• 월간산업보건
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• s.160
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• pp.52-64
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• 2001

• Bulletin of the Korean Chemical Society
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• v.19 no.8
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• pp.812-813
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• 1998

• Bulletin of the Korean Chemical Society
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• v.20 no.11
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• pp.1255-1256
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• 1999

• Proceedings of the PSK Conference
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• 2005.11a
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• pp.114-115
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• 2005

• YAKHAK HOEJI
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• v.57 no.5
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• pp.316-322
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• 2013

The new pyridazinone analogs were synthesized for development of candidates to retain anticancer activity. Various 6-substituted pyridazin-3(2H)-ones were prepared from the pyridazinyl chloride 3a~d via endothermic nucleophilic substitution with hydroxide ion as nucleophile for 2~48 h. Pyridazinyl chloride 3a~d could be converted to hydroxypyridazines (or pyridazin-3(2H)ones) using 1~5 equivalents of water (or 1 equivalent of sodium hydroxide) at reflux in DMF. The tautomerism of lactim form to lactam form was also accomplished in pyridazine derivatives. Formation of pyridazinones 10 was undertaken with stirring using sodium hydroxide at reflux in DMF for 2 h. Synthetic compounds were identified using NMR spectrum.

• Coupled systems mechanics
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• v.9 no.4
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• pp.311-323
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• 2020

This paper deals with the effect of the mode shapes on the dynamic response of a multi-storey frame subjected to moving train loads which are modelled as loads of constant intervals with constant velocity using the finite element method. The multi-storey frame is modelled as a number of Bernoulli-Euler beam elements. First, the first few modes of the multi-storey frame are determined. Then, the effects of force span length to beam length ratio and velocity on dynamic magnification factor (DMF) are evaluated via 3D velocity-force span length to beam length ratio-DMF graphics and its 2D projections. By using 3D and 2D graphics, the directions of critical speeds that force the structure under resonance conditions are determined. Last, the mode shapes related to these directions are determined by the time history and frequency response graphs. This study has been limited by the vibration of the frame in the vertical direction.

• Bulletin of the Korean Chemical Society
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• v.24 no.4
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• pp.460-466
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• 2003

For the drug master file (DMF) of ketoconazole, four impurities (1-4) contained in ketoconazole were synthesized. During the synthesis of 2, a new synthetic method of 1,4-dihydropyrazine was established. To oxidize the aminoalcohol (2j) to the aminal (2j-1), the standard Swern oxidation condition was modified to mask the nucleophilicity of the amino group temporarily using one equivalent of acetic acid. Derivative 3 was synthesized via regioselective bromination at the 2 position of the 4-aminophenol derivative (3a) using $Br_2$ in the presence of p-TsOH. The etherification of aryl bromide with the phenol derivative (1f) was accomplished by a modification of the general Cu-mediated reaction condition using excess 1f itself as a solvent at elevated temperature (190 ℃).

• Journal of Food Hygiene and Safety
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• v.10 no.1
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• pp.1-6
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• 1995

In order to establish the enzyme linked immunosorbent assay(ELISA) of sterigmatocystin produced by Aspergillus versicolor, we experimented and obtained following results. Two of three rabbits which had been immunized with sterigmatocystin-hemiacetal-BSA produced antibodies against sterigmatocystin at 15 weeks. The produced antibodies were specific for sterigmatocystin and sterigmatocystin-hemiacetal but didn't cross react with other sterigmatocystin analogues in a significant degree. DMF : 4% KC1 (18 : 2) mixed solution was most effective to dissolve sterigmatocystin. For the preparation of sample solution to determine sterigmatocystin by ELISA, sample was extracted with CHC13 and dried, than the dried sample was redissolved with 100 ${mu}ell$ DMF + 4% KC1 mixture. 10~1,000 ng/$m\ell$ level of standard sterigmatocystin could be applied to the established ELISA. When artifically contaminated rice were assayed by the ELISA, the average recovery of sterigmatocystin spiked to 25~500 ng/g was 109% (97~116%), and mean interwell coefficient of variation was 21% (11~28%).

• Textile Coloration and Finishing
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• v.8 no.2
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• pp.43-48
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• 1996

Condensation type aromatic polyimides were synthesized in DMF solvent by two step low temperature solution polymerization. By employing monomers as p-phenylene 3diamine and 3 kinds of dianhydrides such as pyromellitic dianhydride, 3,3',4,4'-benzophenone tetracarboxylic dianhydride and trimellitic anhydride chloride, poly(amic acid) precursors were sythesized. These reactions were exothermic and very fast. When synthesized poly(amic acid)s were dissolved in DMF solvent and stood long time, the polymers were hydrolyzed and their degradation reactions were accelerated as the solution concentrations were dilute. Also, when water is added there-to the degradation rates were accelerated 8faster. In addition, in a very dilute solution state, the reduction viscosity is greatly increased to show properties of conventional polyelectrolytes. This also showed properties sensitive to the concentration change as carboxyl groups per unit segment are increased.

• Journal of the korean academy of Pediatric Dentistry
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• v.10 no.1
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• pp.13-23
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• 1983

The purpose of this study was to make a comprehensive study and provide information about the oral status of handicapped. 874 (male: 540, female: 334) persons who are housed by 12 institution aged from 4 to 28 years in Seoul area was examined by considering the DMF rate, periodontal condition and occlusion. The obtained results were as follows: 1. Cerebral palsy, poliomyelitis, mental retardation, and blindness groups had a significant higher DMF rate than that occurring in any of the remaining groups. 2. Prevalence of periodontal disease in blindness, mongolism, cerebral palsy, poliomyelitis groups showed higher than that of the remaining groups. 3. Mongolism group had a significantly higher incidence of malocclusion (69.23%).