocaine, percutaneous absorption studies were performed using excised hairless mouse skin and the penetration of lidocaine via the skin was determined. To increase the skin permeation of lidocine, the effects of $Labrasol^{(R)}$, $Labrafil^{(R)}$, $Labrafac^{(R)}$ and $Transcutol^{(R)}$ were investigated. The skin permeation of lidocaine was increased when $Labrasol^{(R)}$ and $Transcutol^{(R)}$ were used as permeation enhancer. To evaluate the influence of ultrasound, various factors such as application modes (continuous mode and pulsed mode), frequency (1.0 and 3.0 MHz) and intensity (1.0, 1.5 and 2.0 w/$cm^2$) were investigated with lidocaine hydrogel. The pronounced effect of ultrasound on the skin permeation of lidocaine was observed at all ultrasound energy levels. The influence of frequency having an effect on skin permeation rate was higher in the case of using 1 MHz, 2.0 w/$cm^2$ and continuous treatment. As the intensity of ultrasound increased, the permeation of lidocaine was accelerated. The in vivo anesthetic effects were evaluated by two aspects as mechanical threshold and electrical threshold. Six healthy volunteers consented to the randomized, double-blind, and cross-over designed study in each group. In each subject, 3 groups were adapted such as K group (ultrasound with gel base only), L group (lidocaine gel) and B group (ultrasound with lidocaine gel). In conclusion, lidocaine was potent anesthetic which could be block pain threshold effectively. And ultrasound could accelerate the skin penetration of lidocaine. The phonophoretic delivery system could be a good candidate for lidocaine as a local anaesthetic to improve the skin permeation and in vivo anaesthetic effect.