• 산업경영시스템학회지
• /
• 제24권68호
• /
• pp.51-65
• /
• 2001

This study is to make LCIA(Life Cycle Impact Assessment) easier as a methodology of environmental scores(called E-score) that integrated environmental load of each emission substance based on environmental damage such as in human health, ecosystem and resources category. The concept is to analyzes the LCI(Life Cycle Inventory) and defines the level of environment damages for human health, ecosystem and resources to objective impact assessment standard, and makes the base of marginal damage to calculate the damage factor, which can present the indication that can establish the standard value of environmental impact. First, damages to human health are calculated by fate analysis, effect analysis and damage analysis to get the damage factor of health effect as a DALY(Disability Adjusted Life Years) unit. Second, damages to ecosystem are calculated by fate analysis, effect analysis and damage analysis to get the damage factor of the effect as a PDF(Potentially Disappeared Fraction) unit through linking potentially increased disappeared fraction. Third, damages to resources are carried out by resource analysis and damage analysis for linking the lower fate to surplus energy conception to get damage factor as a MJ(Mega Joule) unit. For the ranking of relative environment load level each other, LCIA can be carried out effectively by applying this E-score methodology to the particular emission substances. A case study has been introduced for the emission substances coming out of a tire manufacturer in Korea. It is to show how to work the methodology. Based on such study result, product-designers or producers now can apply the E-scores presented in this study to the substances of emission list, and then calculate the environment load of the product or process in advance at any time and can see the environment performance comparatively and expected to contribute to the environmental improvement in view of environmental pollution prevention.

• Steel and Composite Structures
• /
• 제22권3호
• /
• pp.589-611
• /
• 2016

The primary objectives of this research are to investigate the energy factor response of steel moment resisting frame (MRF) systems equipped with fuses subject to ground motions and to develop an energy-based evaluation approach for evaluating the damage-control behavior of the system. First, the energy factor of steel MRF systems with fuses below the resilience threshold is derived utilizing the energy balance equation considering bilinear oscillators with significant post-yielding stiffness ratio, and the effect of structural nonlinearity on the energy factor is investigated by conducting a parametric study covering a wide range of parameters. A practical transformation approach is also proposed to associate the energy factor of steel MRF systems with fuses with classic design spectra based on elasto-plastic systems. Then, the energy balance is extended to structural systems, and an energy-based procedure for damage-control evaluation is proposed and a damage-control index is also derived. The approach is then applied to two types of steel MRF systems with fuses to explore the applicability for quantifying the damage-control behavior. The rationality of the proposed approach and the accuracy for identifying the damage-control behavior are demonstrated by nonlinear static analyses and incremental dynamic analyses utilizing prototype structures.

• Structural Engineering and Mechanics
• /
• 제70권1호
• /
• pp.33-41
• /
• 2019

The influence of two parameters on fatigue damage predictions of a variably loaded cantilever beam has been examined. The first parameter is the geometry of the cantilever beam and the weld connecting it to a rear panel. Variables of the geometry examined here include the cantilever length, the weld width on the critical cross-section and the angle of the critical cross-section. The second parameter is the safety factor, as set out by the Eurocode 3 standard. An analytical approach has been used to calculate the stresses at the critical cross-section and standard rainflow counting has been used for the extraction of the load cycles from the load history. The results here suggest that a change in the width and angle of the critical cross-section has a non-linear impact on the fatigue damage. The results also show that the angle of the critical cross-section has the biggest influence on the fatigue damage and can cause the weld to withstand fatigue better. The second parameter, the safety factor, is shown to have a significant effect on the fatigue damage calculation, whereby a slight increase in the endurance safety factor can cause the calculated fatigue damage to increase considerably.

• The Korean Journal of Physiology and Pharmacology
• /
• 제24권5호
• /
• pp.423-431
• /
• 2020

This study aimed to evaluate the effect of curcumin on brain hypoxic-ischemic (HI) damage in neonatal rats and whether the phosphoinositide 3-kinase (PI3K)/Akt/vascular endothelial growth factor (VEGF) signaling pathway is involved. Brain HI damage models were established in neonatal rats, which received the following treatments: curcumin by intraperitoneal injection before injury, insulin-like growth factor 1 (IGF-1) by subcutaneous injection after injury, and VEGF by intracerebroventricular injection after injury. This was followed by neurological evaluation, hemodynamic measurements, histopathological assessment, TUNEL assay, flow cytometry, and western blotting to assess the expression of p-PI3K, PI3K, p-Akt, Akt, and VEGF. Compared with rats that underwent sham operation, rats with brain HI damage showed remarkably increased neurological deficits, reduced right blood flow volume, elevated blood viscosity and haematocrit, and aggravated cell damage and apoptosis; these injuries were significantly improved by curcumin pretreatment. Meanwhile, brain HI damage induced the overexpression of p-PI3K, p-Akt, and VEGF, while curcumin pretreatment inhibited the expression of these proteins. In addition, IGF-1 treatment rescued the curcumin-induced down-regulated expression of p-PI3K, p-Akt, and VEGF, and VEGF overexpression counteracted the inhibitory effect of curcumin on brain HI damage. Overall, pretreatment with curcumin protected against brain HI damage by targeting VEGF via the PI3K/Akt signaling pathway in neonatal rats.

• Computers and Concrete
• /
• 제33권2호
• /
• pp.147-162
• /
• 2024

This study presents a random-aggregate mesoscale model integrating the random distribution of the coarse aggerates and the damage mechanics of the mortar and interfacial transition zone (ITZ). This mesoscale model can generate the random distribution of the coarse aggregates according to the prescribed particle size distribution which enables the automation of the current methodology with different coarse aggregates' distribution. The main innovation of this work is to propose the "correction factor" to eliminate the dimensionally dependent mesh sensitivity of the concrete damaged plasticity (CDP) model. After implementing the correction factor through the user-defined subroutine in the randomly meshed mesoscale model, the predicted fracture resistance is in good agreement with the average experimental results of a series of geometrically similar single-edge-notched beams (SENB) concrete specimens. The simulated cracking pattern is also more realistic than the conventional concrete material models. The proposed random-aggregate mesoscale model hence demonstrates its validity in the application of concrete fracture failure and statistical size effect analysis.

• Earthquakes and Structures
• /
• 제17권2호
• /
• pp.175-189
• /
• 2019

The aim of the study is to show the results of complex shaking table experimental investigation focused on the response of two models of cylindrical steel tanks under mining tremors and moderate earthquakes, including the aspects of diagnosis of structural damage. Firstly, the impact and the sweep-sine tests have been carried out, so as to determine the dynamic properties of models filled with different levels of liquid. Then, the models have been subjected to seismic and paraseismic excitations. Finally, one fully filled structure has been tested after introducing two different types of damages, so as to verify the method of damage diagnosis. The results of the impact and the sweep-sine tests show that filling the models with liquid leads to substantial reduction in natural frequencies, due to gradually increasing overall mass. Moreover, the results of sweep-sine tests clearly indicate that the increase in the liquid level results in significant increase in the damping structural ratio, which is the effect of damping properties of liquid due to its sloshing. The results of seismic and paraseismic tests indicate that filling the tank with liquid leads initially to considerable reduction in values of acceleration (damping effect of liquid sloshing); however, beyond a certain level of water filling, this regularity is inverted and acceleration values increase (effect of increasing total mass of the structure). Moreover, comparison of the responses under mining tremors and moderate earthquakes indicate that the power amplification factor of the mining tremors may be larger than the seismic power amplification factor. Finally, the results of damage diagnosis of fully filled steel tank model indicate that the forms of the Fourier spectra, together with the frequency and power spectral density values, can be directly related to the specific type of structural damage. They show a decrease in the natural frequencies for the model with unscrewed support bolts (global type of damage), while cutting the welds (local type of damage) has resulted in significant increase in values of the power spectral density for higher vibration modes.

• 한국환경보건학회지
• /
• 제23권4호
• /
• pp.9-15
• /
• 1997

This experiment was carried out to examine the roles of selenium in arsenic- and chromium-induced oxidative stress, which results in chromosomal damage, such as sister chromatid exchange (SCE) and chromosomal aberration (CA). For this purpose, the frequency of CA and SCE related to the level of 0xidative stress were analyzed. Selenium decreased the frequency of CA induced by As. In order to evaluate the effect of selenium on clastogenic factors, media from As- and Cr-treated cells were ultrafiltered and added again to cells in the presence or absence of selenium. Selenium decreased the frequency of SCE by As and Cr. This observation indicates the possibility of presence of clastogenic factor. In addition, the clastogenic factor would be involed in oxidative stress since selenium decreased the level of oxidative stress. Thus, it is suggested that selenium may play a role as an anti-clastogenic effector by preventing the oxidative stress, thereby decreasing the frequency of Asand Cr-induced chromosomal damage.

• 한국도로학회논문집
• /
• 제16권6호
• /
• pp.27-37
• /
• 2014

PURPOSES : The purpose of this study is to verify the causes of surface scaling at L-shoulder concrete structure. METHODS : From the literature reviews, mechanisms of frost damage were studied and material properties including strength, air void, spacing factor and scaling resistance of L-shoulder concrete structure were analyzed using core specimens taken by real fields. RESULTS : The spacing factor of air void has relatively high correlation of surface conditions : lower spacing factor at good surfacing condition and vice versa. If the compressive strength is high, even thought spacing factor does not reach the threshold value of reasonable durability, the surface scaling resistance shows higher value. Based on these test results, the compressive strength also provide positive effect on the surface scaling resistance. CONCLUSIONS : The main causes of surface scaling of L-shoulder could be summarized as unsuitable aid void amount and poor quality of air void structure. Secondly, although the compressive strength is not the governing factor of durability, but it shows the positive effect on the surface scaling resistance.

• 한국동물위생학회지
• /
• 제46권2호
• /
• pp.107-113
• /
• 2023

Tenebrio molitor, rich in protein, is used as an alternative protein source. Many studies have evaluated Tenebrio molitor larvae (TML) for anti-obesity effects, fatty liver relief, antithrombosis, and antioxidant effects. In this study, we prepared an experimental diet by adding Tenebrio molitor larvae oil (TMLO) to feed and administered it to adult male ICR mice for six weeks. The study assessed the weight gain of mice, prothrombin time (PT), activated partial thromboplastin time (aPTT), blood coagulation time, and the activities of coagulation factor VII and coagulation factor XII. The weight gain of mice was suppressed in the groups fed with TMLO, indicating a potential anti-obesity effect. The blood coagulation time was delayed in the TMLO-fed groups, as evidenced by amplified PT and aPTT values. Furthermore, the activities of coagulation factor VII and coagulation factor XII were diminished in the TMLO-treated groups, indicating a potential thrombosis relieving effect. The concentrations of thromboxane B2 and serotonin declined in the TMLO-fed groups, signifying potential blood circulation effects. Finally, blood triglyceride and LDL-cholesterol concentrations were reduced in the TMLO-fed groups. In summary, TMLO supplementation may have an inhibitory effect on liver damage and blood clot formation caused by obesity.

• Geomechanics and Engineering
• /
• 제15권5호
• /
• pp.1081-1089
• /
• 2018

The deformation and strength of brittle rocks are significantly influenced by the crack closure behavior. The relationship between the strength and deformation of rocks under uniaxial loading is the foundation for design and assessment of such scenarios. The concept of relative crack closure strain was proposed to describe the influence of the crack closure behavior on the deformation and strength of rocks. Considering the crack compaction effect, a new damage constitutive model was developed based on accumulated AE counts. First, a damage variable based on the accumulated AE counts was introduced, and the damage evolution equations for the four types of brittle rocks were then derived. Second, a compaction coefficient was proposed to describe the compaction degree and a correction factor was proposed to correct the error in the effective elastic modulus instead of the elastic modulus of the rock without new damage. Finally, the compaction coefficient and correction factor were used to modify the damage constitutive model obtained using the Lemaitre strain equivalence hypothesis. The fitted results of the models were then compared with the experimental data. The results showed that the uniaxial compressive strength and effective elastic modulus decrease with an increase in the relative crack closure strain. The values of the damage variables increase exponentially with strains. The modified damage constitutive equation can be used to more accurately describe the compressive deformation (particularly the compaction stage) of the four types of brittle rocks, with a coefficient of determination greater than 0.9.