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A comparison of delayed versus immediate reconstruction following lower-extremity sarcoma resection

  • Zhou, Sarah (McGill University Faculty of Medicine) ;
  • Azzi, Alain J (Division of Plastic and Reconstructive Surgery, McGill University Health Center) ;
  • Safran, Tyler (Division of Plastic and Reconstructive Surgery, McGill University Health Center) ;
  • Zadeh, Teanoosh (Division of Plastic and Reconstructive Surgery, McGill University Health Center)
  • Received : 2019.05.28
  • Accepted : 2019.11.28
  • Published : 2020.01.15

Abstract

Background Identifying patients who may be at high risk for wound complications postsarcoma resection and reconstruction is essential for improving functional outcomes and quality of life. Currently, the effect of timing on sarcoma reconstruction has been poorly investigated. The purpose of this study was to compare outcomes of delayed and immediate reconstruction in the setting of sarcoma resection requiring flap reconstruction in the lower extremity. Methods A retrospective review of the senior author's sarcoma reconstruction patients from January 2005 to July 2017 was completed. All patients undergoing flap reconstruction of the lower extremity were included. Complications in the early postoperative period were compared between delayed and immediate reconstructive procedures. Results A total of 32 patients (7 delayed, 25 immediate) were included in this study. There was a significantly increased rate of overall complications (100% vs. 28.0%, P=0.001) and rate of hematomas (28.6% vs. 0.0%, P=0.042) in the delayed reconstruction group. Other complications including dehiscence, seroma, infection, venous thrombosis, and total/partial flap loss were also increased in the delayed reconstruction group, but this was not considered to be significant. Conclusions This study suggests that delayed reconstruction following sarcoma resection of the lower extremity had a higher incidence of overall complications and hematoma formation. We emphasize the importance of early plastic and reconstructive surgeon referral and the necessity to closely monitor delayed reconstruction patients for complications.

Keywords

References

  1. Clark MA, Fisher C, Judson I, et al. Soft-tissue sarcomas in adults. N Engl J Med 2005;353:701-11. https://doi.org/10.1056/NEJMra041866
  2. Sanniec KJ, Swanson S, Casey WJ 3rd, et al. Predictive factors of wound complications after sarcoma resection requiring plastic surgeon involvement. Ann Plast Surg 2013;71: 283-5. https://doi.org/10.1097/SAP.0b013e31827c7973
  3. Marre D, Buendia J, Hontanilla B. Complications following reconstruction of soft-tissue sarcoma: importance of early participation of the plastic surgeon. Ann Plast Surg 2012;69: 73-8. https://doi.org/10.1097/SAP.0b013e31821ee497
  4. Spierer MM, Alektiar KM, Zelefsky MJ, et al. Tolerance of tissue transfers to adjuvant radiation therapy in primary soft tissue sarcoma of the extremity. Int J Radiat Oncol Biol Phys 2003;56:1112-6. https://doi.org/10.1016/S0360-3016(03)00200-1
  5. von Mehren M, Randall RL, Benjamin RS, et al. Soft tissue sarcoma, version 2.2016, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 2016;14:758-86. https://doi.org/10.6004/jnccn.2016.0078
  6. Reece GP, Schusterman MA, Pollock RE, et al. Immediate versus delayed free-tissue transfer salvage of the lower extremity in soft tissue sarcoma patients. Ann Surg Oncol 1994;1:11-7. https://doi.org/10.1007/BF02303536
  7. Sanniec KJ, Velazco CS, Bryant LA, et al. Immediate versus delayed sarcoma reconstruction: impact on outcomes. Sarcoma 2016;2016:7972318.
  8. LeBrun DG, Guttmann DM, Shabason JE, et al. Predictors of wound complications following radiation and surgical resection of soft tissue sarcomas. Sarcoma 2017;2017:5465130.
  9. Moore J, Isler M, Barry J, et al. Major wound complication risk factors following soft tissue sarcoma resection. Eur J Surg Oncol 2014;40:1671-6. https://doi.org/10.1016/j.ejso.2014.10.045
  10. Slump J, Hofer SOP, Ferguson PC, et al. Flap choice does not affect complication rates or functional outcomes following extremity soft tissue sarcoma reconstruction. J Plast Reconstr Aesthet Surg 2018;71:989-96. https://doi.org/10.1016/j.bjps.2018.04.002
  11. Culliford AT 4th, Spector J, Blank A, et al. The fate of lower extremities with failed free flaps: a single institution's experience over 25 years. Ann Plast Surg 2007;59:18-21. https://doi.org/10.1097/01.sap.0000262740.34106.1b
  12. Kang MJ, Chung CH, Chang YJ, et al. Reconstruction of the lower extremity using free flaps. Arch Plast Surg 2013;40: 575-83. https://doi.org/10.5999/aps.2013.40.5.575
  13. Farkas JP, Kenkel JM, Hatef DA, et al. The effect of blood pressure on hematoma formation with perioperative Lovenox in excisional body contouring surgery. Aesthet Surg J 2007;27:589-93. https://doi.org/10.1016/j.asj.2007.08.004
  14. Haubner F, Ohmann E, Pohl F, et al. Wound healing after radiation therapy: review of the literature. Radiat Oncol 2012; 7:162. https://doi.org/10.1186/1748-717X-7-162
  15. Azzi AJ, Zhou S, Safran T, et al. Vascularized tissue reconstruction in previously irradiated sarcoma defects. Ann Plast Surg 2019;82:89-92. https://doi.org/10.1097/SAP.0000000000001652
  16. Bhangu AA, Beard JA, Grimer RJ. Should soft tissue sarcomas be treated at a specialist centre? Sarcoma 2004;8:1-6. https://doi.org/10.1080/13577140410001679185

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  1. The Importance of the Multidisciplinary Approach to Surgical Treatment of Extremity Soft-Tissue Sarcomas vol.11, pp.12, 2020, https://doi.org/10.4236/jct.2020.1112067