• Journal of the Institute of Convergence Signal Processing
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• v.1 no.2
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• pp.145-152
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• 2000

Some evolutional system has been used to promote the efficiency of the DNC(Direct Numerical Control) Controller. However, these are many inconvenience to this operator because it lacks harmony in interaction between the computer and the NC(Numerical Control) Controller. Also, there are some controversial points when data error occurs at the Data Input/Output. Accordingly, this paper explores a new Data Remote Control System. In this study, the NC Controller of the DNC network has to get full data by removing data error in this system. In this system, the main merits are easy manufacturing and the convenience of Data Input/Output. That is, remote control of the NC machine tool is possible without mutual interaction between the computer and itself.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup3
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• pp.219-224
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• 2016

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver making up more than 80 percent of cases. It is known to be the sixth most prevalent cancer and the third most frequent cause of cancer related death worldwide. Epigenetic regulation constitutes an important mechanism by which dietary components can selectively activate or inactivate target gene expression. The miR-34 family members including mir-34a, mir-34b and mir-34c are tumor suppressor micro RNAs, which are expressed in the majority of normal tissues. Several studies have indicated silencing of miR-34 expression via DNA methylation in multiple types of cancers. Bioactive nutrients like curcumin (Cur) have excellent anticarcinogenic activity and minimal toxic manifestations in biological systems. This compound has recently been determined to induce epigenetic changes. However, Cur is lipophilic and has a poor systemic bioavailability and poor absorption. Its bioavailability is increased through employing dendrosome nanoparticles. The aim of the current study was to investigate the effect of dendrosomal nanocurcumin (DNC) on expression of mir-34 family members in two HCC cell lines, HepG2 and Huh7. We performed the MTT assay to evaluate DNC and dendrosome effects on cell viability. The ability of DNC to alter expression of the mir-34 family and DNA methyltransferases (DNMT1, DNMT3A and 3B) was evaluated using semi-quantitative and quantitative PCR. We observed the entrance of DNC into HepG2 and Huh7 cells. Gene expression assays indicated that DNC treatment upregulated mir34a, mir34b and mir34c expression (P<0.05) as well as downregulated DNMT1, DNMT3A and DNMT3B expression (P<0.05) in both HepG2 and Huh7 cell lines. DNC also reduced viability of Huh7 and HepG2 cells through restoration of miR-34s expression. We showed that DNC could awaken the epigenetically silenced miR-34 family by downregulation of DNMTs. Our findings suggest that DNC has potential in epigenetic therapy of HCC.

• Journal of the Korean Society of Industry Convergence
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• v.7 no.2
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• pp.207-213
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• 2004

This paper describes the development of Behind-Tape-Reader (BTR) type DNC system using CYBER 180-830 as a central computer and IBM PC-AT cell control computer and NC lathe with FANUC 5T NC controller. In this system, the connection between central computer and cell control computer is done via RS-232C serial interface board, and that between cell control computer and FANUC 5T controller is done via parallel interface board. The software consists of two module, central computer communication module for NC program downloading and status uploading, NC machine running module for NC operating.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3917-3922
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• 2015

Curcumin, a lipid-soluble compound extracted from the plant Curcuma Longa, has been found to exert immunomodulatory effects via macrophages. However, most studies focus on the low bioavailability issue of curcumin by nano and microparticles, and thus the role of macrophages in the anticancer mechanism of curcumin has received little attention so far. We have previously shown the potential biocompatibility, biodegradability and anti-cancer effects of dendrosomal curcumin (DNC). In this study, twenty-seven BALB/c mice were equally divided into control as well as 40 and 80 mg/kg groups of DNC to investigate the involvement of macrophages in the antitumor effects of curcumin in a typical animal model of metastatic breast cancer. At the end of intervention, the tumor volume and weight were significantly reduced in DNC groups compared to control (P<0.05). Histopathological data showed the presence of macrophages in tumor and spleen tissues. Real-time PCR results showed that DNC increased the expression of STAT4 and IL-12 genes in tumor and spleen tissues in comparison with control (P<0.05), referring to the high levels of M1 macrophages. Furthermore treatment with DNC decreased STAT3, IL-10 and arginase I gene expression (P<0.05), indicating low levels of M2 macrophage. The results confirm the role of macrophages in the protective effects of dendrosomal curcumin against metastatic breast cancer in mice.

• Journal of the Korea Safety Management & Science
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• v.5 no.2
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• pp.87-98
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• 2003

With the development of CNC(Computer Numerical Control) and communication technology, the connotation and functions of Distributed Numerical Control have been greatly enlarged. In this study, we develop and implement a Distributed Numerical Control system that has real time and multi-tasking operation capability for the machining cell with various NC(Numerical Control) and CNC machines. With the consideration of economy, generalization and extension, this system is interfaced with Shop Floor Control System, Machine Control System and Tool Preparation System using advanced networking method. In the implementation phase, we use the ORACLE DBMS (Database Management System) as the DBMS and Microsoft Visual C++ as the programming tools.

• 기계와재료
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• v.2 no.1 s.3
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• pp.101-107
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• 1990

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.12 no.2
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• pp.53-59
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• 2003

• 기계와재료
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• v.7 no.2 s.24
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• pp.96-110
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• 1995

• Journal of the Korean Society of Industry Convergence
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• v.27 no.2_2
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• pp.389-395
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• 2024

The purpose of this study was to evaluate the effect of different washing solvents and washing methods on the flexural strength of 3D printed temporary resin. A bar(25 × 2 × 2 mm) was produced with a layer thickness of 50 ㎛ using an LCD-type 3D printer and divided into 15 groups(n = 10, each) according to washing solution(IPA; 99% isopropyl alcohol, TPM; 93% Tripropylene glycol monomethylether, ETL; Ethanol, TWC; Twin 3D Cleaner, and DNC; DIO navi Cleaner) and washing method(Dip; Dip washing, Ultra; Ultrasonic washing, and Auto; Automated washing). All groups were washed for 5 minutes, and post-cured for 5 minutes using a UV LED light curing machine. The Flexural strength was measured using a three-point bending test using a universal testing machine. For statistical analysis, one-way ANOVA, Tukey HSD post hoc test, Kruskal-Wallis test and post-hoc by Bonferroni-Dunn test(𝛼=.05) were performed depending on whether the normality test was satisfied. In all washing solvents except TPM and DNC, the Dip group showed the lowest flexural strength values, while the Auto group showed the highest flexural strength values except for DNC. Additionally, the washing solution showed completely different flexural strength values depending on the washing method.

• Korean Journal of Computational Design and Engineering
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• v.1 no.2
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• pp.150-157
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• 1996

The hob is considered as an effective gear cutting tool for achieving the various gears such as spur gear, helical gear, worm gear and so on. To enhance the productivity and precision of hobs and the competitive ability of domestic CNC hob relieving lathes, a CAM system for CNC hob relieving lathe needs to be realized. In this study, the CAM system is developed based on the personal computer and C language. Besides the automatic generation of CNC data, the developed CAM system has the various capabilities related to the generation of tool path, the cutting simulation for verifying the generated CNC data and forecasting the cutting time, the DNC operation for communicating the CNC data with CNC controller by RS232C port, and the estimation of undercut length for verifying the hob cutting conditions.