• Journal of Genetic Medicine
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• v.2 no.2
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• pp.49-51
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• 1998

Wolf-Hirschhorn syndrome (WHS) is caused by a deletion of the short arm on chromosome 4 and is characterized by multiple congenital abnormalities, growth and mental retardation. In this case report, we performed amniocentesis for the chromosome analysis on a 25-year-old pregnant woman at 16 weeks of gestation whom we suspected of Edward's syndrome by the triple test of maternal serum and ultrasonography. The result of analysis revealed a karyotype of the fetus with 46,XY,del(4)(p15) by trypsin Giemsa's banding technique. With the result, we were able to diagnose the fetus as having WHS. As such, after therapeutic termination of the pregnancy, we confirmed WHS through the sampling of tissue by both trypsin Giemsa's banding and fluorescence in situ hybridization (FISH) method. To determine the origin of the WHS, we further tested the karyotypes of the parents. As parental karyotypes were found to be normal, we determined the case of the fetal WHS to be de novo.

• The Journal of Korean Medical History
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• v.26 no.2
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• pp.31-61
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• 2013

Objective : The field of specialty in medicine origins from general or comprehensive theories of medicine. "Mokgwaillam" is a book of ophthalmology. However, its contents are from "Dongeuibogam" "Ahn" We need to compare "Mokgwaillam" with "Dongeuibogam" "Ahn" and find out how they are different or similar. Method : Contents comparison between "Mokgwaillam" and "Dongeuibogam" "Ahn" was conducted in contents movement, deletion, transformation and so on. Result : The most content of "Mokgwaillam" derived from "Dongeuibogam" "Ahn" even though "Mokgwaillam" adjusted several parts of "Dongeuibogam" "Ahn" as a book of ophthalmology. Conclusion : Because "Mokgwaillam" contents are not outright and remarkable in ophthalmology field, "Mokgwaillam" has its limit. On the contrast, we suggest that "Mokgwaillam" could represents speciating ophthalmology field in Traditional Korean Medicine. The reason is that "Mokgwaillam" tried to remake "Dongeuibogam" "Ahn" contents as a ophthalmologic book in some aspects ; contents movement, deletion, transformation and so on.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.13 no.6
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• pp.87-93
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• 2004

An experimental is carried out to investigate the characteristics of blanking for nickel alloy Alloy42 (t=0.203mm), a kind of IC lead frame material. By varying clearance between die and punch the shapes of shear profile are examined. Finite element analysis with element deletion algorithm for ductile fracture mode is also carried out to study the effect of clearance theoretically and to compare with experimental results. The rectangular shape specimen with four different comer radius is used to study the characteristics of blanking for straight side and comer region simultaneously. As the result the ratios measured k(m experiment of roll over, burnish and fracture zone based on initial blank thickness are compared with those of FE analysis. Both experiment and FE analysis show that the amount of mil over and fracture is increased as the clearance increases. When the radius of comer is less than thickness of blank it has been found that larger clearance is required than that of straight region in order to maintain same quality of shear profile at the comer region.

• Journal of the Korean Society for Precision Engineering
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• v.18 no.3
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• pp.182-188
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• 2001

An experiment is carried out to investigate the characteristics of blanking for copper alloy C194 (t=0.254mm), a kind of IC lead frame material. By varying clearance between die and punch, the shapes of shear profile are examined. Finite element analysis with element deletion algorithm for ductile fracture mode is also carried out to study the effect of clearance theoretically and to compare with experimental results. The rectangular shape specimen with four different corner radius is used to study the characteristics of blanking for straight side and corner region simultaneously. As the result, the ratios measured from the experiment of roll over, burnish, and fracture zone based on intial blank thickness are compared with those of FE analysis. Both experiment and FE analysis show that the amount of roll over and fracture is increased as the clearance increases. It has been found that larger clearance is required than that of straight region when the radius of corner is less than thickness of blank, in order to maintain same quality of shear profile at the corner region.

• Journal of Life Science
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• v.16 no.3 s.76
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• pp.454-458
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• 2006

HSF1 is the heat shock transcription factor in Saccharomyces cerevisiae. S. cerevisiae KNU5377 can ferment at high temperature such as $40^{\b{o}}C$. We have been the subjects of intense study because Hsf1p mediates gene expression not only to heat shock, but to a variety of cellular and environmental stress challenges. Basing these facts, we firstly tried to construct the hsf1 gene-deleted mutant. PCR-method for fast production of gene disruption cassette was introduced in a thermotolerant yeast S. cerevisiae KNU5377, which allowed the addition of short flanking homology region as short as 45 bp suffice to mediate homologous recombination to kanMX module. Such a cassette is composed of linking genomic DNA of target gene to the selectable marker kanMX4 that confers geneticin (G418) resistance in yeast. That module is extensively used for PCR-based gene replacement of target gene in the laboratory strains. We describe here the generation of hsf1 gene disruption construction using PCR product of selectable marker with primers that provide homology to the hsf1 gene following separation of haploid strain in wild type yeast S. cerevisiae KNU5377. Yeast deletion overview containing replace cassette module, deletion mutant construction and strain confirmation in this study used Saccharomyces Genome Deletion Project (http:://www-sequence.standard.edu/group/yeast_deletion_project). This mutant by genetic manipulation of wild type yeast KNU5377 strain will provide a good system for analyzing the research of the molecular biology underlying their physiology and metabolic process under fermentation and improvement of their fermentative properties.

• Journal of Veterinary Clinics
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• v.32 no.1
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• pp.1-4
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• 2015

This study was performed to survey prevalence of Copper metabolism domain containing 1 (COMMD1) mutation using molecular diagnostic method in a population of Bedlington terriers in Korea. COMMD1 gene (formerly MURR1) functions as a regulator of sodium transport and copper metabolism. The deletion of exon 2 of the COMMD1 gene causes copper toxicosis in Bedlington terriers. Bedlington terriers with this autosomal recessive disorder were shown to have the elevated liver copper levels due to genetic derangement in the biliary copper excretion pathway. DNA samples were extracted from whole blood collected from 257 Bedlington terriers (109 males, 148 females) of pet dog clubs in Korea. A multiplex PCR was carried out to detect of exon 2 deletion of COMMD1 gene. In this study, it was possible to know the existence and prevalence of exon 2 deletion of COMMD1 in Bedlington terriers in Korea. Of the 257 samples, 131 (51%) were wild type homozygous for the normal COMMD1 gene, 108 (42%) were heterozygous, having both normal and mutated copy of the COMMD1 gene. The eighteen (7%) were mutant type homozygous. The results of genetic analysis could help establish proper management strategy and selective breeding program to prevent COMMD1 mutation in Bedlington terriers in Korea.

• Journal of the Korea Society of Computer and Information
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• v.15 no.10
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• pp.113-120
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• 2010

Video proxy server which is located near clients can store the frequently requested video data in storage space in order to minimize initial latency and network traffic significantly. However, due to the limited storage space in video proxy server, an appropriate video selection method is needed to store the videos which are frequently requested by users. Thus, we present a time constraint multiple access technique to efficiently store the video in video proxy server. If the video is requested by user, it is temporarily stored during the predefined interval and then, delivered to the user. A video which is stored is deleted or moved into the storage space of video proxy server depending on the request condition. In addition, we propose a video deletion method in video proxy server for newly stored video data. The simulation results show that the proposed method performs better than other methods in terms of the block hit rate and the number of block deletion.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.14 no.2
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• pp.35-42
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• 2014

This paper suggests a method that obtains the minimum spanning tree (MST) far more easily and rapidly than the present ones. The suggested algorithm, firstly, simplifies a graph by means of reducing the number of edges of the graph. To achieve this, it applies a method of eliminating the maximum weight edge if the valency of vertices of the graph is equal to or more than 3. As a result of this step, we can obtain the reduced edge population. Next, it applies a method in which the maximum weight edge is eliminated within the cycle. On applying the suggested population minimizing and maximum weight edge deletion algorithms to 9 various graphs, as many as the number of cycles of the graph is executed and MST is easily obtained. It turns out to lessen 66% of the number of cycles and obtain the MST in at least 2 and at most 8 cycles by only deleting the maximum weight edges.

• Journal of the Korea Society of Computer and Information
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• v.17 no.6
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• pp.145-152
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• 2012

Due to the large sizes of streaming media, previous delivery techniques are not providing optimal performance. For this purpose, video proxy server is employed for reducing the bandwidth consumption, network congestion, and network traffic. This paper proposes a fast distributed network file system using state transition model in the media streaming system for efficient utilization of video proxy server. The proposed method is composed of three steps: step 1. Training process using state transition model, step 2. base and decision probability generation, and step 3. storing and deletion based on probability. In addition, storage space of video proxy server is divided into each segment area in order to store the segments efficiently and to avoid the fragmentation. The simulation results show that the proposed method performs better than other methods in terms of hit rate and number of deletion. Therefore, the proposed method provides the lowest user start-up latency and the highest bandwidth saving significantly.

• Communications for Statistical Applications and Methods
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• v.14 no.1
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• pp.229-239
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• 2007

We present a diagnostic method for the quasi-likelihood estimators in generalized linear models. Since these estimators can be usually obtained by iteratively reweighted least squares which are well known to be very sensitive to unusual data, a diagnostic step is indispensable to analysis of data. We extend the local influence approach based on the maximum likelihood function to that on the quasi-likelihood function. Under several perturbation schemes local influence diagnostics are derived. An illustrative example is given and we compare the results provided by local influence and deletion.