• BMB Reports
• /
• 제38권6호
• /
• pp.748-754
• /
• 2005

Pseudomonas syringae pv. tomato (Pst) causes a bacterial speck disease in tomato and Arabidopsis. In Chinese cabbage, in which host-pathogen interactions are not well understood, Pst does not cause disease but rather elicits a hypersensitive response. Pst induces localized cell death and $H_2O_2$ accumulation, a typical hypersensitive response, in infiltrated cabbage leaves. Pre-inoculation with Pst was found to induce resistance to Erwinia carotovora subsp. carotovora, a pathogen that causes soft rot disease in Chinese cabbage. An examination of the expression profiles of 12 previously identified Pst-inducible genes revealed that the majority of these genes were activated by salicylic acid or BTH; however, expressions of the genes encoding PR4 and a class IV chitinase were induced by ethephon, an ethylene-releasing compound, but not by salicylic acid, BTH, or methyl jasmonate. This implies that Pst activates both salicylate-dependent and salicylate-independent defense responses in Chinese cabbage.

• Nuclear Engineering and Technology
• /
• 제52권4호
• /
• pp.863-868
• /
• 2020

Co Self-Powered Neutron Detector (SPND) is confronted with the problem of material consumption, which causes the response current can neither reflect the change of neutron flux in time nor be proportional to the neutron flux. In this paper, a deconvolution-based method is established to solve this problem. First of all, a step signal of neutron flux is taken as an example to analyze its performance. When the material consumption of Co SPND is 10%, after compensation, the response current can be in correspondence of neutron flux. Finally, the effects of this model in different Signal-to-Noise Ratio are analyzed, which fully confirms the truth of its excellent performance for compensating Co SPND's signal.

• BMB Reports
• /
• 제49권10호
• /
• pp.529-535
• /
• 2016

The NLRP3 inflammasome is activated by a variety of external or host-derived stimuli and its activation initiates an inflammatory response through caspase-1 activation, resulting in inflammatory cytokine IL-1β maturation and secretion. The NLRP3 inflammasome activation is a kind of innate immune response, most likely mediated by myeloid cells acting as a host defense mechanism. However, if this activation is not properly regulated, excessive inflammation induced by overactivated NLRP3 inflammasome can be detrimental to the host, causing tissue damage and organ dysfunction, eventually causing several diseases. Previous studies have suggested that mitochondrial damage may be a cause of NLRP3 inflammasome activation and autophagy, which is a conserved self-degradation process that negatively regulates NLRP3 inflammasome activation. Recently, mitochondria-selective autophagy, termed mitophagy, has emerged as a central player for maintaining mitochondrial homeostasis through the elimination of damaged mitochondria, leading to the prevention of hyperinflammation triggered by NLRP3 inflammasome activation. In this review, we will first focus on the molecular mechanisms of NLRP3 inflammasome activation and NLRP3 inflammasome-related diseases. We will then discuss autophagy, especially mitophagy, as a negative regulator of NLPP3 inflammasome activation by examining recent advances in research.

• 한국추진공학회지
• /
• 제22권4호
• /
• pp.76-84
• /
• 2018

본 논문에서는 고체 로켓 추진기관에서 내열재 및 단열재로 사용되는 실리카/페놀릭 복합재료의 열반응을 고려한 열전도 수치해석을 수행하였다. 고체 로켓 추진기관의 연소 중 실리카/페놀릭의 삭마와 열분해 과정을 고려한 열전도 해석을 위해 1차원 유한차분법을 이용하여 계산을 수행하였다. 노즐벽에서의 경계조건은 대류열전달계수를 고려하였으며, 이는 적분방정식을 이용하여 계산하였다. 삭마두께 및 숯깊이 해석결과는 목삽입재 평가 모터인 TPEM-10을 이용한 시험결과와 비교분석하였으며, 잘 일치하는 것을 확인할 수 있었다.

• 대한조선학회논문집
• /
• 제31권2호
• /
• pp.65-77
• /
• 1994

본 논문은 SWATH선의 히브 및 피치 제어에 대한 LQ이론의 상세한 응용과정을 제시한다. 부가질량과 감쇄계수를 상하동요 고유주기에서의 값으로 근사함으로써 선형 시불변 2차 연립 미분방정식이 주파수 응답 모델로부터 유도된다. 파기진력은 사인파들의 합으로서 모델링 된다. 좋은 과도응답(transient response)과 적절한 제어핀 운동을 얻기 위하여 상태 및 제어 가중행렬의 체계적인 선택과정이 제시된다. 본 논문의 제어기 설계과정의 타당성이 시간영역 및 주파수 영역에서의 시뮬레이션과 전달함수행렬의 특이값 선도에 의해 철저히 조사되어 진다. 최종 설계된 제어시스템은 본 연구의 응용이 성공적이었음을 나타내는 좋은 전체 성능을 보여준다.

• Journal of Positioning, Navigation, and Timing
• /
• 제11권3호
• /
• pp.181-189
• /
• 2022

The public open signals from Global Navigation Satellite System (GNSS) including Global positioning system (GPS) are used widely by many peoples in the world except for the public regulated restriction signals which are encrypted. Nowadays there are growing concerns about GNSS signal spoofing which can deceive the GNSS receivers by abusing these open services. To counter these spoofing threats, many researches have been studied including array antenna techniques which can detect the direction of arrival by means of Multiple Signal Classification (MUSIC) algorithm. Originally the array antenna techniques were developed to countermeasure the jamming signal in electronic warfare by using the nulling or beamforming algorithm toward a certain direction. In this paper, we study the anti-spoofing techniques using array antenna to overcome the jamming and spoofing issues simultaneously. First, we will present the theoretical analysis results of spoofing signal response of Minimum Variance Distortionless Response (MVDR) algorithm in array antenna. Then the eigenvector algorithm of covariance matrix is suggested and verified to work with the existing anti-jamming method. The modeling and simulation are used to verify the effectiveness of the anti-spoofing algorithm. Also, the field test results show that the array antenna system with the proposed algorithms can perform the anti-spoofing function. This anti-spoofing method using array antenna is very effective in the view point of solving both the jamming and spoofing problems using the same array antenna hardware.

• 한국국방경영분석학회지
• /
• 제2권1호
• /
• pp.185-194
• /
• 1976

A terminal response time analysis for a general class of terminals-to-computer subsystem is presented in this paper. On the point of the front view, it should be considered for R.O.K. Military Defense to set up the communication network in order to facilitate for the currency of the information and the data communication system. The model used to study is based on the advanced data communications system in which terminals are connected to Terminal Control Units(TCU) that are in turn connected to local Front-End Processor(FEP). The line control procedures used to interface a TCU and an FEP may be half-duplex Binary Synchronous Communication(BSC), half-duplex Synchronous Data Link Control(SDLC), or full-duplex SLDC. This paper will contribute to facilitate the initial phase of system design and configuration for the Military Defense Communication Network System in future.

• 전기학회논문지
• /
• 제66권10호
• /
• pp.1523-1531
• /
• 2017

In general, the thrust vector control should be fast and stable in the initial launch phase. Two types of conventional controllers, one is for pitch angle control and the other is for pitch rate control, are designed based on the equation of motion without aerodynamics and are compared in the viewpoints of the stability margin and the time response performance. Also analyzed are the rejection capabilities to cope with high aerodynamic disturbances caused by high angle of attacks in initial booting phase. Additionally, time response features at actuator saturation are investigated. Based on those results, we suggest a controller structure which is more suitable for thrust vector control of missiles at initial booting phase.

• The Korean Journal of Physiology and Pharmacology
• /
• 제22권1호
• /
• pp.1-15
• /
• 2018

Inflammasomes are intracellular multiprotein complexes that coordinate anti-pathogenic host defense during inflammatory responses in myeloid cells, especially macrophages. Inflammasome activation leads to activation of caspase-1, resulting in the induction of pyroptosis and the secretion of pro-inflammatory cytokines including interleukin $(IL)-1{\beta}$ and IL-18. Although the inflammatory response is an innate host defense mechanism, chronic inflammation is the main cause of rheumatic diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), ankylosing spondylitis (AS), and $Sj{\ddot{o}}gren^{\prime}s$ syndrome (SS). Since rheumatic diseases are inflammatory/autoimmune disorders, it is reasonable to hypothesize that inflammasomes activated during the inflammatory response play a pivotal role in development and progression of these diseases. Indeed, previous studies have provided important observations that inflammasomes are actively involved in the pathogenesis of inflammatory/autoimmune rheumatic diseases. In this review, we summarize the current knowledge on several types of inflammasomes during macrophage-mediated inflammatory responses and discuss recent research regarding the role of inflammasomes in the pathogenesis of inflammatory/autoimmune rheumatic diseases. This avenue of research could provide new insights for the development of promising therapeutics to treat inflammatory/autoimmune rheumatic diseases.

• 한국전산유체공학회:학술대회논문집
• /
• 한국전산유체공학회 2006년도 PARALLEL CFD 2006
• /
• pp.292-295
• /
• 2006

The terrorist attack of September $11^{th}$ 2001 has enforced a new examination of the response of modern steel structures, such as those found in large warehouses, auditoriums and airport terminals, to terrorist bomb attack. The effort described in this paper assesses the potential damage to such a newly designed structure form a medium-size car bomb. The structure is mostly composed of a lightweight complex beam structure with large windows and skylights piercing through a corrugated roof. The structural response to the terrorist attack requires the modelling of various physics phenomena including bomb detonation, blast wave propagation, reflections, and refractions and resulting blast impact on the structure. Hence, a fluid/structure coupled methodology is used to perform the assessment.