• IMMUNE NETWORK
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• 제6권1호
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• pp.43-51
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• 2006

Background: The DR-$70^{TM}$ immunoassay is a newly developed cancer diagnostic test which quantifies the serum fibrin degradation products (FDP), produced during fibrinolysis, by antibody reaction. The purpose of this study was to evaluate the potential of DR-$70^{TM}$ Immunoassay in screening malignant tumor. Methods: Sample subjects were 4,169 adults, both male and female, who visited the health promotion center of a general hospital from March 2004 to April 2005 and underwent the DR-$70^{TM}$ immunoassay test and other tests for cancer diagnosis. The patient group was defined as 42 adults out of the sample subjects who were newly diagnosed with cancer during the same time period when the DR-$70^{TM}$ immunoassay test was performed. Final confirmation of a malignant tumor was made by pathological analysis. Results: The mean DR-$70^{TM}$ level was $0.83{\pm}0.65{\mu}g/ml$ (range: 0.00 (0.0001)${\sim}7.42{\mu}g/ml)$ in the control group (n=4,127) as opposed to $2.70{\pm}2.33{\mu}g/ml$ (range: $0.12{\sim}9.30{\mu}g/ml)$ in the cancer group (n=42), and statistical significance was established (p<0.0001, Student t-test). When categorized by the type of malignant tumor, all cancer patients with the exception of the subgroups of colon and rectal cancer showed significantly higher mean DR-$70^{TM}$ levels compared with the control group (p<0.0001, Kruscal-Wallis test). The receiver operating characteristic (ROC) curve analysis revealed ${\geq}1.091{\mu}g/ml$ as the best cut-off value. Using this cut-off value, the DR-$70^{TM}$ immunoassay produced a sensitivity of 71.4%, a specificity of 70.1%, a positive predictability of 69.4%, and a negative predictability of 69.2% (1). Conclusion: A significant increase in the mean DR-$70^{TM}$ value was observed in the cancer group (thyroidal, gastric, breast, hepatic and ovarian) com pared with the control group. In particular, the specificity and sensitivity of the DR-$70^{TM}$ immunoassay was relatively high in the subgroups of breast, gastric, and thyroidal cancer patients. There is need for further studies on a large number of malignant tumor patients to see how the DR-$70^{TM}$ level might be changed according to the differentiation grade and postoperative prognosis of the malignant tumor.

• 한국의학물리학회지:의학물리
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• 제19권4호
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• pp.298-304
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• 2008

본 연구에서는 다양한 관전압 사용에 따른 CR, DR 모의병변 흉부 영상을 이용하여 병변 검출 정도를 ROC 평가하였다. 모의 제작된 미세 폐 병변, 초기 침윤성 병변, 작은 혹 모양의 병변은 아크릴 판을 이용하여 인체형 흉부 팬텀과 포개놓고 영상을 획득하였으며 CR과 DR에서 각각 3개의 관전압(70 kV, 90 kV, 120 kV) 조건을 사용하였다. 총 18,000개의 관찰결과를 ROC평가 하였다. CR에서는 모든 병변에 대하여 70 kV로 획득한 영상이 높은 $A_z$값을 나타내었으나 DR에서는 두 개 병변에서만 70 kV로 획득한 영상이 높은 $A_z$값을 나타내었다. 본 연구내용을 바탕으로 검출기 종류와 관심 병변에 따른 최적의 관전압 조건을 사용하기 위하여 실제 환자에서의 임상 연구가 필요할 것으로 사료된다.

• International Journal of Air-Conditioning and Refrigeration
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• 제14권4호
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• pp.147-155
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• 2006

The drag reduction (DR) and heat transfer efficiency reduction (ER) of non-ionic surfactant were investigated as a function of fluid velocity, temperature, and surfactant concentration. An experimental apparatus consisting of two temperature controlled water storage tanks, pumps, test specimen pipe and the piping network, two flow meters, two pressure gauges, a heat exchanger, and data logging system was built. From the experimental results, it was concluded that existing alkyl ammonium surfactant (CTAC Cethyl Trimethyl Ammonium Chloride) had DR of $0.6{\sim}0.8$ at $1,000{\sim}2,000ppm$ concentration with fluid temperature ranging between $50{\sim}60^{\circ}C$. However, the DR was very low when the fluid temperature was $70{\sim}80^{\circ}C$. The new amine oxide and betaine surfactant(SAOB Stearyl Amine Oxide + Betaine) had lower DR at fluid temperatures ranging between $50{\sim}60^{\circ}C$ compared with CTAC. However, with fluid temperature ranging between $70{\sim}80^{\circ}C$ the DR was $0.6{\sim}0.8$ when the concentration level was $1,000{\sim}2,000ppm$.

• 설비공학논문집
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• 제19권2호
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• pp.133-141
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• 2007

The drag reduction (DR) and heat transfer efficiency reduction (HTER) of nonionic surfactant according to the fluid velocity, temperature and surfactant concentration were investigated experimentally. For this study, several kinds of new surfactant which contains amine-oxide and betaine were developed. And experimental apparatus equipped with two water storage tanks temperature controlled, pumps, testing pipe network, two flowmeters, two pressure gauges, heat exchanger, and data logging system was built. Results showed that existing alkyl ammonium surfactant (CTAC) had DR of $0.6{\sim}0.8$ for $1,000{\sim}2,000\;ppm$ in fluid temperature of $50{\sim}60^{\circ}C$ and had very low DR in fluid temperature over $70^{\circ}C$. And new amino oxide and betaine surfactant (SAOB) had lower DR in fluid temperature of $50{\sim}60^{\circ}C$ compared with CTAC but in fluid temperature of $70{\sim}80^{\circ}C$ DR was $0.6{\sim}0.8$ for 1$1,000{\sim}2,000\;ppm$.

• Journal of Preventive Medicine and Public Health
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• 제53권2호
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• pp.70-70
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• 2020

• 한국방사선학회논문지
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• 제8권7호
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• pp.417-422
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• 2014

본 연구에서는 방사선의 투사에너지에 따라 달라지는 산란선의 영향정도를 객관적이고 정량적인 방법인 PSNR로 평가할 수 있는 새로운 방법은 제시하고자 하였다. Target을 CR로 두었을 때와 Target을 DR로 두었을 때의 MSE와 PSNR의 값에는 변화가 없었으며, 관전압에 따란 MSE와 PSNR값에 변화가 나타났다. CR과 DR 모두 관전압 변화에 따라서 MSE와 PSNR의 변화가 있는 것으로 보아 Computon 산란선 영향이 있는 것으로 나타났다. CR과 DR의 경우 80 kVp영역에서 MSE와 PSNR의 변화가 급격하게 일어나는 현상이 발생하는 것은 광전효과에 의한 광전자와 Computon 산란에 의한 Computon 전자, 그리고 Computon 산란선이 동시에 검출기에 영향을 미친 것으로 나타났다. 향후 CR과 DR장치의 영상에서 광전효과의 에너지 대역인 60 kVp를 기준으로 하여 70 kVp, 80 kVp, 90 kVp, 100 kVp의 MSE와 PSNR 의 값을 비교하여 관전압의 변화에 따라 CR과 DR의 장치의 산란선과 화질저하에 대한 연구가 이루어지길 제안한다.

• Toxicological Research
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• 제24권4호
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• pp.245-251
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• 2008

Dietary restriction (DR) is the most efficacious intervention for retarding the deleterious effects of aging. DR increases longevity, decreases the occurrence and severity of age-related diseases, and retards the physiological decline associated with aging. The beneficial effects of DR have been mostly studied in non-neuronal tissues. However, several studies have showed that DR attenuate neuronal loss after several different insults including exposure to kainate, ischemia, and MPTP. Moreover, administration of the non-metabolizable glucose analog 2-deoxy-D-glucose (2DG) could mimic the neuroprotective effect of DR in rodent, presumably by limiting glucose availability at the cellular level. Based on the studies of chemically induced DR, it has been proposed that the mechanism whereby DR and 2DG protect neurons is largely mediated by stress response proteins such as HSP70 and GRP78 which are increased in neurons of rats and mice fed a DR regimen. In addition, DR, as mild metabolic stress, could lead to the increased activity in neuronal circuits and thus induce expression of neurotrophic factors. Interestingly, such increased neuronal activities also enhance neurogenesis in the brains of adult rodents. In this review, we focus on what is known regarding molecular mechanisms of the protective role of DR in neurodegenerative diseases and aging process. Also, we propose that DR is a mild cellular stress that stimulates production of neurotrophic factors, which are major regulators of neuronal survival, as well as neurogenesis in adult brain.

• 한국수산과학회지
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• 제40권4호
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• pp.187-192
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• 2007

To prepare oligouronic acids from high-molecular-weight alginates prepared from sea tangle (Laminaria japonica), the alginates were hydrolyzed at various temperatures for 1 hr at pH 5.0. The effects of hydrolysis temperature $(H_{Temp})$ on the average molecular weight (AMW) and distribution ratio of MW (DR) in the hydrolyzed alginates were investigated. As $(H_{Temp})$ increased, the AMW of the alginates decreased exponentially; in addition the DR of the alginates with MW>500 kDa decreased exponentially, while the DR of those with MW=50-100 and MW<50 kDa increased exponentially. For the alginates with MW=300-500 and MW=100-300 kDa the DR increased exponentially until $H_{Temp}$ reached $80^{\circ}C$, and then decreased exponentially at above $80^{\circ}C$. AS $H_{Temp}$ increased, the MW cutoff size and AMW Of the alginates fraction With the highest DR both decreased. For $H_{Temp}<60^{\circ}C$, the MW cutoff size with the highest DR was MW>500 kDa; the DR was 39-67% and the AMW 1,000-1,300 kDa. For $H_{Temp}$ $80^{\circ}C$, the MW cutoff size with the highest DR was MW=300-500 kDa and the DR was about 33% and the AMW about 400 kDa. For $H_{Temp}\;100-121^{\circ}C$, the MW cutoff size with the highest DRs was MW=50-100 kDa, with a DR of 39-44% and an AMW of 70-80 kDa.

• 한국응용과학기술학회지
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• 제36권3호
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• pp.1028-1040
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• 2019

본 연구는 내리막 달리기(downhill running, DR) 후 초음파 영상분석을 이용해 대퇴사두근 무리(quadriceps group, QG) 내 근손상의 국소화 여부를 검증하고, DR 동안 운동 강도가 운동유발성 근손상(exercise-induced muscle damage, EIMD) 및 근육 반향세기 변화에 미치는 영향을 규명하려는 목적으로 수행되었다. 규칙적인 신체활동이 없는 건강한 남성 11명이 무작위 교차설계에 따라 서로 다른 강도[low-intensity DR session($50%HR_{max}$), LDR; high-intensity DR session($70%HR_{max}$), HDR]의 DR 운동을 수행하였다. DR 후 EIMD의 심각성은 혈청크레아틴 키나아제(creatine kinase, CK) 활성 수준 변화와 함께 신경근 기능 지수로서 무릎 신전근의 최대 수의적 등척성 수축(maximal voluntary isometric contraction, MVIC) 및 관절가동범위(range of motion, ROM) 변화를 통해 결정되었다. 회색조 분석을 적용한 근육 반향세기 평가는 DR에 따른 QG 내 국소 근육별(rectus femoris, RF; vastus lateralis, VL; vastus medialis, VM; vastus intermedius, VI) 손상 양상을 탐지하기 위해 활용되었다. 모든 세션에서 혈청 CK 활성 수준과 VL 및 VM의 근통증 정도는 운동 후 24시간째(RF의 경우 각각 LDR 24시간째와 HDR 48시간째) 최대에 이르렀으며, 혈청 CK 수준에서 운동 강도에 따른 유의한 차이(p<.05)가 나타난 반면 근통증에서 세션 간 통계적 차이는 없었다. 무릎 관절을 이용한 MVIC 및 ROM과 같은 신경근 기능 지표 및 VM을 제외한 모든 QG 근육 반향세기는 운동 직후 극적으로 감소 또는 증가 후 72시간까지 점진적 회복 양상을 나타내었다. 그러나 신경근 기능 지표에서 운동 강도에 따른 통계적 차이는 없었으나 RF 및 VL 반향세기에서 세션 내 및 세션 간 유의한 차이(p<.01)를 나타내었다. 본 연구의 결과로 ECC를 함유한 DR 운동 시 운동 강도는 DOMS 및 신경근 기능 지표에 부분적으로 영향을 미칠 가능성이 있으며, 특히 혈청 CK 수준과 함께 RF 및 VL의 근육 반향세기는 운동 강도의 영향을 직접적으로 반영한다는 사실을 알 수 있다. 또한, 현재 연구결과는 DR 동안 ECC를 겪는 QG 내 국소 근육 간 근손상 정도가 다를 수 있으며 초음파 근육 반향세기가 국소 근육의 EIMD 심각성을 차별화할 수 있는 유용한 평가기법임을 뒷받침하고 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9871-9873
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• 2014

Brain tumors are a mixed group of neoplasms that originate from the intracranial tissues and the meninges with degrees of malignancy varying greatly from benign to aggressive. Not much is known about the epidemiology of primary malignant brain tumors (PMBTs) in our population in North-East India. In this analysis, an attempt was made to identify the age groups, gender distribution, topography and different histological types of PMBT with data from a hospital cancer registry. A total of 231 cases of PMBT were identified and included for the present analysis. Our analysis has shown that most of PMBT occur at 20-60 years of age, with a male to female ratio of 2.3:1. Some 70.5% of cases occurred in cerebral lobes except for the occipital lobe, and astrocytic tumors were the most common broad histological type. In our population the prevalence of PMBT is 1% of all cancers, mostly affecting young and middle aged patients. As brain tumors are rare, so case-control analytic epidemiological studies will be required to establish the risk factors prevalent in our population.