• Journal of Chest Surgery
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• 제23권4호
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• pp.640-645
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• 1990

We have performed four left lung reimplantation and right pulmonary artery ligation in dogs for six months from March 1989 to September 1989 at the Thoracic & Cardiovascular Surgery department, Yonsei University, College of Medicine, Seoul, Korea. Excised left lungs were perfused with 200cc of 4oC cold saline at a pressure of 60cmH2O through left pulmonary artery & preserved in 4 oC cold saline for about 20 mins. Left lung reimplantation were proceeded with inferior pulmonary vein, superior pulmonary vein, left pulmonary artery and left main bronchus in order. The main pulmonary artery pr. were 39/21[31], 22/12[15], 25/9[15] and 54/17[37] mmHg each after right pulmonary artery ligation on left reimplanted dogs, Right pul a. ligations were performed 9 days, 12 days, 16 days and 19 days after left lung reimplantation. Two dogs died at 10 days 21 days, after right pul. a. ligations in left reimplanted dogs. The remaining two dogs were sacrificed at 18 days, 21 days after right pul. a. ligation in left reimplanted dogs. Autopsy findings showed narrowing of left superior pul. vein anastomotic site in two narrowing of left pulmonary artery anastomotic site in one narrowing of left sup. pul vein & pneumonia of left lung in one. In the lung transplantation, it was thought to be important that the anastomosis of pulmonary artery and especially pulmonary vein be done with particular precaution for early and late stenosis.

• 한국임상수의학회지
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• 제15권2호
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• pp.339-345
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• 1998

This study was performed to investigate the effect of acupuncture in dogs with experimentally induced thoracic disease. Twenty four dogs and 16 cats for the heart study, were divided into four groups(each of 6 in dogs, each of 4 in cats): laserpuncture, electroacupuncture, acupuncture and control group. Heart disease was induced by partial pericardiectomy, and then treatment was done once daily for 4 days. The acupoints used were Xin-shu and Nei-guan. The effect of acupuncture was evaluated by clinical symptom, blood chemical values, electrocardiogram(ECG) and histopathological findings. In dogs, acupuncture group revealed relatively fast recovery and laserpuncture group revealed secondly fast recovery after treatment. In catsl lasewuncture group revealed relatively fast recover and acnpuncture group reveaBed secondly fast recovery after treatment Sixteen dogs for the lung study, were divided into flour groups(each of 4) : laserpuncture, electroacupunchuf, acupuncture and control group. Lung disease was induced by partial lung lobectomy, and then treatment was done once daily for 4 days. The acupoints used were Fei-shu and Shen- zhu. The effect of acupuncture was evaluated by clinical symptoms blood chemical values and histopathological findings. Acupuncture and laserpuncture group revealed relatively fast recovery compared with other groups.

• 한국임상수의학회지
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• 제23권2호
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• pp.91-95
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• 2006

사람에서, Chiari 1형 기형은 소뇌 탈출과 척수공동증이 특정인 발달성 장애이다. 이러한 사람의 Chiari 1형 기형과 유사한 질환이 cavalier King Charles spaniels에서 흔히 나타났다. 그러나, 이러한 Chiari 1형 유사 기형이 다른 종의 개에서 진단 보고된 증례가 거의 없는 실정이다. 이에 본 연구에서는 24 마리의 개에서 자기공명영상 장치를 이용하여 Chiari 1형 유사 기형으로 진단된 증례를 보고하고자 한다. 이 개들은 다양한 신경 증상과 다양한 정도의 소뇌 탈출, 척수공동증, 두개관내 거미막 낭종 또는 뇌수종의 병발 질환들을 나타내었다.

• Toxicological Research
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• 제13권4호
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• pp.449-460
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• 1997

Single and 4 weeks oral administration of l-muscone, a major active ingredient of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs(3 males and 3 females) in acute experiments were administered orally with single dosage of 2,000 mg/kg and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of l-muscone, 0.2 mg/kg/day(low dosage group), 2 mg/kg/day(middle dosage group), or 20 mg/kg/day(high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korean Food and Drug Administration(1996.4.16). $LD_{50}$ value for beagle dogs was more than 2,000 mg/kg on oral route for both male and females. In animals administered with l-muscone, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical signs, urinalysis, eye examination, hematology, serum chemistry, organ weight and other findings. No histolopathological lesions were observed in both control and treatment groups. Above data strongly suggest that l-muscone in beagle dogs is considered to be safe.

• 대한수의학회지
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• 제41권1호
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• pp.79-83
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• 2001

Dirofilaria immitis parasitizes mainly in the pulmonary arteries and in the heart of dogs and cats. The parasite is also of public health importance, because it often elicits nodules in the pulmonary parenchyma and in the subcutaneous tissues, or sometimes parasitize itself in the eyes of human. In this study, we investigated the prevalence of heartworm infection among 165 dogs on three breeding farms in the vicinity of Seoul, Korea. Of 165 dogs, 83 dogs (50.3%) were infected with the parasite, as revealed by an antigen-detecting test using the peripheral blood. Of these, 23 dogs (20.2%) contained microfilaria using the peripheral blood, which are potential source of transmission to uninfected animals and to humans in the endemic area. None of infected dogs showed any clinical signs associated with the disease. Since the three farms were located in the vicinity of Seoul, the unexpectedly high infection rate could imply that the possibility of exposure of both animals and humans living in the metropolitan Seoul area to the parasite is higher than in the other area of Korea.

• 대한수의학회지
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• 제54권3호
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• pp.165-169
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• 2014

The present study compared leptin, adiponectin, and thyroid hormone concentrations in normal and obese dogs, and evaluated the association between leptin and adiponectin concentrations and thyroid function. The serum leptin, adiponectin, thyroid-stimulating hormone (TSH), total thyroxine (tT4), free thyroxine (fT4), triiodothyronine (T3), and cortisol concentrations were measured in 18 normal dogs (body condition score [BCS]: 4-5/9) and 16 obese dogs (BCS: 8-9/9). Leptin and T3 concentrations were higher in the obese group than the normal weight group (p < 0.01 and p < 0.05, respectively). In both groups, the T3 and leptin concentrations were correlated (r = 0.370, p < 0.05), as were the TSH and fT4 and adiponectin concentrations (r = -0.373, p < 0.05 and r = 0.369, p < 0.05, respectively). In the normal weight group, the TSH and fT4 concentrations were correlated with the adiponectin concentrations (r = -0.528, p < 0.05 and r = 0.482, p < 0.05, respectively). The results of the present study suggest that leptin and T3 concentrations are significantly higher in obese dogs than normal weight dogs, and the serum T3 and leptin concentrations are positively correlated.

• 한국동물위생학회지
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• 제41권2호
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• pp.79-83
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• 2018

This study compared serum concentrations of suppression of tumorigenicity 2 (ST2) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) between healthy and heartworm- infected dogs. Eighteen heartworm-infected dogs and five healthy dogs were included in the study. Dogs were diagnosed and categorized by history, clinical signs, and blood assay, thoracic radiography, echocardiography, and commercial ELISA kit results. Serum samples were sent to the IDEXX reference laboratory for NT-proBNP measurement. ST2 was examined by using a canine interleukin 33 receptor ELISA kit with the quantitative sandwich ELISA method. The severely infected group showed significant elevation of NT-proBNP concentration over those of the control (P=0.03) and mildly infected (P=0.04) group. There were no significant difference in ST2 concentrations among the three groups. The usefulness of NT-proBNP as a cardiac biomarker in dogs with severe heartworm disease was confirmed by the results of this study. Further investigations to assess ST2 as a cardiac biomarker are warranted.

• 대한수의학회지
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• 제53권3호
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• pp.177-180
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• 2013

Two dogs were presented with melena, vomiting and depression after accidental swallowing of candy form of Strepsils (flurbiprofen), which is one of non-steroidal anti-inflammatory drugs used in human medicine for controlling a sore throat. These dogs had common signs of anemia induced by gastrointestinal ulceration and hemorrhage with azotemia and leukocytosis. The dogs were treated with blood transfusion, fluid therapy, proton-pump inhibitor, antiemetics, mucus protectant and antibiotic. Although most of clinical signs of two dogs were resolved, azotemic problem with evidence of renal injury have remained.

• 한국임상수의학회지
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• 제27권4호
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• pp.474-482
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• 2010

Hepatocellular carcinoma (HCC) is a primary hepatic neoplasms in dogs. Three types of HCC such as massive, nodular and diffuse form were reported. Massive HCC is most common and has relatively better prognosis than other forms because this type of HCC can be removed surgically and has low frequency of relapse or metastasis. Diagnostic image can provide useful information for shape and internal structure of the hepatic mass as well as the location and adhesion or invasiveness of the mass to establish surgical plan to remove the mass safely. In this study, we investigated diagnostic features of massive HCC in 5 dogs. Radiography showed soft tissue mass in cranial abdomen in 3 dogs. On ultrasonography, all dogs had a solitary hepatic mass with mixed echo pattern with anechoic cysts, which represented necrosis and hemorrhage. The radiographic and ultrasonographic findings of affected hepatic lobe were compared with the macroscopic findings through laparotomy. Computed tomography was performed to check metastasis and figure out the origin of the mass in two dogs. Ultrasonography is useful and relatively sensitive examination for diagnosis and planning for surgery in canine massive HCC.

• 한국임상수의학회지
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• 제29권2호
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• pp.124-129
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• 2012

본 연구의 목적은 건강한 내원견을 대상으로 측정한 망막전위도에 나이 및 성별이 어떠한 영향을 미치는지 알아보는데 있다. 보호자가 임상 실험에 참가하는 것을 동의한 34두의 개를 medetomidine과 tiletamine-zolazepam혼합제로 전신마취하여 ISCEV에서 권고하는 진단용 프로토콜에 따라 망막전위도를 측정하였다. 성별간 비교시는 cone 반응의 a파의 지연시간에서 그리고 나이별 비교시 Hi-int R & C 반응의 a파 지연시간에서 유의성을 각각 나타내었다 (P < 0.05). 나머지 ERG반응들은 나이와 성별에 영향을 받지 않는 것으로 나타났다.