• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.2
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• pp.376-380
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• 2004

The purpose of this study is the develop a questionnaire for measuring Yin-Deficiency and examine the reliability and validity for its' value as a barometer for evaluating Yin-Deficiency. Questionnaire was developed according to the symptoms of Yin-Deficiency suggested in the 'Standardization of diagnostic terms and requirements of Korean Medicine', With and as a reference, each symptom has been worked on to be put on the questionnaire. Visual analogue scales(VAS) was used as a barometer for measuring frequency of manifestation of symptoms. A study was performed to measure validity and reliability of the final questionnaire for analysis. reliability of YinDQ was measured by Cronbach's alpha coefficient and test-retest method. This study utilized factor analysis and clinical validity for evaluation of validity. For the purpose of decreasing the amount of data-the number of factors, and at the same time minimize the loss of information factor analysis was performed Component factors were extracted using Principal Component Analysis. This study evaluated the clinical validity for examination of difference between the normal group and the patient group. Evaluation on the's internal consistency showed strong internal consistency with value of 0.8615. reliability from test-rest with three-week interval, followed by comparisons of the correlation coefficient and mean values of each item between the two. The Spearman correlation coefficient was 0.54-0.79. By factor analyse two factors with Eigen value of greater than 2.2 were selected. Factor 1 consists of items of 'irritable fever on the five Hearts', 'flushing of the zygomatic region in the afternoon', 'tidal fever', 'night sweats', and 'dryness on the mouth or the throat'. Factor two consists of items of 'emaciation', 'dizziness', 'insomnia', 'decreased amount of urine with yellowish color', and 'constipation'. The comparison between the patient group and the normal group showed significant differences for every ten questions. The results implies that YinDQ is a barometer with sufficient reliability and validity. The questionnaire for Yin-Deficiency may not be enough to replace the specific differential diagnosis by a doctor of Oriental medicine. Nevertheless, it can be effectively utilized as an assisting method in consultation or a method of measuring the degree of Yin-Deficiency in a group.

• Journal of Applied Biological Chemistry
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• v.53 no.4
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• pp.225-231
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• 2010

To understand the inhibitory activity with changing hydroxyl substituents ($R_l-R_9$) of polyhydroxy substituted 2-phenyl-l,4-benzopyrone analogues (1-25) against tyrosinase (PDB ID: oxy-form; 1WX2), molecular docking and the three dimensional quantitative structure-activity relationships (3D-QSARs: Comparative molecular field analysis (CoMFA) & Comparative molecular similarity indices analysis (CoMSIA)) were studied quantitatively. The statistically best models were CoMFA 1 and CoMSIA 1 model from the results. The optimized CoMSIA 1 model with the sensitivity of the perturbation and the prediction produced ($dq^2'/dr_{yy'}^2$=1.009 & $q^2$=0.51l) by a progressive scrambling analysis were not dependent on chance correlation. The inhibitory activities with optimized CoMSIA 1 model were dependent upon electrostatic factor (51.4%) of substrate molecules. Contour mapping the 3D-QSAR models to the active site of tyrosinase provides new insight into the interaction between tyrosinase as receptor and 2-phenyl-l,4-benzopyrone analogues as inhibitor. Therefore, the results will he able to apply to the optimization of a new potent tyrosinase inhibitors.

• Journal of the Korean Institute of Intelligent Systems
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• v.22 no.3
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• pp.361-366
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• 2012

This paper presents speed control of an electric motorcycle using a fuzzy controller. The electric motorcycle required to meet not only fast throttle response but also stability, when it is on a cruise. However, a 1.5KW (50cc) electric motorcycles selling in the current market are difficult to cruise under the following conditions which are occupant's weight, load weight, wind resistance and road conditions (dirt roads, asphalt road). Because of these reasons, the rapid speed changing occurs in uphill and downhill road. To solve these problems, The input value for Improved fuzzy controller use the speed error and error variance. The output value for improved fuzzy controller uses Q-axis of the motor controlled variable. The D-axis of the motor output for improved fuzzy control uses D-axis controlled variable in proportional to Q-axis controlled variable. Improved fuzzy controller drives the electric motorcycle equipped with IPMSM. The control subject used in this paper is a 1.5KW electric motorcycle equipped with improved fuzzy controller that was used to control the motor speed. To control IPMSM Type of motor torque, D, Q-axis current controller was used. The Fuzzy controller using the proposed algorithm is demonstrated by experimental hardware simulator.

• Radiation Oncology Journal
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• v.4 no.2
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• pp.89-97
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• 1986

Using as assay for jejunal crypt stem cell survival, dose-response curves for the reproductive capacity of crypt stem cells of mouse jejunum exposed to multifractionated gamma-ray irradiation (single, 2, 3, 4, 5, 8, 10, 12, and 16 fractions) were analyzed and single-dose survival curve of these cells was constructed. The following conclusion were drawn: 1) Survival curves for higher numbers of dose fractions were displaced to higher dose, and characterized by increasingly shallower slopes. 2) The single-dose survival curve had broad shoulder, Dq=460 cGy, remaining near-exponential over initial dose range 0 to 300 cGy, with initial slope 1Do=474 cGy. 3) At fractionated dose En the range of 180 to 450 cGy, the average recovered dose per fraction interval was approximately $50\%$ of the dose per fraction. 4) The value of $\alpha/\beta$ ratio by using of linear regression analysis for the reciprocal dose plots was 8.3 Gy which lied in the range of 6-14 Gy for early-reacting tissues. 5) The linear-quadratic model for dose-response formula offers valid approximations for at 1 doses to be used in radiotherapy, only two parameters to be determined, and considerable convenience in practical applications.

• IMMUNE NETWORK
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• v.23 no.2
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• pp.17.1-17.16
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• 2023

Latent membrane protein 2A (LMP2A), a latent Ag commonly expressed in Epstein-Barr virus (EBV)-infected host cells, is a target for adoptive T cell therapy in EBV-associated malignancies. To define whether individual human leukocyte antigen (HLA) allotypes are used preferentially in EBV-specific T lymphocyte responses, LMP2A-specific CD8⁺ and CD4⁺ T cell responses in 50 healthy donors were analyzed by ELISPOT assay using artificial Ag-presenting cells expressing a single allotype. CD8⁺ T cell responses were significantly higher than CD4⁺ T cell responses. CD8⁺ T cell responses were ranked from highest to lowest in the order HLA-A, HLA-B, and HLA-C loci, and CD4⁺ T cell responses were ranked in the order HLA-DR, HLA-DP, and HLA-DQ loci. Among the 32 HLA class I and 56 HLA class II allotypes, 6 HLA-A, 7 HLA-B, 5 HLA-C, 10 HLA-DR, 2 HLA-DQ, and 2 HLA-DP allotypes showed T cell responses higher than 50 spot-forming cells (SFCs)/5×105 CD8⁺ or CD4⁺ T cells. Twenty-nine donors (58%) showed a high T cell response to at least one allotype of HLA class I or class II, and 4 donors (8%) had a high response to both HLA class I and class II allotypes. Interestingly, we observed an inverse correlation between the proportion of LMP2A-specific T cell responses and the frequency of HLA class I and II allotypes. These data demonstrate the allele dominance of LMP2A-specific T cell responses among HLA allotypes and their intra-individual dominance in response to only a few allotypes in an individual, which may provide useful information for genetic, pathogenic, and immunotherapeutic approaches to EBV-associated diseases.

• Animal Bioscience
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• v.37 no.2
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• pp.193-202
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• 2024

Objective: Oxidative stress (OS) is a pathological process arising from the excessive production of free radicals in the body. It has the potential to alter animal gene expression and cause damage to the jejunum. However, there have been few reports of changes in the expression of long noncoding RNAs (lncRNAs) in the jejunum in piglets under OS. The purpose of this research was to examine how lncRNAs in piglet jejunum change under OS. Methods: The abdominal cavities of piglets were injected with diquat (DQ) to produce OS. Raw reads were downloaded from the SRA database. RNA-seq was utilized to study the expression of lncRNAs in piglets under OS. Additionally, six randomly selected lncRNAs were verified using quantitative real-time polymerase chain reaction (qRT-PCR) to examine the mechanism of oxidative damage. Results: A total of 79 lncRNAs were differentially expressed (DE) in the treatment group compared to the negative control group. The target genes of DE lncRNAs were enriched in gene ontology (GO) terms and Kyoto encyclopedia of genes and genomes (KEGG) signaling pathways. Chemical carcinogenesis-reactive oxygen species, the Foxo signaling pathway, colorectal cancer, and the AMPK signaling pathway were all linked to OS. Conclusion: Our results demonstrated that DQ-induced OS causes differential expression of lncRNAs, laying the groundwork for future research into the processes involved in the jejunum's response to OS.

• Journal of Power Electronics
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• v.14 no.1
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• pp.82-91
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• 2014

This paper proposes a compensation algorithm for the analog rotor position errors caused by nonideal sinusoidal encoder output signals including offset and gain errors. In order to achieve a much higher resolution, position sensors such as resolvers or incremental encoders can be replaced by sinusoidal encoders. In practice, however, the periodic ripples related to the analog rotor position are generated by the offset and gain errors between the sine and cosine output signals of sinusoidal encoders. In this paper, the effects of offset and gain errors are easily analyzed by applying the concept of a rotating coordinate system based on the dq transformation method. The synchronous d-axis signal component is used directly to detect the amplitude of the offset and gain errors for the proposed compensator. As a result, the offset and gain errors can be well corrected by three integrators located on the synchronous d-axis component. In addition, the proposed algorithm does not require any additional hardware and can be easily implemented by a simple integral operation. The effectiveness of the proposed algorithm is verified through several experimental results.

• Journal of Electrical Engineering and Technology
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• v.12 no.1
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• pp.236-248
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• 2017

A direct stator flux vector control scheme in discrete-time domain is proposed in this paper for the interior permanent magnet synchronous motor (IPMSM) drive to remove the proportional-integral (PI) controller from the direct torque control (DTC) scheme applied to IPMSM and to obtain faster dynamic response and lower torque ripple output. The output of speed outer loop is used as the desired torque angle instead of the desired torque in the proposed scheme. The desired stator flux vector in dq coordinate is calculated with a given amplitude. The state-space equations in discrete-time for IPMSM are established, the actual stator flux vector is estimated in deadbeat manner by a full-order state observer, and then the closed-loop control is achieved by the pole placement. The stator flux error vector is utilized to calculate the reference stator voltage vector. Extracting the angle position and amplitude from the estimated stator flux vector and estimating the output torque are eliminated for the direct feedback control of the stator flux vector. The proposed scheme is comparatively investigated with a PI-SVM DTC scheme by experiment results. Experimental results show the feasibility and advantages of the proposed control scheme.

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.55 no.6
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• pp.325-336
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• 2006

This paper deals with the dynamic analysis of variable speed wind power systems with doubly-fed induction generators (DFIG). First, the mathematical modeling of wind farm which consists of turbine rotor, DFIG, rotor side and grid side converter and control systems is presented. In particular, the equation for dynamic modeling of the DFIG and the AC/DC/AC converter is expressed as dq reference frame. And then, on the basis of mathematical modeling for each component of wind farm, dynamic simulation algorithms for speed and pitch angle control of wind turbine and generated active and reactive power control of the DFIG and the AC/DC/AC converter are established. Finally, Using the MATLAB/SIMULINK, this paper presents dynamic simulation model for 6MW wind power generation systems with the DFIG considering distribution systems and performs the dynamic analysis of wind power systems in steady state. Moreover, this paper also presents the dynamic performance for the case when the voltage sag in grid source and phase fault in bus are occurred.

• Korean Journal of Optics and Photonics
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• v.4 no.2
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• pp.220-225
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• 1993

This is the first reported observation of absorption and emission of glasses with a 4d transition metal ion(rhodium). The optical absorption and photoluminescence spectra, and the lifetimes of rhodium ions in phosphate glasses are interpreted on the basis of strong-field scheme of Sugano-Tanabe diagram. We conclude that rhodium ion is present in its divalent form. $^2 E{\rightarrow}^2 T_1$ and $^2 E{\rightarrow}^2 T_2$ transitions are superimposed and observed at 460 nm. Whereas $^2 T_1{\rightarrow}^2 E$ and $^2 T_1{\rightarrow}^2 E$ transitions are observed at 650 nm and 580 nm, respectively.