• BMB Reports
• /
• v.42 no.12
• /
• pp.776-787
• /
• 2009

T helper (Th) 17 cells have recently been described as a third subset of T helper cells, and have provided new insights into the mechanisms that are important in the development of autoimmune diseases and the immune responses that are essential for effective antimicrobial host defense. Both protective and harmful effects of Th17 responses during infection have been described. In general, Th17 responses are critical for mucosal and epithelial host defense against extracellular bacteria and fungi. However, recent studies have reported that Th17 responses can also contribute to viral persistence and chronic inflammation associated with parasitic infection. It has become evident that the type of microorganisms and the setting in which they trigger the Th17 response determines the outcome of the delicate balancethat exists between Th17 induced protection and immunopathogenesis.

• BMB Reports
• /
• v.38 no.6
• /
• pp.748-754
• /
• 2005

Pseudomonas syringae pv. tomato (Pst) causes a bacterial speck disease in tomato and Arabidopsis. In Chinese cabbage, in which host-pathogen interactions are not well understood, Pst does not cause disease but rather elicits a hypersensitive response. Pst induces localized cell death and $H_2O_2$ accumulation, a typical hypersensitive response, in infiltrated cabbage leaves. Pre-inoculation with Pst was found to induce resistance to Erwinia carotovora subsp. carotovora, a pathogen that causes soft rot disease in Chinese cabbage. An examination of the expression profiles of 12 previously identified Pst-inducible genes revealed that the majority of these genes were activated by salicylic acid or BTH; however, expressions of the genes encoding PR4 and a class IV chitinase were induced by ethephon, an ethylene-releasing compound, but not by salicylic acid, BTH, or methyl jasmonate. This implies that Pst activates both salicylate-dependent and salicylate-independent defense responses in Chinese cabbage.

• Nuclear Engineering and Technology
• /
• v.52 no.4
• /
• pp.863-868
• /
• 2020

Co Self-Powered Neutron Detector (SPND) is confronted with the problem of material consumption, which causes the response current can neither reflect the change of neutron flux in time nor be proportional to the neutron flux. In this paper, a deconvolution-based method is established to solve this problem. First of all, a step signal of neutron flux is taken as an example to analyze its performance. When the material consumption of Co SPND is 10%, after compensation, the response current can be in correspondence of neutron flux. Finally, the effects of this model in different Signal-to-Noise Ratio are analyzed, which fully confirms the truth of its excellent performance for compensating Co SPND's signal.

• BMB Reports
• /
• v.49 no.10
• /
• pp.529-535
• /
• 2016

The NLRP3 inflammasome is activated by a variety of external or host-derived stimuli and its activation initiates an inflammatory response through caspase-1 activation, resulting in inflammatory cytokine IL-1β maturation and secretion. The NLRP3 inflammasome activation is a kind of innate immune response, most likely mediated by myeloid cells acting as a host defense mechanism. However, if this activation is not properly regulated, excessive inflammation induced by overactivated NLRP3 inflammasome can be detrimental to the host, causing tissue damage and organ dysfunction, eventually causing several diseases. Previous studies have suggested that mitochondrial damage may be a cause of NLRP3 inflammasome activation and autophagy, which is a conserved self-degradation process that negatively regulates NLRP3 inflammasome activation. Recently, mitochondria-selective autophagy, termed mitophagy, has emerged as a central player for maintaining mitochondrial homeostasis through the elimination of damaged mitochondria, leading to the prevention of hyperinflammation triggered by NLRP3 inflammasome activation. In this review, we will first focus on the molecular mechanisms of NLRP3 inflammasome activation and NLRP3 inflammasome-related diseases. We will then discuss autophagy, especially mitophagy, as a negative regulator of NLPP3 inflammasome activation by examining recent advances in research.

• Journal of the Korean Society of Propulsion Engineers
• /
• v.22 no.4
• /
• pp.76-84
• /
• 2018

In this paper, the numerical analysis for heat conduction of silica/phenolic composite material, used for solid rocket nozzle liners or insulators, is conducted. A 1-dimensional finite difference method for the analysis of silica/phenolic during the firing of a solid rocket motor is used to calculate heat conduction, considering surface ablation and thermal decomposition. The boundary condition at the nozzle wall, considering the convective heat transfer, is obtained via integration equations. The numerical results of the surface ablation and char depth are compared with the results of a TPEM-10 test motor, finding that the result of calculation agrees with the thermal response of the test motor.

• Journal of the Society of Naval Architects of Korea
• /
• v.31 no.2
• /
• pp.65-77
• /
• 1994

This paper presents a derailed application procedure of the linear quadratic(LQ) theory for a SWATH heave and pitch control. A time domain model of coupled, linear time-invariant second order differential equations is derived from the frequency response model with the frequency dependent added mass and damping approximated as constant values at the heave natural frequency. Wave exciting forces are modeled as a sum of sinusoids. A systematic selection procedure of state and control weighting matrices is presented to obtain good transient behavior and acceptable fin movement. The validity of this controller design process is throughly investigated by simulations both in time domain and frequency domain and singular value plots of transfer function matrices. The finally designed control system shows good overall performances revealing that the applicability of the present study is proved successful.

• Journal of Positioning, Navigation, and Timing
• /
• v.11 no.3
• /
• pp.181-189
• /
• 2022

The public open signals from Global Navigation Satellite System (GNSS) including Global positioning system (GPS) are used widely by many peoples in the world except for the public regulated restriction signals which are encrypted. Nowadays there are growing concerns about GNSS signal spoofing which can deceive the GNSS receivers by abusing these open services. To counter these spoofing threats, many researches have been studied including array antenna techniques which can detect the direction of arrival by means of Multiple Signal Classification (MUSIC) algorithm. Originally the array antenna techniques were developed to countermeasure the jamming signal in electronic warfare by using the nulling or beamforming algorithm toward a certain direction. In this paper, we study the anti-spoofing techniques using array antenna to overcome the jamming and spoofing issues simultaneously. First, we will present the theoretical analysis results of spoofing signal response of Minimum Variance Distortionless Response (MVDR) algorithm in array antenna. Then the eigenvector algorithm of covariance matrix is suggested and verified to work with the existing anti-jamming method. The modeling and simulation are used to verify the effectiveness of the anti-spoofing algorithm. Also, the field test results show that the array antenna system with the proposed algorithms can perform the anti-spoofing function. This anti-spoofing method using array antenna is very effective in the view point of solving both the jamming and spoofing problems using the same array antenna hardware.

• Journal of the military operations research society of Korea
• /
• v.2 no.1
• /
• pp.185-194
• /
• 1976

A terminal response time analysis for a general class of terminals-to-computer subsystem is presented in this paper. On the point of the front view, it should be considered for R.O.K. Military Defense to set up the communication network in order to facilitate for the currency of the information and the data communication system. The model used to study is based on the advanced data communications system in which terminals are connected to Terminal Control Units(TCU) that are in turn connected to local Front-End Processor(FEP). The line control procedures used to interface a TCU and an FEP may be half-duplex Binary Synchronous Communication(BSC), half-duplex Synchronous Data Link Control(SDLC), or full-duplex SLDC. This paper will contribute to facilitate the initial phase of system design and configuration for the Military Defense Communication Network System in future.

• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.66 no.10
• /
• pp.1523-1531
• /
• 2017

In general, the thrust vector control should be fast and stable in the initial launch phase. Two types of conventional controllers, one is for pitch angle control and the other is for pitch rate control, are designed based on the equation of motion without aerodynamics and are compared in the viewpoints of the stability margin and the time response performance. Also analyzed are the rejection capabilities to cope with high aerodynamic disturbances caused by high angle of attacks in initial booting phase. Additionally, time response features at actuator saturation are investigated. Based on those results, we suggest a controller structure which is more suitable for thrust vector control of missiles at initial booting phase.

• The Korean Journal of Physiology and Pharmacology
• /
• v.22 no.1
• /
• pp.1-15
• /
• 2018

Inflammasomes are intracellular multiprotein complexes that coordinate anti-pathogenic host defense during inflammatory responses in myeloid cells, especially macrophages. Inflammasome activation leads to activation of caspase-1, resulting in the induction of pyroptosis and the secretion of pro-inflammatory cytokines including interleukin $(IL)-1{\beta}$ and IL-18. Although the inflammatory response is an innate host defense mechanism, chronic inflammation is the main cause of rheumatic diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), ankylosing spondylitis (AS), and $Sj{\ddot{o}}gren^{\prime}s$ syndrome (SS). Since rheumatic diseases are inflammatory/autoimmune disorders, it is reasonable to hypothesize that inflammasomes activated during the inflammatory response play a pivotal role in development and progression of these diseases. Indeed, previous studies have provided important observations that inflammasomes are actively involved in the pathogenesis of inflammatory/autoimmune rheumatic diseases. In this review, we summarize the current knowledge on several types of inflammasomes during macrophage-mediated inflammatory responses and discuss recent research regarding the role of inflammasomes in the pathogenesis of inflammatory/autoimmune rheumatic diseases. This avenue of research could provide new insights for the development of promising therapeutics to treat inflammatory/autoimmune rheumatic diseases.