• Journal of Korean Neurosurgical Society
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• 제29권4호
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• pp.536-542
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• 2000

Objective : This study was performed to evaluate the relationships among intracranial pressure(ICP), cerebral perfusion pressure(CPP), and cerebral arteriovenous oxygen difference($AVDO_2$) which were used as parameters of adequacy of cerebral blood flow to support cerebral metabolism after severe head injury and also to examine the association between delayed cerebral infarction and outcome. Material and Method : The authors studied the ICP, CPP and $AVDO_2$ before and after treatment on 34 head-injured patients from June 1996 to December 1997 and examined the association with the change of an ICP, CPP and $AVDO_2$ following treatment and the development of delayed cerebral infarction. Sixteen patients underwent craniotomy for hematoma evacuation and eighteen patients received mannitol to decrease ICP. Results : The development of delayed cerebral infarction was demonstrated in 3(42.9%) out of 7 patients in no improvement group and 13(48.1%) out of 27 patients in improvement group with an increased ICP following treatment. Also, the development of delayed cerebral infarction was demonstrated in 8(50%) out of 16 patients in no improvement group and 8(44.4%) out of 18 patients in improvement group with a decreased CPP following treatment. The association with changes of ICP and CPP following treatment and development of delayed cerebral infarction was not statistically significant(p>0.01). However, 11(78.6%) out of 14 patients who demonstrated an increase in $AVDO_2$ and 5(25%) out of 20 patients who demonstrated a decrease in $AVDO_2$ following treatment developed delayed cerebral infarction. No improvement(reduction) in $AVDO_2$ following treatment was significantly associated with the development of delayed cerebral infarction(p<0.01). All of 16 patients with delayed cerebral infarction showed poor prognosis. Conlcusion : The change of $AVDO_2$ rather than those of ICP and CPP was considered more important factor for the development of the delayed cerebral infarction and poor outcome.

• 대한소아치과학회지
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• 제49권1호
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• pp.95-103
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• 2022

제1대구치는 악안면 부위의 발달과 교합에 중요한 기능을 갖는다. 이번 연구의 목적은 맹출 지연된 제1대구치의 유형에 따른 특징에 대해 조사하고 치아의 발육 상태 및 선천적 결손과의 연관성에 대해 알아보고자 하는 것이다. 맹출 지연된 제1대구치를 가진 만 8세 환자를 물리적 장애가 있는 75명과 없는 77명으로 구분하였다. 파노라마 방사선 사진에서 맹출 지연된 영역의 제1대구치 및 제2대구치의 발육 상태를 Nolla 방법을 이용하여 분석하였다. 선천적 결손과 제1대구치 맹출 지연 영역과의 연관성도 알아보았다. 제1대구치 맹출 지연은 상악 단독으로 많이 존재했다. 물리적 장애로 인한 맹출 지연은 남자에서 편측성으로 많이 나타났고, 물리적 장애가 없는 경우에는 여자에서 양측성으로 더 많이 나타났다. 맹출 지연된 제1대구치에서 발육 지연이 나타났고, 물리적 장애가 없는 경우에는 인접한 제2대구치의 발육 지연과 해당 영역의 높은 선천적 결손치 비율을 보였다. 제1대구치의 맹출 지연이 관찰된다면, 치아의 발육 상태와 선천적 결손치에 대한 주기적인 임상적, 방사선학적 평가가 필요할 것이다.

• Annals of Clinical Neurophysiology
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• 제13권1호
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• pp.44-47
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• 2011

Background: Miller-Fisher syndrome (MFS) is characterized by the clinical triad of ophthalmoplegia, ataxia, and areflexia, and is considered a variant form of Guillain-Barre syndrome. Although some cases of delayed-onset facial palsy in MFS have been reported, the characteristics of this facial palsy are poorly described in the literature. Methods: Between 2007 and 2010, six patients with MFS were seen at our hospital. Delayed facial palsy, defined as a facial palsy that developed while the other symptoms of MFS began to improve following intravenous immunoglobulin treatment, was confirmed in four patients. The clinical and electrophysiological characteristics of delayed facial palsy in MFS, as observed in these patients, are described here. Results: Four patients with delayed-onset facial palsy were included. Delayed facial palsy developed 8-16 days after initial symptom onset (5-9 days after treatment). Unilateral facial palsy occurred in three patients and asymmetric facial diplegia in one patient. The House-Brackmann score of facial palsy was grade III in one patient, IV in two patients, and V in one patient. None of the patients complained of posterior auricular pain. Facial nerve conduction studies revealed normal amplitude in all four patients. The blink reflex showed abnormal prolongation in two patients and the absence of action potential formation in two patients. Facial palsy resolved completely in all four patients within 3 months. Conclusions: Delayed facial palsy is a frequent symptom in MFS and resolves completely without additional treatment. Thus, standard treatment and patient reassurance are sufficient in most cases.

• 생물정신의학
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• 제12권2호
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• pp.207-215
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• 2005

Objectives:This study was to compare verbal memory ability among patients with schizophrenia, bipolar manic patients and unipolar depressive patients, and to understand their charicteristics of memory process. Methods:All subjects were hospitalized patients and had been interviewed by using the Structured Clinical Interview for DSM-IV(SCID). Schizophrenic patients(N=40), bipolar manic patients(N=17), and unipolar depressive patients(N=20) were assessed with K-AVLT for verbal memory and with K-WAIS for verbal IQ. Three groups were compared regarding total immediate recall, delayed recall, delayed recognition, learning curve, memory retention, and retrieval efficiency under controlled verbal IQ. Multiple regression analysis was performed to find which clinical factors have an influence on verbal memory ability. Results:In MANCOVA, differences of verbal memory test scores among the groups were statistically significant(F=1.800, p<.05). In post hoc analysis, Patients with schizophrenia and bipolar mania showed poorer performance in immediate recall, delayed recall, delayed recognition, retrieval efficiency than unipolar depres- sive patients. And schizophrenics performed poorly in delayed recall, delayed recognition, retrieval efficiency than nonpsychotic affective disorder group, but no difference in total immediate recall, delayed recall, delayed recognition, retrieval efficiency between the schizophrenic group and the psychotic affective group. Conclusions:These results partially confirm previous reports of verbal memory ability among major psychiatric disorders. Our results showed that psychotic symptoms were related with verbal memory, and longer duration of illness was related with poorer performance in schizophrenia and unipolar depression.

• 한국초지조사료학회지
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• 제11권2호
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• pp.137-142
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• 1991

For the constitution of forage cropping system including the double-cropping of corn, attention has been directed towards the early and short maturing varieties of corn such as Comet 80, Comet 85 and Linda as a component forage crop of forage cropping system. Four corn varieties, Comet 80, Comet 85, Linda and Suwon 19 were planted delayedly by each of 45, 55 and 65 days from the recommended sowing date of suwon 19. Under these condition, growth characteristics and late-sowing adaptability of 4 corn varieties were investigated, and the results are summarized as follows; 1. The variety of suwon 19 did not reach the stage of silking in the occasion of late sowing by 50 days from the optimum sowing time for mono cropping of suwon 19. However early varieties such as Comet 80, Comet 85 and Linda silked under the condition of 65 days-delayed sowing from the recommended sowing time of Suwon 19 for mono-cropping. 2. Early varieties of Comet 80, Comet 85 and Linda were so grown by approximately 92% in plant height, 66% in ear height, 88% in stem diameter and 81% in leaf number respectively compared to Suwon 19 at each of three delayed sowing time that exhibited the dwarfish appearance of canopy. 3. Days from sowing to silking decreased as the sowing time was delayed and the average days from sowing to silking in the sowing treatments of 55 days-delayed of Suwon 19, Comet 80, Comet 85 and Linda were 61, 46, 47 and 51 days, respectively. 4. The size of variations of plant height and ear height influenced by delayed-sowing time was comparatively larger in the varieties of Suwon 19 and Linda than in those of Comet 80 and Comet 85. 5. As sowing time was delayed from the optimum sowing time of Suwon 19 for mono-cropping, ear content decreased from 0% of Suwon 19 at 55 day-delayed sowing treatment to 3540% of Comet 80 and Comet 85 at 65 days-delayed sowing treatment.

• Journal of Korean Neurosurgical Society
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• 제56권5호
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• pp.390-394
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• 2014

Objective : In most patients with carpal tunnel syndrome (CTS), pain and/or paresthesia disappeared or decreased in a month after endoscopic carpal tunnel release (ECTR). However, subpopulation of patients showed delayed improvement following ECTR. We analyzed the delayed improvement hands to investigate the characteristics of those patients and to determine the predictable factors of delayed improvement. Methods : Single-portal ECTRs were performed in 1194 hands of 793 CTS patients from 2002 to 2011. Five-hundred seventy hands with minimal 1-year postoperative follow-up were included. We divided the 545 satisfied hands into early (group A) and delayed (group B) groups according to improvement period of 1 month. Demographic data, clinical severity and electrodiagnostic abnormality were compared between groups. Results : Group A included 510 hands and group B included 35 hands. In group B, 11 hands improved in 2 months, 15 hands in 3 months and 9 hands in 6 months, respectively. In group A/B, according to clinical severity, 60/1 hands were graded to I, 345/24 hands to II, 105/10 hands to III. In group A/B, based on electrodiagnostic abnormality, 57/3 hands were classified to mild, 221/11 hands to moderate and 222/21 hands to severe group. Statistical analysis between groups did not reach significance but electrodiagnostic or clinical severity had a tendency to affect the delayed response. Conclusion : It is difficult to predict the factors contributing to postoperatively-delayed response in subpopulation of CTS patients. However, we recommend that postoperative observation for at least 6 months is necessary in patients without symptomatic improvement.

• The Plant Pathology Journal
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• 제24권4호
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• pp.392-399
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• 2008

Detached chili pepper fruits were inoculated with the conidial suspension of Colletotrichum acutatum JC-24 simultaneously (simultaneous inoculation, SI) and at delayed time (delayed inoculation, DI) after wounding with (delayed wound inoculation, DWI) or without additional wounding (delayed non-wound inoculation, DNI) at the inoculation time. Disease severity was significantly lowered by DNI, compared to SI. By DNI, the disease reduction rates were proportional with the length of delayed time, and greater at the high temperature range (18, 23 and $28^{\circ}$) than at the low temperature ($13^{\circ}$) tested. DWI was also effective in reducing the disease severity especially at 18oC; however, its effectiveness was lower than for DNI. In light microscopy, parenchyma cells at the wounding sites were modified structurally, initially forming new cell walls crossing cytoplasm, enlarged with multiple periclinal cell divisions, and finally layered like wound periderms. In DWI, the above structural modifications occurred, showing the restriction of the fungal invasion by the cell walls in enlarged modified cells, while no definite cellular modifications were found with proliferation of fungal hyphae in SI. Sclerenchyma-like cells with thickened cell walls were proliferated around the wounding sites, which were partially dissolved by DWI, probably leading to some disease development. All of these results suggest that the decline of the anthracnose disease in pepper fruit by the delayed inoculations may be derived from the structural modifications related to the healing processes of the previous wound inflicted on the tissues.

• Archives of Plastic Surgery
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• 제47권1호
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• pp.49-53
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• 2020

Background Identifying patients who may be at high risk for wound complications postsarcoma resection and reconstruction is essential for improving functional outcomes and quality of life. Currently, the effect of timing on sarcoma reconstruction has been poorly investigated. The purpose of this study was to compare outcomes of delayed and immediate reconstruction in the setting of sarcoma resection requiring flap reconstruction in the lower extremity. Methods A retrospective review of the senior author's sarcoma reconstruction patients from January 2005 to July 2017 was completed. All patients undergoing flap reconstruction of the lower extremity were included. Complications in the early postoperative period were compared between delayed and immediate reconstructive procedures. Results A total of 32 patients (7 delayed, 25 immediate) were included in this study. There was a significantly increased rate of overall complications (100% vs. 28.0%, P=0.001) and rate of hematomas (28.6% vs. 0.0%, P=0.042) in the delayed reconstruction group. Other complications including dehiscence, seroma, infection, venous thrombosis, and total/partial flap loss were also increased in the delayed reconstruction group, but this was not considered to be significant. Conclusions This study suggests that delayed reconstruction following sarcoma resection of the lower extremity had a higher incidence of overall complications and hematoma formation. We emphasize the importance of early plastic and reconstructive surgeon referral and the necessity to closely monitor delayed reconstruction patients for complications.

• 한국가족관계학회지
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• 제22권3호
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• pp.131-153
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• 2017

Objective: This study aimed to examine the effects of adult children's marriage-delay on their parents' mental health. Furthermore, this study investigated how the influence of adult children's marriage-delay on parents' mental health could vary depending on the coresidence and employment status of the marriage-delayed adult children. Method: Two waves of Korean Longitudinal Study of Ageing (KLoSA) were used for the analyses. Multiple regression models were conducted with 2,938 Korean parents who had at least one child, regardless of gender (aged 33~44). Results: First, adult children's marriage-delay was related to lower levels of parents' life satisfaction. Second, the levels of parents' life satisfaction were low regardless of residing with their marriage-delayed adult children, and the parents who were not living with their marriage-delayed adult children showed lower levels of life satisfaction than parents living with marriage-delayed adult children. Third, only the parents with unemployed marriage-delayed adult children showed significantly higher levels of depression. However, the levels of parents' life satisfaction were low regardless of the employment of marriage-delayed adult children, and the parents of unemployed marriage-delayed adult children showed lower levels of life satisfaction than the parents of employed marriage-delayed adult children. Conclusions: It is necessary to consider the effects of marriage, employment and coresidence of adult children on their parents in order to enhance the mental health of the parents. Also, the effects of marriage-delay on intimate relationships, such as family dynamics, need to be explored more in further research.

• Journal of Periodontal and Implant Science
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• 제52권2호
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• pp.127-140
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• 2022

Purpose: In dental avulsion, delayed replantation usually has an uncertain prognosis. After tooth replantation, complex inflammatory responses promote a return to periodontal tissue homeostasis. Various types of cytokines are produced in the inflammatory microenvironment, and these cytokines determine the periodontal tissue response. This study aimed to identify the gene expression profiles of replanted teeth and evaluate the functional differences between immediate and delayed replantation. Methods: Maxillary molars from Sprague-Dawley rats were extracted, exposed to a dry environment, and then replanted. The animals were divided into 2 groups according to the extra-oral time: immediate replantation (dry for 5 minutes) and delayed replantation (dry for 60 minutes). Either 3 or 7 days after replantation, the animals were sacrificed. Periodontal soft tissues were harvested for mRNA sequencing. Hallmark gene set enrichment analysis was performed to predict the function of gene-gene interactions. The normalized enrichment score (NES) was calculated to determine functional differences. Results: The hallmark gene sets enriched in delayed replantation at 3 days were oxidative phosphorylation (NES=2.82, Q<0.001) and tumor necrosis factor-alpha (TNF-α) signaling via the nuclear factor kappa light chain enhancer of activated B cells (NF-κB) pathway (NES=1.52, Q=0.034). At 7 days after delayed replantation, TNF-α signaling via the NF-κB pathway (NES=-1.82, Q=0.002), angiogenesis (NES=-1.66, Q=0.01), and the transforming growth factor-beta signaling pathway (NES=-1.46, Q=0.051) were negatively highlighted. Conclusions: Differentially expressed gene profiles were significantly different between immediate and delayed replantation. TNF-α signaling via the NF-κB pathway was marked during the healing process. However, the enrichment score of this pathway changed in a time-dependent manner between immediate and delayed replantation.