• Journal of the Korean Society of Food Science and Nutrition
• /
• v.44 no.7
• /
• pp.1079-1083
• /
• 2015

Activating macrophage cells play an important role in the host immune defense system. In this paper, immuno-modulatory activities of polysaccharides separated from Jubak (JPS) in macrophage cells were investigated. Immuno-modulatory activities were estimated based on cell proliferation, nitric oxide (NO) and cytokine production, degree of mitogen-activated protein kinases (MAPKs), and nuclear factor (NF)-${\kappa}B$ phosphorylation in RAW264.7 macrophage cells. JPS (62.5 to $250{\mu}g/mL$) did not induce a cytotoxic event. Additionally, NO and proinflammatory cytokines (tumor necrosis factor-${\alpha}$ and interleukin-6) production significantly increased in a dose-dependent manner. Similarly, phosphorylation of MAPKs and NF-${\kappa}B$ increased upon JPS treatment. Therefore, our results suggest that polysaccharides separated from Jubak can induce macrophage activation through MAPK and NF-${\kappa}B$ signaling and induction of Th1 polarization.

• Journal of the Korea Institute of Military Science and Technology
• /
• v.19 no.2
• /
• pp.195-201
• /
• 2016

An experimental study has been found the air guide grooves for reducing drag. When a bullet is fired and move in the air, the drag is generated. The vortex which is one of the types of drag hinders the movement of the bullet. To solve this phenomenon, cut a negative grooves that we are called the air guiding grooves at the back of bullet. The grooves bullet has identified that the drag compared to conventional ammunition(KM80 and K193) is reduced to 4.480 and 4.054 : 10 % through a Finite Analysis Program($Ansys^{TM}$). Even pressure center was retreating 0.72 % compared to a Bullet(KM80 and K193). Effect obtained with these results is the accuracy of the grooves bullet in a shooting test was improved by over 32 %(KM80: 2.86, air guide grooves : 1.94) compared to conventional ammunition(KM80 and K193). In addition, muzzle velocity is increased 73 m/s. This is expected to be extended the velocity and effective range of bullet. Also, the velocity of the grooves bullet is increased when moving in the air while the velocity of the bullet(KM80 and K193) is reduced. The gas ejected from the muzzle to be balanced and stable flight of the Bullet. Given these effects, we can reckon the air guide grooves have positive influence.

• Journal of the Korea Society for Simulation
• /
• v.27 no.1
• /
• pp.15-24
• /
• 2018

High Level Architecture(HLA) for modeling and simulation is an international technical standard to achieve simulation interoperability and reusability. Building federation through the interworking of federates is being used in various fields and is being used in KR(Key Resolve), UFG(Ulchi-Freedom Guardian) as a representative in domestic military. Currently, United States Department of Defense emphasizes the HLA compliance test, which confirms the compliance of Federate by using HLA. However, due to the limitations of testing tools, an HLA compliance test of DoD is not able to perform some of the functional tests on HLA/RTI services such as federation storage/recovery services and also exclude inspection of exchange data between federates. To solve these problems, this paper proposes an HLA compliance testing system of ROK suitable for domestic situations. This will enable effective HLA compliance testing and improve interoperability between federates.

• Korean Journal of Materials Research
• /
• v.29 no.1
• /
• pp.43-51
• /
• 2019

Nacre of abalone shell features a "brick-and-mortar" microstructure, in which micro-plates of calcium carbonate are bonded by nanometers-thick layers of chitin and proteins. Due to the microstructure and its unique toughening mechanisms, nacre possesses an excellent combination of specific strength, stiffness and toughness. This study deals with the possibility of using nacre fragments obtained from abalone shell for making a bulletproof armor system. A composite plate laminated with abalone shell fragments is made and compression and bend tests are carried out. In addition, a bulletproof test is performed with hybrid armor systems which are composed of an alumina plate, a composite plate, and aramid woven fabric to verify the ballistic performance of nacre. The compressive strength of the composite plate is around 258.3 MPa. The bend strength and modulus of the composite plate decrease according to the plate thickness and are about 149.2 MPa and 50.3 GPa, respectively, for a 4.85 mm thick plate. The hybrid armor system with a planar density of $45.2kg/m^2$, which is composed of an 8 mm thick alumina plate, a 2.4 mm thick composite plate, and 18 layers of aramid woven fabric, satisfy the NIJ Standard 0101.06 : 2008 Armor Type IV. These results show that a composite plate laminated with abalone shell fragments can be used for a bulletproof armor system as an interlayer between ceramic and fabric to decrease the armor system's weight.

• Journal of the Korea Society for Simulation
• /
• v.28 no.1
• /
• pp.57-65
• /
• 2019

Air refueling is expected to increase the efficiency of the air force operations. This follows from the introduction of air refueling aircraft, which should to increase operational time by increasing the range and duration of fighter jets. Despite the effectiveness of the air refueling air crafts, the astronomical costs of adapting the air tankers call for careful discussions on whether to acquire any air craft and if so, how many. However there is no academic study on the subject to our knowledge. Thus, we use the ABM(Agent Based Modeling) technique to calculate the optimal number of air tankers during patrol operation. We have enhanced the reliability of the simulation by entering the specifications of the current aircraft operated by the Korean Air Force. As an optimization tool for determining the optimal number of counts, we use OptQuest built into the simulation tools and show that the optimal number of air tanker is 4.

• Journal of the Korea Society for Simulation
• /
• v.19 no.4
• /
• pp.199-208
• /
• 2010

Positions of tactical objects are represented as Time, Space and Position Information(TSPI) in modeling and simulations(M&S). The format and required information record for TSPI is investigated by referring the TSPI object model of the Test and Training Enabling Architecture(TENA), which has been developed by the United States Department of Defense. The most sophisticated tactical data link, Link-16 has a Precise Participant Location and Information (PPLI) message. We study the data format for exchanging TSPI data based on the PPLI message. To evaluate and track positions of tactical objects, we consider the Kalman filter for linear systems, and the extended Kalman filter and the unscented Kalman filter for nonlinear systems. Based on motion equations of a ballistic missile, the tracking performance for the trajectory of the ballistic missile is simulated by the unscented Kalman filter.

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2022.10a
• /
• pp.28-28
• /
• 2022

This paper presents the first genome assemblies of Philippine mangoes that provide valuable reference for varietal improvement and genomic studies on mango and related fruit crops. WE sequenced whole genomes of3 species, Mangifera odorata (Huani), Mangifera altissima (Paho), and Mangifera indica 'Carabao' (Sweet Elena). 'Carabao' is the major export variety of the Philippines; Paho is identified as vulnerable by the IUCN Red List of Threatened Species; Huani has fruit sap acrid which is the primary defense mechanism against insects and birds. We used Falcon, a diploid aware -de novo assembler to assemble SMRT generated long-read sequences. Falcon-unzip was employed to phase the output assembly producing larger contig sets (primary contigs) and shorter contigs corresponding to haplotypes (haplotigs). Assembly statistics were generated by comparing the assembly to a reference genome, Tommy Atkins, using Quality Assessment Tool (QUAST). Moreover, the extent of duplication and completeness of gene content was measured using Benchmarking Universal Single-Copy Orthologs (BUSCO). Draft assemblies with high duplications were processed using Purge Haplotigs and Purge Dups to lessen duplications with minimal impact on genome completeness. De novo assemblies of Huani, Paho and 'Carabao' were then generated with primary contig sizes of 463.64 Mb, 508.95 Mb and 401.51 Mb respectively. These draft assemblies of Huani, Paho and 'Carabao' showed 96.90%, 95.17% and 99.07% complete BUSCOs respectively which is comparable to 'Tommy Atkins' genome (98.6%). Using two mango transcriptome data (pooled RNA-seq from different mango varieties and tissues), 91-96% or 24-30 million reads were successfully mapped back for each generated assembly indicating high degree of completeness. The results obtained demonstrated the highly contiguous, phased, and near complete genome assembly of three Philippine mango species for structural and functional annotation of gene units, especially those with economic importance.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.45 no.6
• /
• pp.812-818
• /
• 2016

Protective effects of fermented Curcuma longa L. (CL) against alcoholic liver damage were investigated in HepG2/2E1 cells. Fermented CL was extracted by cold water (FCC), hot water, 80% ethanol, and methanol. Of the four extracts, the strongest hepatoprotective effect against ethanol-induced oxidative stress was observed in FCC. Pretreatment with FCC also reduced intracellular reactive oxygen species formation compared to ethanol-alone treated cells. FCC also enhanced catalase, glutathione-S-transferase, glutathione reductase, glutathione peroxidase, and superoxide dismutase, and non-enzymatic antioxidative activities such as glutathione compared to alcohol-treated HepG2/2E1 cells. Our findings suggest that FCC might be considered as a useful agent in the prevention of liver damage induced by oxidative stress by increasing the antioxidant defense mechanism.

• Korean Journal of Optics and Photonics
• /
• v.33 no.4
• /
• pp.167-176
• /
• 2022

Adaptive optics (AO) systems compensate for atmospheric disturbance, especially phase distortion, by introducing counter-wavefront deformation calculated from real-time wavefront sensing or prediction. Because AO system implementations are time-consuming and costly, it is highly desirable to estimate the system's performance during the development of the AO system or its parts. Among several techniques, we mostly apply statistical analysis, computational simulation, and optical-bench tests. Statistical analysis estimates performance based on the sum of performance variances due to all design parameters, but ignores any correlation between them. Computational simulation models every part of an adaptive optics system, including atmospheric disturbance and a closed loop between wavefront sensor and deformable mirror, as close as possible to reality, but there are still some differences between simulation models and reality. The optical-bench test implements an almost identical AO system on an optical bench, to confirm the predictions of the previous methods. We are currently developing an AO system for a 1.6-m ground telescope using a deformable mirror that was recently developed in South Korea. This paper reports the results of the statistical analysis and computer simulation for the system's design and confirmation. For the analysis, we apply the Strehl ratio as the performance criterion, and the median seeing conditions at the Bohyun observatory in Korea. The statistical analysis predicts a Strehl ratio of 0.31. The simulation method similarly reports a slightly larger value of 0.32. During the study, the simulation method exhibits run-to-run variation due to the random nature of atmospheric disturbance, which converges when the simulation time is longer than 0.9 seconds, i.e., approximately 240 times the critical time constant of the applied atmospheric disturbance.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.26 no.1
• /
• pp.149-162
• /
• 2000

Coenzyme Q10 is found in all tissues including skin and it is the well-known coenzyme for mitochondrial enzymes. The electron and proton transfer functions of the quinone ring are of fundamental importance for the oxidative phosphorylation pathway to generate energy in the cells. Coenzyme Q10 has been studied as a potent antioxidant molecule in the skin. It is involved in the skin's response to UVR irradiation. The concentration of this antioxidant in UVR exposed skin is higher than in non-exposed skin. However, recent studies have also shown that coenzyme Q10 is one of the first antioxidants to be depleted when skin is UVR-irradiated. This indicates that coenzyme Q10 is primarily involved in defense mechanisms of the skin. Therefore, we questioned whether coenzyme Q10 shows reulatory effect of melanogenesis. Here we report that coenzyme Q10 inhibits melanin neosynthesis of normal human melanocytes grown in culture, and lightens UVB-induced hyperpigmentation of the guinea pig skin in vivo. We treated human melanocytes with 0.05mM to 0.5mM of coenzyme Q10 for a total of two days. This inhibited melanin neosynthesis of cultured human melanocytes dose-dependently. The inhibitory effect of coenzyme Q10 was as effective as kojic acid or vitamin C on cultured human melanocytes. CoQ10 didn't have direct inhibitory effect on tyrosinase activity in in vitro tyrosine hydroxylase activity To further clarify the effect of coenzyme Q10 on the melanogenesis, we established UVB-induced hyperpigmentation on the shaved backs of brownish guinea pigs. The UVB intensity was 500mJ/$\textrm{cm}^2$ and the total energy dose was 1,500 mJ/$\textrm{cm}^2$. The animals were exposed to UVB radiation one times a week for three consecutive weeks. Coenzyme Q10, kojic acid, Arbutin, vitamin C(1% in vehicle) or vehicle alone as a control were then topically applied daily to the hyperpigmented areas twelve times per week far four successive weeks. The lightening effect was evaluated by visual scoring, chromameter and immunohistochemistry. Coenzyme Q10 had lightening effect on the UVB-induced hyperpigmentation without any other side effects, whereas another compounds showed weak lightening efficacies. Therefore, these results suggest that coenzyme Q10 may be useful for solving physiological hyperpigmenting problems for cosmetic purposes.