• Journal of the Korean Applied Science and Technology
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• v.30 no.4
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• pp.656-663
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• 2013

This study using yogurt of food in order to increase the conservativeness and stability of lactobacillus, to be deliciously flavored and give it visual differential effect, were described regarding making the preparing method of double matrix capsulation in food industries. Our study group was especially made to soft and moisture cream using 5wt% of sucrose ester emulsifier as first capsulation. Double matrix capsulation was formed with the best stabilized bead type capsules when it blended 1:3 ratio of chitosan and alginate. The bead diameter size was about 2.5~4mm (mean diameter: 3mm). Activity of lactobacillus containing cream for depending on various pH variations showed that alkalinity ($pH=10.3{\pm}0.3$) condition was higher than acidity ($pH=4.3{\pm}0.3$) and neutrality ($pH=7.12{\pm}0.2$) conditions. After a month, it also was certified to the activity of lactobacillus in incubated at $37^{\circ}C$ in culture medium. As application of food industry, we developed the containing lactobacillus capsule and 5 colored kinds of double matrix capsulation in yogurt cream. As for above mentioned those results, one of tool to stabilize the living lactobacillus, doubled matrix capsulation greatly be expected to contribute to food industry. Furthermore, it can be expected to apply the drug delivery system (DDS) to active ingredients of stabilizing technologies at drug and cosmetic industries.

• The Journal of Industrial Distribution & Business
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• v.9 no.12
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• pp.63-72
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• 2018

Purpose - In this study, it is classified the service quality dimension of mobile shopping app using Kano model. In addition, it is evaluated quality factors suitable for strategic management from the viewpoint of service provider through mobile application through binary dimension analysis. Research design, data, and methodology - In this study, seven quality dimensions such as information quality, reliability, immediacy, convenience, design, security and customer service were derived through related studies to make binary shopping quality app quality measurement. 37 sub-variables were set by each quality dimensions. Each questionnaire was composed of positive and negative items like Kano's proposed method, and the satisfaction coefficient suggested by Timko(1993) was examined to understand the influence of each factors on customer satisfaction. Results - As a result of research, shopping app users perceived unity quality factor in most items of service quality dimension such as information quality, reliability, immediacy, convenience and customer service. In addition, the satisfaction coefficient showed a good impression, quick response of the result, fast delivery, and the unsatisfactory coefficient showed more interest in personal information such as payment method safety, and transaction security. As a result of research, shopping app users perceived unity quality factor in most items of service quality dimension such as information quality, reliability, immediacy, convenience and customer service. And, in information quality, the information overload was classified as an apathetic quality component, while the related information provision belonged to an attractive quality component. In reliability quality, customized service provision was classified as an attractive quality component. In instant connectivity, the quality of the connection during transport was classified as an attractive quality component. In convenience quality, access to product information was classified as a one-way quality component. All components of designs quality were classified as attractive quality components, and in security quality, all of their components were all classified as one quality component. Lastly, in customer service, they components were all classified as a single quality component. In addition, the satisfaction coefficient showed a good impression, quick response of the result, fast delivery, and the unsatisfactory coefficient showed more interest in personal information such as payment method safety, and transaction security. Conclusion - In the online service environment, which is difficult to differentiate in terms of upward upgrading only by technological implementation and function, the results of this study can be suggested as a differentiating factor for major channels with customers rather than improve the brand image.

• Korean Journal of Veterinary Research
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• v.57 no.2
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• pp.105-111
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• 2017

Hyaluronic acid (HA) has been investigated for biomedical and pharmaceutical applications. This study was conducted to determine the distributions of HA nanoparticles (NPs; size 350-400 nm) and larger HA polymers in mice at intervals after application. $^{177}Lutetium$ (Lu)-labeled HA-NPs or HA polymers were intravenously injected (5 mg/kg) into male ICR mice, and radioactivity levels in blood and target organs were measured from 0.25 h to 28 days post-injection. In blood, the radioactivities of HA-NPs and HA polymer peaked at 0.5 h after injection but were remarkably decreased at 2 h; subsequently, they maintained a constant level until 6 days post-injection. HA-NPs and HA polymers were observed in the liver, spleen, lung, kidney, and heart (in ascending order) but were seldom observed in other organs. After 3 days, both the HA-NP and HA polymer levels showed similar steady decreases in lung, kidney, and heart. However, in liver and spleen, the HA-NP levels tended to decrease gradually after 1 day and both were very low after 14 days, whereas the HA polymer level accumulated for 28 days. The results indicate that HA-NPs, with their faster clearance pattern, may act as a better drug delivery system than HA polymers, especially in the liver and spleen.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.21
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• pp.9249-9258
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• 2014

Background: The encapsulation of curcumin (Cur) in polylactic-co-glycolic acid (PLGA) nanoparticles (Cur-NPs) was designed to improve its solubility and stability. Conjugation of the Cur-NPs with anti-P-glycoprotein (P-gp) antibody (Cur-NPs-APgp) may increase their targeting to P-gp, which is highly expressed in multidrugresistance (MDR) cancer cells. This study determined whether Cur-NPs-APgp could overcome MDR in a human cervical cancer model (KB-V1 cells) in vitro and in vivo. Materials and Methods: First, we determined the MDR-reversing property of Cur in P-gp-overexpressing KB-V1 cells in vitro and in vivo. Cur-NPs and Cur-NPs-APgp, in the range 150-180 nm, were constructed and subjected to an in vivo pharmacokinetic study compared with Cur. The in vitro and in vivo MDR-reversing properties of Cur-NPs and Cur-NPs-APgp were then investigated. Moreover, the stability of the NPs was determined in various solutions. Results: The combined treatment of paclitaxel (PTX) with Cur dramatically decreased cell viability and tumor growth compared to PTX treatment alone. After intravenous injection, Cur-NPs-APgp and Cur-NPs could be detected in the serum up to 60 and 120 min later, respectively, whereas Cur was not detected after 30 min. Pretreatment with Cur-NPs-APgp, but not with NPs or Cur-NPs, could enhance PTX sensitivity both in vitro and in vivo. The constructed NPs remained a consistent size, proving their stability in various solutions. Conclusions: Our functional Cur-NPs-APgp may be a suitable candidate for application in a drug delivery system for overcoming drug resistance. The further development of Cur-NPs-APgp may be beneficial to cancer patients by leading to its use as either as a MDR modulator or as an anticancer drug.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.8 no.4
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• pp.53-64
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• 2009

Inter-vehicular communication that propagates information without infrastructures has drawn a lot of interest. However, it is difficult to apply conventional ad-hoc routing protocols directly in inter-vehicular communication due to frequent changes in the network topology caused by high mobility of the vehicles. MMFP(Multi-hop MAC Forwarding) is a unicast forwarding protocol that transport packets based on the reachability information instead of path selection or position information. However, delivering public safety messages informing road conditions such as collision, obstacles and fog through inter-vehicular communication requires broadcast rather than unicast since these messages contain information valuable to most drivers within a close proximity. Flooding is one of the simplest methods for multi-hop broadcast, but it suffers from reduced packet delivery-ratio and high transmission delay due to an excessive number of duplicated packets. This paper presents two multi-hop broadcast protocols for inter-vehicular communication that extend the MMFP. UMHB(Unreliable Multi-Hop Broadcast) mitigates the duplicated packets of MMFP by limiting the number of nodes to rebroadcast packets. UMHB, however, still suffers from low delivery ratio. RMHB(Reliable Multi-Hop Broadcast) uses acknowledgement and retransmission in order to improve the reliability of UMHB at the cost of increase in transmission delay, which we show through simulation is within an acceptable range for collision avoidance application.

• Applied Microscopy
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• v.40 no.4
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• pp.185-191
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• 2010

Short peptides are potentially effective materials as cosmeceuticals, but their delivery across the skin can be problematic due to the ionic nature of peptides and the structure of the skin. For short peptide to be utilized as cosmeceuticals, its ability to penetrate the skin must be altered. In this study, we conjugated the widely used procollagen type I signal peptide, KTTKS, with oleic acid to improve the lipophilic properties of the peptide, and used the oleic acid-conjugated peptides to construct cosmeceutical nanosomes. Then we examined the penetration of cosmeceutical nanosomes prepared from isotope-labeled peptide into the skin after transdermal application using autoradiography. Because of its hydrophilic property of penta-peptide, the penta-peptide itself was not able to be penetrated through the stratum corneum of the skin. In contrast, nanosomes made from olecic acid conjugated penta-peptide were able to be penetrated through the stratum corneum effectively. Autoradiography showed the precise penetration points to dermal layer, demonstrating the appropriateness of this method for clarifying the mechanism of penetration of transdermal delivery systems.

• Polymer(Korea)
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• v.31 no.3
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• pp.215-220
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• 2007

The control of the surface energy by electrohydrodynamic force provides electrospraying with various potential advantages such as simple particle size control, mono-dispersity, high recovery, and mild processing conditions. The advantages are quite helpful to improve the stability of protein drug and control its release. Herein, the nano-encapsulation of protein drugs using electrospraying was investigated. Albumin as a model protein was processed using uniaxial and co-axial electrospraying, and chitosan, polycaporlactone (PCL), and poly (ethylene glycol) (PEG) were used as encapsulation materials. The major processing parameters such as the conductivity of spraying liquids, flow rate, the distance of electrical potential gradient, etc were measured to obtain the maximum efficiency. In the chitosan systems, mean particles size decreases as flow rate and the distance between nozzle and the collecting part decreases. In the uniaxial technique of the PCL systems, mean particles size decreases as flow rate decreases. In the coaxial technique of the PCL systems, it was found that the particles size gets larger under the application of the higher ratio of inner-to-outer liquid flow rates. The primary particles formed out of an electrospraying nozzle showed narrow particle size distribution, but once they arrived to the collecting part, aggregation behavior was observed obviously. Efficient nano-encapsulation of albumin with PCL, PEG, and chitosan was conveniently achieved using electrospraying at above 12 kV.

• Polymer(Korea)
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• v.36 no.4
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• pp.420-426
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• 2012

In this study, we prepared polymer micelles containing quercetin and rutin, known as antioxidants, using poly(${\varepsilon}$-caprolactone)-b-poly(ethylene glycol), and evaluated in vitro skin permeation of the active materials. Quercetin and rutin loaded micelles were characterized by DSC (differential scanning calorimetry), HPLC (high performance liquid chromatography) and DLS (dynamic light scattering) measurements. The particle size of the polymer micelles increased in a concentration dependent manner (0.5~2.0% PCL-b-PEG). The Zeta potential of quercetin and rutin loaded micelles remained constant. To evaluate the skin penetration of PCL-b-PEG micelles, Franz diffusion cell experiment was performed. The aqueous solutions of quercetin and rutin were used as the control groups. Quercetin and rutin loaded PCL-b-PEG micelles showed more efficient skin permeation than the control groups. Safety assessment (patch test) of quercetin and rutin loaded PCL-b-PEG micelles on skin was performed to test application possibility of the polymer micelles to cosmetics. Any adverse symptoms were not observed.

• Journal of Environmental Science International
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• v.16 no.3
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• pp.333-345
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• 2007

As analyzed the estimated values of the daily delivery loads from thirteen major side streams such as Naesung-river, Keumho-river, Hwang-river, Nam-river during five years (from 1999 to 2003), the daily BOD inflow into the main stream of Nakdong river in 2003 shows the highest quantity as 31.1 ton and the daily BOD inflows in 1999, 2000, 2001, and 2002 are 26.7 ton, 22.5 ton, 21.0 ton, 25.8 ton, respectively. The daily TN in-flow into the main stream of Nakdong river in 2003 shows also the highest quantity as 64.9 ton and the daily TN inflows in 1999, 2000, 2001, and 2002 are 55.19 ton, 46.27 ton, 39.5 ton, 53.38 ton, respectively. The daily TP inflow into the main stream of Nakdong river in 2003 shows the highest quantity as 2.70 ton likewise and the daily TP inflows in 1999, 2000, 2001, and 2002 are 2.17 ton, 1.87 ton, 1.60 ton, 2.10 ton, respectively The rate of BOD loads from each side main stream into the main stream of Nakdong river shows that the BOD loads of Keumho-river are the highest as the values range from 32.8 % (2002) ${\sim}$ 35.1 % (2003) and the BOD loads of Nam-river, Naesung-river, Hwang-river are high in the order named. The rate of TN loads to the main stream is also similar to the trend of BOD loads. The contribution of the TN loads of Geumho-river to the contamination of the main stream is also the highest having a range from 27.0 % (2002) to 28.8 % (1999) among the main side streams and the TN loads of Naesung-river, Nam-river, and Heachun-river are high in the order named. The rate of TP loads is quite different from the trend of BOD and TN loads. The TP rate of Keumho-river, however, is still the highest as ranging 58.6 % (2002) to 61.7 % (2003) and the river has the biggest portion (over 50%) of the entire pollution to the main stream of Nakdong river.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.4
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• pp.321-330
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• 2021

By reviewing domestic and international papers, this study examines various fields in which drones are used, and based on the results, fields are suggested in which drones can be used for the work of firefighters. Overall, the research results show that drones are most commonly used for search (51%), disaster and fire monitoring (35%), and delivery (14%). Specifically, in the search field, using a drone is more efficient in terms of manpower, equipment, time, and cost than using people, which is the current practice. Secondly, in disaster and fire monitoring, drones can analyze and identify disasters and fire sites in real time. Therefore, it was confirmed that the use of drones is helpful in securing the safety of firefighters and identifying a disaster site. Third, research in logistics shows that drones can secure the so-called golden time in emergency situations by delivering rescue and relief supplies, emergency medicine, and blood in short order. In a rapidly changing disaster environment, and considering aging in firefighters, this study is meaningful in that it promotes drone utilization in the firefighting field by investigating basic data on drone utilization plans.