• Proceedings of the Korean Geotechical Society Conference
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• 2002.10a
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• pp.85-95
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• 2002

A substantial portion of the cost of deep excavations in urban environments is devoted to prevent ground movements and their effects on adjacent buildings and utilites. Prediction of ground movements and assessment of the risk of damage to adjacent structures has become an essential part of the planning, design, and construction of a deep excavation project in the urban environments. This paper presents damage assessment techniques for buildings and utilities adjacent deep excavation, which can be readily used in practice.

• Advances in materials Research
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• v.5 no.1
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• pp.11-20
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• 2016

In bonded composite repair of aircraft structures, the damage of the adhesive can thus reduce significantly the efficiency and the durability of the bonded composite repair. The adhesive damage models using critical zone have proven their effectiveness due to simplicity and ap-plicability of the damage criteria in these models. The scope of this study is to analyze the effects of the patch thickness and the adhesive thickness on the damage damage in bonded composite repair of aircraft structures by using modified damage zone theory. The obtained results show that, when the thickness of adhesive increases the damage zone increases and the adhesive loses its rigidity, inversely when the patch is reduced the adhesive damage be-comes more significant.

• Journal of Ginseng Research
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• v.47 no.1
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• pp.65-73
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• 2023

Background: Age-related macular degeneration (AMD) is a significant visual disease that induces impaired vision and irreversible blindness in the elderly. However, the effects of ginseng berry extract (GBE) on the retina have not been studied. Therefore, this study aimed to investigate the protective effects of GBE on blue light (BL)-induced retinal damage and elucidate its underlying mechanisms in human retinal pigment epithelial cells (ARPE-19 cells) and Balb/c retina. Methods: To investigate the effects and underlying mechanisms of GBE on retinal damage in vitro, we performed cell viability assay, pre-and post-treatment of sample, reactive oxygen species (ROS) assay, quantitative real-time PCR (qRT-PCR), and western immunoblotting using A2E-laden ARPE-19 cells with BL exposure. In addition, Balb/c mice were irradiated with BL to induce retinal degeneration and orally administrated with GBE (50, 100, 200 mg/kg). Using the harvested retina, we performed histological analysis (thickness of retinal layers), qRT-PCR, and western immunoblotting to elucidate the effects and mechanisms of GBE against retinal damage in vivo. Results: GBE significantly inhibited BL-induced cell damage in ARPE-19 cells by activating the SIRT1/PGC-1α pathway, regulating NF-kB translocation, caspase 3 activation, PARP cleavage, expressions of apoptosis-related factors (BAX/BCL-2, LC3-II, and p62), and ROS production. Furthermore, GBE prevented BL-induced retinal degeneration by restoring the thickness of retinal layers and suppressed inflammation and apoptosis via regulation of NF-kB and SIRT1/PGC-1α pathway, cleavage of caspase 3 and PARP, and expressions of apoptosis-related factors in vivo. Conclusions: GBE could be a potential agent to prevent dry AMD and progression to wet AMD.

• Journal of the Korean Institute of Gas
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• v.25 no.4
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• pp.1-9
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• 2021

The process and facilities of modern chemical plants are becoming increasingly complex, there is possibility of potential risk. Internal chemicals generate stress concentration when operated due to turbulence, laminar flow, pressure, temperature, friction, etc. It causes cumulative fatigue damage, which can damage or rupture chemical facilities and devices. The statistics of chemical accidents found that the highest rate of occurrence was in summer, and in the last five years statistics on chemical accidents, leakage incidents make up a decent percentage of accidents. Chemical leaks can cause serious human damage and economic damage, including explosions and environmental pollution. In this study, based on the leak accident of chemical plant, the risk analysis, and damage effects assessment were estimated using a 3D scanner and FLACS. As a result, if chemicals leak in summer, the risk is higher than in other seasons, the seasonal safety management measures, and countermeasure were estimated.

• Proceedings of the Korea Concrete Institute Conference
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• 1993.10a
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• pp.190-194
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• 1993

This paper focuses on the development of the tangent modulus to describe the nonlinearity of concrete based on the continuum damage mechanics. This tangent modulus includes the effects of elasticity, damage and plasticity of concrete.

• Toxicological Research
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• v.13 no.4
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• pp.327-330
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• 1997

Hepatitis, liver cirrhosis and liver cancer caused by viral infection are among the most prevalent causes of death in Korea. Several medicines have been in use despite their nonsatisfactory effects on these disease. Some herbal medicines put to use recently have not shown beneficial effects, either. This paper evaluates the effects of extracts from 10 traditional Korean herbal medicines on rats with hepatic damage induced by galactosamine. Rubus coreanus showed an anti-inflammatory effect as shown on the data of activities of serum transaminases.

• Geomechanics and Engineering
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• v.12 no.2
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• pp.269-294
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• 2017

This study aimed to realize the creation of fuzzy stochastic damage to describe reliability more essentially with the analysis of harmony of damage conception, probability and fuzzy degree of membership in interval [0,1]. Two kinds of fuzzy behaviors of damage development were deduced. Fuzzy stochastic damage models were established based on the fuzzy memberships functional and equivalent normalization theory. Fuzzy stochastic damage finite element method was developed as the approach to reliability simulation. The three-dimensional fuzzy stochastic damage mechanical behaviors of Jianshan mine slope were analyzed and examined based on this approach. The comprehensive results, including the displacement, stress, damage and their stochastic characteristics, indicate consistently that the failure foci of Jianshan mine slope are the slope-cutting areas where, with the maximal failure probability 40%, the hazardous Domino effects will motivate the neighboring rock bodies' sliding activities.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.26 no.5
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• pp.960-968
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• 2002

In this research, the effects of fiber stacking sequence on damage behaviors of FML(Fiber Metal Laminates) subject to indentation loading. SOP (Singly Oriented Ply) FML and angle ply FML were fabricated to study fiber orientation effects and angle ply effects. FML were fabricated by using 1050 aluminum laminate and carbon/epoxy prepreg. To increase adhesive bonding strength, Al laminate was etched using FPL methods. The static indentation test were conducted by using UTM under the 2side clamped conditions. During the tests, load and displacement curve and crack initiation and propagation behaviors were investigated. As fiber orientation angle increases, the crack initiation load of SOP FML increases because the stiffness induced by fiber orientation is increased. The penetration load of SOP FML is influenced by the deformation tendency and boundary conditions. However, the macro-crack of angle ply FML was initiated by fiber breakage of lower ply because angle plies in Angle ply FML prevents the crack growth and consolidation. The Angle ply FML has a critical cross-angle which prevent crack growth and consolidation. Damage behavior of Angle ply FML is changed around the critical cross-angle.

• Transactions of Materials Processing
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• v.19 no.3
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• pp.160-166
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• 2010

In this paper, the process parameters of thread rolling were designed based on the numerical analysis results. Firstly, the effective analysis conditions that guarantee the reliability of the analysis results were found. To find the effective analysis conditions, the analyses were carried out for various numbers of teeth. And then, the effects of the process parameters such as tool shape and temperature on the thread rolling performance were investigated. The formability in thread rolling process was evaluated in terms of Cockcroft-Latham damage value. In order to evaluate formability, Cockcroft-Latham damage value was normalized by the critical damage value which was obtained from the analysis of uniaxial tensile test. The analyses were carried out using DEFORM-3D. The results showed that the flank angle and crest round had an effect on the thread rolling load. It was also shown that temperature had significant effects on the effective strain distribution, rolling load, and damage. With the reduced formability of stainless steel at higher temperature, it was shown that the normalized damage values increased as the process temperature.

• Safety and Health at Work
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• v.4 no.4
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• pp.177-186
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• 2013

The use of nanoparticles (NPs) in industry is increasing, bringing with it a number of adverse health effects on workers. Like other chemical carcinogens, NPs can cause cancer via oxidative DNA damage. Of all the molecules vulnerable to oxidative modification by NPs, DNA has received the greatest attention, and biomarkers of exposure and effect are nearing validation. This review concentrates on studies published between 2000 and 2012 that attempted to detect oxidative DNA damage in humans, laboratory animals, and cell lines. It is important to review these studies to improve the current understanding of the oxidative DNA damage caused by NP exposure in the workplace. In addition to examining studies on oxidative damage, this review briefly describes NPs, giving some examples of their adverse effects, and reviews occupational exposure assessments and approaches to minimizing exposure (e.g., personal protective equipment and engineering controls such as fume hoods). Current recommendations to minimize exposure are largely based on common sense, analogy to ultrafine material toxicity, and general health and safety recommendations.