• Journal of the Korea Convergence Society
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• v.9 no.2
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• pp.331-340
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• 2018

The purpose of this study is to verify resilience's mediation effects in the effects of adolescents' experience of abuse damage on aggressiveness in the convergence era. Towards this end, this study used the 7th year data (2016) (4th grade to the first year of high school) of Korea Children & Youth Panel Survey (KCYPS). The findings of this study are as follows: First, the correlations between experience of abuse damage, aggressiveness, and resilience variables were confirmed using multicollinearity VIF values. Second, adolescent's abuse experiences significantly affected their aggressiveness. Third, the partial mediation effects of resilience were shown in the effects of adolescents' experience of abuse damage on their aggressiveness. For the verification of mediation effects' significance, the Sobel test was carried out. The findings of this study are meaningful, as this study provides empirical data. Based on the findings, this study proposed the need of resilience consolidation programs for adolescents in the practice of social welfare.

• BMB Reports
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• v.43 no.10
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• pp.683-687
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• 2010

Previous studies have shown that one of the primary causes of increased iron content in the brain may be the release of excess iron from intracellular iron storage molecules such as ferritin. Free iron generates ROS that cause oxidative cell damage. Carnosine and related compounds such as endogenous histidine dipetides have antioxidant activities. We have investigated the protective effects of carnosine and homocarnosine against oxidative damage of DNA induced by reaction of ferritin with $H_2O_2$. The results show that carnosine and homocarnosine prevented ferritin/$H_2O_2$-mediated DNA strand breakage. These compounds effectively inhibited ferritin/$H_2O_2$-mediated hydroxyl radical generation and decreased the mutagenicity of DNA induced by the ferritin/$H_2O_2$ reaction. Our results suggest that carnosine and related compounds might have antioxidant effects on DNA under pathophysiological conditions leading to degenerative damage such as neurodegenerative disorders.

• The Journal of Korean Medicine
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• v.21 no.4
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• pp.37-46
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• 2000

Objective : The purpose of this study was to investigate the effects of Angelicae Gigantis Radix on brain damage and the cardiovascular system. Method : By administration Angelicae Gigantis Radix, we compared treated groups with not treated groups, in view of five points as follows $\circled1$ the intervascular eNOS, $\circled2$ the blood pressure of SHR, $\circled3$ the transcription of the Kir6.2, $\circled4$ the survival time of the rats when common carotid artery was ligated, and $\circled5$ antiplatelet aggregation. Result : In this experiment, Angelicae Gigantis Radix treated group showed significant produced in the intervascular eNOS and decreased the blood pressure of SHR, increased the transcription of the Kir6.2 and SUR significantly in all Treated groups, prolonged the survival time of the rats when common carotid artery, showed the effects on antiplatelet aggregation. Conclusion : According to the above results, Angelicae Gigantis Radix can protect the brain damage and have cardiovascular system effect.

• Journal of Korean Society for Atmospheric Environment
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• v.2 no.3
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• pp.19-26
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• 1986

The degree of air pollution is usually presented in terms of concentration. But, in evaluating the environmental impacts or air pollution control policies, the concentration values need to be interpreted in terms of damage effects on property and human health. The damage effect varies with the types of pollution, subjects and land use pattern of an affected area. Therefore, this study is aimed at developing a method of analyzing effects of various types of air pollutions on surrounding environmental setting with the EIMS (Environmental Information Management System) developed for land suitability analysis. Using the method formulated in this study, the long- term effects of such pollutants as $SO_2$ and HF on types of vegetation and residents, and potential, short-term effects of HCl leak accidents from manufacturing facilities in Ulsan and Onsan Industrial complex are analyzed. The presentation of the damage effects of air pollution rather than the concentration of pollutants will be useful for the preparation of environmental impact statements, the formulation of environmental policies, and the development of land use plans in heavily industrialized areas.

• Journal of the Korean Institute of Telematics and Electronics
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• v.15 no.4
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• pp.26-32
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• 1978

For a long life photovoltaic cell the degradation of the device characteristics with 1 MeV electron radiation must be known so as to be able to predict the life of the cell. Hence, a study was made of radiation damage effects on the bulk properties of the silicon crystal. From the results of the data, it is concluded that there appeared to be a steads rotate damage level reached in f type material.

• Journal of Mechanical Science and Technology
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• v.15 no.10
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• pp.1408-1416
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• 2001

It is very important to well understand the dynamic characteristics of damaged structures to successfully develop or to choose a most appropriate structural damage identification method (SDIM) as the means of non-destructive testing. In this pope., the dynamic equation of motion for damaged plates is derived by introducing a damage distribution function, which may characterize the effective state of structural damages. It is found that structural damages may induce the coupling between modal coordinates. The effects of damages on the vibration characteristics of a plate depending on their locations, sizes, and magnitudes are numerically investigated in a systematic way. The numerical investigations are also given to the effects of damage-induced modal coupling on the changes in vibration characteristics and to the minimum number of natural modes required to predict sufficiently accurate vibration characteristics of damaged plates.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2003.11a
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• pp.608-613
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• 2003

In this paper, the variability of modal properties caused by temperature effects is assessed to adjust modal data used for frequency-based damage detection in plate-girder bridges. First, experiments on model plate-girder bridges are described. Next, the relationship between temperature and natural frequencies is assessed and a set of empirical frequency-correction formula are analyzed for the test structure. Finally, a frequency-eased method is used to locate and estimate severity of damage in the test structure using experimental modal data which are adjusted by the frequency-correction formula. Here, local damage in beam-type structures is detected by using measured frequencies and analytical mode shapes.

• Structural Engineering and Mechanics
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• v.5 no.6
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• pp.679-689
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• 1997

The damage of concrete subjected to multiaxial complex loading involves strong anisotropy due to its highly heterogeneous nature and the geometrically anisotropic characteristic of the microcracks. A comprehensive description of concrete damage is proposed by introducing a fourth-order anisotropic damage tenser. The evolution of damage is assumed to be related to the principal components of the current states of stress and damage. The unilateral effect of damage due to the closure and opening of microcracks is taken into account by introducing projection tensors that are also determined by the current state of stress. The proposed damage model considers the different kinds of damage mechanisms that result in different failure modes and different patterns of microdefects that cause different unilateral effects. This damage model is embedded in a thermomechanically consistent constitutive equation in which hardening and the triaxial compression caused shear-enhanced compaction can also be taken into account. The validity of the proposed model is verified by comparing theoretical and experimental results of plain and steel fiber reinforced concrete subjected to complex triaxial stress histories.

• Environmental Analysis Health and Toxicology
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• v.21 no.2 s.53
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• pp.127-138
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• 2006

In urban areas, diesel exhaust particles (DEP) are probably a major component of particulate matters, especially in Korea where drive many diesel vehicles. The aim of this study was to investigate genotoxic effects of DEP using single ceil gel electrophoresis. In order to evaluate the mechanisms of DEP genotoxicity, the rat microsome mediated and DNA repair enzyme treated comet assays together with conventional comet assay were performed. Total diesel particles (DEPT) was collected without site fractionation from diesel engine bus and dichloromethane extract was obtained. The organic extract of DEPT revealed DNA damage itself in NIH/3T3 cells. The level of DNA breaks plus oxidative DNA lesions and microsome mediated DNA damage was assessed by modified single cell gel eletrophoresis. DEPT was able to induce oxidative DNA damage as well as microsome mediated DNA damage. Vitamin C as an model antioxidant reduced DNA damage in endonuclase III treated comet assay. One of flavonoid, galangin as a CYP1A1 inhibitor. reduced DNA damage in the presence of S-9 mixture. $DEP_T$ is the sources of oxidative stress, but antioxidants can significantly reduce oxidative DNA dmage. And $DEP_T$ may contain indirect mutagens which can be inhibited by CYP1A1 inhibitors. The ethanol extracts of the mixed vegetables (BV) or the mixed fruits (BF) were evaluated for their in vitro antigenotoxic effects. BV and BF showed potent Inhibitory effects against DEPT induced DNA damage with oxidative DNA lesions and in the prescence of S-9 mixture. These results indicate that BV and BF could prevent cellular DNA damage by inhibiting oxidative stress and suppressing cytochrome P4501A1 in cell culture.

• Journal of Radiation Protection and Research
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• v.41 no.3
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• pp.206-210
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• 2016

Background: Ionizing radiation causes cellular damage and death through the direct damage and/or indirectly the production of ROS, which induces oxidative stress. This study was designed to evaluate the in vivo radioprotective effects of a bio-active material coated fabric (BMCF) against ${\gamma}$-irradiation-induced cellular damage in Sprague-Dawley (SD) rats. Materials and Methods: Healthy male SD rats wore bio-active material coated (concentrations in 10% and 30%) fabric for 7 days after 3 Gy of ${\gamma}$-irradiation. Radioprotective effects were evaluated by performing various biochemical assays including spleen and thymus index, WBC count, hepatic damage marker enzymes [aspartate transaminase (AST) and alanine transaminase (ALT)] in plasma, liver antioxidant enzymes, and mitochondrial activity in muscle. Results and Discussions: Exposure to ${\gamma}$-irradiation resulted in hepatocellular and immune systemic damage. Gamma-irradiation induced decreases in antioxidant enzymes. However, wearing the BMCF-30% decreased significantly AST and ALT activities in plasma. Furthermore, wearing the BMCF-30% increased SOD (superoxide dismutase) and mitochondrial activity. Conclusion: These results suggest that wearing BMCF offers effective radioprotection against ${\gamma}$-irradiation-induced cellular damage in SD rats.