• Journal of Korean Neurosurgical Society
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• v.64 no.4
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• pp.543-551
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• 2021

Objective : Hemorrhagic stroke (HS) and hypertensive retinopathy are known end organ damage of the brain and eye respectively, with HS having deleterious consequence to the patients. This study is to correlate between hypertensive retinopathy and HS in hypertensive disease. Methods : A control group of hypertensive patients only, and an investigated group of hypertensive HS patients. Fundoscopic examination to determine the grade of retinopathy was performed and then divided into low or high severity hypertensive retinopathy. Clinical and radiological parameter included are demography, vital signs, Glasgow coma scale (GCS) on admission, clot volume, site of clot, Intracerebral hemorrhage (ICH) score and Glasgow outcome scale (GOS). Data were correlated with the severity of hypertensive retinopathy. Results : Fifty patient in the control group and 51 patients in the investigated group were recruited. In the hypertensive HS group, 21 had low severity retinopathy (no or mild retinopathy) accounting for 41.2% and 30 patients had high severity (moderate or severe retinopathy). In the hypertensive patients 49 had low severity and one had high severity (p-value of 0.001). In HS group low severity showed better GCS score of 9-15 on admission (p-value of 0.003), clot volume less than 30 mL (p-value 0.001), and also a better 30 days mortality rate by using the ICH score (p-value 0.006), GOS score of 4 and 5 the low severity retinopathy fair better than the high severity retinopathy (p-value of 0.001), and the relative risk to develop HS in low severity and high severity retinopathy was 0.42 and 29.4, respectively. Conclusion : Hypertensive retinopathy screening could be used as an indicator in hypertensive patient, to evaluate the risk of developing hypertensive HS in the future.

• Journal of Convergence for Information Technology
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• v.11 no.1
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• pp.199-207
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• 2021

This study was attempted to understand the effect of the violence victim experience of Korean adolescents on smoking using the data of the 15th (2019) online youth health behavior survey. The subjects of this study were 57,303 people, and the data were analyzed using the SPSS / Win 26.0 program for frequency analysis of complex samples, cross sample analysis (Rao-Scott ��2 test), and logistic regression analysis of complex samples. The main result was 12.7% of the smoking subjects. Those who smoked were significantly more 9.6% and 22.0%, respectively, compared to those who had no more than 1 or 2 times of violence. Smoking of Korean adolescents adjusted for gender, grade, academic record, economic status, drinking, family living, and usual stress increased the odds ratio for smoking by 1.66 times when the degree of violence damage experience increased by 1 unit. As a result of the above, as the degree of violence victimization of adolescents increases, the likelihood of smoking increases. Therefore, it is necessary to multidisciplinary convergence effort to the prevention and management of violence of adolescents, and to reduce the smoking of adolescents.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.24 no.3
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• pp.295-305
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• 2021

Purpose: Hepcidin levels have previously been reported to be correlated with liver damage. However, the association between hepcidin levels and liver fibrosis in children with fatty liver disease remains unclear. This study therefore aimed to investigate the pathophysiology of fibrosis in children with fatty liver disease and its association with hepcidin levels. Methods: This retrospective case series included 12 boys aged 6-17 years who were diagnosed with nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH) at the Tokyo Medical University Hospital. Sixteen liver biopsy samples from 12 subjects were analyzed. Serum hepcidin levels were assayed using enzyme-linked immunosorbent assay. Immunostaining for hepcidin was performed, and the samples were stratified by staining intensity. Results: Serum hepcidin levels were higher in pediatric NAFLD/NASH patients than in controls. Conversely, a significant inverse correlation was observed between hepcidin immunostaining and Brunt grade scores and between hepcidin scores and gamma-glutamyltranspeptidase, hyaluronic acid, and leukocyte levels. We observed inverse correlations with a high correlation coefficient of >0.4 between hepcidin immunostaining and aspartate aminotransferase, alanine aminotransferase, total bile acid, and platelet count. Conclusion: There was a significant inverse correlation between hepcidin immunoreactivity and fibrosis in pediatric NAFLD patients; however, serum hepcidin levels were significantly higher, suggesting that these patients experienced a reduction in the hepcidin-producing ability of the liver in response to iron levels, leading to subsequent fibrosis. Therefore, hepcidin levels can be used as markers to identify the progression of fibrosis in patients with NAFLD.

• Journal of the Korea Institute of Building Construction
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• v.23 no.1
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• pp.57-68
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• 2023

To maintain the normal function of an aging building, regular inspection, repair, and reinforcement must be performed. However, the form of information and decision-making generated in the current building maintenance stage still depends on inefficient methods. This causes an increase in cost and waste of time in building maintenance. Therefore, this study proposed a COBie-IM document for building inspection and maintenance information management by benchmarking COBie, and suggested a method of checking information by linking it with BIM. In addition, a method for visualizing the designation of colors according to the damage grade of defects occurring in the building was suggested. Through this, we are able to systematically integrate and manage the information generated during inspection and maintenance in the building maintenance stage. This is expected to increase work efficiency by supporting decision-making that determines the priority of repair and reinforcement for defects.

• Journal of the Korea Safety Management & Science
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• v.26 no.2
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• pp.23-31
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• 2024

In the military, ammunition and explosives stored and managed can cause serious damage if mishandled, thus securing safety through the utilization of ammunition reliability data is necessary. In this study, exploratory data analysis of ammunition inspection records data is conducted to extract reliability information of stored ammunition and to predict the ammunition condition code, which represents the lifespan information of the ammunition. This study consists of three stages: ammunition inspection record data collection and preprocessing, exploratory data analysis, and classification of ammunition condition codes. For the classification of ammunition condition codes, five models based on boosting algorithms are employed (AdaBoost, GBM, XGBoost, LightGBM, CatBoost). The most superior model is selected based on the performance metrics of the model, including Accuracy, Precision, Recall, and F1-score. The ammunition in this study was primarily produced from the 1980s to the 1990s, with a trend of increased inspection volume in the early stages of production and around 30 years after production. Pre-issue inspections (PII) were predominantly conducted, and there was a tendency for the grade of ammunition condition codes to decrease as the storage period increased. The classification of ammunition condition codes showed that the CatBoost model exhibited the most superior performance, with an Accuracy of 93% and an F1-score of 93%. This study emphasizes the safety and reliability of ammunition and proposes a model for classifying ammunition condition codes by analyzing ammunition inspection record data. This model can serve as a tool to assist ammunition inspectors and is expected to enhance not only the safety of ammunition but also the efficiency of ammunition storage management.

• Childhood Kidney Diseases
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• v.2 no.2
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• pp.138-144
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• 1998

Purpose : The use of cyclosporine and mitomycin in various immunologic or neoplastic disorders has been known to cause wide-ranged nephrotoxic effects including thrombotic microangiopathy. However, the mechanism of nephrotoxicity of these drugs has not been studied adequately, so that present experimental study has been undertaken to find out whether these drugs can cause direct damage to the kidney and to clarify the pathogenetic mechanism of nephrotoxic effect of these drugs. Materials and methods : Sprague-Dawley rats weighing 250-300 gm were used for experimental animals and unilateral renal perfusion technique, modified from the method described by Hoyer et al was used. Isolation of left kidney from systemic circulation was made by clamping aorta and left renal vein and a hole was punctured in the anterior wall of the left renal vein. Cyclosporine (2.5 mg in 4 ml solution) and mitomycin (1.6 mg in 4ml solution) were infused through left renal artery and normal saline was used in control rats. Forty-eight hours after infusion of the drugs, animals were sacrificed and left kidney removed and processed for histologic examination. Total ischemic time of left kidney was less than 15 minutes: Results : Cyclosporine-perfused group showed severe swelling of glomerular endothelial ceil along with swelling of glomerular epithelial cell and interstitial vascular endothelial cell. Mitomycin-perfused group also showed severe swelling of glomerular endothelial and epithelial cells. And in addition to these findings, they demonstrated platelets aggregation, swelling and degranulation of platelets and fibrin accumulation in some of the capillaries, indicating occurrance of thrombotic microangiopathy. Conclusion : present experiment indicates that cyclosporine and mitomycin can cause direct toxic injury to renal endothelial cell. And this direct toxic damage to endothelial cell seems to be an important initiating event for the development of thrombotic microangiopathy.

• Journal of Conservation Science
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• v.27 no.1
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• pp.101-114
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• 2011

The rock-carved Buddha statue at Dosolam (Korea Treasure No. 1200) of the Seonunsa temple in Gochang is unique style sculptured on natural rock cliff of 13.0m height. The Buddha statue is composed of volcanic complex with tuff, dacitic tuff breccia, tuff bereccia and lithic tuff. Especially, the Buddha statue is characterized by hydrothermal alteration and fragmentation on the upper and lower part. As a result of damage diagnosis, exfoliation and detachment of physical weathering are high of 11.3% and 9.3%, respectively. Infrared thermography analysis, exfoliation and micro-cracks occurred in the measuring parts that have not been confirmed by naked eyes. Chemical index of alteration and weathering potential index of host rock for the Buddha statue are 55.16 to 64.01 and 6.14 to 9.92 which are represented within highly weathering degree. In surface, dark black, reddish brown and white discoloration are observed prominently in the lower. Brown discoloration 6.9% is highest. According to the P-XRF measurements, high concentration of Fe in common, in part of dark black discoloration was Mn, white and brown discoloration in part of S and Ca content were higher. Biological weathering that yellowish brown and dark gray crustoes lichenes appeared by 20.8% and 13.3%, respectively. Therefore, comprehensive deterioration rate of Buddha statue show physical damage by 21.2%, discoloration for inorganic contaminants by 10.8% and biological damage by 39.4%. Ultrasonic velocity measurement carried out of Buddha statue on the surface by 555 points. Measured value of ultrasonic velocity was about 2,273m/s(1,067 to 3,215m/s, and weathering coefficient is 0.5(0.4 to 0.8) that progress on MW(moderately weathered) to HW(highly weathered) grade of rocks.

• Journal of the Korean Society of Food Science and Nutrition
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• v.35 no.9
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• pp.1139-1145
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• 2006

In this study, antioxidant activities of enzymatic and methanolic extracts from E. cava stem and leave were evaluated by measuring the scavenging activities on 1,1 diphenyl 2 picrylhydrazyl (DPPH), hydroxyl radical, hydrogen peroxide and the inhibitory effects on DNA damage induced by oxidative stress of cells. Enzymatic extracts were prepared by enzymatic hydrolysis of both stem and leave using food grade five different carbohydrases (Viscozyme, Celluclast, AMG, Termamyl, Ultraflo) and five proteases (Protamex, Kojizyme, Neutrase, Flavourzyme, Alcalase). The enzymatic extracts were lower than methanolic extracts in polyphenol contents, but higher in extraction yield by approximately 30%. The enzymatic extracts were superior to methanolic extracts in DPPH and H2O2 scavenging activities and DNA damage protective effect. There were no significant antioxidant activity difference between stem and leave, but the extracts of leave were relatively better than those of stem. In this study it is suggested that E. cava stem as well as its leave would be a good raw materials for antioxidants compound extraction and enzymatic hydrolysis would be a good strategy to prepare antioxidant extracts from seaweeds.

• Journal of the Korea Concrete Institute
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• v.19 no.6
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• pp.755-762
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• 2007

For the evaluation of the load carrying capacity of the deteriorated PSC I girder bridge in service load state and the verification of the grade to the reinforcement effect of actual bridge strengthened by external prestressing tendons, the field test using vehicles is applied widely. Because this teat was executed in elastic range, the investigation of the characteristics of behavior caused by live load is only available. And it is impossible to estimate load carrying capacity in limit state and nonlinear behavior after that a crack is appeared. In this study, the 27-year-old prestressed concrete girder bridge is used and various load tests are performed, so we evaluate the behavior characteristics of the bridge in service load state and ultimate load state, and estimate the load carrying capacity of bridge. In addition, the artificial damages are induced from cutting internal tendons, and external tendons is added to strengthen it as much as vanished internal tendons. Next we compare the damage state with the strengthening state. In case of the application of external prestressing method to PSC I girder bridge, the present experiment result may decide more exactly the load carrying capacity of actual bridge, the amount for reinforcement, and the standard of quality control etc. at reinforcement work.

• Childhood Kidney Diseases
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• v.5 no.1
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• pp.15-21
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• 2001

Purpose : Urinary tract infections (UTIs) of children require prompt and correct diagnosis and treatment to reduce the risk of renal damage. As a first step to improve the outcome of UTI in Korea, we investigated the practical variations in the methods of diagnosis, treatment, and evaluation of children with UTI and UTI prevention. Method :A questionnaire related to the individual policy on UTI diagnosis. treatment, imaging test, and prevention was submitted to 26 experts. Result Majority of the experts used bag-collected urine specimen for infants and mid-stream urine specimen for children for urinary culture. With a negative result of culture study, they diagnosed UTI when there was pyuria, positive results of the nitrite test, or bacteriuria. 80 $\%$ of experts prescribed prophylactic antibiotics after upper tract UTI. Operative treatment of vesicoureteral reflux (VUR) was indicated for children older than one or two years old with high-grade VUR, refractory breakthrough infections, or recurrent UTIs. Most of them performed kidney ultrasonography on the diagnosis of UTI and more than half of them evaluated children treated of UTI with vesicocystourethrogram and/or DMSA scintigraphy. Majority did not recommend circumcision. Half of the experts were screening siblings of VUR patients. Conclusion : Considering the variations exposed through this study systematic guidelines for management of children with UTI in Korean would be necessary. (J. Korean Soc Pediatr Nephrol 5 : 15-21, 2001)