• ETRI Journal
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• 제27권6호
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• pp.802-805
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• 2005

A dynamic bandwidth allocation (DBA) scheme, an inter -optical network unit (ONU) bandwidth scheduling, is presented to provide quality of service (QoS) to different classes of packets in Ethernet passive optical networks (EPONs). This scheme, referred to as TADBA, is based on efficient threshold reporting from, and adaptive polling order rearranging of, ONUs. It has been shown that the network resources are efficiently allocated among the three traffic classes by guaranteeing the requested QoS, adaptively rearranging the polling orders, and avoiding nearly all fragmentation losses. Simulation results using an OPNET network simulator show that TADBA performs well in comparison to the available allocation scheme for the given parameters, such as packet delay and channel utilization.

• Nuclear Engineering and Technology
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• 제51권7호
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• pp.1776-1783
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• 2019

To accurately analyze the accidents in nuclear reactors, a thermohydraulic-neutronic coupling calculation is required to solve fluid dynamics and nuclear reactor kinetics equations in fine cells simultaneously and evaluate the local effects of neutronic and thermohydraulic parameters on each other. In the present study, a 3D thermohydraulic-neutronic coupling model is developed, validated and then applied for Isfahan MNSR (Miniature Neutron Source reactor) safety analysis. The proposed model is developed using FLUENT software and user defined functions (UDF) are applied to simulate the neutronic behavior of MNSR. The validation of the proposed model is first evaluated using 1mk reactivity insertion experiment into Isfahan MNSR core. Then, the developed coupling code is applied for a design basis accident (DBA) scenario analysis with the insertion of maximum allowed cold core reactivity of 4 mk. The results show that the proposed model is able to predict the behavior of the reactor core under normal and accident conditions with a good accuracy.

• 한국식품조리과학회:학술대회논문집
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• 한국식품조리과학회 2004년도 학술대회
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• pp.87-87
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• 2004

• 한국통신학회논문지
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• 제28권11A호
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• pp.859-866
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• 2003

본 논문에서는 Ethernet PON에서 서비스 우선 순위를 고려한 상향 채널 대역 할당 기법을 설계하였다. 제안된 대역 할당 기법의 목적은 광 라인 장치인 OLT(Optical Line Termination) 또는 광 단말 장치인 ONU(Optical Network Unit)에서 전송 제어시 서비스의 우선 순위를 고려하도록 하여 차별화 된 전송 품질을 제공하는데 있다. 이를 위하여 OLT 측에 이중 스케줄링 기법을 적용하여 전송 지연에 민감한 서비스에 대해서는 고정 대역 할당기법을, 전송 지연에 덜 민감한 best-effort 서비스에 대해서는 동적 대역 할당 기법을 동시에 제공할 수 있도록 하고, 동적 대역 할당에 의해 허락된 전송 지속 시간 동안 ONU에서 트래픽 특성별로 계층화된 우선 순위를 적용하여 전송을 제어하도록 하였다. 따라서 제안된 전송 제어 알고리즘에 의해 T$_1$, E$_1$등의 고정 대역 서비스와 전용선 서비스, best-effort 서비스 내에서 실시간과 비 실시간 서비스 등을 서비스 특성에 따라 차별화 된 전송 품질로 제공할 수 있다. 본 논문에서는 OPNET을 이용한 모델링과 시뮬레이션 결과를 통해 기존 대역 할당 기법과 제안된 대역 할당 기법의 성능을 비교하였다.

• The Korean Journal of Pain
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• 제21권1호
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• pp.18-26
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• 2008

Background: Because genetic manipulation is commonly accomplished in mice, mouse models for pain have advanced our understanding of the mechanisms of persistent pain. The purpose of this experimental study is to develop a mouse model for understanding incision induced postoperative pain. Methods: A longitudinal incision was made at the hindpaw of male DBA/2 mice. The withdrawal frequency(WF) from applications of von Frey filaments and the response frequency (RF) to blunt mechanical stimulation were examined in an incision group and a control grouP. The withdrawal latency (WL) to radiant heat and a pain score based on weight bearing were also measured. Tests were performed 1 day before incision, and 2 hours, 1-3 days, 5 days and 7 days after incision. Results: The WF for the strongest filament was $35.0{\pm}9.1%$ before incision and this increased to $100.0{\pm}0%$ at 2 hours and to $65.0{\pm}9.1%$ at 7 days after incision. The RF to the blunt stimulus was $4.1{\pm}4.1%$ before incision and $100.0{\pm}0.0%$ at 2 hours and $42.8{\pm}10.8%$ at 7 days after incision. The WL was $6.6{\pm}0.5sec$ before incision and $2.4{\pm}0.3sec$ at 2 hours and $5.9{\pm}0.6sec$ at 7 days after incision. The pain score increased from $1.1{\pm}0.8$ to $7.4{\pm}1.5$ at 2 days after incision. Conclusions: A mouse model of acute postoperative pain was developing by making a surgical incision in the mouse hindpaw. Mechanical hyperalgesia and allodynia lasting for several days demonstrate that this model has similarities to the human post-operative pain state. Future studies will allow us to further investigate the genetic and molecular mechanisms of incisional pain.

• 한국통신학회논문지
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• 제29권11B
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• pp.891-899
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• 2004

높은 대역폭과 이더넷의 저비용 확장성 그리고 망 구성의 효율성 측면에서 장점을 가지고 있는 Ethernet Passive Optical Network (EPON)이 새로운 광 가입자망 기술로써 많은 관심을 받고 있다. EPON 시스템의 상향 링크는 다수의 사용자들에 의하여 공유되기 때문에 사용자들에게 상향 링크의 대역을 효율적으로 할당해 주는 대역할당 방식이 매우 중요한 역할을 하고 있다. 또한 사용자들로부터 요구되는 다양한 서비스 요구사항을 만족시키기 위하여 EPON 시스템에서의 QoS 지원에 대한 연구가 요구되고 있다. 최근 EPON 시스템을 위한 다양한 동적대역할당 방식들이 제안되었으나 사용자들에게 만족스러운 QoS를 지원하기에는 부족하였다. 본 논문에서는 EPON 시스템에서의 QoS 지원과 동시에 동적으로 대역할당이 가능한 가변 윈도우 방식을 제안한다. 기존 방식들의 가장 높은 우선순위 클래스 위주의 QoS 지원 방식과는 다르게 가변 윈도우 방식은 가장 높은 우선순위 클래스의 QoS를 보장하는 동시에 우선순위가 낮은 클래스들에게도 필요시 동적으로 대역을 할당하여 향상된 QoS 성능을 제공할 수 있는 장점이 있다. 성능평가를 통하여 가변 윈도우 방식의 QoS 성능을 기존에 제안된 방식들과 비교 평가하여 그 성능의 우수성을 입증하였다.

• IMMUNE NETWORK
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• 제10권2호
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• pp.46-54
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• 2010

Background: Graft-versus-host disease (GVHD) is initiated when alloreactive donor T cells are primed by host APCs to undergo clonal expansion and maturation. Since there is a controversy regarding the role of nonhematopoietic cells in GVHD, we wanted to investigate the influence of MHC disparity on nonhematopoietic cells on the pathogenesis of GVHD in the MHC-haplomismatched C57BL/6 ($H-2^b$) or DBA/2 $(H-2^b){\rightarrow}$unirradiated ($C57BL/6{\times}DBA/2$) $F_1(BDF_1;\;H-2^{b/d})$ murine model of acute GVHD (aGVHD) or chronic GVHD (cGVHD). Methods: We generated ($BDF_1{\rightarrow}C57BL/6$), ($BDF_1{\rightarrow}DBA/2$), and ($BDF1{\rightarrow}BDF_1$) chimeras and examined GVHD-related parameters and donor cell engraftment in those chimeras. Results: Using this experimental system, we found that 1) severe aGVHD across MHC Ag barrier depends on the expression of nonhematopoietically rather than hematopoietically derived alloAgs for maximal GVHD manifestations; 2) host APCs were sufficient to break B cell tolerance to self molecules in cGVHD, whereas host APCs were insufficient to induce autoimmunity in aGVHD; 3) donor cell engraftment was greatly enhanced in the host with MHC-matched nonhematopoietic cells. Conclusion: Taken together, our results provide an insight into how MHC disparity on GVHD target organs contribute to the pathogenesis of GVHD.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.5287-5290
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• 2012

Throughout human history, plant products have been used for many purposes including as medicines. Herbal products and spices can be used as preventive agents against cancer due to their antimicrobial, antioxidant and antitumorigenic properties. This study was designed to evaluate the potential protective effect of curcum in rats administered nitrosamine precursors; dibutylamine (DBA) and sodium nitrate (NaNO3); and infected with Escherichia coli (E. coli) and also to monitor changes in nuclear factor the Kappa B p65 (NF-${\kappa}B$ p56) pathway and its downstream products, Bcl-2 and interleukin-6 (IL-6), in parallel with nitrosamine precursors, E. coli and curcum treatment. Rats were divided into three groups (n=25 each; except of control group, n+20). Group I a normal control group, group II administered DBA/NaNO3 in drinking water and infected with E. coli and group III was administered DBA/NaNO3 in drinking water, infected with E. coli and receiving standard diet containing 1% curcum powder. Histopathological examination reflected that the curcum treated group featured a lower incidence of urinary bladder lesions, and lower levels of NF-${\kappa}B$, Bcl-2 and IL-6, than the group receiving nitrosamine precursor and infected with E. coli. These findings suggested that curcum may have a protective role during the process of bladder carcinogenesis by inhibiting the NF-${\kappa}B$ pathway and its downstream products.

• Biomolecules & Therapeutics
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• 제21권4호
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• pp.290-298
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• 2013

This study examined the effects of calcium (Ca) gluconate on collagen-induced DBA mouse rheumatoid arthritis (CIA). A single daily dose of 200, 100 or 50 mg/kg Ca gluconate was administered orally to male DBA/1J mice for 40 days after initial collagen immunization. To ascertain the effects administering the collagen booster, CIA-related features (including body weight, poly-arthritis, knee and paw thickness, and paw weight increase) were measured from histopathological changes in the spleen, left popliteal lymph node, third digit and the knee joint regions. CIA-related bone and cartilage damage improved significantly in the Ca gluconate-administered CIA mice. Additionally, myeloperoxidase (MPO) levels in the paw were reduced in Ca gluconate-treated CIA mice compared to CIA control groups. The level of malondialdehyde (MDA), an indicator of oxidative stress, decreased in a dose-dependent manner in the Ca gluconate group. Finally, the production of IL-6 and TNF-${\alpha}$, involved in rheumatoid arthritis pathogenesis, were suppressed by treatment with Ca gluconate. Taken together, these results suggest that Ca gluconate is a promising candidate anti-rheumatoid arthritis agent, exerting anti-inflammatory, anti-oxidative and immunomodulatory effects in CIA mice.

• 동의생리병리학회지
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• 제24권3호
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• pp.490-503
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• 2010

This study was carried out to know the effects of Gwanjul9-bang (hereinafter reffered to GJ9) on the inhibition of arthritis induced by collagen on DBA/1J mouse. For this purpose, GJ9 was orally administered to mouse with arthritis induced by collagen II. Cytotoxicity, hepatotoxicity, arthritis index, value of immunocyte in draining lymph node and paw joint, rheumatoid factor (IgG, IgM) in serum were measured in vivo. The cytotoxicity against hFCs was not measured in any concentration. The hepatotoxicity was low in GJ9 treated group compared with MTX group. The arthritis index was decreased significantly. In total cell counts of DLN and paw joint, the cells in DLN increased significantly while there was significantly decrease in paw joint. In lymph nodes, $CD19^+$, $CD3^+$, $CD4^+$, $CD3^+CD69^+$, $CD8^+$, $CD4^+CD25^+$, $CD3^+CD49b^+$, $CD4^+CD44^+$, $CD3^+CD8^+$ cells increased significantly, $B220^+CD23^+$cells decreased significantly. In joints, $CD3^+$, $CD4^+$, $CD4^+CD25^+$, $CD11b^+Gr-1^+$ cells decreased significantly. The levels of IgG and IgM was significantly decreased compared with control. Anti-collagen II in serum was significantly decreased compared with control. The degree of arthritis induced damage of joint of GJ9 group is slight compared with control group in histopathologic observation (Hematoxylin & Eosin, Masson's Trichrome). Comparison of the results for this study showed that GJ9 had immunomodulatory effects. So we expect that GJ9 should be used as a effective drugs for not only rheumatoid arthritis but also another auto-immune disease. Therefore we have to survey continuously in looking for the effective substance and mechanism in the future.