• Journal of Preventive Medicine and Public Health
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• v.37 no.4
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• pp.381-389
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• 2004

Objective : To compare the efficacy between SKI306X and Diclofenac by using generalized estimating equations (GEE) methodology in the analysis of correlated bivariate binary outcome data in Osteoarthritis (OA) diseases. Methods : A randomized, double-blind, active comparator-controlled, non-inferiority clinical trial was conducted at 5 institutions in Korea with the random assignment of 248 patients aged 35 to 75 years old with OA of the knee and clinical evidence of OA. Patients were enrolled in this study if they had at least moderate pain in the affected knee joint and a score larger than 35mm as assessed by VAS (Visual Analog Scale). The main exposure variable was treatment (SKI 306X vs. Diclofenac) and other covariates were age, sex, BMI, baseline VAS, center, operation history (Yes/No), NSAIDS (Y/N), acupuncture (Y/N), herbal medicine (Y/N), past history of musculoskeletal disease (Y/N), and previous therapy related with OA (Y/N). The main study outcome was the change of VAS pain scores from baseline to the 2nd and 4th weeks after treatment. Pain scores were obtained as baseline, 2nd and 4th weeks after treatment. We applied GEE approach with empirical covariance matrix and independent(or exchangeable) working correlation matrix to evaluate the relation of several risk factors to the change of VAS pain scores with correlated binary bivariate outcomes. Results : While baseline VAS, age, and acupuncture variables had protective effects for reducing the OA pain, its treatment (Joins/Diclofenac) was not statistically significant through GEE methodology (ITT:aOR=1.37, 95% CI=(0.8200, 2.26), PP:aOR=1.47, 95% CI=(0.73, 2.95)). The goodness-of-fit statistic for GEE (6.55, p=0.68) was computed to assess the adequacy of the fitted final model. Conclusions : Both ANCOVA and GEE methods yielded non statistical significance in the evaluation of non-inferiority of the efficacy between SKI306X and Diclofenac. While VAS outcome for each visit was applied in GEE, only VAS outcome for the fourth visit was applied in ANCOVA. So the GEE methodology is more accurate for the analysis of correlated outcomes.

• Journal of Plant Biotechnology
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• v.37 no.1
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• pp.12-24
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• 2010

Plant metabolomics is a research field for identifying all of the metabolites found in a certain plant cell, tissue, organ, or whole plant in a given time and conditions and for studying changes in metabolic profiling as time goes or conditions change. Metabolomics is one of the most recently developed omics for holistic approach to biology and is a kind of systems biology. Metabolomics or metabolite fingerprinting techniques usually involves collecting spectra of crude solvent extracts without purification and separation of pure compounds or not in standardized conditions. Therefore, that requires a high degree of reproducibility, which can be achieved by using a standardized method for sample preparation and data acquisition and analysis. In plant biology, metabolomics is applied for various research fields including rapid discrimination between plant species, cultivar and GM plants, metabolic evaluation of commercial food stocks and medicinal herbs, understanding various physiological, stress responses, and determination of gene functions. Recently, plant metabolomics is applied for characterization of gene function often in combination with transcriptomics by analyzing tagged mutants of the model plants of Arabidopsis and rice. The use of plant metabolomics combined by transcriptomics in functional genomics will be the challenge for the coming year. This review paper attempted to introduce current status and prospects of plant metabolomics research.

• Journal of Broadcast Engineering
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• v.18 no.6
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• pp.835-849
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• 2013

Joint Collaborative Team on Video Coding (JCT-VC), which have founded ISO/IEC MPEG and ITU-T VCEG, has standardized High Efficiency Video Coding (HEVC). Standardization of HEVC has started with purpose of twice or more coding performance compared to H.264/AVC. However, flexible and hierarchical coding block and recursive coding structure are problems to overcome of HEVC standard. Many fast encoding algorithms for reducing computational complexity of HEVC encoder have been proposed. However, it is hard to implement a real-time HEVC encoder only with those fast encoding algorithms. In this paper, for implementation of software-based real-time HEVC encoder, data-level parallelism using SIMD instructions and CPU/GPU multi-threading methods are proposed. And we also proposed appropriate operations and functional modules to apply the proposed methods on HM 10.0 software. Evaluation of the proposed methods implemented on HM 10.0 software showed 20-30fps for $832{\times}480$ sequences and 5-10fps for $1920{\times}1080$ sequences, respectively.

• Explosives and Blasting
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• v.17 no.4
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• pp.67-88
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• 1999

Ground settlements induced by tunnel excavation cause the foundations of the neighboring superstructures to deform. An expert system called NESASS was developed to analyze the structural safety of such superstructures. NESASS predicts the trend of ground settlements to be resulted from tunnel excavation and carries out a safety analysis for superstructures on the basis of the predicted ground settlements. Using neural network techniques, NESASS learns a data base consisting of the measured ground settlements collected from numerous actual fields and infers a settlement trend at the field of interest. NESASS calculates the magnitudes of angular distortion, deflection ratio, and differential settlement of the structure and, in turn, determines the safety of the structure. In addition, NESASS predicts the patterns of cracks to be formed on the structure using Dulacskas model for crack evaluation. In this study, the ground settlements measured from the Seoul subway construction sites were collected and sorted with respect to the major factors influencing ground settlement. Subsequently, a database of ground settlement due to tunnel excavation was built. A parametric study was performed to verify the reliability of the proposed neural network structure. A comparison of the ground settlement trends predicted by NESASS with the measured ones indicates that NESASS leads to reasonable predictions. An examples is presented in this paper where NESASS is used to evaluate the safety of a structure subject to deformation due to tunnel excavation near to the structure.

• Journal of Korean Society for Geospatial Information Science
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• v.23 no.2
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• pp.39-48
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• 2015

Lately, Unmanned Aerial Vehicles(UAV), Unmanned Aerial Systems(UAS) or also often known as drones, as a data acquisition platform and as a measurement instrument are becoming attractive for many photogrammetric surveying applications, especially generation of the high density point clouds(HDPC). This paper presents the performance evaluation of a low-cost rotary wing quadrocopter UAS for generation of the HDPC in a test bed environment. Its performance was assessed by comparing the coordinates of UAS based HDPC to the results of Network RTK GNSS surveying with 62 ground check points. The results indicate that the position RMSE of the check points are ${\sigma}_H={\pm}0.102m$ in Horizonatal plane, and ${\sigma}_V={\pm}0.209m$ in vertical, and the maxium deviation of Elevation was 0.570m within block area of ortho-photo mosaic. Therefore the required level of accuracy at NGII for production of ortho-images mosaic at a scale of 1:1000 was reached, UAS based imagery was found to make use of it to update scale 1:1000 map. And also, since this results are less than or equal to the required level in working rule agreement for airborne laser scanning surveying of NGII for Digital Elevation Model generation of grids $1m{\times}1m$ and 1:1000 scale, could be applied with production of topographic map and ortho-image mosaic at a scale of 1:1000~1:2500 over small-scale areas.

• Journal of Korean Medicine Rehabilitation
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• v.30 no.1
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• pp.79-93
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• 2020

Objectives While sciatic neuropathy is one of the common symptoms which have the lifetime incidence of 13~40%, still there is no consensus about the standardized and the most effective conservative treatment. In addition, the importance of systematic review and meta-analysis of preclinical are growing as they could suggest possible effective treatment strategy for future studies. Therefore, we conducted systematic review and meta-analysis to estimate analgesic effect of acupuncture on sciatica in rat models. Methods Systematic search was conducted for all controlled comparative preclinical trials which assessed analgesic effect of acupuncture in sciatica rat models. Database of PubMed, EMBASE, Web of Science, CNKI and 6 Korean databases were used. The primary outcome was pain, which is evaluated by stimulus behavior tests in rat models. We assessed the methodological quality with Systematic Review Centre for Laboratory Animal Experimentation's risk of bias tool. RevMan 5.3 was used for meta-analysis and subgroup analysis was conducted according to treatment site, acupuncture point, treatment period and frequency used in electroacupuncture. Results 14 studies were finally included following our inclusion criteria. The data from meta-analysis indicated that the acupuncture significantly improved the result values of behavior tests for pain evaluation, compared to no-treatment control group in animal models (standardized mean difference=4.43, 95% confidence interval 3.16 to 5.69, Z=6.84, p<0.00001; χ²=68.02, p<0.00001; I²=82%). The results of subgroup analysis indicate that acupuncture treatment of unilateral site, distal acupoints, longer treatment period and applying 2/100 Hz frequency in electroacupuncture could be more effective. Conclusions Systematic review and meta-analysis of animal studies are getting important for the future clinical studies and the improvement of heatlh care. Therefore the results of the study would provide evidence and better design for the forthcoming studies.

• Journal of The Korean Association For Science Education
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• v.35 no.5
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• pp.885-893
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• 2015

In this study, we compared the use of information and communications technology (ICT) by middle school teachers in Korea and other countries utilizing the teacher survey data of the IEA International Computer and Information Literacy Study (ICILS) 2013. The ICILS target population consisted of all students in the eighth grade. We compared Korea with Australia, the Czech Republic, Norway, and Poland, which are nations showing the highest achievements in computer and information literacy. We selected nine questions from the teacher questionnaire and divided them into the categories of computer use, use of ICT for teaching and learning, and the ICT support environment in school. In comparison to their counterparts in other countries, Korean middle school science teachers used computers frequently and also had high ICT self-efficacy. They were confident in their ability to use computers for general tasks, but not in their ability to use computers for teaching and learning. The Korean teachers also had a high percentage of utilization of presentation and graphics software. Also, the proportion of activities concerning the information provided and teacher-led tasks was high, but the proportion of activities for student collaboration or peer interaction was low. In Korea, middle school science teachers had more negative than positive views of using ICT in teaching and learning. The teachers thought that computer-related resource support and digital learning materials were insufficient and that the computer model was outdated in schools. Therefore, we propose to build an ICT infrastructure and to develop and disseminate ICT teaching and learning methods for student activities.

• Management & Information Systems Review
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• v.33 no.1
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• pp.45-63
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• 2014

A trading system is a computer trading program that automatically submits trades to an exchange. Mechanical a trading system to execute trade is spreading in the stock market. However, a trading system to trade a single asset might occur instability of the profit because payoff of this system is determined a asset movement. Therefore, it is necessary to develop a trading system that is trade two assets such as a pair trading that is to sell overvalued assets and buy the undervalued ones. The aim of this study is to propose a relative value based trading system designed to yield stable and profitable profits regardless of market conditions. In fact, we propose a procedure for building a trading system that is based on the rough set analysis of indicators derived from a price ratio between two assets. KOSPI 200 index futures and S&P 500 index futures are used as a data for evaluation of the proposed trading system. We intend to examine the usefulness of this model through an empirical study.

• Journal of Digital Convergence
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• v.10 no.11
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• pp.47-58
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• 2012

This study selects political and military decision factors of Participatory Government's Wartime Operational Control(OPCON) Transition and analyzes, both quantitatively and qualitatively, the effects and relations between those factors. Previous research utilizing the Analytic Hierarchy Process(AHP) selected their decision factors based on academic data and field experience, requiring more objective analysis of the factors. For this study, we conducted a survey among security subject matter experts(SME) both online and offline. The results show that OPCON transition's decision factors were to 'recover military sovereignty', 'set the conditions for peaceful reunification' and 'improve ROK image through enhancing national power' which differs little from the previous AHP method studies. It also showed that 'recover military sovereignty' and 'set the conditions for peaceful reunification' had no relationship to each other and that the key factor that decided the OPCON Transition was actually 'recover military sovereignty' which represents the interest of the liberal party in ROK. This study finds its meaning by analyzing the decision factors of Participartory Government's OPCON Transition thorugh Delphi and DEMATEL method.

• Informatization Policy
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• v.27 no.3
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• pp.39-55
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• 2020

This study was designed to analyze the relationship among the motivations for the use of digital devices, attitudes toward the use of digital devices and performance resulting from the use of digital devices in middle-aged and elderly groups by using a path analysis. For an empirical analysis, the 2018 Survey on the Digital Divide by the National Information Society Agency was referenced, analyzing the data of 1,664 people, selected through listwise deletion from total 2,303 people aged 55 or over. A close examination of how measuring variables reflect potential variables (motivations for, attitudes toward and performance resulting from the use of digital devices) showed a significance of 0.001, which suggests that each individual measuring variable does reflect the potential variables. Evaluation of the pathway factors of the structural model from the motivations for the use of digital devices to the attitudes toward the use of digital devices (β=0.847) and from the attitudes toward the use of digital devices to the performance resulting from the use of digital devices (β= 0.745) revealed significant statistical effects. The results of this study suggest that the motivations for the use of digital devices does not directly enhance the digital device use performance, but that it can improve the attitudes toward the use of digital devices, which can in turn increase the performance resulting from the use of digital devices. The analysis holds significance that it has presented practical and policy implications.