• Proceeding of EDISON Challenge
• /
• 2015.03a
• /
• pp.212-216
• /
• 2015

Oseltamivir, also known as Tamifu, is an inhibitor of neuraminidase protein which plays an essential role in proliferation and replication of influenza virus. Binding to the active site of neuraminidase, the oseltamivir prevents the protein from enzyme reaction. Conformational change of the protein(neuraminidase) should be accompanied by the enzyme reaction, but the drug inhibits the protein to deform. In this study, we examine the influence of oseltamivir on protein's conformational change in the structural and mechanical point of view. Finite element analysis of the protein can be an useful approach to investigate the influence of oseltamivir on the deformation of a protein. We suggest the finite element based protein model, and then perform the linear static analysis with the displacement loading condition based on the first two largest motion which can be obtained from the normal mode analysis. The results show that it takes more energy to change shape of the protein with an oseltamivir attached than the protein without an oseltamivir.

• Fibers and Polymers
• /
• v.3 no.3
• /
• pp.120-127
• /
• 2002

Ever since the ideal forming theory has been developed for process design purposes, application has been limited to sheet forming and, for bulk forming, to two-dimensional steady flow. Here, application for the non-steady case was made under the plane-strain condition. In the ideal flow, material elements deform fellowing the minimum plastic work path (or mostly proportional true strain path) so that the ideal plane-strain flow can be effectively described using the two-dimensional orthogonal convective coordinate system. Besides kinematics, schemes to optimize preform shapes for a prescribed final part shape and also to define the evolution of shapes and frictionless boundary tractions were developed. Discussions include numerical calculations made for a real automotive part under forging.

• 한국정보디스플레이학회:학술대회논문집
• /
• 2000.01a
• /
• pp.89-90
• /
• 2000

A new technology realizing interconnection between Plastic Film LCDs panel and a driving circuit was developed under the processing condition of low temperature and pressure with ACFs developed for Plastic Film LCDs. The conduction failure of interconnection of the two resulted from elasticity, low thermal resistance and high thermal expansion of plastic substrates. Conductive particles with elasticity similar to the plastic substrate did not damaged a ITO electrode on plastic substrates, and low temperature and pressure process also did not deform the surface of plastic substrates. As a result highly reliable interconnection with minimum contact resistance was accomplished.

• Proceedings of the Computational Structural Engineering Institute Conference
• /
• 1998.04a
• /
• pp.175-182
• /
• 1998

The object of this study is shape finding and cutting pattern generation of membrane structures under the following assumptions : (1) material is linearly elastic (2) stress state is plane stress. Cable and membrane structures should introduce the nonlinear analysis considering geometric nonlinearity because these structures deform largely under the external loads. The analysis procedure is consisted of three steps considering geometric nonlinearity unlike any other structures. First step is the shape finding analysis to determine the initial equilibrium shape. Second step is the stress-deformation analysis to investigate the behaviors of structures under various external loads. Once a satisfactory shape has been found, a cutting pattern based on the shape finding analysis may be generated from the view point of construction. In this paper, (1) shape finding analysis formulation and an example, (2) cutting pattern determination procedure using weighted least-square minimization flattening method and some results are presented.

• Proceedings of the Computational Structural Engineering Institute Conference
• /
• 1998.10a
• /
• pp.266-273
• /
• 1998

The object of this study is shape finding and cutting pattern generation of membrane structures under the following assumptions: (1) material is linearly elastic (2) stress state is plane stress. Cable and membrane structures should introduce the nonlinear analysis considering geometric nonlinearity because these structures deform largely under the external loads. The analysis procedure is consisted of three steps considering geometric nonlinearity unlike any other structures. First step is the shape finding analysis to determine the initial equilibrium shape. Second step is the stress-deformation analysis to investigate the behaviors of structures under various external loads. Once a satisfactory shape has been found, a cutting pattern based on the shape finding analysis may be generated from the view point of construction. In this paper, after shape finding analysis, cutting pattern determination procedure using weighted least-square minimization flattening method and some results are presented.

• Transactions of Materials Processing
• /
• v.11 no.8
• /
• pp.710-715
• /
• 2002

This paper describes the numerical determination of optimum blank diameter for sound material flow and high precise thread profile of a spindle screw through external thread rolling using two-three roll dies. Initial blank diameter affects the dimensional accuracy and surface finish qualities of a spindle screw in thread rolling process, therefore it is very important to determine the optimum blank diameter in thread rolling process. In order to determine the optimum blank diameter, this paper suggests the calculation method of initial bland diameter considering the real shape of tooth. The finite element code DEFORM is applied to analyze the metal flow of tooth, and these analytical results are verified by thread rolling experiment for spindle screw.

• Transactions of Materials Processing
• /
• v.9 no.2
• /
• pp.152-158
• /
• 2000

A finite element analysis has been performed to investigate the effect of die clearance on shear planes in the fine blanking of a part of automobile safety belt. For the analysis, S45C is selected as an material, which is used in manufacturing the part of automobile safety belt, and Cockcroft-Latham fracture criterion is applied. Effect of die Clearance on die-roll width, die-roll depth, burnish zone, and fracture zone has been investigated in the finite element analysis by a rigid-plastic FEM code, DEFORM-2D. From the analysis, it has been found that die-roll depth and depth of the shear plane increase with increasing die clearance. And the burnish zone decreases with increasing die clearance, but the variation of fracture zone is opposite to that of burnish zone because the increase in die clearance requires less fracture energy. Theoretical predictions are compared with experimental results. There is a good agreement between theory and experiment.

• Proceedings of the Korean Society for Technology of Plasticity Conference
• /
• 2009.05a
• /
• pp.337-340
• /
• 2009

In hot press forming process, the desired high strength can be obtained through quenching process after cold forming of product. The quenching process, however, accompanies undesired distortion due to the volume change during the phase transformation as well as by thermal contraction. In this study the numerical simulation with DEFORM3D-Microstructure is used to predict the deformed shape during the quenching for the quenching fixture design.

• Proceedings of the Korean Society for Technology of Plasticity Conference
• /
• 2009.05a
• /
• pp.129-134
• /
• 2009

The dimension of forged part is different from that of die. Therefore, a more precise die dimension is necessarys to produce the precise part, considering the dimensional changes from forging die to final part. In this paper, both experimental and FEM analysis are performed to investigate the effect of several features including die dimension at each forging step and heat-treatment on final part accuracy in the closed-die upsetting. The dimension of forged part is checked at each stage as machined die, cold forged, and post-heat-treatment steps. The elastic characteristics and thermal influences on forging stage are analyzed numerically by the DEFORM-$2D^{TM}$. The effect of residual stress after heat-treatment on forged part could be considered successfully by using DEFOAM-$HT^{TM}$.

• Transactions of Materials Processing
• /
• v.20 no.4
• /
• pp.291-295
• /
• 2011

The injector housing has two functions, namely, positioning the injector and protecting it from coolant. The conventional manufacturing process of the injector housing by machining has some drawbacks such as considerable loss of material and environmental pollution caused by excessive use of cutting oil. In this paper, precision cold forging is proposed as a new manufacturing process in order to improve these issues. A numerical study was conducted to compute the metal flow, strain, load and other process variables using DEFORM-2D, a finite element analysis(FEA) code for metal forming. Two process methods were investigated and optimal conditions were computed with the FEA code. A prototype was manufactured from the optimal process method and the metal flow and hardness were obtained from the prototype.