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Effects of AIF on Knee Osteoarthritis Patients: Double-blind, Randomized Placebo-controlled Study

  • Park, Sung-Hoon;Kim, Seong-Kyu;Shin, Im-Hee;Kim, Hyung-Gun;Choe, Jung-Yoon
    • The Korean Journal of Physiology and Pharmacology
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    • v.13 no.1
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    • pp.33-37
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    • 2009
  • Anti-inflammatory factor(AIF) is a water soluble extract of three herbs, Panax notoginseng(Burk.) F. H. Chen, Rehmannia glutinosa Libosch and Eleutherococcus senticosus. The present study aimed to investigate the safety and efficacy of herb extracts, AIF, on Korean knee osteoarthritis patients for six weeks. Fifty seven patients with knee osteoarthritis, ranging from 43 to 73 years of age, who fulfilled the "American College of Rheumatology"(ACR) classification of idiopathic osteoarthritis of knee and radiographic criteria were randomly selected and enrolled for the study. After initial screening and resting period, two capsules each of AIF(Each capsule contains; 400 mg) and similar identical placebo were administered twice a day to both groups. Pain intensity at second, fourth, and sixth weeks of study as well as one week after discontinuation of drugs was assessed by using 100 mm visual analogue scale(VAS). Changes in the Korean version of the Western Ontario and McMaster Universities(K-WOMAC) index score were compared at the initiation and completion of the study. VAS assessed by patients were significantly reduced(at visit 2; $54.64{\pm}14.72$, at visit 4, $37.32{\pm}16.58$, p<0.001) after AIF administration. Results showed an improvement in the physical function of K-WOMAC scale which was significantly higher(p=0.013) in AIF than placebo group, and decreases of total K-WOMAC score were also significantly higher(p=0.030) in AIF groups than placebo group. No serious adverse effect was observed, and there was no difference in incidence of adverse effect between AIF and placebo groups. In this population of Korean patients with knee osteoarthritis, AIF was found to be safe, tolerable and effective for symptomatic improvement of pain and physical function.

The Effect of Mechanical Traction on Pain and Physical Function in Patients With Knee Osteoarthritis (기계적 견인이 슬관절 골관절염 환자의 통증과 신체 기능에 미치는 효과)

  • Lee, Nam-yong;Kwon, Chun-suk;Kim, Suhn-yeop
    • Physical Therapy Korea
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    • v.22 no.3
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    • pp.23-32
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    • 2015
  • The purpose of this study was to identify the effects of mechanical traction applied to the knee joint on pain, knee range of motion (ROM), timed up and go (TUG) and Western Ontario and MacMaster Universities Osteoarthritis (WOMAC) in patients with knee osteoarthritis (KOA) of Kellgren-Lawrence radiological rating scale II or III. Twenty three patients participated in the experiment for a period of four weeks. After baseline assessment, the patients with KOA were randomized into two groups: the traction group ($n_1=12$), which received traction with general physical therapy; and the control group ($n_2=11$), which received general physical therapy only on unilateral knee joints. Patients received interventions once a day, three times a week, for four weeks. Wilcoxon signed-rank test was used to analyze the change of dependent variances within the group during pre and post intervention. Mann-Whitney U test was used to analyze the change of dependent variances as TUG and passive ROM between the two groups. Analysis of covariance was used to analyze the change of dependent variances as numeric pain rating scale (NPRS) and WOMAC score between the two groups. In Wilcoxon signed-rank test, the traction group improved significantly with regard to NPRS (p<.01), passive knee flexion ROM (p<.01), passive knee extension (p<.05), TUG (p<.01) and WOMAC scores (p<.01) after intervention for four weeks, but not for the control group. In the Mann-Whitney U test and analysis of covariance, no significant difference was seen among all the dependent variances after intervention for four weeks between the two groups. These outcomes suggest that further studies should be carried out to determine the effects of mechanical traction prior to using it for the treatment of patients with knee osteoarthritis.

Clinical investigation of child dose of herb medicine (소아의 한약복용에 관한 임상적 실태 조사)

  • Seo, Jung-Min;Lee, Sang-Gon;Hwang, Sun-Yi;Kim, Sang-Chan;Wang, Hyang-Ran;Jo, Sung-Eon;Baek, Jung-Han
    • The Journal of Pediatrics of Korean Medicine
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    • v.20 no.3
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    • pp.33-50
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    • 2006
  • Objectives : Oriental medicine has set the no herb medicamentous dose for child, on the other hand the western medicine has it standardizing of age, weight or dimension of body. Therefore, we aimed to research the herb medicamentous dose for child being in being used in clinic. Methods : We made up a question of the oriental medical doctors of the master's and doctor's course in ○○ university. Results : 1. Child dose of herb medicine a time likes this. 1 pack is written prescription most at children patients under 1 year. 1 pack and 2 packs are written prescription most at children patients over 1 under 2. 2 packs are written prescription most at children patients over 2 under 3. 4 packs are written prescription most at children patients over 3 under 4. 10 packs are written prescription most at children patients over 8 under 14. Dose of herb medicine written prescription at children patients over 5 under 8 is in decentralization from 2 to 10 packs. 2. 2 or 3 times are most in a number of taking medicine a day. 3. 3 days are common in period of taking medicine under 5, over 10 days are common over 5. 4. It is necessary to regulating child dose of herb medicine.

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A STUDY ON FRACTURE STRENGTH OF CONVENTIONAL AND COPY-MILLED IN-CERAM CROWNS (Copy-milled Celay In-Ceram 전부도재관의 파절강도에 관한 연구)

  • Hwang, Jung-Won;Yang, Jae-Ho;Lee, Sun-Hyung;Chung, Hun-Young
    • The Journal of Korean Academy of Prosthodontics
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    • v.35 no.2
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    • pp.417-430
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    • 1997
  • The purpose of this study was to compare the fracture resistance of copy-milled and conventional In-Ceram crown. Four groups of ten uniform sized all-ceramic crowns were fabricated. In-Ceram Spinell and In-Ceram Alumina crowns were fabricated as control group, Celay In-Ceram Spinell and Celay In-Ceram Alumina crowns were fabricated as test group. All specimen were cemented on stainless steel master die with resin cement, and stored in $37^{\circ}C$ water for 1 day prior to loading in Instron testing machine. Using a steel ball at a crosshead surfed of 0.5mm/min, the crowns were loaded at $30^{\circ}C$ angle until catastrophic failure occurred. The results obtained were as follows : 1. With the value of $984.8N{\pm}103.67N$, the strength of Celay In-Ceram Alumina crowns had a significantly higher fracture strength than conventional In-Ceram Alumina crowns ($876.2N{\pm}92.20N$) (P<0.05) 2. The fracture strength of Celay In-Ceram Spinell crowns($706.3{\pm}70.59N$) was greater than that of conventional In-Ceram Spinell crowns($687.4{\pm}90.26N$), but there was no significant difference(P>0.05). 3. The In-Ceram Alumina crowns had a significantly higher fracture strength than In-Ceram Spinell crowns in both methods(P<0.05). 4. Ther order of fracture strength was as followed : Celay In-Ceram Alumina, In-Ceram Alumina, Celay In-Ceram Spinell and In-Ceram Spinell crowns

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Bacterial leakage and micro-computed tomography evaluation in round-shaped canals obturated with bioceramic cone and sealer using matched single cone technique

  • Yanpiset, Kallaya;Banomyong, Danuchit;Chotvorrarak, Kanet;Srisatjaluk, Ratchapin Laovanitch
    • Restorative Dentistry and Endodontics
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    • v.43 no.3
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    • pp.30.1-30.12
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    • 2018
  • Objectives: To evaluate sealing ability of root canals obturated with bioceramic-impregnated gutta percha cone (BCC) or gutta percha (GP), with bioceramic sealer (BCS) or AH Plus (AH; Dentsply-Maillefer), in roundly-prepared canals using matched single-cone technique, based on bacterial leakage test, and to analyze obturation quality using micro-computed tomography (CT) analysis. Materials and Methods: Ninety-two distobuccal roots of maxillary molars were prepared using nickel-titanium files to apical size 40/0.06. The roots were divided into 4 groups (n = 20) that were obturated with a master cone and sealer: GP/AH, BCC/AH, GP/BCS, and BCC/BCS. Bacterial leakage model using Enterococcus faecalis was used to evaluate sealing ability for 60-day period. Obturated samples from each group (n = 4) were analyzed using micro-CT. Results: All groups showed bacterial leakage at 20%-45% of samples with mean leakage times of 42-52 days. There were no significant differences in bacterial leakage among the groups. Micro-CT showed minimal gaps and voids in all groups at less than 1%. Conclusions: In roundly-prepared canals, the single cone obturation with BCC/BCS was comparable to GP/AH for bacterial leakage at 60 days.

A study on upper extremity muscle fatigue changes of train driver (기관사 상지 근육의 피로도 변화에 대한 연구)

  • Jang, Hye-Yoen;Lee, Yung-Gi;Jang, Jae-Ho;Kim, Tae-Sik;Hong, Sung-Jun;Han, Chang-Soo;Han, Jung-Soo;Ahn, Jae-Yong
    • Journal of the Korean Society for Railway
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    • v.10 no.5
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    • pp.576-581
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    • 2007
  • The purpose of this study is to investigate changes in the forearm-muscle fatigue of a train driver operating the MasCon by using EMG (electromyogram) measurement technique. Train drivers usually use their forearm 4hours/day for normal operation. Accordingly, few different EMG signals of deltoid, biceps brachii, brachioradialis, flexor carpi ulnaris muscle of upper extremity have been measured and analyzed. The raw EMG Signals have been converted into median frequency using spectrum analysis. As the result, 80% of 10 subjects (real train drivers) showed that median frequency value of all four muscles has been reduced after 30 minutes of train operation. This results demonstrated that operating MasCon for 30 minutes could induce muscle fatigue.

On Intensive E-learning TOEIC Course (E-학습 중심의 TOEIC 집중교육에 대하여)

  • Sung, Taesoo
    • Journal of the Korea Society of Computer and Information
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    • v.18 no.12
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    • pp.217-223
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    • 2013
  • The purpose of this paper is to compare and analyze TOEIC scores of two kinds of courses opened at a university and the distribution of TOEIC scores of two groups. In addition, this paper will examine the ability of participants and the used instructional materials and equipment. The university has two kinds of TOEIC courses; one is a four-week intensive course opened in summer and winter vacations, where students participate in the classes from 9:00 a.m. to 4:00 p.m. The other is a regular TOEIC course, offering one-hour class every day from Monday to Friday during the university semester (15 weeks). This paper points out how important, the EFL/ESL teacher education, teaching materials, teaching methods and e-learning in operating more effective classes. The intensive TOEIC course and the regular TOEIC course include 120 hours and 75 hours a semester, respectively. Unfortunately, both courses have such a limited amount of time that students cannot achieve their fluent and perfect command of English. For Korean student to master English in a limited amount of both time and resources, the development of effective and qualitative EFL/ESL Intensive courses is essential.

A Clinical Trial to Verity the Quality of Life Improvement Efficacy of Dangguijakyak-san and Gyejibongnyeong-hwan Granulation in Postmenopausal Women. (한방 과립제의 폐경 후 삶의 질 개선 효과에 관한 연구 - 당귀작약산 및 계지복령환 과립제의 폐경후 삶의 질 개선에 대한 임상연구)

  • Park, Jea-Min;Yang, Jeong-Min;Kim, Dong-Il
    • The Journal of Korean Obstetrics and Gynecology
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    • v.20 no.3
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    • pp.213-228
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    • 2007
  • Purpose: This master‘s thesis to evaluate the grade of life after medication a Dangguijakyak-san(pasabu) and Gyejibongnyeong-hwan(cheongwal) with in postmenopausal women get lowering quality of life caused by vasomotor symptoms with hot flush. Methods: A subject who signing on the clinical trial written consent by self-will is registered this clinical trial after decided suitable by selection and exception standard, after take a medical experiment and checkup according to clinical trial plan. Registered subject should valuated by settled schedule after take the testing medicine 1,2 during thirty-day. In this period, a subject allocated at relatively better suited experimental group by oriental doctor after consideration of general efficacy and nature of a medicine at second visiting. Results: The result of comparison in the remedial value with sixteen patients who ended the experiment is like next list. 1. There's no regarded difference of comparison in general conditions between two patient groups. 2. There's no regarded difference during observation period before take medicine. 3. By period of measurement, there's something regarded differences most of patients of two parts after taking medicine. 4. There's no regarded difference at alteration phase of each standard according to kind of medicine. 5. There's no abnormal views reflected at allergy, Laboratory and Physical Examination during experiment. Conclusion: This experiment evidence a Dangguijakyak-san and Gyejibongnyeong-hwan can help for improvement generally life quality of postmenopausal women and certify safety of herbs.

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Comparison of seaweed pack and mudpack as treatment for knee osteoarthritis: a prospective randomized controlled study

  • Lee, Sang Hee;Han, Ji Hoon;Lee, Sung Jae;Cho, Hwi Young;Baek, Jung Heum;Kim, Jae Gyoon
    • Physical Therapy Rehabilitation Science
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    • v.8 no.1
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    • pp.22-31
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    • 2019
  • Objective: For knee osteoarthritis (OA), there is a demand for alternative modalities in order to delay surgery and to avoid the side effects of medications. This study compared the effects of applying seaweed pack and mudpack for the treatment of knee OA. Design: Randomized controlled trial. Methods: Twenty-five patients with knee OA who satisfied the criteria were included. The patients were divided into two groups according to the treatment method: mudpack (n=12) and seaweed pack (n=13). The two groups were treated for 20 minutes, twice a day for five continuous days at the Ocean Healing Center at Wando Island, South Korea. Participants were assessed by clinical scores (Western Ontario and McMaster Universities Osteoarthritis Index, Hospital for Special Surgery Knee Score, Knee injury and Osteoarthritis Outcome Score and 36-Item Short Form Health Survey) and lab results (erythrocyte sedimentation rate, C-reactive protein, insulin-like growth factor-1 [IGF-1], tumor necrosis $factor-{\alpha}$ [$TNF-{\alpha}$]) during the follow-up period. Results: For the most part, clinical scores improved after therapy and maintained improvements for four weeks in both groups (p<0.05). In the seaweed group, $TNF-{\alpha}$ was significantly decreased at two weeks post-therapy (p<0.05). In both groups, IGF-1 was significantly increased immediately post-therapy (p<0.05). There were no statistically significant differences after therapy between the groups in clinical scores and labs. Conclusions: Seaweed packs and mudpacks had similar positive effects for knee OA. Additionally, the seaweed pack group showed decreased levels of $TNF-{\alpha}$ at two weeks post-treatment, which may explain the reduced inflammatory reaction. For rehabilitation therapy, use of seaweed packs may serve as an alternative modality for the treatment of knee OA.

Radio and Senior Generation: Focused on Radio Program for Senior (라디오와 노인: 라디오 노인 대상 프로그램을 중심으로)

  • Hong, Myungshin
    • 한국노년학
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    • v.30 no.4
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    • pp.1329-1344
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    • 2010
  • This study is intended to find out how production people have been creating senior radio program. For this purpose, the study set up the three research questions and employed in-depth interviews with ten production people: First, production people find out senior radio listeners who have been very royal attendance of the program for a long time. And they examined senior listeners prefer to listen about health care, information about elderly life and singing contest. They have been made para-social interaction with master of ceremonies (MC). Second, unlike other radio program, the senior radio program has concentrated on the radio station's image and public interest rather than financial profit and viewing rate. Normally, it was known that radio program for senior used carried on break of the day. But some program has been broadcasted on prime time in the afternoon. Target audience of senior radio program has been expanded over the forties and the fifties from sixties. Thirdly, in general the role of producer is critically important to produce program. However, MC and scriptwriter are far more experienced and specialized on the field than producer in radio program for senior.