• Medical Lasers
• /
• 제10권2호
• /
• pp.61-67
• /
• 2021

Advances in nanobiotechnology have presented numerous possibilities of more effective diagnostic and therapeutic options. In particular, gold nanoparticles have demonstrated the potential for application in molecular imaging and treatment of cancers, including drug delivery system of certain target molecules, enhancement of radiation therapy, and photothermal treatment. This review discusses the properties, mechanism of action, and clinical application of gold nanoparticles. Although the safety of nanoparticles is yet to be ascertained, there is no doubt that in the future, nanotechnology will play an important role in the development and enhancement of a wide range of diagnostic and treatment modalities.

• 한국환경농학회지
• /
• 제31권1호
• /
• pp.16-23
• /
• 2012

BACKGROUND: To improve the Daechung reservoir water quality, a quantitative estimation of the delivery load from upper watershed need to be conducted prior to others. To do so, an intensive monitoring is necessary because of the complexity and uncertainty of the delivery load from uppper watershed. However, intensive monitoring need to invest much time, cost, and effort. So, many researcher have developed an equation to estimate the delivery loads. But, relatively little research has been conducted on the applicability of pre-developed equation using other sites. Therefore, the objective of this study was to evaluate application of the equation for BOD, T-N and T-P delivery load. METHODS AND RESULTS: To verify the applicability of the equation, the following equation was used; Delivery loads(kg/day)=generated pollutant loads${\times}(1-{\alpha}){\times}$(daily outflow/${\beta})^{\gamma}$. The equations could be calculated the daily delivery loads of streams without any data of water quality, only with the data of daily runoff of study sites. The equations were applied to Youngdogcheon, Chogangcheon, Bocheongcheon, Sookcheon to examine its applicability using monitoring data. The results showed that the estimated delivery loads were in a good agreement with the observed data and indicated reasonable applicability of the equations. CONCLUSION(s): Overall, the equations were satisfactory in estimation of delivery loads at upper watershed of the Daechung reservoir. Therefore, the equations could be contributed to better water quality management in the Daechung reservoir.

• 한국프랜차이즈경영연구
• /
• 제11권1호
• /
• pp.45-60
• /
• 2020

Propose: The expansion of the delivery market in franchise business is a positive means of advertising and promotion for franchisees and contributes to substantial sales growth for stores. However, unrestricted and uncontrolled delivery sales and business activity of franchisee directly lead to encroachment of business territory between franchisees, resulting in increased operating costs of franchisees and conflicts between franchisees over rights and interests on franchise business. Moreover, in relation to the restrictions on the opening of competitors, it is incapacitating the law intent of prohibiting unfair encroachment of business territory, in the issue of the Fair Franchise Act in regard to guarantee of exclusive sales and business activity rights of franchisee. This study aims to point out major problems arising out of franchisee's infinite competition on delivery sales and business activity that are not restricted or controlled and then suggest legal supplements, policy tasks, and practical implications for improvement on the issues. Literature Review: In franchising business transactions, vertical restraints are associated with the exclusive territory establishment, control of transaction area, restriction of intangible sales and business activity of franchisee. Therefore, in the franchise business, it is necessary to take positive interpretation and application on e-commerce, the area of e-commerce, and delivery trading area and find proper and practical ways, by virtue of constructive attitude of each actor, to reduce the encroachment of business territory and various conflicts caused by unrestricted delivery trading area. Conclusion and suggestion: The finding shows that unrestricted or uncontrolled delivery sales and business activity of franchisees cause encroachment of business territory and many conflicts among franchisees. And this matters also weaken the legislation of the law on the protection of the business territory and can be negative factors that disrupt the protection of identity and sound development of the franchise industry in the long run. Therefore, in the franchise business, it is necessary to take positive interpretation and application on e-commerce, the area of e-commerce, and delivery trading area and find proper and practical ways, by virtue of constructive attitude of each actor, to reduce the encroachment of business territory and various conflicts caused by unrestricted delivery trading area.

• Journal of Pharmaceutical Investigation
• /
• 제37권3호
• /
• pp.159-166
• /
• 2007

In order to develop an optimum formulation for iontophoretic delivery of vitamine C-2-phosphate (VCP) from Carbopol hydrogel, we have investigated various factors which can affect the iontophoretic flux through skin. Such factors as drug concentration, current density, current profile, current duration, ionic strength, pH and percutaneous enhancers (ethanol, glycerine, propylene glycerol, sorbitol, urea) were studied. Compared to the flux by passive or anodal delivery, the flux by cathodal delivery increased markedly, and thus, only cathodal delivery was used in the rest of the flux experiments. Flux increased linearly as the drug concentration and current density increased. As the duration of current application increased from 30 min to 120 min, flux increased linearly, however the AUC was not directly proportional to the applied amount of current. Flux also increased as the pH increased, possibly due to the increase in ionization of phosphate group. As the ionic strength increased, flux decreased. No significant increase in flux was observed after enhancer application, indicating that the effect of current on flux is dominating over the effect of percutaneous enhancers (P>0.05). These results provide important informations that are needed for optimal formulation of iontophortic delivery for VCP.

• 한국BIM학회 논문집
• /
• 제7권2호
• /
• pp.25-35
• /
• 2017

Building information modeling (BIM) can improve to communicate with project participants by early construction involvement (ECI) from the beginning of the project. Therefore, they can minimize design changes and improve design quality and construction. However, because there is insufficient research on the scope and application level of BIM according to project delivery system and project characteristics, construction companies have efficiently not been using the BIM. Therefore, this study intends to conduct basic research as a basis for confirming appropriate BIM application and level according to project delivery system and project characteristics. To do this, we investigated the project delivery system and project characteristics of domestic and foreign projects that have successfully applied BIM, and compare and analyze them based on BIM application and BIM level framework derived from theory reviews and experts. Therefore, this study can be used as a basis for strategically establishing the scope and level of BIM according to project delivery system and project characteristics through the result of this study.

• Archives of Pharmacal Research
• /
• 제24권1호
• /
• pp.1-15
• /
• 2001

Gene therapy has emerged as a new concept of therapeutic strategies to treat diseases which do not respond to the conventional therapies. The principle of gene therapy is to Introduce genetic materials into patient cells to produce therapeutic proteins in these cells. Gene therapy is now at the stage where a number of clinical trials have been carried out to patients with gene-deficiency disease or cancer. Genetic materials for gene therapy are generally composed of gene expression system and gene delivery system. For the clinical application of gene therapy in a way which conventional drugs are used, researches have been focused on the design of gene delivery system which can offer high transfection efficiency with minimal toxicity. Currently, viral delivery systems generally provide higher transfection efficiency compared with non-viral delivery systems while non-viral delivery systems are less toxic, less immunogenic and manufacturable in large scale compared with viral systems. Recently, novel strategies towards the design of new non-viral delivery system, combination of viral and non-viral delivery systems and targeted delivery system have been extensively studied. The continued effort in this area will lead us to develop gene medicine as "gene as a drug" in the near future.

• 유통과학연구
• /
• 제22권4호
• /
• pp.91-104
• /
• 2024

Purpose: The study aims to assess the current status of domestic public food delivery apps and analyze the process through which sellers choose between private delivery apps and public delivery apps. This involves exploring strategiesto achieve the original purpose of public food delivery apps, which is to enhance the small business owners income and promote consumer welfare by preventing the monopoly of private food delivery apps. Research design, data and methodology: the research methodology is based on a model that introduces adjustments for non-economic effects, considering the preferences of multi-homing consumers, to more realistically reflect the benefits of sellers' choices. For data analysis, real business performance data from 'Daeguro', 'Meokkaebi', and 'Somunnan Shop' were used. Results: The study revealed that if the market share of public delivery apps within a specific region increases beyond a certain level, the benefits for small-business sellers also increase. This leads to the strategic advantage of simultaneously using both delivery apps. Furthermore, the results exhibit a tendency similar to real social phenomena. Conclusions: This analysis confirmed the role of public food delivery apps in the domestic delivery app market and presents policy recommendations, including application integration and the implementation of exclusive public interest functions, to effectively fulfill this role.

• 한국치위생학회지
• /
• 제19권4호
• /
• pp.493-502
• /
• 2019

Objectives: This study aimed to investigate the current status of oral health applications developed for smartphones because they can be used as a new educational medium to manage and improve oral health. Methods: This study examined 60 basic oral health applications provided by Google Play Store and Apple App Store as of May 2019 and examined delivery contents, delivery methods, application types, and other information. Results: Apple included 65.4% of oral apps in the game category whereas Android included 64.3% in the education category (p>0.05). All Apple's apps and 71.4% of Android apps were developed overseas (p<0.01). The delivery contents were 61.5% for Brushing + tooth decay in Apple, and 78.6% for others (oral care products and gum diseases) in Android (p>0.05). For the delivery method, game + video was 65.4% in Apple, and game and other methods (text, image, augmented reality) was 42.9% in Android (p>0.05). In the case of application type, play type was the most common with 88.5% in Apple, and 46.4% play type and 39.3% other type (text, appreciation, problem-solving types) in Android (p<0.01). In addition, play type was high in both education (53.8%) and game (90.0%) categories (p>0.05). The average review score was 4.30 in the education category, 4.34 in the case of brushing and care (delivery contents), 4.37 in the case of using game + video (delivery methods), and 4.57 in the case of Play + other types (application type) (p>0.05). Conclusions: The use of healthcare apps is expected to increase owing to improved lifestyles, an increase in the elderly population, cost-effectiveness, and convenience that is not affected by time and place. Effective use of oral health apps will require the participation of dental professionals in the development process to identify the exact status, expand subjects, and provide appropriate information.

• 한국IT서비스학회지
• /
• 제16권2호
• /
• pp.129-138
• /
• 2017

This paper is concerned with an Internet of Things (IoT)-based unmanned home-delivery box system, in which the system is developed with a prototype using a weight sensor, shock sensor, the Arduino and Raspberry-Pi of open-source hardware platforms. The developed system provides several functions such as a safe storage means, prevention of delivery-theft, and remote control of the home-delivery box, etc. Specifically, the system recognizes the arrival of goods by detecting the weight of deliveries and sends the arrived message of deliveries to the recipient' smartphone, and also controls (i.e., open and close) the locker of the unmanned home-delivery box system remotely with the smartphone. Furthermore, the developed system provides automatically a warning alarm around the unmanned home-delivery box when an external shock is applied to the home-delivery box, and sends a message on the shock to the recipient' smartphone. The major functions of the developed home-delivery box system have been verified in a realistic environment, and confirmed to work well. With the application of the developed home-delivery box system to the homes and offices where recipients are always not to stay, it is expected to significantly improve the safety of delivered goods as well as to effectively prevent the delivery operatives posing as a crime.

• 한국건설관리학회:학술대회논문집
• /
• 한국건설관리학회 2008년도 정기학술발표대회 논문집
• /
• pp.591-596
• /
• 2008

건설 공사에서 발주방식은 프로젝트의 성패에 많은 영향을 준다. 이 논문은 대형공사에 효율적인 기술제안형 입찰방식 적용에 관한 연구를 목적을 갖는다. 본 연구의 연구절차는 다음과 같다. 대형공사 발주 및 발주방식에 대한 이론적 고찰 실시하였고, 다음 국내 외 발주제도 방식을 조사하여 분석하였고, 이에 따른 대형공사의 발주 실태 및 문제점을 도출하였다. 이에 따라 대형공사의 경우 프로젝트의 특징 및 목적을 잘 반영하지 못한다는 문제점 등이 분석되었고, 분석된 문제점을 보안하기 위해서 기술제안형 입찰방식을 도입하기 위해서 현재 재정된 기술제안형 입찰 방식의 개념 및 절차에 대한 분석을 하였고, 이를 통하여 결과적으로 대형건설공사에 효율적으로 적용하기 위해서 기술제안서 작성 및 평가 반영을 위한 비가격 요소와 가격 요소로 분류하고 각 요소별 항목을 제시하였다.