• Clinical and Experimental Pediatrics
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• v.59 no.sup1
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• pp.10-13
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• 2016

Chromosome 11q13 deletion syndrome has been previously reported as either otodental syndrome or oculo-oto-dental syndrome. The otodental syndrome is characterized by dental abnormalities and high-frequency sensorineural hearing loss, and by ocular coloboma in some cases. The underlying genetic defect causing otodental syndrome is a hemizygous microdeletion involving the FGF3 gene on chromosome 11q13.3. Recently, a new form of severe deafness, microtia (small ear) and small teeth, without the appearance of eye abnormalities, was also reported. In this report, we describe a 1-year-old girl presenting with ptosis of the left upper eyelid, right auricular deformity, high-arched palate, delayed dentition, simian line on the right hand, microcephaly, and developmental delay. In this patient, we identified a deletion in the chromosome 11q13.2-q13.3 (2.75 Mb) region by using an array-comparative genomic hybridization analysis. The deletion in chromosome 11q13 results in a syndrome characterized by variable clinical manifestations. Some of these manifestations involve craniofacial dysmorphology and require a functional workup for hearing, ophthalmic examinations, and long-term dental care.

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.107.1-107.1
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• 2014

We have developed and commercialize a time-of-flight - medium energy ion scattering spectrometry (TOF-MEIS) system (model MEIS-K120). MEIS-K120 adapted a large solid acceptance angle detector that results in high collection efficiency, minimized ion beam damage while maintaining a similar energy resolution. In addition, TOF analyzer regards neutrals same to ions which removes the ion neutralization problems in absolute quantitative analysis. A TOF-MEIS system achieves $7{\times}10^{-3}$ energy resolution by utilizing a pulsed ion beam with a pulse width 350 ps and a TOF delay-line-detector with a time resolution of about 85 ps. TOF-MEIS spectra were obtained using 100 keV $He^+$ ions with an ion beam diameter of $10{\mu}m$ with ion dose $1{\times}10^{16}$ in ordinary experimental condition. Among TOF-MEIS applications, we report the quantitative compositional profiling of 3~5 nm CdSe/ZnS QDs, As depth profile and substitutional As ratio of As implanted/annealed Si, Ionic Critical Dimension (CD) for FinFET, Direct Recoil (DR) analysis of hydrogen in diamond like carbon (DLC) and InxGayZnzOn on glass substrate.

• Restorative Dentistry and Endodontics
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• v.43 no.1
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• pp.13.1-13.7
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• 2018

Dental erosion is frequently overlooked in clinical practice. The management of erosion-induced damage to the dentition is often delayed, such that extensive occlusal rehabilitation is required. These cases can be diagnosed by a careful clinical examination and a thorough review of the patient's medical history and/or lifestyle habits. This case report presents the diagnosis, categorization, and management of a case of gastro-esophageal reflux disease-induced palatal erosion of the maxillary teeth. The early management of such cases is of utmost importance to delay or prevent the progression of damage both to the dentition and to occlusal stability. Non-invasive adhesively bonded restorations aid in achieving this goal.

• Korean System Dynamics Review
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• v.17 no.2
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• pp.5-32
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• 2016

Purpose of this paper is to review series of Limits to Growth studies from its original Rome Club Report published in 1972 to the most recent one in 2012 by Jorgen Randers and finds its implications on concept and strategy of sustainable development. For this purpose first, this paper reviewed series of Limits to Growth studies in details with focus on scenarios used in simulation of world model. Second, response to the original Limit to Growth was reviewed and to see validity of its scenario based simulations, simulated results of interest variables and actual historical data up to the year 2010 was compared. Third, structure and key arguments in both studies, Limit to Growth studies and Our Common Future was explained and compared. Finally, implications of the Limit to Growth studies on concept and strategy for sustainable development was discussed. Based on the comparison, this paper argued that even if the term sustainable development was not used in the Limit to Growth at all, concept and strategies for sustainable development implied in the Limit to Growth are more clear and specific than those of Our Common Future. Since Limit to Growth studies were simulation based ones that produce detailed behaviors on interest variables, it clarifies more clearly the abstract concept of sustainable development and thus, provides specific guidelines for the direction of sustainable policy which has been suffering long from vagueness of concept of sustainable development.

• The Academic Congress of Korean Shoulder and Elbow Society
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• 2009.03a
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• pp.160-160
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• 2009

Compartment syndrome is not uncommon in the forearm or lower extremity, but it is relatively rare in the upper arm. This rarity might delay the diagnosis, especially in the unconscious or intoxicated patient. Therefore, a high index of suspicion is needed to make an accurate, early diagnosis. Although excessive muscle strain leading to localized compartment syndrome is seldom encountered in the upper arm, three cases of compartment syndrome in the upper arm after blunt injury have been reported. Interestingly, there were no bony injuries in any of these patients. However, there are only two reports of isolated dorsal compartment syndrome after blunt trauma. The present report presents the case of a patient who had blunt trauma to the upper arm that resulted in the development of compartment syndrome in the isolated dorsal compartment of the upper arm.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.16 no.3
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• pp.190-194
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• 2013

Internal hernia (IH) is a rare cause of small bowel obstruction occurs when there is protrusion of an internal organ into a retroperitoneal fossa or a foramen in the abdominal cavity. IH can be presented with acute or chronic abdominal symptom and discovered by accident in operation field. However, various kinds of imaging modalities often do not provide the assistance to diagnose IH preoperatively, but computed tomography (CT) scan has a high diagnostic accuracy. We report a case of congenital IH in a 6-year-old boy who experienced life threatening shock. CT scan showed large amount of ascites, bowel wall thickening with poor or absent enhancement of the strangulated bowel segment. Surgical exploration was performed immediately and had to undergo over two meters excision of strangulated small bowel. To prevent the delay in the diagnosis of IH, we should early use of the CT scan and take urgent operation.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.16 no.3
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• pp.195-199
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• 2013

Congenital chloride diarrhea (CLD) is a rare inherited autosomal recessive disorder. Mutations of the solute carrier family 26 member 3 gene cause profuse, chloride ion rich diarrhea, which results in hypochloremia, hyponatremia and metabolic alkalosis with dehydration. If a fetal ultrasound shows bowel dilatation suggestive of bowel obstruction, or if a neonate shows persistent diarrhea and metabolic alkalosis, CLD should be considered in the differential diagnosis. The severity of CLD varies, but early detection and early therapy can prevent complications including growth failure. We report a case of dizygotic twins affected by CLD who had been born to non-consanguineous parents. Both of them showed growth failure, but one of the twins experienced worse clinical course. He showed developmental delay, along with dehydration and severe electrolyte imbalance. He was diagnosed with CLD first at 6-month age, and then the other one was also diagnosed with CLD.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.13 no.1
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• pp.30-36
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• 2013

6-pyruvoyltetrahydropterin synthase (PTPS) deficiency is autosomal recessive disorder and the most common type of tetrahydrobiopterin (BH4) deficiency. It is caused by deficiency of PTPS, a cofactor involved in the biosynthesis of BH4 from guanosine triphosphate (GTP). Unlike classical phenylketonuria, which needs restriction of dietary phenylalanine for whole life, BH4 deficiency is treated by tetrahydrobiopterin, levodopa, and 5-hydroxytryptophan replacement. So it is important to make accurate diagnosis and initiate treatment as soon as possible for a better prognosis. There is no retrospective study of Korean patients undergoing long-term treatment for PTPS deficiency. We report 9 Korean patients with PTPS deficiency and their laboratory findings including BH4 loading tests, urine pterin tests, genotypes, dihydropteridine reductase (DHPR) activities and clinical manifestations including medication and developmental delay existence.

• The Korean Journal of Pain
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• v.8 no.1
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• pp.156-158
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• 1995

Total spinal anesthesia is a well documented serious life threatening complication which results from an attempted spinal or epidural analgesia. We had an accidental total spinal anesthesia associated with a cranial nerve paralysis and an eventual unconsciousness during epidural analgesia. A 45-year-old female with an uterine myoma was scheduled for a total abdominal hysterectomy under the epidural analgesia. A lumbar tapping for the epidural analgesia was performed in a sitting position at a level between $L_{3-4}$, using a 18 gauge Tuohy needle. Using the "Loss of Resistance" technique to identify the epidural space, the first attempt failed; however, the second attempt with the same level and the technique was successful. The epidural space was identified erroneously. However, fluid was dripping very slowly through the needle, which we thought was the fluid from the normal saline which was injected from the outside to identify the space. Then 20 ml of 2% lidocaine was administered into the epidural space. Shortly after the spinal injection of lidocaine, many signs of total spinal anesthesia could be clearly observed, accompanied by the following progressing signs of intracrainal nerve paralysis: phrenic nerve, vagus nerve, glossopharyngeal nerve and trigeminal nerve in that order. Then female was intubated and her respiration was controlled without delay. The scheduled operation was carried out uneventfully for 2 hours and 20 minutes. The patient recovered gradually in th4e reverse order four hours from that time.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.6B
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• pp.601-609
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• 2002

In multi-path wireless channels with time-variant delay profile, a mobile station measures the received signal strength and report it to network which performs network control function such as handover. In order to improve the maximum ratio combining (MRC) gain, it also should search the strongest signal paths and measure their time offsets fast and exactly. This paper proposes some methods of fast and exactly measuring the multi-path signal strength and time offset. Since the W-CDMA system adopts antenna diversity technique for the next generation high speed packet access (HSDPA) service, we derive the optimum design parameter values for the proposed methods through computer simulations under the HSDPA conditions o( low speed of mobile, of no power control, and of multi-path wireless environment with transmit and receive antenna diversity. Finally, we prove the validity of the proposed methods by showing the improvement of the bit error rate (BER) performance.