• Biomolecules & Therapeutics
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• v.24 no.2
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• pp.156-162
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• 2016

Iridoid glycosides (mainly geniposide) and crocetin derivatives (crocins) are the two major active constituents in Gardenia jasminoides Ellis. In the present study, geniposide, crocins, crocin-1 and crocetin were separated from gardenia chromatographically. Then, mice were orally administrated with geniposide (400 mg/kg b.w.), crocins (400 mg/kg b.w.), crocin-1 (400 mg/kg b.w.) and crocetin (140 mg/kg b.w.) once daily for 7 days with $CCl_4$. Hepatoprotective properties were evaluated by biochemical parameters: Administration of geniposide, crocins, crocin-1and crocetin significantly lowered serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) levels in $CCl_4$-treated mice. The reduced glutathione (GSH) levels and antioxidant enzymes (SOD and CAT) activities were also increased by geniposide, crocins, crocin-1 and crocetin. Histopathological examination of livers showed that these components reduced deformability, irregular arrangement and rupture of hepatocyte in $CCl_4$-treated mice. These biochemical results and liver histopathological assessment demonstrated that geniposide, crocetin derivatives and crocetin show comparative beneficial effects on $CCl_4$-induced liver damage via induction of antioxidant defense. Therefore, contents of geniposide and crocetin derivatives should be both considered for hepatoprotective efficacy of Gardenia jasminoides Ellis.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.5
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• pp.549-554
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• 2011

Recently, technical advances have been made in high efficiency gas turbine power plants. In domestic gas turbine facilities, the material properties of the blade and vane are degraded by the daily start-stop operations arising from the thermo mechanical cycle. We surveyed the time dependent degradation of the HP blade and vane to gather basic data for life assessment and damage analysis. The EOH(equivalent operating hours) of the blades were 23,686, 27,909, and 52,859 and the EOH of the vanes were 28,714 and 52,859, respectively. With increased operating hours, the shape of the primary ${\gamma}$' precipitate transformed from cubic to spherical, and its average size also increased. The leading edge area of the blades and the center of the vanes had the worst morphology, and this tendency agrees with the microhardness results. The thickness of the thermally grown oxide at the outer surface of the bond coat increased with increased operating hours.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.5
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• pp.665-671
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• 2013

In a Korean Generation IV prototype sodium-cooled fast reactor (SFR), various types of high-temperature heat exchangers such as IHX (intermediate heat exchanger), DHX (decay heat exchanger), AHX (air heat exchanger), FHX (finned-tube sodium-to-air heat exchanger), and SG (steam generator) are to be designed and installed. In this study, the high-temperature design and integrity evaluation of the sodium-to-air heat exchanger AHX in the STELLA-1 (sodium integral effect test loop for safety simulation and assessment) test loop already installed at KAERI (Korea Atomic Energy Research Institute) and FHX in the SEFLA (sodium thermal-hydraulic experiment loop for finned-tube sodium-to-air heat exchanger) test loop to be installed at KAERI have been performed. Evaluations of creep-fatigue damage based on full 3D finite element analyses were conducted for the two heat exchangers according to the high-temperature design codes, and the integrity of the high-temperature design of the two heat exchangers was confirmed.

• Ocean Systems Engineering
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• v.4 no.2
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• pp.137-150
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• 2014

In the marine industry although there has been significant growth towards safety, security and risk assessments or risk-based strategies such as marine insurance and regulations to avoid the risks of damage to properties and the environment or the prospect of premature death caused by accidents etc, the moves toward managing the risks which are linked directly to the business functions and decision making processes have been very slow. Furthermore in the marine industry most perceptions, methodologies and frameworks of dealing with hazards, risks, safety and security issues are for their assessment rather than their management. This trend reveals the fact that in different marine industry sectors such as logistics and shipping there is a lack of coherent risk management framework or methodology from which to understand the risk-based decisions especially for the purpose of design, construction, operation, management and even decommissioning of the marine related applications. On the other hand risk management is not yet viewed holistically in the marine industry in order to, for example, assign a right person, i.e. risk manager, who can act as a coordinator and advisor with responsibilities that are only specific to risk management. As a result this paper, by examining the present physical borders and risk-based activities in the marine industry, aims to propose an appropriate risk management methodology in addition to the emergent role of risk managers which will enable the industry users initially to become familiar with the concept of risk management at its holistic level. In the later stages this eventually can lead to development of risk management capabilities at an exclusive level and its integration into the marine industry functions in future.

• Nuclear Engineering and Technology
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• v.23 no.3
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• pp.285-298
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• 1991

An example application of the fuzzy set theory is first made to a simple portion of a given accident progression event tree with typical qualitative fuzzy input data, and thereby computational algorithms suitable for application of the fuzzy set theory to the accident progression event tree analysis are identified and illustrated with example applications. Then the procedure used in the simple example is extended to extremely complex accident progression event trees with a number of phenomenological uncertainty issues, i.e., a typical plant damage state‘SEC’of the Zion Nuclear Power Plant risk assessment. The results show that the fuzzy averages of the fuzzy outcomes are very close to the mean values obtained by current methods. The main purpose of this paper is to provide a formal procedure for application of the fuzzy set theory to accident progression event trees with imprecise and qualitative branch probabilities and/or with a number of phenomenological uncertainty issues.

• Korean Journal of Ecology and Environment
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• v.41 no.3
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• pp.331-337
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• 2008

Polycyclic aromatic hydrocarbons (PAHs) derived from leakage of fossil fuels and incomplete combustion of organic materials have been considered as harmful contaminants in environments. This study evaluated the effect of benzo[k]fluoranthene (BkF), one of the PAHs, using the multiple biomarkers and applied the integration model with those biomarker responses. After 10 days of the exposure at the measured concentrations of BkF (6, 25, and 45 ${\mu}g\;L^{-1}$), the changes of the four biomarkers, that is, 7-ethoxyresorufin-O-deethylase (EROD), DNA single-strand breaks (Comet), acetylcholinesterase (AChE) and vitellogenin (VTG) in the common carp (Cyprinus carpio) were observed. The standardized values of four biomarker responses were computed and integrated as star plots, representing Integrated Biomarker Respnse (IBR) values. DNA damage was induced in a dose-dependent manner, and increased significantly compared with that in the control. EROD and VTG levels were significantly elevated at low concentrations of BkF. On the other hand, AChE activities were not altered by BkF. IBR values increased as the exposure concentrations increased. Thus, the metabolic, endocrine and genetic changes of the biomarker responses in the common carp exposed to BkF should be considered in the case of the ecological risk assessment of the BkF in fish and it can be used as a biomonitoring tool in aquatic ecosystems. In addition, star plots can be used as a useful analysis tool in multibiomarker integration approach.

• Journal of Ocean Engineering and Technology
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• v.23 no.1
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• pp.89-95
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• 2009

The purpose of the present study was to evaluate the safety under extreme environmental conditions and the dynamic safety under service environment conditions, of oceanographic buoy mooring systems consisting of a variety of materials, including chain, wire rope, nylon rope, and polypropylene rope. For the static safety assessment of a mooring system, after the calculation of external forces and the division of a mooring system into finite elements, the numerical integral was conducted to yield the elemental static tension until satisfying the geometrical convergence condition. To evaluate the dynamic safety, various processes were considered, including data collection about the anticipated areas for mooring, a determination of the parameters for the interpretation, the interpretation of the dynamic characteristics based on an analytic equation that takes into account the heave motion effect of a buoy hull and a mooring system, and a fatigue analysis of the linear cumulative damage. Based on the analysis results, a supplementary proposal for a wire rope that has a fracture in an actual mooring area was established.

• Journal of Ocean Engineering and Technology
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• v.32 no.4
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• pp.272-278
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• 2018

Recently, the use of hazardous chemicals has been continuously increasing. Therefore, the international trade volume is growing and chemical accidents have increased. Nowadays, the safety awareness of the public has increased. As a result, the management and supervision of hazardous chemicals have been strengthened. However, the port policy of Korea has focused on increasing the volume of cargo through facility development. Thus, the port management of hazardous chemicals has been relatively neglected. For national economic growth and society, the port management of hazardous chemicals should be considered to efficiently ensure safety and economic growth. Therefore, this study assumed scenarios where hazardous materials were moved in a dangerous container, not only on appropriate wharfs but also in ports that were close to a big city. The BTX substances were selected among the toxic chemicals with large import and export volumes, and the risk distance and damage effects were predicted using various risk assessment programs. It is expected that this could be used to improve a port safety management system and could be utilized to determine the safety distance in case of an accident.

• Journal of the Korean Geotechnical Society
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• v.21 no.9
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• pp.35-44
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• 2005

Recently, underground cavities such as limestone cavity and abandoned mine give rise to a lot of damage in SOC facilities. But there are many difficult problems such as delay of the working terms and enormous economic losses in finding a new method and changing construction design. In this study, a new filling material for underground cavities was developed using the stone-dust classified as industry waste polluting environment. As a result of test, filling material properties was that a compressive strength was $34{\~}60\;kgf/cm^2$, a change ratio in length was $0.268{\~}0.776\%$ and water absorption was $34.3{\~}46.9\%$. Also as a result of suspended mass test and pH test, it was confirmed that the developed filling material has a characteristic of non-separating in water and it was an environmentally friendly material.

• Journal of the Korean Institute of Gas
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• v.18 no.2
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• pp.69-72
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• 2014

If LNG is leaked from 9% Ni steel inner tank by damage, LNG is retained by outer concrete tank. Then large tensile stress can be caused at cylindrical bottom of outer tank by temperature difference between outer and inner surface of outer tank. Therefore, in order to reduce the tensile stress is caused by temperature difference, corner-protection is installed with insulation and 9% Ni steel as a second barrier. In this paper, using finite element method, structural analysis was performed for rectangular and circular shape of knuckle and based on the results, fatigue life of welds of corner protection was predicted. As a consequence of structural analysis, safety factor of circular knuckle shows 33% bigger than rectangular one shows, and circular knuckle has 25% bigger fatigue life time than rectangle has. These results can be applied to life time assessment and design optimization in the future.