• Communications for Statistical Applications and Methods
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• 제10권2호
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• pp.305-317
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• 2003

We suggest methods to measure the changes in $x^2$ statistic when a row is deleted from a two-way contingency table. The influence function is extended and the deletion method is applied. Two examples are presented and we compare the results obtained from the influence function method and the deletion method.

• 대한기계학회논문집A
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• 제32권6호
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• pp.496-503
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• 2008

With the improvement of computer power and technology, fracture modelling by finite element methods has become a topic of extensive studies. However, fracture simulation much limited to an academic study of crack propagation with a fine mesh. Element deletion method is a useful tool for estimating damage due to accidental or extreme loads on structures, provided that an effective and realistic criterion is established for simulating the material failure and subsequent element deletion. In this study, ABAQUS/Explicit is used to simulate the material failure on the basis of experimental results by X. Huang et al. Through numerical experiments, we suggest a formulation to determine the failure strain associated with the size and thickness of removed elements.

• Journal of applied mathematics & informatics
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• 제19권1_2호
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• pp.521-525
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• 2005

Case deletion diagnostic for multiple correlation coefficient is considered. A method of detecting observations that can hide or create multicollinearity is suggested. A numerical example is given for illustration.

• Journal of Microbiology and Biotechnology
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• 제16권9호
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• pp.1338-1346
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• 2006

Ansamitocin P-3 is a potent antitumor agent produced by A. pretiosum. A deletion mutant of A. pretiosum was constructed by deleting the asm2 gene, a putative transcriptional repressor. The deletion mutant showed a 9-fold enhanced ansamitocin P-3 productivity. The response surface method with central composite design was employed to further optimize the culture medium composition for ansamitocin P-3 production by the deletion mutant. The concentrations of four medium ingredients, dextrin, maltose, cotton seed flour, and yeast extract, which have been reported as major components for ansamitocin production, were optimized through a series of flask culture experiments. The optimum concentrations of the selected factors were found to be dextrin 6.0%; maltose 3.0%; cotton seed flour 0.53%; and yeast extract 0.45%. The maximum titer of ansamitocin P-3 was 78.3 mg/l with the optimized composition, about 15-folds higher than the unoptimized titer of 5.0 mg/l obtained with YMG medium.

• Clinical and Experimental Pediatrics
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• 제59권sup1호
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• pp.19-24
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• 2016

Constitutional interstitial deletions of the long arm of chromosome 5 (5q) are quite rare, and the corresponding phenotype is not yet clearly delineated. Severe mental retardation has been described in most patients who present 5q deletions. Specifically, the interstitial deletion of chromosome 5q33.3q35.1, an extremely rare chromosomal aberration, is characterized by mental retardation, developmental delay, and facial dysmorphism. Although the severity of mental retardation varies across cases, it is the most common feature described in patients who present the 5q33.3q35.1 deletion. Here, we report a case of a de novo deletion of 5q33.3q35.1, 46,XY,del(5)(q33.3q35.1) in an 11-year-old boy with mental retardation; to the best of our knowledge this is the first case in Korea to be reported. He was diagnosed with severe mental retardation, developmental delay, facial dysmorphisms, dental anomalies, and epilepsy. Chromosomal microarray analysis using the comparative genomic hybridization array method revealed a 16-Mb-long deletion of 5q33. 3q35.1(156,409,412-172,584,708)x1. Understanding this deletion may help draw a rough phenotypic map of 5q and correlate the phenotypes with specific chromosomal regions. The 5q33.3q35.1 deletion is a rare condition; however, accurate diagnosis of the associated mental retardation is important to ensure proper genetic counseling and to guide patients as part of long-term management.

• Communications for Statistical Applications and Methods
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• 제21권3호
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• pp.253-260
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• 2014

The intraclass correlation model has a long history of applications in several fields of research. Case deletion diagnostic methods for the intraclass correlation model are proposed. Based on the likelihood equations, we derive a formula for a case deletion diagnostic method which enables us to investigate the influence of observations on the maximum likelihood estimates of the model parameters. Using the Taylor series expansion we develop an approximation to the likelihood distance. Numerical examples are provided for illustration.

• Communications for Statistical Applications and Methods
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• 제7권3호
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• pp.677-686
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• 2000

Outliers may occur with respect to any of the random components in mixed linear models. We develop a use of simple, inexpensive updating formulas to consider the effect of case-deletion for mixed linear models. The method described here requires inversions of an n x n matrix, where n is the number of nonempty cells. A numerical example illustrates the use of computational formulas.

• Journal of the Korean Statistical Society
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• 제16권2호
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• pp.55-70
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• 1987

The principal components regression is one of the substitues for least squares method when there exists multicollinearity in the multiple linear regression model. It is observed graphically that the performance of the principal components regression is strongly dependent upon the values of the parameters. Accordingly, a new deletion criterion which determines proper principal components to be deleted from the analysis is developed and its usefulness is checked by simulations.

• 한국컴퓨터산업학회논문지
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• 제3권7호
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• pp.921-926
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• 2002

B+-Tree는 데이터베이스 관리 시스템에서 대용량의 데이터를 효율적으로 관리하기 위해서 가장 널리 사용되는 인덱스이다. 하지만 기존의 B+-Tree는 데이터베이스를 처음 구성할 때나, 인덱스를 새로 구성할 시, 많은 DISK/IO가 발생하고, 삭제 연산이 빈번할 시에는 색인 구조 변경연산이 많이 발생하여 동시성이 떨어진다는 단점이 있다. 이러한 문제점을 해결하기 위해서 대부분의 데이터베이스 시스템에서는 일괄구성과 지연삭제를 이용한다. 하지만 일괄구성 및 지연(Lazy) 삭제 방법을 적용한 B+-Tree를 데이터 베이스 관리 시스템에 적용 하려면 동시성 제어 및 회복 기법이 필수적으로 요구되지만, 이에 대한 연구가 미흡하여 실제 시스템에 적용하기에는 문제가 있다. 본 연구에서는 일괄구성과 지연삭제 방법을 적용한 B+-Tree를 실제 데이터베이스 시스템에 적용할 수 있도록 동시성 및 회복기법을 제안했다. 제안기법은 트랜잭션 Pending 리스트를 사용하여 연속적인 철회(Cascade Rollback)가 발생하지 않고, 재구성시 베이스 테이블에 대한 삽입, 삭제를 가능하게 하여 동시성을 높였으며, 시스템 Queue를 사용하여 일괄구성 연산을 사용자의 트랜잭션에서 수행하지 않고 따로 시스템 트랜잭션으로 처리하여 사용자의 트랜잭션의 응답시간을 줄였다.

• Tuberculosis and Respiratory Diseases
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• 제45권5호
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• pp.975-983
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• 1998

연구배경: 3p는 종양억제유전자의 존재가 강력히 의심되는 염색체의 부위로 폐암을 비롯한 여러 암에서 변이가 관찰되고 있다. 본 연구에서는 한국인의 비소세포폐암을 대상으로 3p의 4부위의 microsatellite locus에 대한 PCR-LOH를 시행하여 deletion의 빈도를 관찰하고 그 임상적 의의를 알아보고자 하였다. 방 법: 3p의 3부위의 CA repeat [D3S1228 (3p14.1-14.3), D3S1067 (3p14.3-21.1), D3S1029 (3p21.1-21.3)] 및 1부위의 tetra repeat [D3S1537 (3p22-24.2)] 의 microsatellite를 대상으로 PCR을 시행한 후 polyacrylamide gel에서 전기영동 후 X-ray film에 현상하였다. 정상 폐의 DNA의 PCR product와 폐암 DNA의 PCR product의 band를 비교하여 LOH가 있는 경우를 관찰하였다. 결 과: 62명의 비소세포폐암환자 중 59명에서 informative case이었고 이중 31명 (52.5%)에서 PCR-LOH를 보여 3p의 deletion이 있음을 관찰하였다. 3p deletion의 유무에 따라 환자의 흡연력, 병기 및 병리소견의 차이(squamous cell carcinoma : 55%, adenocarcinoma : 47%)를 관찰할 수 없었다. 또한 3p deletion의 유무는 비소세포폐암환자의 생존기간에도 영향을 주지 못 했으며 squamous cell carcinoma 및 adenocarcinoma로 나눈 군에서도 생존기간에 차이가 없었다. 결 론: 본 연구의 결과로 3p deletion은 한국인의 비소세포폐암 환자에서 많이 관찰되어 중요 역할을 하고 있으나 임상적인 특정과의 연관성은 관찰할 수 없었다.