• 한국산학기술학회논문지
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• 제21권7호
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• pp.255-261
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• 2020

본 실험은 국내와 유럽에서 비육돈 생산 시 종료웅돈으로 이용되는 품종과 이를 활용한 교잡돈의 성장, 체형형질 및 도체 부분육 생산량을 알아보기 위해 수행하였다. 본 실험을 위해 산육형질 분석은 D(Duroc) 147두, DPP(Duroc×Pietrain×Pietrain) 101두, 도체 부분육 생산량 분석은 D, DPP 각각 16두를 사용하였다. 실험결과 등지방두께는 DPP는 12.69±3.25 mm, D는 14.07±0.24 mm로 높은 유의적 차이를 보였고, 일일사료섭취량은 DPP는 1,909 g, D는 2,101 g으로 조사되었다(p<0.001). 체고, 흉심, 흉폭은 D가 DPP에 비해 높은 유의적 차이를 보였지만(p<0.001), 체장은 비슷하게 조사되었다. D의 도체 부분육 생산량 비중은 후지, 삽겹살, 전지 순서였고, 각각 31.17, 23.40 및 16.54%를 차지하였으며, DPP의 도체 부분육 생산량 비중은 각각 33.43, 19.55 및 16.87%를 차지하였다. 부위별 도체 부분육 생산량 비율 차이를 살펴보면, 후지는 DPP 33.43%, D 31.17%로 2.26% P 차이를 보인 반면, 삼겹살은 D 23.40%, DPP 19.55% 로 3.85% P 차이를 보였다. 따라서 DPP는 D 보다 사료효율이 우수하고, 최근 건강을 생각하는 소비자들의 선호도가 높은 저지방 부위의 생산 증대 효과를 기대할 수 있다고 판단된다. 이러한 각각 품종의 특성은 우수한 품종개발에 기초자료로써 활용 될 수 있을 것으로 사료된다.

• BMB Reports
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• 제53권2호
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• pp.88-93
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• 2020

Cisplatin is a widely used anti-cancer agent. However, the effectiveness of cisplatin has been limited by the commonly developed drug resistance. This study aimed to investigate the potential effects of endoplasmic reticulum (ER) stress to overcome drug resistance using the cisplatin-resistant A2780/CisR ovarian cancer cell model. The synthetic chalcone derivative (E)-3-(3,5-dimethoxyphenyl)-1-(2-methoxyphenyl)prop-2-en-1-one (named DPP23) is an ER stress inducer. We found that DPP23 triggered apoptosis in both parental cisplatin-sensitive A2780 and cisplatin-resistant A2780/CisR ovarian cancer cells due to activation of reactive oxygen species (ROS)-mediated unfolded protein response (UPR) pathway in the endoplasmic reticulum. This result suggests that ROS-mediated UPR activation is potential in overcoming drug resistance. DPP23 can be used as a target pharmacophore for the development of novel chemotherapeutic agents capable of overcoming drug resistance in cancer cells, particularly ovarian cancer cells.

• Ocean and Polar Research
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• 제30권4호
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• pp.401-406
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• 2008

Early gonadal development and sexual differentiation of dark-banded rockfish (Sebastes inermis Cuvier) were followed from parturition to 400 days post parturition (dpp). During this period, average total length (TL) increased from 0.57 to 13.18 cm. Primordial germ cells (PGCs) were first detected at 0.68 cm TL (10 dpp). When fish reached 1.52 cm TL (50 dpp), initial stages of ovarian differentiation were identified by the presence of PGCs containing condensed chromatin and their transformation into meiotic oocytes. At 10.23 cm TL (300 dpp), the ovaries gradually developed into oocytes in the primary yolk stages. Ovary growth was rapid after sex differentiation, but testis tissue continued to multiply without growing until fish reached 6.97 cm TL (200 dpp), after which the production of spermatocytes, spermatogonia, and cyst cells was apparent. Histological analysis of gonadal structure suggested a gonochoristic sexual development pathway. Our analysis of the sex ratio at 400 dpp showed a significantly higher proportion of males.

• Archives of Pharmacal Research
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• 제23권3호
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• pp.197-201
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• 2000

In an aqueous piperacillin sodium solution, a well-defined single wave or single peak was observed by direct current(DC) polarography or differential pulse polarography(DPP). The peak potential change per pH unit was -54 mV in the phosphate buffer at $18^{\circ}C$, which indicated that protons were involved in the electrochemical reduction of the 2,3-dioxopiperazine moiety of piperacillin sodium with a $H^{+}e^{-}$ ratio of one. Using a phosphate buffer of pH 4.3, the $1.0{times}10^{-7}$ M piperacillin sodium single peak could be determined by DPP with relative standard deviation of 1.6 %(n=3). Piperacillin sodium could be analyzed with-out interference from penicillin G-potassium, which enabled the employment of DPP as a fast and simple technique for monitoring the synthetic process of the antibiotic.

• The Korean Journal of Physiology and Pharmacology
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• 제23권5호
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• pp.329-334
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• 2019

Diabetes is associated with an increased risk of cardiovascular complications. Dipeptidyl peptidase-4 (DPP-IV) inhibitors are used clinically to reduce high blood glucose levels as an antidiabetic agent. However, the effect of the DPP-IV inhibitor gemigliptin on ischemia/reperfusion (I/R)-induced myocardial injury and hypertension is unknown. In this study, we assessed the effects and mechanisms of gemigliptin in rat models of myocardial I/R injury and spontaneous hypertension. Gemigliptin (20 and 100 mg/kg/d) or vehicle was administered intragastrically to Sprague-Dawley rats for 4 weeks before induction of I/R injury. Gemigliptin exerted a preventive effect on I/R injury by improving hemodynamic function and reducing infarct size compared to the vehicle control group. Moreover, administration of gemigliptin (0.03% and 0.15%) powder in food for 4 weeks reversed hypertrophy and improved diastolic function in spontaneously hypertensive rats. We report here a novel effect of the gemigliptin on I/R injury and hypertension.

• Animal Bioscience
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• 제37권6호
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• pp.1096-1109
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• 2024

Objective: This research aims to explore the nutritional and bioactive peptide properties of goat meat taken from various primal cuts, including the breast, shoulder, rib, loin, and leg, to produce these bioactive peptides during in vitro gastrointestinal (GI) digestion and absorption. Methods: The goat meat from various primal cuts was obtained from Boer goats with an average carcass weight of 30±2 kg. The meat was collected within 3 h after slaughter and was stored at -80℃ until analysis. A comprehensive assessment encompassed various aspects, including the chemical composition, cooking properties, in vitro GI digestion, bioactive characteristics, and the bioavailability of the resulting peptides. Results: The findings indicate that the loin muscles contain the highest protein and essential amino acid composition. When the meats were cooked at 70℃ for 30 min, they exhibited distinct protein compositions and quantities in the sodium dodecyl sulfate-polyacrylamide gel electrophoresis profile, suggesting they served as different protein substrates during GI digestion. Subsequent in vitro simulated GI digestion revealed that the cooked shoulder and loin underwent the most significant hydrolysis during the intestinal phase, resulting in the strongest angiotensin-converting enzyme (ACE) and dipeptidyl peptidase-IV (DPP-IV) inhibition. Following in vitro GI peptide absorption using a Caco-2 cell monolayer, the GI peptide derived from the cooked loin demonstrated greater bioavailability and a higher degree of ACE and DPP-IV inhibition than the shoulder peptide. Conclusion: This study highlights the potential of goat meat, particularly cooked loin, as a functional meat source for protein, essential amino acids, and bioactive peptides during GI digestion and absorption. These peptides promise to play a role in preventing and treating metabolic diseases due to their dual inhibitory effects on ACE and DPP-IV.

• 한국지역사회생활과학회지
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• 제23권4호
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• pp.411-418
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• 2012

Phthalates and di-2-ethylhexyladipate are both widely used as industrial chemicals and exposure high levels over long periods of time can cause toxicity, estrogenic responses and endocrine disruption properties in both humans and animals. So far, their global monitoring in environmental matrices has been performed continuously. A developed method, including modified SPEED'98 (Japan Environment Agency) and USEPA was established for simple and rapid determination of phthalates and di-2-ethylhexyladipate in various matrices. This method was applied to explore the distribution levels in domestic environmental media such as water, soil and sediment. Eight phthalates (DEP(di-ethyl), DEHP(di-[2-ethyl-hexyl]), DprP (di-propyl), DBP(di-n-butyl), DPP(di-n-pentyl), DHP(di-n-hexyl), DCHP(di-cyclohexyl), BBP(butyl benzyl) and Adipate (di-2-ethylhexyl adipate) were investigated by seasonal sampling(spring, autumn) at 24 domestic sites. Phthalates and adipate were not detected in water samples and DEP, DBP, and DEHP were mainly detected in soil and sediment samples. The concentrations of DEP and DBP excluding DEHP in spring were higher in soil than those of sediment. Total concentrations of phthalates were significantly decreased in autumn for both soil and sediment.

• The Korean Journal of Physiology and Pharmacology
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• 제23권6호
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• pp.459-466
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• 2019

Dipeptidyl peptidase (DPP)-4 inhibitors, or gliptins, are a class of oral hypoglycemic drugs that have been widely used as a second-line treatment for type 2 diabetes. Gliptins, which were introduced for clinical use a decade ago, have been shown to be beneficial against nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NASH) in animals and humans. Cenicriviroc (CVC), a dual antagonist of C-C chemokine receptor type 2 and 5, is currently under investigation against NASH and fibrosis. It was previously discovered that evogliptin (EVO) reduces hepatic steatosis in diet-induced obese animals but the effectiveness of EVO on NASH remains unexplored. Here, we compared the effectiveness of EVO and CVC against NASH and fibrosis in mice fed a high-fat and high-fructose diet (HFHF). Biochemical and histological analyses showed that mice fed a HFHF for 20 weeks developed severe hepatic steatosis and inflammation with mild fibrosis. Administration of EVO (0.2% wt/wt) for the last 8 weeks of HFHF feeding significantly reduced hepatic triglyceride accumulation, inflammation, and fibrosis as well as restored insulin sensitivity, as evidenced by lowered plasma insulin levels and the improvement in insulin tolerance test curves. Treatment of mice with CVC (0.1% wt/wt) inhibited hepatic inflammation and fibrogenesis with similar efficacy to that of EVO, without affecting hepatic steatosis. CVC treatment also reduced plasma insulin concentrations, despite no improvement in insulin tolerance. In conclusion, EVO administration efficiently ameliorated the development of NASH and fibrosis in HFHF-fed mice, corroborating its therapeutic potential.

• 한국가금학회지
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• 제23권4호
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• pp.169-175
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• 1996

An experiment was conducted with male broiler chicks to determine the effect of different dietary phosphorus sources and evaluate the biological availability of phosphorus sources. The biological availability of phosphorus from dicalcium phosphate (DCP) was used as a reference standard (100%) compared to defluorinate phosphate (DFP). DCP and DFP was supplemented to a corn-soy basal diet at levels of 0.05, 0.15, 0.25, 0.35%. Each of 24 pens of 10 male broiler chicks with three replications was used for three weeks. The results indicated that weight gain, feed in-take, feed efficiency, nonphytic phosphorus (NPP) and tibia ash were significantly different among treatments. Dietary supplemental phosphorus of DFP improved weight gain, NPP intake and feed efficiency consistently, whereas supplements of DCP did not show consistent increase. Regression equations was used for the availability of DPP compared with DCP when percent bone ash was a function of total phosphorus in the diet. The percent (%) bone ash of DFP groups compared to that of DCP groups showed a value of 59.98% as a slope ratio. DFP indicated lower biological availability compared to DCP, but it's dietary supplementation tended to increase bone ash and maximize the growth of young broiler chicks.

• 한국인터넷방송통신학회논문지
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• 제23권2호
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• pp.73-78
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• 2023

식사하는 철학자 문제는 5명의 철학자(프로세서)들이 원형 탁자에 둘러 앉아 함께 스파게티(또는 국수) 식사를 하는데 있어 자신의 양쪽에 있는 젓가락(자원) 한 쌍(2개)을 모두 가져야만 식사가 가능한 경우로 모든 철학자가 우측의 젓가락 1개씩 모두 가진 경우 아무도 식사를 못하는 교착상태(deadlock)를 해결하는 문제이다. 교착상태는 병행 시스템(concurrent system)에서 빈번히 발생하는 문제로 현행 운영체제(OS)에서는 이를 예방하는 방법은 채택되지 않고 있다. 본 논문은 2≤n≤∞의 모든 프로세서들이 다중 병행(parallel concurrency)처리 능력을 갖고 있는 OS에서 교착상태를 전혀 유발하지 않는 묘책을 제안한다. 제안된 방법은 ⌊n/2⌋개의 홀수 프로세서들이 그룹을 형성하여 동시에 수행하는 방법으로 실행이 종료되면 다음 프로세서로 우측 이동(shift right)시키는 그룹 라운드-로빈 방법이다. 제안된 방법은 1-라운드의 모든 프로세서를 실행시키려면 짝수 프로세서인 경우 2회, 홀수 프로세서는 3회를 수행하면 되고, n회를 수행하면 짝수 프로세서인 경우는 n/2회, 홀수 프로세서는 (n-1)/2회를 수행하는 방식이다.