• Herbal Formula Science
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• v.23 no.1
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• pp.101-110
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• 2015

Objectives : The purpose of this study was to investigate the anti-cancer effects of Oldenlandia diffusa extract on WiDr human colorectal adenocarcinoma cells. Methods : We examined cell death by (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) MTT assay and the caspase 3 and 9 activity assay with Oldenlandia diffusa extract. To examine the inhibitory effects of Oldenlandia diffusa extract, we performed a cell cycle (sub-G1) analysis and mitochondrial membrane potential for the WiDr cells after 24 hours with Oldenlandia diffusa extract. Results : 1. Oldenlandia diffusa extract induced cell death in WiDr cells. 2. The sub-G1 peak was increased by Oldenlandia diffusa extract in WiDr cells. 3. Oldenlandia diffusa extract leads to increase the mitochondrial membrane depolarization in WiDr cells. 4. Oldenlandia diffusa extract increases caspase 3 and 9 activities in WiDr cells. 5. Oldenlandia diffusa extract combined with several anti-cancer drugs (paclitaxel, 5-fluorouracil, cisplatin, ectoposide, doxorubicin and docetaxel) markedly inhibited the growth of WiDr cells compared to Oldenlandia diffusa extract and anti-cancer drugs alone. Conclusions : Oldenlandia diffusa extract has an apoptotic role in human colorectal cancer cells and a potential role in developing therapeutic agents against colorectal cancer.

• Convergence Security Journal
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• v.8 no.4
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• pp.97-104
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• 2008

Recently, the wireless positioning techniques and mobile computing techniques have rapidly developed to use location data of moving objects. The more the number of moving objects is numerous and the more periodical sampling of locations is frequent, the more location data of moving objects become very large. Hence the system should be able to efficiently manage mass location data, support various spatio-temporal queries for LBS, and solve the uncertainty problem of moving objects. Therefore, in this paper, innovating the location data of moving object effectively, we propose Rend 3DR-tree method to decrease the dead space and complement the overlapping of nodes by utilizing 3DR-tree with the indexing structure to support indexing of current data and history data.

• Journal of Pharmacopuncture
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• v.16 no.3
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• pp.7-10
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• 2013

Objectives: This study aimed to evaluate the evidence available in the literature for the safety and efficacy of Dioscoreae Rhizoma (DR) for the treatment of peripheral neuropathy. Methods: Literature searches were performed in MEDLINE and three Korean medical databases up to April 2013. All studies evaluating the effects on peripheral neuropathy or the safety of DR monopreparations were considered. Results: Three studies - DR extract per os (po) on diabetic neuropathy in mice, DR extract injection on the peripheral sciatic nerve after crush injury in rats and DR extract injection to patients with peripheral facial paralysis proved that DR treatments were effective for the treatment of nerve injuries. Conclusions: In conclusion, we found the DR has a strong positive potential for the treatment of peripheral neuropathy, but studies addressing direct factors related to the nerve still remain insufficient.

• Journal of Acupuncture Research
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• v.30 no.1
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• pp.43-55
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• 2013

I investigated whether snake venom toxin(SVT) from Vipera lebetina turanica enhances the apoptosis ability of tumor necrosis factor(TNF)-related apoptosis-inducing ligand(TRAIL) in cancer cells. TRAIL inhibited HCT116 cell growth in a dose-dependent manner. Consistent with cell growth inhibition, the expression of TRAIL receptors; DR4 and DR5 was significantly increased as well as apoptosis related proteins such as cleaved caspase-3, 8, 9 and Bax. However, the expression of survival proteins(eg, cFLIP, survivin, XIAP and Bcl2) was suppressed by the combination treatment of SVT and TRAIL. Pretreatment with the reactive oxygen species(ROS) scavenger N-acetylcysteine reduced the SVT and TRAIL-induced upregulation of DR4 and DR5 expression and expression of the apoptosis related protein such as caspase-3 and-9 as well as cell growth inhibitory effects. The collective results suggest that SVT facilitates TRAIL-induced apoptosis in human colorectal cancer HCT116 cells through up-regulation of the TRAIL receptors; DR4 and DR5 via ROS pathway signals.

• Bulletin of the Korean Chemical Society
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• v.30 no.8
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• pp.1711-1714
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• 2009

We have described an efficient synthesis of quino[2,3-b][1,5]benzoxazepine α-aminophosphonate derivatives by the nucleophilic addition of triethyl phosphite to substituted quino[2,3-b][1,5]benzoxazepines promoted by easily available, inexpensive and mild catalyst KAl(S$O_4)_2{\cdot}12H_2$O(alum). The reactions proceed smoothly at room temperature under solvent-free reaction conditions and providing high yield of product in very short reaction time.

• Proceedings of the Korea Information Processing Society Conference
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• 2001.10b
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• pp.1179-1182
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• 2001

본 논문에서는 차량합법시스템에서 위치정확도 향상을 위한 방법으로 GPS/DR 통합시스템을 사용하여 DLM(Dynamic Linear Model) 알고리즘을 적용한 개선된 통합필터를 제안하였다. GPS/DR 통합 시스템의 성능을 개선하기 위해서는 DR 센서의 오류요소를 정확히 모델링 하여야 한다. GPS 로부터 위치를 계산하기 위해서는 적어도 3개 이상의 가시위성이 필요하다. 그러나 도심지에서는 고층빌딩이나 가로수 등에 의한 장애물로 인해서 3개 이상의 가시위성을 확보하기가 힘든 경우가 많다. 본 논문에서는 가시위성의 확보가 힘든 고층 빌딩이나 가로수길 등에서도 우수한 성능을 보이는 GPS 의사거리 및 의사거리율 정보를 이용하는 CPS/DR 통합 DLM 필터를 이용하여 성능을 개선시키는 방법을 제시한다.

• Bulletin of the Korean Chemical Society
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• v.30 no.5
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• pp.1057-1060
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• 2009

Boric acid ($BO_3H_3$) is an inexpensive, efficient and mild catalyst for the synthesis of 2,4,5-triaryl-1H-imidazoles in excellent yields from the one-pot three-component condensation of benzil/benzoin, an aldehydes and ammonium acetate in aqueous media under ultrasound at room temperature. The remarkable advantages offered by this method are green catalyst, mild reaction conditions, simple procedures, much faster reactions and excellent yield of products.

• Bulletin of the Korean Chemical Society
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• v.31 no.7
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• pp.1859-1862
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• 2010

A convenient one-pot condensation route has been developed for obtaining 5-[(2-(piperidin-1-yl) quinolin-3-yl) methylene]-2,4-thiazolidinediones using multicomponents, 2-chloro-3-formyl quinolines, piperidine, 2,4-thiazolidinedione and safer medium/mediator, polyethylene glycol-400.

• Bulletin of the Korean Chemical Society
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• v.30 no.11
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• pp.2812-2814
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• 2009

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.50 no.2
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• pp.72-79
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• 2001

In the GPS/DR integrated system, the GPS position(or velocity) is used to compensate the DR output and to calibrate errors of the DR sensor. This synergistic relationship ensures that the calibrated DR accuracy can be maintained even when the GPS signal is blocked. Because of the observability problem, however, the DR sensors are not sufficiently calibrated when the vehicle speed is low. This problem can be solved if we use a multi-antenna GPS receiver for attitude determination instead of conventional one. This paper designs a two-antenna GP receiver integrated with DR sensors. The proposed integration system has three remarkable features. First, the DR sensor can be calibrated regardless of the vehicle speed with the aid of two-antenna GPS receiver. Secondly, the search space of integer ambiguities in GPS carrier-phase measurements is reduced to a part of the surface of the sphere using DR heading. Thirdly, the detection resolution of cycle-slips in GPS carrier-phase measurements is improved with the aid of DR heading. From the experimental result, it is shown that the search space is drastically reduced to about 3/20 of the non-aided case and the cycle-slips of 1 or half cycle can be detected.