• Journal of Ginseng Research
• /
• v.28 no.2
• /
• pp.87-93
• /
• 2004

The effect of ginsenoside-Rb2, one of a major pharmacological component of Panax ginseng C.A. Meyer, on low density lipoprotein (LDL) receptor expression was investigated and compared with hypocholesterolemic drug lovastatin. In HepG2 cell, exogenous cholesterol decreased LDL receptor mRNA expression, but ginsenoside-Rb2 recovered this reduction of LDL receptor mRNA up to normal expression level. Lovastatin also increased LDL receptor mRNA expression as similar as ginsenoside-Rb2 did. The reduction of sterol regulatory element binding protein (SREBP) transcription by exogenous cholesterol was also similarly recovered by ginsenoside-Rb2 and lovastatin addition. Compound K, a metabolite of ginsenoside-Rb2 and -Rb1 by human intestinal bacteria also increased the SREBP mRNA expression in cholesterol-enriched condition. Ginsenoside-Rb2 seems to up-regulate LDL receptor mRNA expression through the induction of de novo SREBP transcription. Therefore, increased expression of SREBP mRNA by ginsenoside-Rb2 elevated the LDL receptor mRNA expression in HepG2 cells, and these inductions possibly drop the plasma cholesterol level in hypercholesterolemia patients, in vivo, as likely in case of lovastatin.

• Genomics & Informatics
• /
• v.15 no.1
• /
• pp.2-10
• /
• 2017

Early detection and proper management of kidney rejection are crucial for the long-term health of a transplant recipient. Recipients are normally monitored by serum creatinine measurement and sometimes with graft biopsies. Donor-derived cell-free deoxyribonucleic acid (cfDNA) in the recipient's plasma and/or urine may be a better indicator of acute rejection. We evaluated digital PCR (dPCR) as a system for monitoring graft status using single nucleotide polymorphism (SNP)-based detection of donor DNA in plasma or urine. We compared the detection abilities of the QX200, RainDrop, and QuantStudio 3D dPCR systems. The QX200 was the most accurate and sensitive. Plasma and/or urine samples were isolated from 34 kidney recipients at multiple time points after transplantation, and analyzed by dPCR using the QX200. We found that donor DNA was almost undetectable in plasma DNA samples, whereas a high percentage of donor DNA was measured in urine DNA samples, indicating that urine is a good source of cfDNA for patient monitoring. We found that at least 24% of the highly polymorphic SNPs used to identify individuals could also identify donor cfDNA in transplant patient samples. Our results further showed that autosomal, sex-specific, and mitochondrial SNPs were suitable markers for identifying donor cfDNA. Finally, we found that donor-derived cfDNA measurement by dPCR was not sufficient to predict a patient's clinical condition. Our results indicate that donor-derived cfDNA is not an accurate predictor of kidney status in kidney transplant patients.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.18 no.10
• /
• pp.454-461
• /
• 2017

The purpose of this study is to investigate the types of domestic safety accidents involving children and to verify the difference of safety knowledge according to variables of parents. Subjects include 226 parents who have 3-5 year old infants enrolled in kindergartens and day care centers in I-city, Jeollabuk-do. The study tools are modified and complemented questionnaire for the study purpose referred to the preceding research data and the literature. For the processing of collected data, frequency analysis, descriptive statistics, one-way ANOVA, and the Duncan post-test were utilized using the SPSS program. The results of this study are as follows: First, safety accidents occurred at the majority of homes which have infant children. On average, the occurrence frequency was 1.78 times per six months. The accidents involving infants occurred in the order of drop or slip, crash or impact, stricture or jamming, fall, stab or cut, burn, swallow or inhalation. Second, both parents had an average level of safety knowledge. There was a distinction in the areas of 'fall' and 'first aid' according the mother's age. In addition, stay-at-home mothers had the higher level of safety knowledge compared with working mothers in the areas of 'general safety knowledge' and 'fire'. There was a distinction in the area of 'fire' according to the father's age. Given these findings, safety training programs for parents to improve safety knowledge needs to be developed.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.14 no.6
• /
• pp.2915-2925
• /
• 2013

This study examined the moral judgments and ethical decision-making and analyzed ethical dilemmas experienced in practice by nursing students. The data were collected using self-reported questionnaires and reports from 189 college students in their 2nd ~ 4th grades. Data collection period was from Nov 6th - 20th in 2012. Each grade's P(%) scores were 47.92, 43.74, and 43.75 respectively.. For stage 4 score, each grade's scores were 22.37, 22.98, and 19.74. This result shows that, compared to juniors, senior student's P(%) scores did not drop and stage 4 scores rather decreased, which is in line with the results of previous studies about the effects of ethics education. This finding could be attributed to the regular and voluntary case presentations and discussions required for the senior participants. Regarding ethical decision-making type, the most favored was type 3(35.45%). Among seven categories of the ethical dilemmas facing the students, the most commonly reported was the patient's rights and dignity, followed by practices based on nursing standards, arranging for dying patients. This study raises the need that the curriculum is revised to encourage student's participation in the analysis of ethical issues they confront in the field.

• Korean Journal of Food Science and Technology
• /
• v.36 no.6
• /
• pp.943-951
• /
• 2004

As storing ginger roots under optimum conditions takes high cost, ginger roots are commonly stored in underground tunnels where the maintenance of optimum temperature and humidity is difficult. One of the methods fur long term storage of ginger roots is freezing. The objective of this research was to evaluate effect of storage temperatures and packaging methods on the quality of minced ginger prepared with frozen stored ginger. The minced ginger prepared with frozen stored ginger at $-20^{\circ}C$ was packed in bags, glass bottles and tubes, and then stored at 5 and $-20^{\circ}C$ for quality evaluation at 4 and 15 week-intervals. The changes of surface color, total free sugars, free amino acids and volatile compounds were less in the combined treatment samples than in control during storage, regardless of the storage temperature. The tube packing was the best for maintaining quality of minced ginger during storage among tested packaging methods. Sensory results showed that the minced ginger with the combined treatment and packed in tubes could be stored at 5 and $-20^{\circ}C$ for 12 and 45 weeks, respectively, without a significant drop in palatability.

• The Journal of Engineering Geology
• /
• v.26 no.2
• /
• pp.177-185
• /
• 2016

This work investigates whether stress changes induced by an earthquake can be estimated using the deformation measured by high-resolution borehole strainmeters. We estimate the changes in the orientation and magnitude of the principal compression stresses using borehole strainmeter data recorded before and after the M7.2 El Mayor-Cucapah earthquake on April 4, 2010. Clear differences in the stress orientations and magnitudes are apparent before and after the event. The change in stress orientation appears related to subtle increases of stress in the tectonic maximum principal orientation, which is in agreement with the earthquake focal mechanism solution. The sudden stress drop at the onset of the earthquake was 10⁻³-10⁻² MPa in the principal orientations. The Coulomb stress transfer model, which can estimate stress transfer, predicts a shear stress increase of (0.1-0.6) × 10⁻² MPa at the strainmeter site, which is in line with the measured data (0.3-0.8) × 10⁻² MPa. Overall, our results suggest that borehole strainmeter data reflect the subtle stress changes associated with earthquake occurrence, and that such data can be utilized for earthquake-related research.

• Korean Journal of Plant Resources
• /
• v.20 no.4
• /
• pp.342-347
• /
• 2007

The present study was conducted to examine the effect of prunus mume extract on the Kimchi fermentation. The physicochemical and microbiological properties of Kimchi with the addition of various levels(0, 0.1, 0.3 or 0.5%)of prunus mume extract was measured up to 30 days at $4^{\circ}C$. pH was decreased sharply in control after 2 days . A typical decreasing pattern in pH values was noted in all treatments during the initial 18 days of fermentation followed by a gradual decrease afterwards. Total acidity was decreased by the addition of prunus mume extract. Reducing sugar content was reduced to approximately 70% by day 10-12 in prunus mume extract treatments. Total vitamin C content was reached to maximum on 6 days of fermentation and then decreased in all treatments. Reducing sugar and total vitamin C contents were slightly increased by the addition of prunus mume. Total viable cell number increased to reach peak on day 8 and then slowly decreased during the fermentation. Lactobacillus cell number in control treatment continued to increase to reach peak on day 12, while the numbers in prunus mume treatments reached peak on day 8-12 and then gradually decreased throughout the fermentation. The results of this study indicate that prunus mume extract causes to delay the Kimchi fermentation by slowing down pH drop and inhibiting the Lactobacillus cell growth.

• Journal of Korean Society of Environmental Engineers
• /
• v.32 no.9
• /
• pp.887-893
• /
• 2010

Role of the perforated pipe is to drain the water with equal pressure and velocity through the holes of perforated pipe. The perforated pipe is being used in many processes of water treatment system, however, the design parameter of perforated pipe is not standardized in korea. In this study, we have found the design parameter of perforated pipe in the water treatment system using the Computational Fluid Dynamics (CFD). The uniformity of outflow from the perforated pipe is directly affected according to area ratio (gross area of holes/surface area of the perforated pipe). In other words, the uniformity of outflow is improved as area ratio is smaller. Also, at the same area ratio, the uniformity of outflow is improved as number of holes is increase. Specially, in case of the two holes per length of pipe diameter (2/D) shows the most uniformity of outflow and the best hydraulic with the smaller pressure drop. When the inlet velocity of pipe is about 0.06m/sec, the flux of pipe has decreased as from front to backward. When the inlet velocity is 3 m/s, the flux of pipe has increased as from front to backward.

• Journal of the Korean Home Economics Association
• /
• v.25 no.2
• /
• pp.39-54
• /
• 1987

One's Clothing Satisfaction, has a great influence on his role behavior in a society. Especially, as for the teacher's and the professors whose role is teaching, it can not be too emphaszed. Above all, high school girls and college women are the most likely to be influenced by their teachers' clothing behavior, to whom they pay their respect in every way. From this point of view, this study was aimed at explaining, the correlation between the teachers/professors' clothing behaviors and the learning efficiency. On clothing behaviors assessed 30 items related with the learning efficiency, selected from the instruments of preceding studies, and modified by the factors dealing with modesty, color, and design. The questionnaires were composed of two major categories: those for students and for teachers/progessors. The subjects of this study were included students and teachers/professors of high school and universities in Seoul. The data were analyzed statically by mean, standard Deviation, and F-test. The results of this study were summerized as follows; 1. The clothing behaviors of the teachers/professors influenced on the learning efficiency. Namely teachers' clothing satisfaction is in direct proportion to them teaching efficiency and students' learning efficiency. 2. Among the clothing behavior variables, modesty had a great influence on the learning efficiency, especially as for that of teachers more than professors. 3. The influence of the teachers'/professors' clothing behaviors on the learning efficiency showed no significance between high school girls and college women, but some significance between the grades of collegians. 4. As for the teachers'/professors' clothing behavior, male teachers/professors gave priority to design and female teachers/professors to modesty, color showed no significance between them irrespective of age. 5. As for the clothing behavior variabels, both the teachers/professors and the students showed some significance. In class the teachers/professors highly responded to their own clothing behaviors than the students. 6. According to priority the most favorable clothing colors for male teachers/professors are navy blue, gray, indigo blue, and black, and the most disgusting ones red, mud yellow, violet, pink, and green. The most favorable clothing colors for female teachers/professors are beign, white, pale yellow, and black, and the most disgusting ones red, mud yellow, and yellow and yellow according to priority. It is that teachers/professors should wear modestly and in color harmony to invite the desirable students' will to study. Teachers'/professors' colorful appearance and heavy toilet bring about a drop in the students' will to study.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.20 no.2
• /
• pp.306-316
• /
• 2016

In this paper, an NMOS-diode eFuse OTP (One-Time Programmable) memory cell is proposed using a parasitic junction diode formed between a PW (P-Well), a body of an isolated NMOS (N-channel MOSFET) transistor with the small channel width, and an n+ diffusion, a source node, in a DNW (Deep N-Well) instead of an NMOS transistor with the big channel width as a program select device. Blowing of the proposed cell is done through the parasitic junction formed in the NMOS transistor in the program mode. Sensing failures of '0' data are removed because of removed contact voltage drop of a diode since a NMOS transistor is used instead of the junction diode in the read mode. In addition, a problem of being blown for a non-blown eFuse from a read current through the corresponding eFuse OTP cell is solved by limiting the read current to less than $100{\mu}A$ since a voltage is transferred to BL by using an NMOS transistor with the small channel width in the read mode.