• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.6863-6870
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• 2015

Background: Breast cancer accounted for almost 25% of all cancers in women globally in 2012. Although breast cancer is the most prevalent cancer in India, there is no organised national breast cancer screening programme. Local studies on the burden of breast cancer are essential to develop effective context-specific strategies for an early detection breast cancer programme, considering the cultural and ethnic heterogeneity in India. This study examined the knowledge, attitudes, and practices about breast cancer in rural women in Central India. Materials and Methods: This community-based cross sectional study was conducted in Wardha district, located in Maharashtra state in Central India in 2013. The sample included 1000 women (609 rural, 391 urban) aged 13-50 years, selected as representative from each of the eight development blocks in the district, using stratified cluster sampling. Trained social workers interviewed women and collected demographic and socio-economic data. The instrument also assessed respondents' knowledge about breast cancer and its symptoms, risks, methods of screening, diagnosis and treatment, as well as their attitudes towards breast cancer and selfreported practices of breast cancer screening. Chi-square and t-test were applied to assess differences in the levels of knowledge, attitude, and practice (the outcome variables) between urban and rural respondents. Multivariable linear regression was conducted to analyse the relationship between socio-demographic factors and the outcome variables. Results: While about two-thirds of rural and urban women were aware of breast cancer, less than 7% in rural and urban areas had heard about breast self-examination. Knowledge about breast cancer, its symptoms, risk factors, diagnostic modalities, and treatment was similarly poor in both rural and urban women. Urban women demonstrated more positive attitudes towards breast cancer screening practices than their rural counterparts. Better knowledge of breast cancer symptoms, risk factors, diagnosis, and treatment correlated significantly with older age, higher levels of education, and being office workers or in business. Conclusions: Women in rural Central India have poor knowledge about breast cancer, its symptoms and risk factors. Breast self-examination is hardly practiced, though the willingness to learn is high. Positive attitudes towards screening provide an opportunity to promote breast self-examination.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5427-5432
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• 2012

Background and Purpose: Ovarian cancer is the leading cause of death among gynecologic cancers because of the lack of effective early detection methods. Accuracies of the human epididymis protein 4 (HE4) and mesothelin in detecting ovarian cancer have never been systematically assessed. The current systematic review aimed to tackle this issue. Methods: MEDLINE, EMBASE, and Cochrane databases were searched (September 1995-November 2011) for studies on the diagnostic performances of HE4 and mesothelin in differentiating ovarian cancer from other benign gynecologic diseases. QUADAS items were used to evaluate the qualities of the studies. Meta-DiSc software was used to handle data from the included studies and to examine heterogeneity. All included studies for diagnostic performance were combined with sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratios (DORs) with 95% confidence intervals (CIs), summary receiver operating characteristic (SROC) curves, and areas under the SROC curves (AUC). Results: A total of 18 studies and 3,865 patients were eligible for the final analysis. The pooled sensitivity estimates for HE4 (74.4%) were significantly higher than those for mesothelin (49.3%). The pooled specificity estimates for mesothelin (94.5%) were higher than those for HE4 (85.8%). The pooled DOR estimates for HE4 (26.22) were higher than those for mesothelin (24.01). The SROC curve for HE4 showed better diagnostic accuracy than that for mesothelin. The PLR and NLR of HE4 were 6.33 (95% CI: 3.58 to 11.18) and 0.27 (95% CI: 0.21 to 0.34), respectively. The PLR and NLR for mesothelin were 11.0 (95% CI: 6.21 to 19.59) and 0.51 (95% CI: 0.42 to 0.62), respectively. The combination of the two tumor markers or their combination with CA-125 increased sensitivity and specificity to different extents. Conclusion: The diagnostic accuracy of HE4 in differentiating ovarian cancer from other benign gynecologic diseases is better than that of soluble mesothelin-related protein. Combinations of two or more tumor markers show more sensitivity and specificity.

• 환경정책연구
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• 제10권4호
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• pp.3-37
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• 2011

한국과 중국, 일본 세 국가의 1971년부터 2006년까지의 시계열 자료를 바탕으로 이산화탄소 배출량과 경제성장 그리고 경제개방도의 인과관계를 파악하고, 환경 쿠즈네츠 곡선(Envirionmental Kuznets Curve, EKC)의 존재여부에 대해 분석하였다. 경제개방도나 경제성장에 따른 이산화탄소 배출량은 국가별로 상이한 형태를 보였다. 추정된 EKC는 국가별로 다른 패턴을 보이는데, 경제성장과 $CO_2$ 배출량의 경우 한국은 U자 곡선, 중국은 상승추세, 일본은 역 N자 형태를 보였다. 일본은 약 30,000달러의 경제성장을 달성하면서 이산화탄소 배출 감소구간을 보이고 있다. 이와 같은 결과를 통해, EKC의 최고점에 이르지 않고도 선진국의 경험과 기술을 이용하여 터널을 거쳐 환경이 개선될 수 있다는 가능성을 확인할 수 있었다. 경제개방도와 $CO_2$ 배출량의 관계를 보면 한국은 역 U자 곡선, 중국의 경우 U자곡선, 일본은 증가추세를 보였다. 또한 벡터자기회귀모형(vector auto regression, VAR)과 벡터오차수정모형(vector error correction model, VECM)을 사용하여 변수들 간의 동태적 관계를 분석하였다. 각 국가의 경제성장, 개방화 정도에 따른 이산화탄소 배출과의 관계를 보다 가시적으로 접근했다는 데 의의가 있다.

• 한국수자원학회논문집
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• 제41권11호
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• pp.1135-1142
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• 2008

하천제방의 붕괴 요인중 구조물(배수통문) 주변 제방의 붕괴는 전체 요인의 l0% 이상을 차지하고 있으며, 특히 2002년 홍수시 낙동강에서 발생한 제방 유실 지점은 거의 배수통문 주위에서 발생하였다. 이러한 제방 파괴는 이질 재료인 통문 구조물과 제체 접합부 사이에 공극이나 공동이 형성된 후 홍수시 내부 침식으로 인해 공동이 확대되어 발생하는 파괴구조를 가지고 있다. 이러한 상황에서 하천제방의 안전관리를 위해 배수통문 주변의 공동발생 여부 혹은 공동내의 흐름 인지 등을 목적으로 한 연구가 진행되고 있으며, 본 연구에서는 Flex센서와 Fiber bragg grating 센서의 변이 계측에 대한 실험을 통해 두 센서의 특징을 파악하고, 하천제방의 안전관리를 위해 보다 적합한 센서의 결정이 가능하도록 하였다. 실험결과 현 시점에서 변이 계측과 관련하여 계측치의 일관성, 미소변이 계측 등 Flex센서의 단점을 보완할 수 있는 FBG센서의 여러 특징을 확인할 수 있었다.

• 한국광물학회지
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• 제28권2호
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• pp.109-126
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• 2015

단층비지는 단층의 중심부에 분포하면서 연약대를 형성하므로 단층비지의 광물학적 특성과 물성은 암반의 안정성에 크게 영향을 미친다. 본 연구에서는 단열구조도를 참고하여 중, 대규모의 주요 단층을 선정하였으며, 총 16지역의 단층 코어부분에서 51종류의 시료를 채취하였다. XRD, SEM을 이용한 광물학적 분석과 단위중량, 마찰각, 점착력을 측정하였다. 점토광물은 대표적으로 카올리나이트, 일라이트, 스멕타이트로 나눠질 수 있으며, 화산암에는 일라이트 > 스멕타이트 > 카올리나이트와 녹니석의 순으로 함유된다. 퇴적암에는 카올리나이트와 녹니석 > 일라이트 > 스멕타이트의 순으로 풍부하다. 화강암에는 일라이트 > 스멕타이트 > 카올리나이트와 녹니석 순으로 함유된다. 마찰각은 점토함량이 높을수록 감소하며, 점착력은 분산이 심하게 나타났다. 점토광물의 함량이 45% 이하에서는 점토광물의 함량이 증가할수록 점착력이 높아지나 45% 이상에서는 점착력이 낮아지는 추세를 보인다. 이는 단층비지가 불균질하며, 점토광물의 종류와 함량에서도 넓은 범위를 가지기 때문인 것으로 보인다.

• 한국항해항만학회지
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• 제37권3호
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• pp.275-281
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• 2013

선박표준 네트워크는 2005년 IMO MSC 제 81차 회의에서 e-navigation을 공동 의제로 제출되었다. 2006년 MSC 81의 WG 프로그램으로 승인된 후 2008년까지 e-navigation 구현전략을 수립하기로 결정됨으로써 선박 네트워크의 표준화 작업은 본격화되었다. 이는 선박의 안전 항해 뿐 아니라 400여종의 이기종 항해통신장비 및 기관 장비를 탑재하는 선박에서의 효율적인 정보 교환을 지원하기 위한 것이기도 하다. 그 가운데 4S 네트워크는 육상과 선박, 선박과 선박사이의 무선통신을 말하며 선박과 육상 간 통신채널을 항상 연결하도록 해주는 기본이 된다. 4S 네트워크는 이를 기반으로 다양한 서비스를 제공할 수 있는 많은 활용 분야가 존재하기 때문에 향후 e-navigation이 적용되면 다양한 시장 창출이 가능할 것으로 보이나 현재 이에 대한 구체적인 기반 기술 연구나 시제품 개발은 전무한 상태이다. 본 논문에서는 육해상간 효율적이고 저렴한 통신환경을 제공하도록 하는 4S 다중매체 스위칭 서버와 육해상 정보교환 시스템을 개발하고, 구현한 시스템의 성능을 TTA(Telecommunications Technology Association) V&V(Verification and Validation) 인증을 통해 확인하였다.

• Journal of Preventive Medicine and Public Health
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• 제31권1호
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• pp.27-48
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• 1998

This study was conducted to integrate the results of studies which evaluated or identified the risk factors of CVD(cerebrovascular disorders) for Koreans. We retrieved the literature published in Korean by manual search and the English literature by Medline database to identify studies on the relationship between reported risk factors and CVD conducted for the Korean from 1980 to August, 1997. Hypertension and total serum cholesterol were selected as subjects of quantitative meta-analysis on risk factors of CVD in Koreans. The overall effect sizes of the risk of CVD due to hypertension and total serum cholesterol were calculated by common odds ratio(OR) and average standardized mean difference, retrospectively. Before the integration of each effect sizes into common effect sizes, the heterogeneity tests were conducted. Also, sensitivity tests were conducted for the estimated common effect sizes. Regarding hypertension and CVD, a total of 9 epidemiologic studies were identified with a total of 2,271 cases of CVD. The overall OR of hypertension associated CVD was 4.10(95% confidence interval[CI] 3.56 to 4.71). The OR of hypertension associated with hemorrhagic CVD and ischemic CVD were 6.56(95% CI : 4.92 to 8.80) and 3.28 (95% CI : 2.77 to 3.90), retrospectively. The OR of hypertension in relation to hemorrhagic CVD was significantly higher than that of hypertension in relation to overall CVD or ischemic CVD. Regarding total serum cholesterol and ischemic CVD, total 9 epidemiologic studies were identified with a total of 843 cases of ischemic CVD. Average mean difference as an effect size was 0.76, which was judged an important value according to Cohen's criteria. Our data suggested that hypertension was an important risk factor of overall CVD and its subtypes, and that the total serum cholesterol was associated with ischemic CVD in Koreans. For the lack of reliable prospective studies, however, we concluded that further research designed longitudinally would be required in this area.

• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1233-1239
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• 2014

Background: The incidence of brain metastases (BM) varies in patients with non-small cell lung cancer (NSCLC), calls into question the value of prophylactic cranial irradiation (PCI). It is possible that clinicopathologic characteristics are associated with the development of BM, but these have yet to be identified in detail. Thus, we conducted the present meta-analysis on risk factors for BM and the value of PCI in patients with NSCLC. Methods: Eligible data were extracted and the risk factors for BM and the value of PCI in patients with NSCLC were analyzed by calculating the pooled odds ratio (OR). Heterogeneity was detected using Q and I-squared statistics, and publication bias was tested by funnel plots and Egger's test. Results: Six randomized controlled trials with a focus on the value of PCI and 13 eligible studies with a focus on risk factors for BM were included. PCI significantly reduced the incidence of BM in patients with NSCLC (p=0.000, pooled OR=0.34, 95% confidence interval = 0.37-0.59). Compared with non-squamous cell carcinoma, squamous cell carcinoma was associated with a low incidence of BM in patients with NSCLC (p=0.000, pooled OR=0.47, 95% confidence interval =0.34-0.65). The funnel plot and Egger's test suggested that there was no publication bias in the current meta-analysis. Conclusions: This meta-analysis provides statistical evidence that compared with non-squamous cell carcinoma, squamous cell carcinoma can be used as a predictor for BM in patients with NSCLC, and PCI might reduce the incidence of BM in patients with NSCLC, but does not provide a survival benefit.

• Asian Pacific Journal of Cancer Prevention
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• 제15권12호
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• pp.4829-4837
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• 2014

The present systematic review and meta-analysis was conducted to assess any association between breastfeeding and the risk of ovarian cancer. A systematic search of published studies was performed in PUBMED and EMBASE and by reviewing reference lists from retrieved articles through March 2013. Data extraction was conducted independently by two authors. Pooled relative risk ratios were calculated using random-effect models. Totals of 5 cohort studies and 35 case-control studies including 17,139 women with ovarian cancer showed a 30% reduced risk of ovarian cancer when comparing the women who had breastfed with those who had never breastfed (pooled RR = 0.70, 95% CI: 0.64-0.76; p = 0.00), with significant heterogeneity in the studies (p = 0.00; I2 = 76.29%). A significant decreasd in risk of epithelial ovarian cancer was also observed (pooled RR = 0.68, 95% CI: 0.61-0.76). When the participants were restricted to only parous women, there was a slightly attenuated but still significant risk reduction of ovarian cancer (pooled RR = 0.76, 95% CI: 0.69-0.83). For total breastfeeding duration, the pooled RRs in the < 6 months, 6-12 months and > 12 months of breastfeeding subgroups were 0.85 (95% CI: 0.77-0.93), 0.73 (95% CI: 0.65-0.82) and 0.64 (95%CI: 0.56-0.73), respectively. Meta-regression of total breastfeeding duration indicated an increasing linear trend of risk reduction of ovarian cancer with the increasing total breastfeeding duration (p = 0.00). Breastfeeding was inversely associated with the risk of ovarian cancer, especially long-term breastfeeding duration that demonstrated a stronger protective effect.

• 한국지역지리학회지
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• 제20권4호
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• pp.393-408
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• 2014

본 연구에서는 우리나라 여름철 극한강수현상 발생의 시 공간적 특성을 밝히고자 하였다. 분석에 사용된 자료는 최근 10년간(2002~2011년) 기상청 산하 전국 약 360여개 방재기상관측장비 및 종관기상관측장비의 일강수량 자료이다. 일강수량 80mm 이상의 극한강수현상과 일강수량 극값은 여름장마기(6월 하순~7월 중순)에 전국적으로 높게 나타났지만, 장마전선이 북상하는 장마휴지기(7월 하순~8월 초순)에는 경기북부~강원 영서 북부 지역에, 장마전선이 남하하는 늦장마기(8월 중순~9월 초순)에는 경기도~강원 영서 남부 지역 및 지리산, 한라산 주변지역에서 높게 나타났다. 세부 지역별로 극한강수현상의 발생빈도와 극값 분포를 살펴보면, 종관규모인 장마전선의 위치뿐만 아니라 해발고도와 사면의 방향성과 같은 지형요소와 기류의 유입 등이 극한기후현상의 시 공간성에 영향을 미치는 기후인자임을 알 수 있었다. 이러한 결과는 우리나라 각 지역과 여름철 시기별로 상이하게 나타나는 극한강수현상의 발생빈도와 강도를 고려하여 지역별로 차별화된 호우 피해 저감 대책이 필요함을 시사한다.