• Journal of Computing Science and Engineering
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• v.9 no.2
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• pp.83-97
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• 2015

IEEE 802.15.4 is a global standard designed for emerging applications in low-rate wireless personal area networks (LR-WPANs). The standard provides beneficial features, such as a beacon-enabled mode and guaranteed time slots for realtime data delivery. However, how to optimally operate those features is still an open issue. For the optimal operation of the features, this paper proposes a holistic optimization method that jointly optimizes three cross-related problems: cluster-tree construction, nodes' power configuration, and duty-cycle scheduling. Our holistic optimization method provides a solution for those problems so that all the real-time packets can be delivered within their deadlines in the most energy-efficient way. Our simulation study shows that compared to existing methods, our holistic optimization can guarantee the on-time delivery of all real-time packets while significantly saving energy, consequently, significantly increasing the lifetime of the network. Furthermore, we show that our holistic optimization can be extended to take advantage of the spatial reuse of a radio frequency resource among long distance nodes and, hence, significantly increase the entire network capacity.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.3
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• pp.1330-1347
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• 2018

Mobile Ad hoc Network (MANET) is a collection of nodes or communication devices that wish to communicate without any fixed infrastructure and predetermined organization of available links. The effort has been made by proposing a scheme to overcome the critical security issue in MANET. The insufficiency of security considerations in the design of Ad hoc On-Demand Distance Vector protocol makes it vulnerable to the threats of collaborative black hole attacks, where hacker nodes attack the data packets and drop them instead of forwarding. To secure mobile ad hoc networks from collaborative black hole attacks, we implement our scheme and considered sensor's energy as a key feature with a better packet delivery ratio, less delay time and high throughput. The proposed scheme has offered an improved solution to diminish collaborative black hole attacks with high performance and benchmark results as compared to the existing schemes EDRIAODV and DRIAODV respectively. This paper has shown that throughput and packet delivery ratio increase while the end to end delay decreases as compared to existing schemes. It also reduces the overall energy consumption and network traffic by maintaining accuracy and high detection rate which is more safe and reliable for future work.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.5
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• pp.1790-1806
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• 2015

Utility-based routing is a special type of routing approach using a composite utility metric when making routing decisions in ad hoc and sensor networks. Previous studies on the utility-based routing all use fixed retry limit and a very simple distance related energy model, which makes the utility maximization less efficient and the implementation separated from practice. In this paper, we refine the basic utility model by capturing the correlation of the transmit power, the retry limit, the link reliability and the energy cost. A routing algorithm based on the refined utility model with adaptive transmit power and retry limit allocation is proposed. With this algorithm, packets with different priorities will automatically receive utility-optimal delivery. The design of this algorithm is based on the observation that for a given benefit, there exists a utility-maximum route with optimal transmit power and retry limit allocated to intermediate forwarding nodes. Delivery along the utility-optimal route makes a good balance between the energy cost and the reliability according to the value of the packets. Both centralized algorithm and distributed implementations are discussed. Simulations prove the satisfying performance of the proposed algorithm.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.9 no.3
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• pp.9-17
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• 2009

A Mobile Ad hoc network(MANET) is a network consisting of a set of wireless mobile nodes, which communicate with each other without centralized control or established infrastructure. In this paper, to obtain a better understanding of AODV(Ad hoc On-Demand Distance Vector Routing Protocol)and OLSR(Optimized Link State Routing Protocol) routing protocols, different performances are simulated and analyzed using OPNET modeler 14.5 with the various performance metrics, such as packet delivery ratio, end-to-end delay and routing overhead. As a conclusion, in static analysis, the routing overhead of OLSR is affected by the number of nodes, but not data traffic. In AODV case, it is affected by both data traffic and number of nodes. In mobility analysis, routing overhead is not greatly affected by mobility speed in AODV and OLSR, and the PDR(Packet Delivery Ration) of OLSR is decreased as the node speed increased, while AODV is not changed. AS to delay, AODV is always higher than OLSR in both static and nobility cases.

• Journal of Communications and Networks
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• v.15 no.1
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• pp.54-60
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• 2013

In this paper, a novel method called location-based delivery (LBD), which combines the short message service (SMS) and global position system (GPS), is proposed, and further, a realistic system for tracking a target's movement is developed. LBD reduces the number of short message transmissions while maintaining the location tracking accuracy within the acceptable range. The proposed approach, LBD, consists of three primary features: Short message format, location prediction, and dynamic threshold. The defined short message format is proprietary. Location prediction is performed by using the current location, moving speed, and bearing of the target to predict its next location. When the distance between the predicted location and the actual location exceeds a certain threshold, the target transmits a short message to the tracker to update its current location. The threshold is dynamically adjusted to maintain the location tracking accuracy and the number of short messages on the basis of the moving speed of the target. The experimental results show that LBD, indeed, outperforms other methods because it satisfactorily maintains the location tracking accuracy with relatively fewer messages.

• Industrial Engineering and Management Systems
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• v.13 no.2
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• pp.163-171
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• 2014

Under amazing increase in markets and certain demand on qualified service in the delivery system, global logistic optimization is becoming a keen interest to provide an essential infrastructure coping with modern competitive prospects. As a key technology for such deployment, we have been engaged in the practical studies on vehicle routing problem (VRP) in terms of Weber model, and developed a hybrid approach of meta-heuristic methods and the graph algorithm of minimum cost flow problem. This paper extends such idea to multi-depot VRP so that we can give a more general framework available for various real world applications including those in green or low carbon logistics. We show the developed procedure can handle various types of problem, i.e., delivery, direct pickup, and drop by pickup problems in a common framework. Numerical experiments have been carried out to validate the effectiveness of the proposed method. Moreover, to enhance usability of the method, Google Maps API is applied to retrieve real distance data and visualize the numerical result on the map.

• Journal of Microbiology and Biotechnology
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• v.29 no.7
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• pp.1009-1013
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• 2019

Polymeric nanoparticles are widely used for drug delivery due to their biodegradability property. Among the wide array of polymers, chitosan has received growing interest among researchers. It was widely used as a vehicle in polymeric nanoparticles for drug targeting. This review explored the current research on the antimicrobial activity of chitosan nanoparticles (ChNP) and the impact on the clinical applications. The antimicrobial activities of ChNP were widely reported against bacteria, fungi, yeasts and algae, in both in vivo and in vitro studies. For pharmaceutical applications, ChNP were used as antimicrobial coating for promoting wound healing, preventing infections and combating the rise of infectious disease. Besides, ChNP also exhibited significant inhibitory activities on foodborne microorganisms, particularly on fruits and vegetables. It is noteworthy that ChNP can be also applied to deliver antimicrobial drugs, which further enhance the efficiency and stability of the antimicrobial agent. The present review addresses the potential antimicrobial applications of ChNP from these few aspects.

• Korean Journal of Applied Biomechanics
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• v.14 no.3
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• pp.149-163
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• 2004

This study analyzed kinematic variables about the cross step, the delivery and the release for women's javelin athletics recorded over 50m in the 2004 Busan International Athletics Competition. It was used the Kwon3D Motion Analysis Package Ver. 3.1 Program(Kwon, 2000) for analysing the kinematic variables about the distance, the velocity, and the angle, then we had the results as follows; 1 In the Cross step phase, the COG velocity was low because their step length was short. To keep the CM velocity from the approach to the last cross over step contact, the athletes have to keep the longer step length within about 130% of the athletics' height. 2. In the Delivery phase, the athletics' COG height was gradually lower, and the deceleration of the COG was going up. As the same in the cross step, Therefore the athletes have to increase the step length within about 100% of their height, in order to increasing the COG velocity. And it was shown they have to make small angle of the elbow as possible from the right foot contact to the left foot contact in order to being the big acceleration of the upperarm at the release phase. 3. In the release phase, it was shown to being low position of the release point as the COG was low and then the release velocity of the upperarm was low. Specially when the shoulder lean lateral angle is big at the release phase, it was shown they have a excessive release angle. And, when it was shown the high rotation angle of the shoulder, the shoulder was opened forward bigger than the trunk was opened forward. So the transmission of velocity from the proximal segments was a fast change.

• Journal of Pharmaceutical Investigation
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• v.35 no.6
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• pp.403-409
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• 2005

For transdermal delivery of large molecular drugs such as vaccine and protein drugs, novel microneedle treatment device with roll was designed. The roll dimension is 1.43 cm diameter and 2.8 cm perimeter. Total number of microneedle on the roll is 3,360 with $230\;{\mu}m$ height and $740\;{\mu}m$ distance. The pore with $150\;{\mu}m$ depth and $35\;{\mu}m$ diameter on the skin was made by the designed microneedle device. This system could be achieved without pain. The permeation rates of FITC labelled ovalbumin (FITC-OVA, molecular weight: 45,000 g/mol) as a model protein were determined by modified Franz diffusion cells using skins of hairless mice or SD rats which were treated by using microneedle device two or four times. The average penetration fluxes of model protein increased from 674 to $872\;{\mu}g/cm^{2}{\cdot}hr$ as the number of treatment to make pore increased from two to four times. In conclusion, we confirmed the possibility of using the designed microneedle treatment device for transdermal delivery of the large molecular drugs.

• Journal of Periodontal and Implant Science
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• v.48 no.5
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• pp.326-333
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• 2018

Purpose: The present study investigated the outcomes of a newly-developed, simple, and practical nonsurgical treatment modality suitable for most forms of intrabony defects around failing dental implants using intrasulcular delivery of chlorhexidine solution and minocycline hydrochloride (HCl). Methods: Forty-five dental implants in 20 patients diagnosed with peri-implantitis were included. At baseline and the study endpoint, the probing pocket depth (PPD), clinical attachment level (CAL), and the presence of bleeding on probing (BOP) at 6 sites around each implant were recorded. The radiographic osseous defect morphology at the mesial or distal proximal aspect of each implant was classified as 1) narrow or wide and 2) shallow or deep. For a comparative analysis of bone changes according to the defect morphology, the distance from the implant shoulder to the most coronal bone-to-implant contact point (DIB) at the mesial and distal aspects of each implant was measured at baseline and the endpoint. Patients were scheduled to visit the clinic every 2-4 weeks for intrasulcular irrigation of chlorhexidine and delivery of minocycline HCl. Results: We observed statistically significant decreases in PPD, CAL, and BOP after treatment. At the endpoint, bone levels increased in all defects, regardless of the osseous morphology of the intrabony defect. The mean DIB change in deep defects was significantly greater than that in shallow defects. Although the mean bone gain in narrow defects was greater than in wide defects, the difference was not statistically significant. Conclusions: We propose that significant and sustainable improvements in both clinical and radiographic parameters can be expected when intrabony defects around dental implants are managed through a simple nonsurgical approach involving combined intrasulcular chlorhexidine irrigation and local delivery of minocycline HCl.