• Journal of Chest Surgery
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• 제56권3호
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• pp.220-223
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• 2023

Well-differentiated papillary mesothelial tumor (WDPMT) is an uncommon tumor, formerly named well-differentiated papillary mesothelioma in the 2015 World Health Organization classification. It has a characteristic papillary architecture, bland cytologic features, a tendency toward superficial spread without invasion, and a good prognosis due to its clinically indolent behavior with prolonged survival. Rare cases with superficial invasion are termed WDPMT with invasive foci. WDPMT occurs primarily in the peritoneum of reproductive-age women, but also rarely in the pleura. We report a case of a 60-year-old woman who developed WDPMT with minimal invasion in the pleura with atypical radiological features and a family history of mesothelioma and indirect asbestos exposure.

• 디지털융복합연구
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• 제18권6호
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• pp.225-235
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• 2020

본 연구의 목적은 창업기업의 품질경영시스템 실행이 차별화 경쟁우위 및 경영성과에 미치는 영향을 확인하고, 품질경영시스템 실행과 차별화 경쟁우위의 관계에서 기업 규모의 조절효과를 검증하는 것이다. 창업기업을 대상으로 설문을 진행하여 259부를 SmartPLS 2.0을 사용하여 분석하였다. 연구결과 첫째, 리더십, 기획, 지원, 운영, 성과평가, 개선은 차별화 경쟁우위에 긍정적인 영향을 미치며, 조직의 상황은 긍정적인 영향을 미치지 못하는 것으로 나타났다. 둘째, 차별화 경쟁우위는 재무적 및 비재무적 성과에 긍정적인 영향을 미치는 것으로 나타났다. 셋째, 기업 규모는 리더십, 지원, 운영, 개선과 차별화 경쟁우위의 관계에서 조절 역할을 하는 것으로 나타났다. 연구의 결과는 품질경영시스템이 창업기업의 품질을 개선하여 경영성과에 긍정적인 영향을 준다고 해석할 수 있다. 그리고 품질경영시스템을 실행할 때 조직의 상황과 기업 규모가 고려되어야 한다는 시사점을 준다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5811-5815
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• 2012

Background: Non-invasive oral verrucous carcinoma (OVC) and invasive well-differentiated oral squamous cell carcinoma (OSCC) have similar histopathologic findings but different biological behavior. These two malignancies must be correctly differentiated by pathologists. The aim of this study was to determine immunohistochemical (IHC) expression of Ki67 in OVC and well-differentiated OSCC. Methods: Expression of Ki67 was evaluated by IHC in 15 cases of epithelial hyperplasia with no dysplasia (A group), 15 cases of OVC (B group), 12 cases of microinvasive OSCC(C group) and 15 cases of well-differentiated OSCC (D group). Results: There was a significant difference in Ki67 expression based on pattern distribution of immunostaining positive cells, with quantitative and semi-quantitative analyses, among the four groups ; also, between A group and each of the other three groups (P=0.0001). But there was no significant difference between B and C, C and D, and B and D groups (P>0.05). Conclusions: The three evaluation methods of Ki67 expression showed Ki67 (Mib-1) is not a good immunohistochemical marker to assess invasion status and differentiate OVC from well-differentiated OSCC; also, it cannot be used as a diagnostic tool to distinguish between variants of OSCC with similar grade.

• 한국초등과학교육학회지:초등과학교육
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• 제34권4호
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• pp.394-405
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• 2015

The purpose of this study was to develop and apply a differentiated instruction-learning reflecting various characteristics and demands of the gifted underachievers, and thereby help to develop the study attitude and study achievement of the gifted underachievers. To achieve the purpose, a case study on five gifted underachievers who are in $6^{th}$ grade of elementary school was conducted. By collecting and analyzing a variety of data including standardized tests, interviews with teachers, students, and parents, and observation journals, this researcher examined the characteristics and demands of the gifted underachievers. For the development of the program, differentiated strategies were designed according to students' interest and concern, their multiple-intelligence, and their learning styles. As a result of the application of them, a program with a total of 20 sections was finally developed. The result of the application for the differentiated instruction-learning program revealed improvements in their academic achievements. In addition, it was found that their learning motives were improved. The program was also found to affect their self-concept and their attitude toward learning. The study showed that developing an education program for the gifted underachievers should begin from the analysis of each student's characteristics. Also, it was found that a differentiation strategy could become an alternative to apply various characteristics and demands of the gifted underachievers to the development of a program. The gifted underachievers' intellectual and definitive characteristics were changed even by the short-term mediation. Therefore, the new issue about educating the gifted is to provide a differentiated instruction-learning program fitting their characteristics and demands and help them exert their potential as best as they could.

• 한국초등과학교육학회지:초등과학교육
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• 제37권3호
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• pp.233-253
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• 2018

Since open inquiry of science was formally introduced at the 2007 Revised Science Curriculum Course, the purpose and effect of it has been positively evaluated, and it is underlined continuously until the revised science education course in 2015. However, through many previous studies, there is still a lack of awareness of open inquiry of both students and teachers in the field, and it was revealed they are continually appealing confusion and difficulties. Therefore, in this research, we analyzed the causes that make it difficult to execute open inquiry, and developed differentiated open inquiry guide materials that can contribute to the realization of teachers and students. They were developed by the brain-based evolutionary approach to provide students with authentic science. The brain-based evolutionary approach is reflecting the evolutionary attributes and the brain functions associated activities of scientists. It was revealed that, in the same way as the pilot test results, the usefulness of the differentiated guide materials were very high, and there was a statistically significant difference in the science attitude. It was found that the application of the brain-based evolutionary approach had positively influenced the stage of determining the inquiry themes, and self-confidence that could be able to do as a scientist. Analysis of top and sub group types on the basis of inquiry ability showed that both groups are improved at science attitude by the differentiated guide materials. There was a positive effect on change in the self-perception of scientific creativity. We were able to see a positive change in the post survey for open inquiry-efficacy. The developed differentiated open inquiry guide materials contributed to the improvement of open inquiry-efficacy for both the teacher and student.

• 한국통신학회논문지
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• 제29권7B호
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• pp.697-710
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• 2004

네트웍 환경에서 quality of service(QoS) 에 대한 요구가 증대함에 따라 여러 가지 방안들이 제시되고 있는 가운데, Differentiated services (DiffServ) 모델은 확장성을 보장하며 QoS를 제공할 수 있는 방법으로서 제시되고 있다. 그러나 대부분의 DiffServ 관련 연구들은 통합된 트래픽에 관한 확장성 문제와, 단일 도메인에서의 per hop behavior(PHB)에 관한 문제에만 관심을 두고 있기 때문에, 시간적으로 변화하는 네트웍 조건하에서 다중 도메인의 단대단 QoS를 제공하는 데 있어서는 많은 어려움 들이 있다. 따라서 본 연구에서는 다중 DiffServ 도메인에서 네트웍 cost를 최소화하는 가운데 멀티미디어 데이터의 단대단 QoS를 제공할 수 있는 동적 클래스 재협상알고리즘을 제안하였다. 본 논문은 DiffServ의 relative 서비스 모델을 효과적으로 구현할 수 있는 방법과 QoS 레벨 전달 메카니즘, 그리고 동적 클래스 재협상 방법으로 구성되어 있으며, 실험 결과를 통해 제안된 알고리즘의 성능을 측정한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8847-8853
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• 2014

The aim of this study was to establish the expression and localization of E-cadherin and ${\beta}$-catenin in oral squamous cell carcinomas (OSCC) so that we could correlate the findings with prognostic-relevant histopathological variables. E-cadherin and ${\beta}$-catenin expression in normal oral epithelia and in oral squamous cell carcinomas was examined immunohistochemically, and associations with histopathological differentiation and prognosis were then analyzed in 33 patients who had been operated on for OSCC. E-cadherin expression was found in (82%) of the squamous cells of well differentiated OSCC, (61%) of moderately differentiated and (39%) of poorly differentiated. E-cadherin expression was significantly associated with histological grade (p=0.000). No nuclear staining was detected. In (19.5%) of the cells E-cadherin localized in the cytoplasm, with no correlation to the histological grade (p=0.106). ${\beta}$-Catenin expression was found in 87% of the squamous cells of well differentiated OSCC, 67% of moderately differentiated and 43% of poorly differentiated, the expression was significantly associated with histological grade (p=0.000). the nuclear ${\beta}$-Catenin expression appeared in 3.3% of the cells and it was correlated to the histological grade (p=0.000). In (23.5%) of the cells ${\beta}$-Catenin localized in the cytoplasm, with correlation to the histological grade (p=0.002). According to this study the expression of ${\beta}$-catenin and E-cadherin were independent prognostic factors for histological grade. E-cadherin was closely linked to ${\beta}$-catenin expression in OSCC (p=0.000) and to tumor differentiation. That reflects a structural association and the role of both in tumor progression.

• 한국가축번식학회지
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• 제26권4호
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• pp.377-384
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• 2002

To investigate the expression patterns of proteins and growth factor signals in differentiated rabbit embryonic stem (ES) cells, ES cells with confluent stage grown of feeder layer and differentiated cells into embryoid bodies (EB) without feeder cell were applied to protein gel and Western blotting analysis. There were 66kDa and 28kDa specifically expressed in differentiated ES cell but not in undifferentiated ES cell while 25kDa protein band showed up in only undifferentiated ES cells. Also there were some difference of protein bands in several area of gel between differentiated and undifferentiated ES cells such as about 100 kDa, 50kDa and 27kDa areas, but there was no difference in band pattern of one-dimensional gel analysis between mouse ES cells and rabbit ES cells. IGF-I receptor and EGF receptor were expressed in differentiated cells and undifferentiated cells. And ICF-I and EGF were not expressed in both differentiated and undifferentiated cells. These results indicated that ES cells express their own proteins to inhibit differentiation while EB cells synthesize different proteins to differentiate, and 16F-I receptor and EGF receptor were expressed in both ES and EB cells probably for the different functions.

• 한국정보과학회논문지:정보통신
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• 제30권5호
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• pp.621-630
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• 2003

본 논문에서는 NGN(Next Generation Network)을 고려하여 IPv6와 차별화된 호 처리 기법을 지원하는 SIP(Session Initiation Protocol) 프로토콜을 설계하고 구현하였다. NGN에서 다양한 응용 서비스들은 SIP를 통하여 호를 설정한다. 따라서, 소프트스위치(Softswitch) 및 SIP 서버는 호를 처리 할 때 팩스(Fax), 망 관리(Network Management), 홈 네트워킹(Home Networking)과 같이 호 설정 시간에 아주 민감한 서비스에 우선순위를 부여할 수 있어야 한다. 또한, ALL-IP를 고려하여 IPv6를 지원하여야 한다. 이러한 문제들을 해결하기 위해, 본 논문에서는 차별화된 호 처리 기법을 제안하였다. 차별화된 호 처리 기법은 우선순위에 따라 세 단계의 서비스품질을 사용하여, 호 처리에 대한 차별화 정책을 지원한다. 또한, 본 논문에서 정의된 서비스품질은 IPv6 헤더의 Flow Label 필드를 통하여 값을 설정한다. 성능분석 결과, SIP 서버 내에서 호가 처리 될 때 높은 우선순위를 가지는 호에 대한 처리율이 현저히 빠르게 나타났다. 이러한 결과는 NGN에서 호 설정 시간에 민감한 응용 서비스에 적용 할 경우, 호 설정 시간을 줄임으로서 응용 서비스의 성능을 향상시킬 수 있음을 증명한다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권6호
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• pp.2805-2810
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• 2016

Background: Differentiated thyroid cancer is the most common endocrine malignancy with a generally good prognosis. Knowing long-term outcomes of each patient helps management planning. The study was conducted to develop and validate a clinical prognostic score for predicting disease remission in patients with differentiated thyroid cancer based on patient, tumor and treatment factors. Materials and Methods: A retrospective cohort study of 1,217 differentiated thyroid cancer patients from two tertiary-care hospitals in the Northeast of Thailand was performed. Associations between potential clinical prognostic factors and remission were tested by Cox proportional-hazards analysis in 852 patients (development cohort). The prediction score was created by summation of score points weighted from regression coefficients of independent prognostic factors. Risks of disease remission were estimated and the derived score was then validated in the remaining 365 patients (validation cohort). Results: During the median follow-up time of 58 months, 648 (76.1%) patients in the development cohort had disease remission. Five independent prognostic factors were identified with corresponding score points: duration from thyroid surgery to $^{131}I$ treatment (0.721), distant metastasis at initial diagnosis (0.801), postoperative serum thyroglobulin level (0.535), anti-thyroglobulin antibodies positivity (0.546), and adequacy of serum TSH suppression (0.293). The total risk score for each patient was calculated and three categories of remission probability were proposed: ${\leq}1.628$ points (low risk, 83% remission), 1.629-1.816 points (intermediate risk, 87% remission), and ${\geq}1.817$ points (high risk, 93% remission). The concordance (C-index) was 0.761 (95% CI 0.754-0.767). Conclusions: The clinical prognostic scoring model developed to quantify the probability of disease remission can serve as a useful tool in personalized decision making regarding treatment in differentiated thyroid cancer patients.