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http://dx.doi.org/10.4014/jmb.1904.04065

Potential Antimicrobial Applications of Chitosan Nanoparticles (ChNP)  

Rozman, Nur Amiera Syuhada (Universiti Kuala Lumpur, Branch Campus Malaysian Institute of Chemical and Engineering Technology)
Yenn, Tong Woei (Universiti Kuala Lumpur, Branch Campus Malaysian Institute of Chemical and Engineering Technology)
Ring, Leong Chean (Universiti Kuala Lumpur, Branch Campus Malaysian Institute of Chemical and Engineering Technology)
Nee, Tan Wen (School of Distance Education, Universiti Sains Malaysia)
Hasanolbasori, Muhammad Ariff (Nanotechnology and Catalyst Research Centre (Nanocat), University of Malaya)
Abdullah, Siti Zubaidah (Universiti Kuala Lumpur, Branch Campus Malaysian Institute of Chemical and Engineering Technology)
Publication Information
Journal of Microbiology and Biotechnology / v.29, no.7, 2019 , pp. 1009-1013 More about this Journal
Abstract
Polymeric nanoparticles are widely used for drug delivery due to their biodegradability property. Among the wide array of polymers, chitosan has received growing interest among researchers. It was widely used as a vehicle in polymeric nanoparticles for drug targeting. This review explored the current research on the antimicrobial activity of chitosan nanoparticles (ChNP) and the impact on the clinical applications. The antimicrobial activities of ChNP were widely reported against bacteria, fungi, yeasts and algae, in both in vivo and in vitro studies. For pharmaceutical applications, ChNP were used as antimicrobial coating for promoting wound healing, preventing infections and combating the rise of infectious disease. Besides, ChNP also exhibited significant inhibitory activities on foodborne microorganisms, particularly on fruits and vegetables. It is noteworthy that ChNP can be also applied to deliver antimicrobial drugs, which further enhance the efficiency and stability of the antimicrobial agent. The present review addresses the potential antimicrobial applications of ChNP from these few aspects.
Keywords
Chitosan; nanoparticle drug delivery; chitosan nanoparticle; microbial infection;
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