• Journal of Yeungnam Medical Science
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• v.23 no.1
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• pp.82-89
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• 2006

Background: Matrix metalloproteinases (MMPs) are involved in the degradation of the extracellular matrix, which is an important step in tumor invasion and metastasis. A positive correlation between the expression of MMP-9 and aggressive behavior of renal cell carcinomas (RCCs) has been reported. MMP-9 expression in RCCs and adjacent normal kidney tissues were examined in this study. Materials and Methods: Twenty-five patients pathologically diagnosed as clear cell RCCs, from specimens obtained at radical nephrectomy, between May 2003 and December 2004 were enrolled in this study. MMP-9 activity was estimated using gelatin zymography, and quantified using a laser densitometer. The results were compared with clinicopathological characteristics. Results: The expression of MMP-9 was significantly elevated in the RCC compared with non-tumor kidney specimens (p<0.01). The levels of MMP-9 expression in the RCC patients with large tumors (>4 cm) or vascular invasion were significantly higher than in those without these clinical manifestations (p<0.01). There were also significant differences in the expression of MMP-9 among T stages (p<0.01). The tissue MMP-9 level was the highest in nuclear grade 4, but there was no statistical significance between the histological grades (p=0.17). Conclusions: These results suggest that enhanced MMP-9 expression contributes to carcinogenesis and tumor progression in the later stages of RCC.

• Proceedings of the KWS Conference
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• 2009.11a
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• pp.217-220
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• 2009

Conductive adhesives have been investigated for use in microelectronics packaging as a lead-free solder substitute due to their advantages, such as low bonding temperature. However, high resistivity and poor mechanical behavior may be the limiting factors for the development of conductive adhesives. The metal fillers and the polymer resins provide electrical and mechanical interconnections between surface mount device components and a substrate. As metal fillers used in conductive adhesives, silver is the most commonly used due to its high conductivity and the stability. However the cost of conductive adhesives with silver fillers is much higher than usual lead-free solders and silver has poor electro-migration performance. So, copper can be a promising candidate for conductive filler metal due to its low resistivity and low cost, but oxidation causes this metal to lose its conductivity. In this study, electrically conductive adhesives (ECAs) using surface modified copper fillers were developed. Especially, in order to overcome the problem associated with the oxidation of copper, copper particles were coated with silver, and the silver-coated copper was tested as a filler metal. Especially the effect of silver coating on the electrical resistance just after curing and after aging was investigated. As a result, it was found that the electrical resistance of ECA with silver-coated copper filler was clearly lower and more stable than that of ECA with pure copper filler after curing process. And, during high temperature storage test, the degradation rate of electrical resistance for ECA with silver coated copper filler was quite slower than that for ECA with pure copper filler.

• Korean Journal of Metals and Materials
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• v.47 no.7
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• pp.433-439
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• 2009

Ti and Ti based hydrogen storage alloys have been thought to be the third generation of alloys with a high hydrogen capacity, which makes it difficult to handle because of high reactivity. In order to solve the problem, the activation of a wide range of hysteresis of hydriding/dehydriding and without degradation of hydrogen capacity due to the hydriding/dehydriding cycle have to be improved in order to be aplied. Ti-Cr alloys have a high capacity about 0.8 wt.% in an ambient atmosphere. When the Ti-Cr alloys are added to Nb and Ta elements, they formed a laves phase in the alloy system. The Nb element was expected to make easy diffuse hydrogen in the Ti-Cr storage alloy, which was a catalytic element. In this study, the Ti-Nb-Cr ternary alloy was prepared by melt spinning. As-received specimens were characterized using XRD (X-ray Diffraction), SEM (Scanning Electron Microscopy) with EDX (Energy Dispersive X-ray) and TG/DSC (Thermo Gravimetric Analysis/Differential Scanning Calorimetry). In order to examine hydrogenation behavior, the PCI (Pressure-Composition-Isotherm) was performed at 293, 323, 373 and 423 K.

• Food Science of Animal Resources
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• v.39 no.5
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• pp.780-791
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• 2019

This study aimed to extend the retention of flavor in coffee-containing milk beverage by microencapsulation. The core material was caramel flavor, and the primary and secondary coating materials were medium-chain triglyceride and maltodextrin, respectively. Polyglycerol polyricinoleate was used as the primary emulsifier, and the secondary emulsifier was polyoxyethylene sorbitan monolaurate. Response surface methodology was employed to determine optimum microencapsulation conditions, and headspace solid-phase microextraction was used to detect the caramel flavor during storage. The microencapsulation yield of the caramel flavor increased as the ratio of primary to secondary coating material increased. The optimum ratio of core to primary coating material for the water-in-oil (W/O) phase was 1:9, and that of the W/O phase to the secondary coating material was also 1:9. Microencapsulation yield was observed to be approximately 93.43%. In case of in vitro release behavior, the release rate of the capsules in the simulated gastric environment was feeble; however, the release rate in the simulated intestinal environment rapidly increased within 30 min, and nearly 70% of the core material was released within 120 min. The caramel flavor-supplemented beverage sample exhibited an exponential degradation in its flavor components. However, microcapsules containing flavor samples showed sustained flavor release compared to caramel flavor-filled samples under higher storage temperatures. In conclusion, the addition of coffee flavor microcapsules to coffee-containing milk beverages effectively extended the retention of the coffee flavor during the storage period.

• Structural Engineering and Mechanics
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• v.55 no.6
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• pp.1139-1155
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• 2015

In this study, a new retrofitting method for improving the seismic performance of reinforced concrete column was presented, in which prestressed steel strips were utilized as retrofitting stuff to confine the reinforced concrete column transversely. In order to figure out the seismic performance of concrete column specimen retrofitted by such prestressed steel strips methods, a series of quasi-static tests of five retrofitted specimens and two unconfined column specimen which acted as control specimens were conducted. Based on the test results, the seismic performance including the failure modes, hysteresis performance, ductility performance, energy dissipation and stiffness degradation of all these specimens were fully investigated and analyzed. And furthermore the influences of some key parameters such as the axial force ratios, shear span ratios and steel strips spacing on seismic performance of those retrofitted reinforced concrete column specimens were also studied. It was shown that the prestressed steel strips provided large transverse confining effect on reinforced concrete column specimens, which resulted in improving the shearing bearing capacity, ductility performance, deformation capacity and energy dissipation performance of retrofitted specimens effectively. In comparison to the specimen which was retrofitted by the carbon fiber reinforced plastics (CFRP) strips method, the seismic performance of the specimens retrofitted by the prestressed steel strips was a bit better, and with much less cost both in material and labor. From this research results, it can be concluded that this new retrofitting method is really useful and has significant advantages both in saving money and time over some other retrofitting methods.

• Journal of the Korean Solar Energy Society
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• v.33 no.3
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• pp.58-66
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• 2013

Recently, PV module that the most important part of the photovoltaic system is more widened to lower manufacturing costs for module. However, the broad PV module results to the serious mechanical damage corning from installation circumstances such as snow, wind etc of snow and finally lead to the dramatic degradation of the electrical behavior of PV module. In this paper, 3 kinds of PV modules that consist of the different thickness and area of front glass and the diverse cross sectional structures of the frame are prepared for this experiment. The drooped length and electrical outputs of the PV modules are measured by means of applying 600Pa mechanical load to the PV modules from 1200Pa to 5400Pa base on the mechanical load test procedure of K SC IEG 61215 standard. The simulation data are obtained by the simulation tool as ANSYS and those are validate by comparing with the those experimental results figure out relations between the deformation and the constituent part of PV module.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.19 no.10
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• pp.98-104
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• 2020

Recently, friction stir welding of dissimilar materials has become one of the biggest issues in lightweight and eco-friendly bonding technology. In this study, a lightweight torsion beam axle, which is an automobile chassis component, was used in the welding to cast aluminum material. The friction stir welding process of A357 cast aluminum and FB590 high-strength steel as well as the effects of the process parameters were investigated and optimized using a novel definitive screening design (DSD). ANOVA was used to predict the importance of the process parameters with 13 degradation experiments using the proposed DSD. Also, FSWed experiments were conducted using an optical microscope analysis to investigate the tensile strength behavior in the weld area. In addition to determining the interaction between the tool's rotational speed and the plunge speed, results indicate that the influence of the plunge depth was the most significant.

• Korean Journal of Metals and Materials
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• v.46 no.8
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• pp.495-505
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• 2008

With the high proportion of zinc coated steels in body-in-white assembly, newly developed surface roughness textured galvannealed steel sheets have been introduced. In this study, zinc coated and surface roughness textured steel sheets were welded by resistance spot welding to investigate its weldability including electrode wear test. Based on the results of tensile-shear test, nugget diameter changes, and electrode tip growth test, it was clear that both surface roughness textured steels (GA-T and GA-E) showed good weldability. Also, there was no large difference in weldability and electrode wear behavior between GA-T and GA-E steels which have different surface roughness morphology. An analysis of electrode degradation showed Fe and Zn penetration through the electrode tip surface at 2400 welds reached $55{\sim}60{\mu}m$ and $75{\sim}80{\mu}m$, respectively. Therefore, there is no significant effect of surface roughness morphology on spot weldability of surface roughness textured galvannealed steel sheets. However, slight difference in thickness of alloying layers existing on electrode tip was found between GA-T and GA-E steels.

• Structural Engineering and Mechanics
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• v.77 no.2
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• pp.179-196
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• 2021

Experimental investigations on the seismic behaviors of the PVC-FRP Confined Reinforced Concrete (PFCRC) columns under low cyclic loading are carried out and two variable parameters including CFRP strips spacing and axial compression ratio are considered. The PFCRC column finally fails by bending and is characterized by the crushing of concrete and yielding of the longitudinal reinforcement, and the column with a high axial compression ratio is also accompanied by the cracking of the PVC tube and the fracture of CFRP strips. The hysteretic curves and skeleton curves of the columns are obtained from the experimental data. With the increase of axial compression ratio, the stiffness degradation rate accelerates and the ductility decreases. With the decrease of CFRP strips spacing, the unloading sections of the skeleton curves become steep and the ductility reduces significantly. On the basis of fiber model method, a numerical analysis approach for predicting the skeleton curves of the PFCRC columns is developed. Additionally, a simplified skeleton curve including the elastic stage, strengthening stage and unloading stage is suggested depending on the geometric drawing method. Moreover, the loading and unloading rules of the PFCRC columns are revealed by analyzing the features of the skeleton curves. The quantitative expressions that are used to predict the unloading stiffness of the specimens in each stage are proposed. Eventually, an analytical model for the PFCRC columns under low cyclic loading is established and it agrees well with test data.

• Structural Engineering and Mechanics
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• v.83 no.5
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• pp.693-707
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• 2022

Bonded joints have proven their performance against conventional joining processes such as welding, riveting and bolting. The single-lap joint is the most widely used to characterize adhesive joints in tensile-shear loadings. However, the high stress concentrations in the adhesive joint due to the non-linearity of the applied loads generate a bending moment in the joint, resulting in high stresses at the adhesive edges. Geometric optimization of the bonded joint to reduce this high stress concentration prompted various researchers to perform geometric modifications of the adhesive and adherends at their free edges. Modifying both edges of the adhesive (spew) and the adherends (bevel) has proven to be an effective solution to reduce stresses at both edges and improve stress transfer at the inner part of the adhesive layer. The majority of research aimed at improving the geometry of the plate and adhesive edges has not considered the effect of temperature and water absorption in evaluating the strength of the joint. The objective of this work is to analyze, by the finite element method, the stress distribution in an adhesive joint between two 2024-T3 aluminum plates. The effects of the adhesive fillet and adherend bevel on the bonded joint stresses were taken into account. On the other hand, degradation of the mechanical properties of the adhesive following its exposure to moisture and temperature was found. The results clearly showed that the modification of the edges of the adhesive and of the bonding agent have an important role in the durability of the bond. Although the modification of the adhesive and bonding edges significantly improves the joint strength, the simultaneous exposure of the joint to temperature and moisture generates high stress concentrations in the adhesive joint that, in most cases, can easily reach the failure point of the material even at low applied stresses.