Browse > Article
http://dx.doi.org/10.4062/biomolther.2013.040

Effects of Calcium Gluconate, a Water Soluble Calcium Salt on the Collagen-Induced DBA/1J Mice Rheumatoid Arthritis  

Sohn, Ki Cheul (Department of Preventive Medicine, School of Medicine, Catholic University of Daegu)
Kang, Su Jin (The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University)
Kim, Joo Wan (Glucan Corporation and Marine Bio-Industry Development Center)
Kim, Ki Young (Glucan Corporation and Marine Bio-Industry Development Center)
Ku, Sae Kwang (The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University)
Lee, Young Joon (The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University)
Publication Information
Biomolecules & Therapeutics / v.21, no.4, 2013 , pp. 290-298 More about this Journal
Abstract
This study examined the effects of calcium (Ca) gluconate on collagen-induced DBA mouse rheumatoid arthritis (CIA). A single daily dose of 200, 100 or 50 mg/kg Ca gluconate was administered orally to male DBA/1J mice for 40 days after initial collagen immunization. To ascertain the effects administering the collagen booster, CIA-related features (including body weight, poly-arthritis, knee and paw thickness, and paw weight increase) were measured from histopathological changes in the spleen, left popliteal lymph node, third digit and the knee joint regions. CIA-related bone and cartilage damage improved significantly in the Ca gluconate-administered CIA mice. Additionally, myeloperoxidase (MPO) levels in the paw were reduced in Ca gluconate-treated CIA mice compared to CIA control groups. The level of malondialdehyde (MDA), an indicator of oxidative stress, decreased in a dose-dependent manner in the Ca gluconate group. Finally, the production of IL-6 and TNF-${\alpha}$, involved in rheumatoid arthritis pathogenesis, were suppressed by treatment with Ca gluconate. Taken together, these results suggest that Ca gluconate is a promising candidate anti-rheumatoid arthritis agent, exerting anti-inflammatory, anti-oxidative and immunomodulatory effects in CIA mice.
Keywords
Calcium gluconate; Rheumatoid arthritis; Anti-inflammation; Anti-oxidation; Immunomodulation;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Bae, S. C., Kim, S. J. and Sung, M. K. (2003) Inadequate antioxidant nutrient intake and altered plasma antioxidant status of rheumatoid arthritis patients. J. Am. Coll. Nutr. 22, 311-315.   DOI
2 Binder, L. S. (1989) Acute arthropod envenomation. Incidence, clinical features and management. Med. Toxicol. Adverse Drug Exp. 4, 163-173.   DOI
3 Bracken, W. M., Cuppage, F., McLaury, R. L., Kirwin, C. and Klaassen, C. D. (1985) Comparative effectiveness of topical treatments for hydrofl uoric acid burns. J. Occup. Med. 27, 733-739.
4 Brahn, E., Banquerigo, M. L., Firestein, G. S., Boyle, D. L., Salzman, A. L. and Szabo, C. (1998) Collagen induced arthritis: reversal by mercaptoethylguanidine, a novel antiinfl ammatory agent with a combined mechanism of action. J. Rheumatol. 25, 1785-1793.
5 Cavallini, M., de Boccard, F., Corsi, M. M., Fassati, L. R. and Baruffaldi Preis, F. W. (2004) Serum pro-infl ammatory cytokines and chemi-cal acid burns in rats. Ann. Burns Fire Disasters 17, 84-87.
6 Cho, M. L., Heo, Y. J., Park, M. K., Oh, H. J., Park, J. S., Woo, Y. J., Ju, J. H., Park, S. H., Kim, H. Y. and Min, J. K. (2009) Grape seed proanthocyanidin extract (GSPE) attenuates collagen-induced arthritis. Immunol. Lett. 124, 102-110.   DOI   ScienceOn
7 Drabikova, K., Perecko, T., Nosal, R., Bauerova, K., Ponist, S., Mihalova, D., Kogan, G. and Jancinova, V. (2009) Glucomannan reduces neutrophil free radical production in vitro and in rats with adjuvant arthritis. Pharmacol. Res. 59, 399-403.   DOI   ScienceOn
8 Feldmann, M., Brennan, F. M. and Maini, R. N. (1996a) Rheumatoid arthritis. Cell 85, 307-310.   DOI   ScienceOn
9 Feldmann, M., Brennan, F. M. and Maini, R. N. (1996b) Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14, 397-440.   DOI   ScienceOn
10 Filippin, L. I., Vercelino, R., Marroni, N. P. and Xavier, R. M. (2008) Redox signalling and the infl ammatory response in rheumatoid arthritis. Clin. Exp. Immunol. 152, 415-422.   DOI   ScienceOn
11 Frolova, O. A. and Isakova, V. I. (1990) [The therapeutic effect of a biogenic paste in experimental chronic periodontitis]. Stomatologiia (Mosk) 69, 20-22.
12 Isaacs, A. (1995) Lymphokines and Cytokines. In Immunology an introduction (I. R. Tizard, Ed.), pp. 155-169. Saunders College Pub., Philadelphia.
13 Iseri, S. O., Sener, G., Yuksel, M., Contuk, G., Cetinel, S., Gedik, N. and Yegen, B. C. (2005) Ghrelin against alendronate-induced gastric damage in rats. J. Endocrinol. 187, 399-406.   DOI   ScienceOn
14 Ishikaw, J., Okada, Y., Bird, I. N., Jasani, B., Spragg, J. H. and Yamada, T. (2002) Use of anti-platelet-endothelial cell adhesion molecule-1 antibody in the control of disease progression in established collagen-induced arthritis in DBA/1J mice. Jpn. J. Pharmacol. 88, 332-340.   DOI   ScienceOn
15 Karnad, A. S., Patil, P. A. and Majagi, S. I. (2006) Calcium enhances anti-infl ammatory activity of aspirin in albino rats. Indian J. Pharmacol. 38, 397-402.   DOI
16 Liaudet, L., Mabley, J. G., Pacher, P., Virag, L., Soriano, F. G., Marton, A., Hasko, G., Deitch, E. A. and Szabo, C. (2002) Inosine exerts a broad range of antiinfl ammatory effects in a murine model of acute lung injury. Ann. Surg. 235, 568-578.   DOI   ScienceOn
17 Larsen, C., Ostergaard, J., Larsen, S. W., Jensen, H., Jacobsen, S., Lindegaard, C. and Andersen, P. H. (2008) Intra-articular depot formulation principles: role in the management of postoperative pain and arthritic disorders. J. Pharm. Sci. 97, 4622-4654.   DOI   ScienceOn
18 Lee, H. S. and Ku, S. K. (2008) Effects of Picrorrhiza Rhizoma on acute infl ammation in mice. Biomol. Ther. 16, 137-140.   DOI   ScienceOn
19 Lee, Y. C., Kim, S. H., Roh, S. S., Choi, H. Y. and Seo, Y. B. (2007) Suppressive effects of Chelidonium majus methanol extract in knee joint, regional lymph nodes, and spleen on collagen-induced arthritis in mice. J. Ethnopharmacol. 112, 40-48.   DOI   ScienceOn
20 Mabley, J. G., Liaudet, L., Pacher, P., Southan, G. J., Groves, J. T., Salzman, A. L. and Szabo, C. (2002) Part II: benefi cial effects of the peroxynitrite decomposition catalyst FP15 in murine models of arthritis and colitis. Mol. Med. 8, 581-590.
21 Nagatomo, F., Gu, N., Fujino, H., Okiura, T., Morimatsu, F., Takeda, I. and Ishihara, A. (2010) Effects of exposure to hyperbaric oxygen on oxidative stress in rats with type II collagen-induced arthritis. Clin. Exp. Med. 10, 7-13.   DOI
22 Nandakumar, K. S. and Holmdahl, R. (2006) Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis. Arthritis Res. Ther. 8, 223.   DOI   ScienceOn
23 Newbould, B. B. (1964) Lymphatic drainage and adjuvant-induced arthritis in rats. Br. J. Exp. Pathol. 45, 375-383.
24 Ono, Y., Inoue, M., Mizukami, H. and Ogihara, Y. (2004) Suppressive effect of Kanzo-bushi-to, a Kampo medicine, on collagen-induced arthritis. Biol. Pharm. Bull. 27, 1406-1413.   DOI   ScienceOn
25 Slifman, N. R., Gershon, S. K., Lee, J. H., Edwards, E. T. and Braun, M. M. (2003) Listeria monocytogenes infection as a complication of treatment with tumor necrosis factor alpha-neutralizing agents. Arthritis Rheum. 48, 319-324.   DOI   ScienceOn
26 Samira, S., Ferrand, C., Peled, A., Nagler, A., Tovbin, Y., Ben-Hur, H., Taylor, N., Globerson, A. and Lapidot, T. (2004) Tumor necrosis factor promotes human T-cell development in nonobese diabetic/severe combined immunodefi cient mice. Stem. Cells 22, 1085-1100.   DOI   ScienceOn
27 Sethi, G., Sung, B., Kunnumakkara, A. B. and Aggarwal, B. B. (2009) Targeting TNF for treatment of cancer and autoimmunity. Adv. Exp. Med. Biol. 647, 37-51.   DOI   ScienceOn
28 Shahnazari, M., Martin, B. R., Legette, L. L., Lachcik, P. J., Welch, J. and Weaver, C. M. (2009) Diet calcium level but not calcium supplement particle size affects bone density and mechanical properties in ovariectomized rats. J. Nutr. 139, 1308-1314.   DOI   ScienceOn
29 Smith, M. M., Ghosh, P., Numata, Y. and Bansal, M. K. (1994) The effects of orally administered calcium pentosan polysulfate on infl ammation and cartilage degradation produced in rabbit joints by intraarticular injection of a hyaluronate-polylysine complex. Arthritis Rheum. 37, 125-136.   DOI   ScienceOn
30 Sollmann, T. (1942) Manual of pharmacology and its applications to therapeutics and toxicology. WB Saunders Co., Philadelphia.
31 Sullivan, G. W., Sarembock, I. J. and Linden, J. (2000) The role of infl ammation in vascular diseases. J. Leukoc. Biol. 67, 591-602.   DOI
32 Trentham, D. E., Townes, A. S. and Kang, A. H. (1977) Autoimmunity to type II collagen an experimental model of arthritis. J. Exp. Med. 146, 857-868.   DOI   ScienceOn
33 Van Snick, J. (1990) Interleukin-6: an overview. Annu. Rev. Immunol. 8, 253-278.   DOI   ScienceOn
34 Zhu, P., Li, X. Y., Wang, H. K., Jia, J. F., Zheng, Z. H., Ding, J. and Fan, C. M. (2007) Oral administration of type-II collagen peptide 250-270 suppresses specifi c cellular and humoral immune response in collagen-induced arthritis. Clin. Immunol. 122, 75-84.   DOI   ScienceOn
35 Whiting, S. J. and Pluhator, M. M. (1992) Comparison of in vitro and in vivo tests for determination of availability of calcium from calcium carbonate tablets. J. Am. Coll. Nutr. 11, 553-560.   DOI
36 Wolfe, F. and Hawley, D. J. (1998) The longterm outcomes of rheumatoid arthritis: Work disability: a prospective 18 year study of 823 patients. J. Rheumatol. 25, 2108-2117.
37 Yoon, H. S., Kim, J. W., Cho, H. R., Moon, S. B., Shin, H. D., Yang, K. J., Lee, H. S., Kwon, Y. S. and Ku, S. K. (2010) Immunomodulatory effects of Aureobasidium pullulans SM-2001 exopolymers on the cyclophosphamide-treated mice. J. Microbiol. Biotechnol. 20, 438-445.
38 Zimmerman, B. J., Grisham, M. B. and Granger, D. N. (1990) Role of oxidants in ischemia/reperfusion-induced granulocyte infi ltration. Am. J. Physiol. 258, G185-190.   DOI
39 Zimmerman, D. H., Taylor, P., Bendele, A., Carambula, R., Duzant, Y., Lowe, V., O'Neill, S. P., Talor, E. and Rosenthal, K. S. (2010) CEL-2000: A therapeutic vaccine for rheumatoid arthritis arrests disease development and alters serum cytokine/chemokine patterns in the bovine collagen type II induced arthritis in the DBA mouse model. Int. Immunopharmacol. 10, 412-421.   DOI   ScienceOn