• Title/Summary/Keyword: Data validation

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Accuracy of Ventricular Volume and Ejection Fraction Measured by Gated Tl-201 Perfusion Single Photon Emission Tomography (심전도 게이트 심근관류 Tl-201 SPECT로 측정된 좌심실 기능 및 좌심실 용적의 정확성)

  • Pai, Moon-Sun;Moon, Dae-Hyuk
    • The Korean Journal of Nuclear Medicine
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    • v.39 no.2
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    • pp.94-99
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    • 2005
  • Electrocardiogram-gated single photon omission computed tomography (SPECT) provides valuable information in the assessment of both myocardial perfusion and ventricular function. Tl-201 is a suboptimal isotope for gating. Tl-201 images are more blurred compared with Tc-99m tracers due to the increased amount of scattered photons and use of a smooth filter. The average myocardial count densities are approximately one-half those of conventional technetium tracers. However, Tl-201 is still widely used because of its well-established utility for assessing myocardial perfusion, viability and risk stratification. Gated SPECT with Tl-201 enables us to assess both post-stress and rest left ventricular volume and function. Previous studies with gated Tl-201 SPECT measurements of ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV) have shown high correlation with first-pass radionuclide angiography, gated blood pool scan, Tc-99m-MIBI gated SPECT, contrast ventriculography, echocardiography, and 3-dimensional magnetic resonance imaging. However, problems related to these studies include few agreement data of EDV and ESV, use of a reference method that is likely to have the same systemic errors (gated Tc-99m-MIBI SPECT), and other technical factors related to the count density of gated SPECT. With optimization of gated imaging protocols and more validation studies, gated Tl-201 SPECT would be an accurate method to provide perfusion and function information in patients with coronary artery disease.

Current Status of the Numerical Models for the Analysis of Coupled Thermal-Hydrological-Mechanical Behavior of the Engineered Barrier System in a High-level Waste Repository (고준위폐기물처분장 공학적방벽시스템의 열-수리-역학적 복합거동 해석 모델 개발 현황)

  • Cho, Won-Jin;Kim, Jin Seop;Lee, Changsoo;Choi, Heui-Joo
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.10 no.4
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    • pp.281-294
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    • 2012
  • The current status of the computer codes for the analysis of coupled thermal-hydrological-mechanical behavior occurred in a high-level waste repository was investigated. Based on the reported results on the comparison between the predictions using the computer codes and the experimental data from the in-situ tests, the reliability of the existing computer codes was analyzed. The presented codes simulated considerably well the coupled thermal-hydrological-mechanical behavior in the near-field rock of the repository without buffer, but the predictions for the engineered barrier system of the repository located at saturated hard rock were not satisfactory. To apply the current thermal-hydrological-mechanical models to the assessment of the performance of engineered barrier system, a major improvement on the mathematical models which analyze the distribution of water content and total pressure in the buffer is required.

Quality monitoring of complex manufacturing systems on the basis of model driven approach

  • Castano, Fernando;Haber, Rodolfo E.;Mohammed, Wael M.;Nejman, Miroslaw;Villalonga, Alberto;Lastra, Jose L. Martinez
    • Smart Structures and Systems
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    • v.26 no.4
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    • pp.495-506
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    • 2020
  • Monitoring of complex processes faces several challenges mainly due to the lack of relevant sensory information or insufficient elaborated decision-making strategies. These challenges motivate researchers to adopt complex data processing and analysis in order to improve the process representation. This paper presents the development and implementation of quality monitoring framework based on a model-driven approach using embedded artificial intelligence strategies. In this work, the strategies are applied to the supervision of a microfabrication process aiming at showing the great performance of the framework in a very complex system in the manufacturing sector. The procedure involves two methods for modelling a representative quality variable, such as surface roughness. Firstly, the hybrid incremental modelling strategy is applied. Secondly, a generalized fuzzy clustering c-means method is developed. Finally, a comparative study of the behavior of the two models for predicting a quality indicator, represented by surface roughness of manufactured components, is presented for specific manufacturing process. The manufactured part used in this study is a critical structural aerospace component. In addition, the validation and testing are performed at laboratory and industrial levels, demonstrating proper real-time operation for non-linear processes with relatively fast dynamics. The results of this study are very promising in terms of computational efficiency and transfer of knowledge to manufacturing industry.

Development and Validation of Single Nucleotide Polymorphism (SNP) Markers from an Expressed Sequence Tag (EST) Database in Olive Flounder (Paralichthys olivaceus)

  • Kim, Jung Eun;Lee, Young Mee;Lee, Jeong-Ho;Noh, Jae Koo;Kim, Hyun Chul;Park, Choul-Ji;Park, Jong-Won;Kim, Kyung-Kil
    • Development and Reproduction
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    • v.18 no.4
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    • pp.275-286
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    • 2014
  • To successful molecular breeding, identification and functional characterization of breeding related genes and development of molecular breeding techniques using DNA markers are essential. Although the development of a useful marker is difficult in the aspect of time, cost and effort, many markers are being developed to be used in molecular breeding and developed markers have been used in many fields. Single nucleotide polymorphisms (SNPs) markers were widely used for genomic research and breeding, but has hardly been validated for screening functional genes in olive flounder. We identified single nucleotide polymorphisms (SNPs) from expressed sequence tag (EST) database in olive flounder; out of a total 4,327 ESTs, 693 contigs and 514 SNPs were detected in total EST, and these substitutions include 297 transitions and 217 transversions. As a result, 144 SNP markers were developed on the basis of 514 SNP to selection of useful gene region, and then applied to each of eight wild and culture olive flounder (total 16 samples). In our experimental result, only 32 markers had detected polymorphism in sample, also identified 21 transitions and 11 transversions, whereas indel was not detected in polymorphic SNPs. Heterozygosity of wild and cultured olive flounder using the 32 SNP markers is 0.34 and 0.29, respectively. In conclusion, we identified SNP and polymorphism in olive flounder using newly designed marker, it supports that developed markers are suitable for SNP detection and diversity analysis in olive flounder. The outcome of this study can be basic data for researches for immunity gene and characteristic with SNP.

Development and Validation of Simulation Model for A Scroll Compressor (스크롤 압축기 해석 모델 개발 및 검증)

  • Yim, Sang-Sik;Lee, Young-Seon;Park, Sung-Young;Kim, Ki-Bum
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.5
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    • pp.1976-1982
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    • 2012
  • Compressor is one of the most widely employed component in fluid machinery system. It takes tremendous efforts to improve compressor efficiency which affects the coefficient of performance of air-conditioning and refrigeration systems directly. Among various types of compressor, scroll-type compressor is commonly prevalent one with its high compression capability despite relatively small size and weight. Numerous experimental studies have been done to develop for the scroll-type compressor; however, computational models to evaluate the compressor performance or efficiency are not much available in the course of compressor designing process. In this study, a computational model was developed on the basis of geometrical theory using 1-D commercial software AMESim. A simulation study was carried out using the model, and the simulation result was validated with analytical data. This research is expected to provide a viable tool for developing and optimizing a scroll-type compressor.

A Study on Certification of Electronic Engine Controls (항공기 엔진제어시스템 인증기술 개발)

  • Lee, Kang-Yi;Han, Sang-Ho;Jin, Young-Kwon;Lee, Sang-Joon;Kim, Kui-Soon
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.33 no.1
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    • pp.104-109
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    • 2005
  • The aircraft gas turbine engines with the Electronic Engine Controls(EEC) had been developed to save fuel and enhance their performance in the early days, and had employed the health monitoring function in the Full Authority Digital Engine Controls(FADEC) to improve their reliability. This has led to an increasing demand for the certification technology of these controls. The design and certification issues of power supply, aircraft supplied data, failure modes, software verification/validation, and lightning requirements need to be addressed. This paper presents the design considerations and the certification techniques applied to the electronic engine controls. And it is believed that this paper will be basis to establish a requirement in Korean Airworthiness Standard.

Dynamic Summarization and Summary Description Scheme for Efficient Video Browsing (효율적인 비디오 브라우징을 위한 동적 요약 및 요약 기술구조)

  • 김재곤;장현성;김문철;김진웅;김형명
    • Journal of Broadcast Engineering
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    • v.5 no.1
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    • pp.82-93
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    • 2000
  • Recently, the capability of efficient access to the desired video content is of growing importance because more digital video data are available at an increasing rate. A video summary abstracting the gist from the entirety enables the efficient browsing as well as the fast skimming of the video contents. In this paper, we discuss a novel dynamic summarization method based on the detection of highlights which represent semantically significant content and the description scheme (DS) proposed to MPEG-7 aiming to provide summary description. The summary DS proposed to MPEG-7 allows for efficient navigation and browsing to the contents of interest through the functionalities of multi-level highlights, hierarchical browsing and user-customized summarization. In this paper, we also show the validation and the usefulness of the methodology for dynamic summarization and the summary DS in real applications with soccer video sequences.

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Experimental Validation of Multiple UAVs with Vector Field Guidance for SEAD(Suppression of Enemy Air Defense) (벡터필드 유도기법이 적용된 다수 무인기를 이용한 적 방공망 제압 임무의 실험적 검증)

  • Jung, Wooyoung;Kim, Ki-Duck;Lee, Seongheon;Bang, Hyochoong
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.43 no.3
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    • pp.282-287
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    • 2015
  • In modern warfare, the importance of SEAD(Suppression of Enemy Air Defense) mission is being emphasized. However, this mission runs the risk of hull damage or casualties of our friendly air forces. Because of these risks, research on the way of minimizing damages and enhancing mission capability is under active discussion. As a part of this research, SEAD mission planning with multiple UAVs has been covered using vector field guidance. This guidance method not only applies to various forms of flight path but also requires less computational power than other guidance methods. Therefore, in this paper, planning methods of SEAD mission for multiple UAVs using vector field guidance and experimental data from flight experiments regarding designed mission has been covered.

Development of Landsat-based Downscaling Algorithm for SMAP Soil Moisture Footprints (SMAP 토양수분을 위한 Landsat 기반 상세화 기법 개발)

  • Lee, Taehwa;Kim, Sangwoo;Shin, Yongchul
    • Journal of The Korean Society of Agricultural Engineers
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    • v.60 no.4
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    • pp.49-54
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    • 2018
  • With increasing satellite-based RS(Remotely Sensed) techniques, RS soil moisture footprints have been providing for various purposes at the spatio-temporal scales in hydrology, agriculture, etc. However, their coarse resolutions still limit the applicability of RS soil moisture to field regions. To overcome these drawbacks, the LDA(Landsat-based Downscaling Algorithm) was developed to downscale RS soil moisture footprints from the coarse- to finer-scales. LDA estimates Landsat-based soil moisture($30m{\times}30m$) values in a spatial domain, and then the weighting values based on the Landsat-based soil moisture estimates were derived at the finer-scale. Then, the coarse-scale RS soil moisture footprints can be downscaled based on the derived weighting values. The LW21(Little Washita) site in Oklahoma(USA) was selected to validate the LDA scheme. In-situ soil moisture data measured at the multiple sampling locations that can reprent the airborne sensing ESTAR(Electronically Scanned Thinned Array Radiometer, $800m{\times}800m$) scale were available at the LW21 site. LDA downscaled the ESTAR soil moisture products, and the downscaled values were validated with the in-situ measurements. The soil moisture values downscaled from ESTAR were identified well with the in-situ measurements, although uncertainties exist. Furthermore, the SMAP(Soil Moisture Active & Passive, $9km{\times}9km$) soil moisture products were downscaled by the LDA. Although the validation works have limitations at the SMAP scale, the downscaled soil moisture values can represent the land surface condition. Thus, the LDA scheme can downscale RS soil moisture products with easy application and be helpful for efficient water management plans in hydrology, agriculture, environment, etc. at field regions.

Validation of One-Step Real-Time RT-PCR Assay in Combination with Automated RNA Extraction for Rapid Detection and Quantitation of Hepatitis C Virus RNA for Routine Testing in Clinical Specimens

  • KIM BYOUNG-GUK;JEONG HYE-SUNG;BAEK SUN-YOUNG;SHIN JIN-HO;KIM JAE-OK;MIN KYUNG-IL;RYU SEUNG-REL;MIN BOK-SOON;KIM DO-KEUN;JEONG YONG-SEOK;PARK SUE-NIE
    • Journal of Microbiology and Biotechnology
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    • v.15 no.3
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    • pp.595-602
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    • 2005
  • A one-step real-time quantitative RT-PCR assay in combination with automated RNA extraction was evaluated for routine testing of HCV RNA in the laboratory. Specific primers and probes were developed to detect 302 bp on 5'-UTR of HCV RNA. The assay was able to quantitate a dynamic linear range of $10^7-10^1$ HCV RNA copies/reaction ($R^2=0.997$). The synthetic HCV RNA standard of $1.84{\pm}0.1\;(mean{\pm}SD)$ copies developed in this study corresponded to 1 international unit (IU) of WHO International Standard for HCV RNA (96/790 I). The detection limit of the assay was 3 RNA copies/reaction (81 IU/ml) in plasma samples. The assay was comparable to the Amplicor HCV Monitor (Monitor) assay with correlation coefficient r=0.985, but was more sensitive than the Monitor assay. The assay could be completed within 3 h from RNA extraction to detection and data analysis for up to 32 samples. It allowed rapid RNA extraction, detection, and quantitation of HCV RNA in plasma samples. The method provided sufficient sensitivity and reproducibility and proved to be fast and labor-saving, so that it was suitable for high throughput HCV RNA test.