• Proceedings of the PSK Conference
• /
• 2003.10b
• /
• pp.187.1-187.1
• /
• 2003

Type 2 diabetes is characterized by high level of blood glucose and insulin and impaired action. In recent years, the treatment of type 2 diabetes has been revolutionized with the advent of thiazolidinedione (TZD) class of molecules that ameliorate insulin resistance and thereby normalize elevated blood glucose levels. These TZDs are synthetic, high-affinity ligands of peroxisome proliferator activated receptor-gamma (PPAR${\gamma}$); a member of the nuclear receptor family that controls the expression of genes in the target tissues of insulin action. (omitted)

• Proceedings of the PSK Conference
• /
• 2003.10b
• /
• pp.181.4-182
• /
• 2003

Telomeres are DNA-protein complexes at the ends of chromosomes, which play an essential protective role against DNA degradation and aberrant recombination during cell divisions. Several telomerase inhibitors have been reported as candidates for new antitumor drugs. Among them, 2-thiobenzylpyridines, developed by Geron. Co Ltd. as a telomerase inhibitor, were chosen as lead compounds. Twenty-one pyridine-2- carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. (omitted)

• Journal of The Korean Society of Integrative Medicine
• /
• v.10 no.1
• /
• pp.13-26
• /
• 2022

Purpose : The purpose of this study was to investigate the effect of Dang Dang integrated corrective therapy including myofascial release, chuna therapy, and exercise therapy on height, muscle mass, body fat, and body water in patients with body imbalance. The secondary aim was to investigate whether the percent of change in height, muscle mass, body fat, and body water varied by age group. Methods : In total, 279 patients with body imbalance between the ages of 10 and 79 were recruited at hospitals. All participants had Dang Dang integrated corrective therapy including myofascial release, chuna therapy, and exercise therapy. The patients' height, muscle mass, body fat, and body water were measured before and after Dang Dang integrated corrective therapy using InBody. Results : The height, muscle mass, and body water significantly increased after Dang Dang integrated corrective therapy in all age groups except for the 70~79 age group and body fat significantly decreased (p < .05). The age group comparison of the percent change in height, muscle mass, and body water showed significant differences (p < .05). In the post hoc test, the percent change of height in the 10~19 age group was significantly greater than in the other age groups except for the 70~79 age group. The percent change of muscle mass and body water in the 10~19 age group was significantly greater than in the 30~39 age group. Conclusion : These findings suggest that applying Dang Dang integrated corrective therapy to patients with body imbalance, excluding patients aged 70~79, may be a useful method to increase height, muscle mass, and body water and decrease body fat through spinal and joint realignment. The best results were observed in teenagers.

• Journal of Environmental Health Sciences
• /
• v.3 no.1
• /
• pp.4-8
• /
• 1976

Authors investigated the hematological examinations of 993 persons at rural region among the 1,7 41 of residents in-the part of Dang Jin (M:268, F:247) and Young Joo (M:270, F:208) in the Korea which was indicated as follows. 1. Average value and standard deviation of hematological items represents as follows: i) Hemoglobin Men Dang Jin-13.99$\pm$0.52. Man Young Joo-14.93$\pm$0.57 Women Dang Jin-12.56$\pm$0.38 women Young Joo-13.65$\pm$0.48 ii)Hematocrit Men Dang Jin-42.68$\pm$1.09 Man Young Joo-44.61$\pm$1.42 Women Dang Jin-38.16$\pm$0.93 women Young Joo-40.33$\pm$1.27 iii) Mean Corpuscular hemoglobin concentration Men Dang Jin-32.79$\pm$1.06. Man Young Joo-33.46$\pm$0.36 Women Dang Jin-32.92$\pm$0.75 women Young Joo-33.83$\pm$0.82 iv) WBC Men Dang Jin-7.130$\pm$880. Man Young Joo-7.490$\pm$910 Women Dang Jin-6.030$\pm$1.150 women Young Joo-7.320$\pm$1.040 2. The aspect of blood type at Young Joo and Dang Jin was same indicated in the order of A,O,B, and AB. 3. There are higher values of hemoglobin, hernatocrit, M.C.H.C. and WBC in men and women at Young Joo than Dang Jin.

• YAKHAK HOEJI
• /
• v.42 no.4
• /
• pp.431-436
• /
• 1998

The pharmacokinetics of CKD-602, a new camptothecin anticancer derivative, were studied in mice, rats and dogs following a single or multiple intravenous administration, and the following results were obtained. The blood levels of CKD-602 declined in biphasic fashions with peak plasma levels $(C_0)$ of $2.63{\mu}g/ml$ in mice, $2.27{\mu}g/ml$ in tumor bearing mice, $2.84{\mu}g/ml$ in rats at a dose of 20mg/kg, and of 0.02mcg/ml in dogs at a dose of 0.5mg/kg. The plasma half-lives $(t_{1/2}{\beta})$ were 9.55hr in mice, 9.94hr in tumor bearing mice, 9.98hr in rats and 12.75hr in dogs. AUC of CKD-602 was increased linearly with the dose at a range from 5 to 20mg/kg. Moreover, Cltot and Vdss were also not significantly changed with increasing the dose. On the other hand, after 5 daily intravenous bolus injection of CKD-602 (5mg/kg) in rats, $t_{1/2}{\beta}$, AUC and MRT of CKD-602 were 11.90hr, $3.19{\mu}g{\cdot}hr/ml$, and 11.61hr, respectively, which were slightly higher than after the single bolus injection.

• Journal of architectural history
• /
• v.8 no.3 s.20
• /
• pp.9-22
• /
• 1999

The purpose of this study is to analyse the architectural character of JE-DAMG at farm village in Ulsan. JE-DANG means the building for DONG-JE (the sacrificial rite of a village). The regions of this study are KANG-DONG MYEN, and UNG-CHON MYEN in Ulsan. The method of this study is the analysis of them after the actual field surveys of 47 JE-DANGs in these regions The survey contains the area, the height, the period of the erection, the architectural structure, the roof shape, the material, the landowner, SHIN-CHE (means a god's name and shape), DANG-SU tree and so on. Methods of the survey are the field survey, the interview of villager, the analysis of reference data and so on. Results of the study are below. JE-DANGs(buildings) of these regions had been built first in the period of Japanese occupancy and erections of them had continued until 1970's. Since then, they have been rebuilt. The primary JE-DANG is characterized by a tiled roof, a wooden post lintel, a mud-plastered wall, and a wooden door. After rebuilding, characters are a flat slab, a tiled roof, a structure of using red bricks, and the area is getting larger than the primary JE-DANG, but 1 KAN persists without variety. Most of houses in the inland area like UNG-CHON MYEN face the south, and ones in the coastal area like KANG-BONG MYEN face the east. Generally there is DANG-SU tree behind JE-DANG. That proves DANG-SU tree to be the object of the rite. The species of DANG-SU is a pine in general ,but various in UNG-CHON MYEN. In general names of the god are DONG-SHIN , DANG-SAN SHIN and SUNG-HWANG SHIN. I think that the landownership of JE-DANG should change the private ownership into the village ownership to preserve JE-DANG though most of lands of JE-DANG are private ones.

• Journal of Trauma and Injury
• /
• v.22 no.2
• /
• pp.260-263
• /
• 2009

Renal artery pseudoaneurysm after blunt renal trauma is an uncommon complication of delayed hemorrhage, and diagnostic difficulties are experienced due to its rarity. Delayed hemorrhage after renal trauma is a life-threatening complication. Angiography is considered the gold standard to diagnose a traumatic renal artery pseudoaneurysm. We report here a case of delayed bleeding from a renal artery pseudoaneurysm that was diagnosed at 17 days after the injury and that was managed successfully with selective renal artery embolization without medical complication.

• Journal of architectural history
• /
• v.28 no.6
• /
• pp.31-42
• /
• 2019

The harsh economic conditions of Buddhist temples in late Joseon dynasty, and the prevalence of the Buddhānusmrti(念佛) practice, which is a practice of reciting Amita Buddha(阿彌陀佛), led Buddhist temples to organize the Buddhānusmrti association(念佛契) in the nineteenth and early twentieth centuries. For the practices and the activities of organization, an architectural facility was required; thereby, many temples had a Yeombul-dang(念佛堂). However, only a few of the Yeombul-dang have survived and are known today. This research investigates the ways temples tried to acquire Yeombul-dang buildings during the period and their architecture characteristics by reviewing historical records and documentary works of literature. In this research, Yeombul-dang is found to have various types of building names and building forms. Different hall names such as Amitābha Hall(佛殿), Yosa(寮舍) and Daebang(大房) were used as Yeonbul-dang. The commonalities and differences in terms of building forms, spatial elements composition and layouts were found depending on how they were acquired. The Yeombul-dang were most commonly built as multi-complex buildings consisting of worshiping rooms and residential areas. Most of Yeombul-dang were located in the central areas of the temple site. On this basis, this research suggests the possibility that many Yeombul-dang is still being used under different names and for different purposes.

• Journal of Nutrition and Health
• /
• v.36 no.10
• /
• pp.1013-1021
• /
• 2003

Anemia, the condition of the diminished concentration of hemoglobin per erythrocyte is common in patients with cancer and is a frequent complication of myelosuppressive chemotherapy. Cham-Dang-Gui (Angelicae Gigantis Radix) has been used in traditional Korean medicine to treat hematologic deficiencies. In this study, Cyclophosphamide (CYP), an alkylating agent that has a broad spectrum of anti-cancer activities, was intraperitoneally injected into the experimental animals to suppress the bone marrow thereafter, causing anemia. The hemopoietic effects of Cham-Dang-Gui were examined using anemic rat model. Rats were divided into five groups: CON (control group), ANS (CYP-injected + normal diet), AND (CYP-injected + normal diet + Cham-Dang-Gui), ALS (CYP-injected + low iron diet), and ALD (CYP-injected + low iron diet + Cham- Dang-Gui) groups. CYP (30 mg/kg) was intraperitoneally injected to rats for 3 days to induce anemic condition. Saline or Cham-Dang-Gui was administrated orally during the entire experimental period. CYP injection decreased body weight gain and food consumption in comparison with CON group. Oral administration of Cham-Dang-Gui extract with normal iron diet significantly prevented the lower body weight gain. The blood level of hemoglobin, iron status (serum iron, transferrin, ferritin and TIBC) and blood level of vitamin B-12 in Cham-Dang-Gui treated groups were significantly higher than those of Cham-Dang-Gui untreated groups regardless of amount of iron in the diet. Taken together, it could be concluded that the Cham-Dang-Gui extract could improve anemic condition induced by CYP injection by improving hematological value, iron status and vitamin B12 status in rats.

• Journal of architectural history
• /
• v.30 no.4
• /
• pp.17-29
• /
• 2021

Young-dang(影堂) is a ritual pavilion where figures of a dedicated person is enshrined. According to literature, establishment of Young-dang architecture is thought to have the affinity with Buddhist tradition in the beginning of its history. A tradition of enshrining figure could be found especially in Buddhism. Until the mid Joseon dynasty, enshrining figure made of wood, clay and bronze was quite often at Young-dang. In Confucian ritual tradition, a pavilion where enshrining ancestor's sprit tablet called Sadang(祠堂) or Myo(廟). In regarding portrait is a sort of figure, it has to be concerned with Buddhist ritual tradition. For this reaseon, Young-dang started to be distinguished from older aspect of existence in mid Joseon dynasty when the study of Confucian courtesy widely spread. It show the transformation process of Young-dang architecture from Buddhist tradition to Confucian tradition in J oseon dynasty.