• Polymer(Korea)
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• v.32 no.2
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• pp.103-108
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• 2008

Osmotic pellet, which consisted of water-swellable seed layer, drug layer, and porous membrane layer, has been widely utilized in oral drug delivery system. In this work, we describe the preparation of osmotic pellet with nifedipine as model drug and a mixture of cellulose acetate (CA) and Eudragit RS as membrane layer, and then examined the drug release behavior on the variation of the thickness change of membrane layer (CA and Eudragit RS) and release media. Furthermore, we examined the nifedipine release behavior using sodium alginate as a potential membrane candidate. Osmotic pellet was obtained in the quantitative yield by fluidized bed coater. Osmotic pellet exhibited the round morphology and the size ranging $1500{\sim}1700{\mu}m$ in SEM. The nifedipine release decreased as the thickness of membrane layer (CA and Eudragit RS) increased. In addition, it observed that there is difference of release amount in between intestinal juice (pH 6.8) and gastric juice (pH 1.2). In the case of osmotic pellet coated with sodium alginate, nifedipine release behavior depended on the crosslinking of sodium alginate layer. In conclusion, we found that various membrane layers could control the release amount of nifedipine.

• Information Systems Review
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• v.13 no.3
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• pp.165-183
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• 2011

IT organizations have been consistently required to change in order to cope with business and technological changes. However, the practical methodologies or guidelines about IT organization redesign are deficient. This research investigates IT organization's redesign methods and procedures focused on K public corporation which fundamentally redesigned IT organization recently. In K public corporation, to-be model of IT organization was designed with job analysis for IT organization redesign, task redesign was performed, and IT organization and personnel was assessed. 1) In task analysis, core activities are identified and 96 standard tasks are drawn. 2) with to-be organization design, IT support, IT delivery, IT operation teams and BuKyoung and Jeju teams were divided. 3) Previous job organization was restructured, IT organization personnel were finally confirmed through FTE and internal review. K public corporation strengthened IT planning task instead of reducing operational IT task, improved IT management process which was lower than other companies, and improved IT outsourcing management system and IT users' satisfactions. This research has practical implications for many companies which struggle with IT organization redesign method and process.

• International Commerce and Information Review
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• v.18 no.4
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• pp.3-29
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• 2016

Recently, the market size of the global electronic-commerce is rapidly growing. The global market size of an overseas direct-purchase is expected to reach 1 trillion won by 2020. This study intends to determine the decision making factors of B2B overseas direct-purchase(DP) and reverse direct-purchase(RDP), and the impact on the vitalization of the small to middle-sized companies'(SMC) overseas DP and RDP. Ultimately, the purpose of this study is to provide a policy insight on the expansion of exports by SMC. For this, we determined the necessary elements for getting good results by Korean SCM in the overseas DP and RDP market through a preceding research based on resource-based theory and industry structure theory. Afterwards, we used the multiple regression model for positive analysis of the survey documents. We were able to confirm through analysis that the company information, logistics delivery, customs process, law and regulations have positive effects on the overseas DP and RDP. This study surveyed the entire overseas DP market, rather than focusing on the cases of harm and responses of the overseas DP, which was the topic for the preceding research, and can be differentiated from the previous study by deducting influence factors for the Korean SMC to succeed in the overseas DP and RDP market. Moreover, the results of this study is meaningful in proposing a strategic direction for the SMC participating in the overseas DP market and the government enacting policies.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.31 no.3
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• pp.193-197
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• 2009

Background: Though it is clear that many types of viruses can infect the oral mucosa, its condition for infection is unclear. The purpose of this study was to analyze the conditions for viral infection of normal oral mucosa and explore the possibility of topical gene therapy to oral mucosa using a viral vector. Methods: Freshly taken fragments of the palate and the tongue of mice were used for organ culture. The specimens were exposed to green fluorescent protein (GFP)-adenoviral vector for 1 hour except for the control. Initial viral titer was $6.3{\times}10^{11}\;pfu/ml$ and the virus was diluted to working concentrations. The dilution ratio was 1:1,000 ($6.3{\times}10^8\;pfu/ml$), 1:10,000 ($6.3{\times}10^7\;pfu/ml$), and 1:100,000 ($6.3{\times}10^6\;pfu/ml$). They were then cultured on a stainless steel wire mesh in an organ culture dish. The specimens were stereoscopically examined every 24 hours for 6 days, after which they were fixed and analyzed through immunohistochemical methods Results: There was no visible expression in the control, $6.3{\times}10^6\;pfu/ml$, and $6.3{\times}10^7\;pfu/ml$ groups. Initial expression was observed at 24 hours after infection in both the palate and the tongue in $6.3{\times}10^8\;pfu/ml$ and the expression significantly increased until 3 days in the palate and 2 days in the tongue after infection (P<0.05). In both groups, the expression was mostly observed at the resection margin. Immunohistochemical studies showed that the epithelial cells were positive to GFP. Conclusion: The present study showed that topically applied adenovirus containing specific genetic information of GFP could successfully transduce GFP in normal oral epithelial cells at the resection margin in organ culture in terms of dose and exposure time.

• The korean journal of orthodontics
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• v.22 no.3 s.38
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• pp.531-556
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• 1992

The majority of the commonly used protraction headgears for the protraction of small and/or retropositioned maxilla not allow a change in the point of force application or direction of the force delivery to attain predictable results because of the position of the upper and lower lips to avoid discomfort to the patient. The purpose of this study was to investigate the initial reaction of maxillofacial complex according to the change of force variables such as direction and point of force application with designing an antenna type-modified protraction head gear. A macerated human skull with well aligned upper teeth was used to experimental model and the investigation was done by double exposure holographic interferometry. Fringe patterns of each protraction conditions were compared and analized. The results were as follows. (Frontal view) 1. The Counterclockwise rotation of the maxilla was showed by parallel protraction to occlusal plane and the fringe was decreased in number as higher point of force application. 2. Generally, the number of fringe was increased in 500gm of protraction force than in 300gm. 3. When apply the protraction force to the maxilla with rapid palatal expansion, the direction of fringe patterns was differed from the protraction without expansion. 4. In most of cases, the counterclockwise rotation was decreased in case of the direction of the force is $20^{\circ}$ downward to occlusal plane compared to the parallel direction. 5. At the point of force application is 15mm above and the direction of force is 20 downward to occlusal plane , the translation of the maxillary complex was showed. (Lateral view) 6. The direction of fringe patterns of the facial bones were differed each other by the sutures, and showed almost parallel when apply the 300gm and 500gm of protraction force. 7. In case of rapid palatal expansion with protraction of the maxilla, the fringe patterns between the maxillary area and the area from the posterior of the maxillary first molar to the pterygomaxillary fissure were differed. In case without rapid palatal expansion, the changes of direction and point of the force application did not affect to the direction and the number of the fringe patterns.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.43 no.5 s.347
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• pp.7-16
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• 2006

IPTV is referred to the service which provide integrated IPTV services for providing video, 10/100-Mbit/sec Internet, voice, video-on-demand (VOD), and other broadband applications including home security, video conferencing, and telemedicine. All services are integrated into an IP (Internet Protocol) architecture designed specifically for Gigabit Ethernet FTTH systems, HFC or xDLC. It is absolutely necessary that telecon operators provide IP video delivery platforms that enable service providers to transform their business. With their own products, they can better manage their existing services and generate new revenues from broadcast TV, movies on demand and multimedia. Triple-play is a combination of broadcast, telephony and broadband services offered through IPTV networks. With cable operators allowed to offer a triple-play bundle, the nation's telecom operators are beginning to get a little anxious. Cable operators assert that triple-play is a must-have and natural extension of the cable service bundle. The Korean Cable TV Association asserts that the triple-play model is of paramount importance to the cable industry's future growth. But the telecom sector considers itself unfairly disadvantaged, saying they cannot compete until regulatory issues are resolved. The start of web-based television in Korea may still be some time off with a confrontation between the nation's IT regulator and broadcasting sector over the service's legal boundaries shows no signs of being resolved my time soon. korea should be is the fastest-growing provider of IPTV solutions in the industry, with over worldwide customers.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.9
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• pp.425-435
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• 2017

Structural analysis is used not only for large enterprises, but also for small and medium sized ones, as a necessary procedure for strengthening the certification process for product delivery and shortening the time in the process from concept design to detailed design. Open-source solvers that can be used atlow cost differ from commercial solvers. If there is a problem with the input data, such as with the grid, errors or failures can occur in the calculation step. In this paper, we propose a pre- and post-processor that can be easily applied to the analysis of mechanical structural problems by using the existing structural analysis open source solver (Caculix, Code_Aster). In particular, we propose algorithms for analyzing different types of data using open source solvers in order to extract and generate accurate information,such as 3D models, grids and simulation conditions, and develop and apply information analysis. In addition, to improve the accuracy of open source solvers and to prevent errors, we created a grid that matches the solver characteristics and developed an automatic healing function for the grid model. Finally, to verify the accuracy of the system, the verification and utilization results are compared with the software used.

• Journal of Periodontal and Implant Science
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• v.47 no.5
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• pp.292-311
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• 2017

Purpose: Beyond the limited scope of non-specific polyclonal regulatory T cell (Treg)-based immunotherapy, which depends largely on serendipity, the present study explored a target Treg subset appropriate for the delivery of a novel epitope spreader Pep19 antigen as part of a sophisticated form of immunotherapy with defined antigen specificity that induces immune tolerance. Methods: Human polyclonal $CD4^+CD25^+CD127^{lo-}$ Tregs (127-Tregs) and $na\ddot{i}ve$ $CD4^+CD25^+CD45RA^+$ Tregs (45RA-Tregs) were isolated and were stimulated with target peptide 19 (Pep19)-pulsed dendritic cells in a tolerogenic milieu followed by ex vivo expansion. Low-dose interleukin-2 (IL-2) and rapamycin were added to selectively exclude the outgrowth of contaminating effector T cells (Teffs). The following parameters were investigated in the expanded antigen-specific Tregs: the distinct expression of the immunosuppressive Treg marker Foxp3, epigenetic stability (demethylation in the Treg-specific demethylated region), the suppression of Teffs, expression of the homing receptors CD62L/CCR7, and CD95L-mediated apoptosis. The expanded Tregs were adoptively transferred into an $NOD/scid/IL-2R{\gamma}^{-/-}$ mouse model of collagen-induced arthritis. Results: Epitope-spreader Pep19 targeting by 45RA-Tregs led to an outstanding in vitro suppressive T cell fate characterized by robust ex vivo expansion, the salient expression of Foxp3, high epigenetic stability, enhanced T cell suppression, modest expression of CD62L/CCR7, and higher resistance to CD95L-mediated apoptosis. After adoptive transfer, the distinct fate of these T cells demonstrated a potent in vivo immunotherapeutic capability, as indicated by the complete elimination of footpad swelling, prolonged survival, minimal histopathological changes, and preferential localization of $CD4^+CD25^+$ Tregs at the articular joints in a mechanistic and orchestrated way. Conclusions: We propose human $na\ddot{i}ve$ $CD4^+CD25^+CD45RA^+$ Tregs and the epitope spreader Pep19 as cellular and molecular targets for a novel antigen-specific Treg-based vaccination against collagen-induced arthritis.

• Information Systems Review
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• v.8 no.1
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• pp.81-99
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• 2006

Recently, the area of ubiquitous has gained a great attention both in academics and in business organizations as we are entering an ubiquitous society where people can interact at "anytime" and "anywhere". To preoccupy the leading status for the next generation of IT technology, many countries such as Korea, Japan, and US are concerned the ubiquitous. In this tendency, companies want to identify what factors make people use ubiquitous in order to develop the effective ubiquitous service and to supply the higher quality service. However, prior researches on ubiquitous are focused on technical area such as higher data delivery, efficient compression of images, so they do not have given companies beneficial materials for making fascinating ubiquitous services. To offer the service materials for development, from the viewpoint of the customer, important factors to use ubiquitous services are investigated in this study. Moreover, the study was progressed up to the new area of investigation how much these factors influenced ubiquitous service actual usage. To achieve these goals, Ubiquitous service adopting reflected in ubiquitous service characteristics was suggested in this study. The results of this study are as follows. First, contextual offer, ubiquity, invisibility are positively related to perceived value. Second, perceived value is positively related to usage intention but perceived risk is negatively related to usage intention. Third, usage intention is positively related to usage frequency. Based on these results, managerial implications for ubiquitous service vitalization are discussed. Lastly, the limitation of this research and further research issues are suggested.

• Archives of Plastic Surgery
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• v.37 no.5
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• pp.600-606
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• 2010

Purpose: Although traditional and current treatment strategies may demonstrate success, persistence or recurrence of difficult-to-heal wounds remain significant problems. A novel product, Hyalomatrix$^{(R)}$ (Fidia Advanced Biopolymer, Abano Terme, Italy) is a bilayer of an benzyl esterified hyaluronan scaffold beneath a silicone membrane. The scaffold delivers hyaluronan to the wound, and the silicone membrane acts as a temporary epidermal barrier. We present the results obtained with Hyalomatrix$^{(R)}$ in the treatment of difficult-to-heal wounds. Methods: From November, 2008 to March, 2010, Hyalomatrix$^{(R)}$ has been used on total 10 patients with wounds that were expected difficult to heal with traditional and other current strategies. After average 37.4 days from development of wounds, Hyalomatrix$^{(R)}$ was applied after wound debridement. On the average, Hyalomatrix$^{(R)}$ application period was 17.6 days. After average 16.5 days from removal of Hyalomatrix$^{(R)}$, skin grafts was performed. Results: In all cases, regeneration of fibrous granulation tissues and edge re-epithelization were present after the application of the Hyalomatrix$^{(R)}$. And all of the previous inflammatory signs were reduced. After skin grafts, no adverse reactions were recorded in 9 cases. But in one case, postoperative wound infection occured due to a lack of efficient fibrous tissues. In this model, the Hyalomatrix$^{(R)}$ acts as a hyaluronan delivery system and a barrier from the external environments. In tissue repair processes, the hyaluronan performs to facilitate the entry of a large number of cells into the wounds, to orientate the deposition of extracellular matrix fibrous components and to change the microenvironment of difficult-to-heal wounds. Conclusion: Our study suggests that Hyalomatrix$^{(R)}$ could be a good and feasible approach for difficult-to-heal wounds. The Hyalomatrix$^{(R)}$ improves microenvironments of difficult-to-heal wounds, reduces infection rates and physical stimulus despite of aggravating factors.