• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2009.01a
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• pp.376-380
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• 2009

Peer-to-Peer content delivery technology recently begins to be used not only for file sharing applications such as eDonkey but also for every kind of content services. KBS, a broadcasting company in Korea, is aggressively driving to apply Peer-to-Peer technology to KBS's commercial internet video service but we found that there are two big huddles. First, end users may refuse to share their own resources for KBS's cost reduction using Peer-to-Peer content delivery technology. Second, it may cause that the number of free-riders increases and the efficiency of the overall system would fall. From commercial service provider's perspective, we have to avoid that end users have unfavorable impressions on the service and the usefulness of Peer-to-Peer technology decreases. In order to overcome these problems, we studied how to offer incentive to end users and how much incentive would be reasonable, and then applied the result to real service for verification.

• Management Science and Financial Engineering
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• v.18 no.1
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• pp.27-37
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• 2012

This paper is motivated by a military cargo-plane routing problem which is a pickup-and-delivery problem in which load splits and node revisits are allowed (PDPLS). Although this recent evolution of a VRP-model enhances the efficiency of routing, a solution method is more of a challenge since the node revisits entail closed walks in modeling vehicle routes. For such a case, even a compact IP-formulation is not available and an effective method had been lacking until Nowak et al. (2008b) proposed a heuristic based on a tabu search. Their method provides very reasonable solu-tions as demonstrated by the experiments not only in their paper (Nowak et al., 2008b) but also in ours. However, the computation time seems intensive especially for the class of problems with dynamic transportation requests, including the military cargo-plane routing problem. This paper proposes a more scalable algorithm hybridizing a tabu search for pricing subproblem paused as a single-vehicle routing problem, with a column generation approach based on Dantzig-Wolfe decomposition. As tested on a wide variety of instances, our algorithm produces, in average, a solution of an equiva-lent quality in 10~20% of the computation time of the previous method.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.9 no.4
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• pp.87-97
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• 2009

A Mobile Ad hoc Network (MANET) is characterized by multi-hop wireless connectivity, frequently changing network topology with mobile nodes and the efficiency of the dynamic routing protocol plays an important role in the performance of the network. In this paper, the performance of five routing protocols for MANET is compared by using OPNET modeler: AODV, DSR, GRP, OLSR and TORA. The various performance metrics are examined, such as packet delivery ratio, end-to-end delay and routing overhead with varying data traffic, number of nodes and mobility. In our simulation results, OLSR shows the best performance in terms of data delivery ratio in static networks, while AODV has the best performance in mobile networks with moderate data traffic. When comparing proactive protocols (OLSR, GRP) and reactive protocols (AODV, DSR) with varying data traffic in the static networks, proactive protocols consistently presents almost constant overhead while the reactive protocols show a sharp increase to some extent. When comparing each of proactive protocols in static and mobile networks, OLSR is better than GRP in the delivery ratio while overhead is more. As for reactive protocols, DSR outperforms AODV under the moderate data traffic in static networks because it exploits caching aggressively and maintains multiple routes per destination. However, this advantage turns into disadvantage in high mobility networks since the chance of the cached routes becoming stale increases.

• Archives of Plastic Surgery
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• v.48 no.4
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• pp.448-456
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• 2021

Background Locoregional stem cell delivery is very important for increasing the efficiency of cell therapy. Amnisite BA (Amnisite) is a freeze-dried amniotic membrane harvested from bovine placenta. The objective of this study was to investigate the retention of cells of the stromal vascular fraction (SVF) on Amnisite and to determine the effects of cell-loaded Amnisite in a porcine radiation-induced chronic wound model. Methods Initially, experiments were conducted to find the most suitable hydration and incubation conditions for the attachment of SVF cells extracted from pig fat to Amnisite. Before seeding, SVFs were labeled with PKH67. The SVF cell-loaded Amnisite (group S), Amnisite only (group A), and polyurethane foam (group C) were applied to treat radiation-induced chronic wounds in a porcine model. Biopsy was performed at 10, 14, and 21 days post-operation for histological analysis. Results Retaining the SVF on Amnisite required 30 minutes for hydration and 1 hour for incubation. A PKH67 fluorescence study showed that Amnisite successfully delivered the SVF to the wounds. In histological analysis, group S showed increased re-epithelialization and revascularization with decreased inflammation at 10 days post-operation. Conclusions SVFs had acceptable adherence on hydrated Amnisite, with successful cell delivery to a radiation-induced chronic wound model.

• Journal of Microbiology and Biotechnology
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• v.32 no.9
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• pp.1209-1216
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• 2022

To better understand the effects of PEGylation and biotinylation on the delivery efficiency of proteins, the cationic protein lysozyme (LZ) and anionic protein bovine serum albumin (BSA) were chemically conjugated with poly(ethylene glycol) (PEG) and biotin-PEG to primary amine groups of proteins using N-hydroxysuccinimide reactions. Four types of protein conjugates were successfully prepared: PEGylated LZ (PEG-LZ), PEGylated BSA (PEG-BSA), biotin-PEG-conjugated LZ (Bio-PEG-LZ), and biotin-PEG-conjugated BSA (Bio-PEG-BSA). PEG-LZ and Bio-PEG-LZ exhibited a lower intracellular uptake than that of LZ in A549 human lung cancer cells (in a two-dimensional culture). However, Bio-PEG-BSA showed significantly improved intracellular delivery as compared to that of PEG-BSA and BSA, probably because of favorable interactions with cells via biotin receptors. For A549/fibroblast coculture spheroids, PEG-LZ and PEG-BSA exhibited significantly decreased tissue penetration as compared with that of unmodified proteins. However, Bio-PEG-BSA showed tissue penetration comparable to that of unmodified BSA. In addition, citraconlyated LZ (Cit-LZ) showed reduced spheroid penetration as compared to that of LZ, probably owing to a decrease in protein charge. Taken together, chemical conjugation of targeting ligands-PEG to anionic proteins could be a promising strategy to improve intracellular delivery and in vivo activity, whereas modifications of cationic proteins should be more delicately designed.

• Particle and aerosol research
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• v.17 no.2
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• pp.29-36
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• 2021

In this study, the clean air delivery rate (CADR) of ceiling air circulator (CAA) was determined under indoor environmental simulation conditions. An air filter was used to provide air cleaning ability to the CAA. The CADR of filter adapted CAA was evaluated and compared with the value of commercial air purifier. The installation of mesh-shaped filter on the CAA showed particle reduction effect on the particles over 0.4 ㎛ in diameter, but the CADR was up to 0.25 m³/min. When the filter having 99.9% in collection efficiency was installed on the CAA, its CADR was 1.52 m³/min, while the CADR of commercial air purifier was 3.19 m³/min.

• International Journal of Computer Science & Network Security
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• v.23 no.6
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• pp.107-114
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• 2023

Successful implementations of DevOps practices significantly improvise software efficiency, collaboration and security. Most of the organizations are adopting DevOps for faster and quality software delivery. DevOps brings development and operation teams together to overcome all kind of communication gaps responsible for software failures. It relies on different sets of alternative tools to automate the tasks of continuous integration, testing, delivery, deployment and monitoring. Although DevOps is followed for being very reliable and responsible environment for quality software delivery yet it lacks many quantifiable aspects to prove it on the top of other traditional and agile development methods. This research evaluates quantitative performance of DevOps and traditional/ agile development methods based on software metrics. This research includes three sample projects or code repositories to quantify the results and for DevOps integrated selective tool chain; current research considers our earlier proposed and implemented DevOps hybrid model of integrated automation tools. For result discussion and validation, tabular and graphical comparisons have also been included to retrieve best performer model. This comparative and evaluative research will be of much advantage to our young researchers/ students to get well versed with automotive environment of DevOps, latest emerging buzzword of development industries.

• Advances in Computational Design
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• v.7 no.4
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• pp.345-369
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• 2022

Infectious disease emergency hospitals are usually temporarily built during the pneumonia epidemic with higher requirements regarding diagnosis and treatment efficiency, hygiene and safety, and infection control.This study aims to identify how the Building Information Modeling (BIM) + Industrialized Building System (IBS) approach could rapidly deliver an infectious disease hospital and develop site epidemic spreading algorithms. Coronavirus-19 pneumonia construction site spreading algorithm model mind map and block diagram of the construction site epidemic spreading algorithm model were developed. BIM+IBS approach could maximize the repetition of reinforced components and reduce the number of particular components. Huoshenshan Hospital adopted IBS and BIM in the construction, which reduced the workload of on-site operations and avoided later rectification. BIM+IBS integrated information on building materials, building planning, building participants, and construction machinery, and realized construction visualization control and parametric design. The delivery of Huoshenshan Hospital was during the most critical period of the Coronavirus-19 pneumonia epidemic. The development of a construction site epidemic spreading algorithm provided theoretical and numerical support for prevention. The agent-based analysis on hospital evacuation observed "arched" congestion formed at the evacuation exit, indicating behavioral blindness caused by fear in emergencies.

• Journal of Sensor Science and Technology
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• v.32 no.6
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• pp.418-424
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• 2023

Natural killer (NK) cells play a crucial role in combating infections and tumors. However, their therapeutic application in solid tumors is hindered by challenges, such as limited lifespan, tumor penetration, and delivery precision. Our research introduces a novel ultrasonic actuation technique to navigate NK cells more effectively in the vascular system, particularly at vessel bifurcations where targeted delivery is most problematic. We use a hemispherical ultrasonic transducer array that generates phase-modulated traveling waves, focusing on an ultrasound beam to steer NK cells using blood-flow dynamics and a focused acoustic field. This method enables the precise obstruction of non-target vessels and efficiently directs NK cells toward the tumor site. The simulation results offer insights into the behavior of NK cells under various conditions of cell size, radiation pressure, and fluid velocity, which inform the optimization of their trajectories and increase targeting efficiency. The experimental results demonstrate the feasibility of this ultrasonic approach for enhancing NK cell targeting, suggesting a potential leap forward in solid tumor immunotherapy. This study represents a significant step in NK cell therapeutic strategies, offering a viable solution to the existing limitations and promising enhancement of the efficacy of cancer treatments.

• Journal of Environmental Health Sciences
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• v.32 no.5 s.92
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• pp.478-484
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• 2006

There was no significant difference in the CADR (Clean Air Delivery Rate) between physical aerosols, NaCl and smoke, and biological aerosols, airborne MS2 virus and P. fluorescens, which implicate that the hybrid-type of air purifier, applying the unipolar ion emission and the radiant catalytic ionization, imposed identical reduction effect on both physical aerosol and bioaerosol. Ventilation decreases the efficiency of air cleaning by unipolar ionization because high ventilation diminishes the particle concentration reduction effect. The particle removal efficiency decreases with increase in the chamber volume because of the augmented ion diffusion and higher ion wall loss rate. Particle size affects the efficiency of air ionization. The efficiency is high for particles with very small diameter because reduction of charge increases with particle size. If there is no increasing supply of ions, the efficiency of air cleaning by unipolar ionization increases with respect to initial concentration of particles because of the large space charge effect at high particle concentration and amplified electric field.