• Journal of Acupuncture Research
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• 제23권2호
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• pp.125-137
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• 2006

Objectives : The effect of water extract of the pilose antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe (Nokyong), a traditional immuno-suppressive and immuno-activating Korean oriental medicine, on collagen-induced arthritis (CIA) mice model was studied. Identification of common Nokyong capable of affording protection or modulating the onset and severity of arthritis may have important human health implications. Methods : Nokyong has shown to possess anti-inflammatory and anticarcinogenic properties in experimental animals. In this study we determined the effect of DAE on collagen-induced arthritis in mice. Results : In three independent experiments mice given DAE in water exhibited significantly reduced incidence of arthritis (33% to 50%) as compared with mice given no DAE in water (84% to 100%). The arthritis index also was significantly lower in DAE-fed animals. Western blot analysis showed a marked reduction in the expression of inflammatory mediators such as cyclooxygenase 2 (Cox-2), $Interferon-{\gamma}\;(INF-{\gamma})$, and tumor necrosis factor ${\alpha}\;(TNF-{\alpha})$ in arthritic joints of DAE-fed mice. The neutral endopeptidase (NEP) activity was approximately 6-fold higher in arthritic joints of non-DAE-fed mice in comparison to nonarthritic joints of nonimmunized mice whereas it was only 2-fold higher in the arthritic joints of DAE-fed mice. Additionally, total IgG and type II collagen-specific IgG levels were lower in the arthritic joints of DAE-fed mice. Conclusion : Taken together our studies suggest that DAE may be useful in the prevention of onset and severity of arthritis.

• 멤브레인
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• 제23권6호
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• pp.450-459
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• 2013

폴리이미드 기체 분리막의 기체 분리 성능을 향상시키기 위해서 2,3,5,6-Tetramethyl-1,4-phenylenediamine(TMPD) 구조를 지닌 폴리이미드를 1,2-Diaminoethane (DAE)과 1,6-Diaminohexane (DAH)으로 가교시켜 분리막을 제조하였다. Fourier transform infrared spectroscopy (FT-IR)를 이용해 가교 후 이미드 고리가 아미드 그룹으로 전환됨을 확인하였다. 폴리이미드의 열분해 온도는 가교 후 감소하였으며, 이는 가교제의 알킬기 분해 때문이다. 가교된 폴리이미드 분리막의 d-spacing은 가교 시간이 증가함에 따라 감소하였다. 가교 후 $CH_4$, $N_2$, $O_2$, $CO_2$ 기체의 투과도는 가교 전 보다 감소하였으며, DAH로 가교된 분리막이 DAE보다 더 높은 투과도를 나타냈다. 투과도와 달리 $CO_2/CH_4$, $CO_2/N_2$, $O_2/N_2$ 기체 선택도 모두 가교 시간이 길어질수록 증가된 결과가 나타났다. $CO_2/CH_4$ 기체의 선택도는 DAE로 6분 가교 시 최대 증가치를 나타냈으며 39.5%까지 증가하였다. $O_2/N_2$ 선택도 또한 DAE로 6분 가교 시 최대 증가치를 가지며 20.5%까지 증가하였다. 이를 통해서 DAE가 DAH보다 선택도 증가에 적합한 가교제임을 예상할 수 있으며 이와 달리 $CO_2/N_2$ 선택도는 DAE로 3분 가교 시 감소해 $CO_2/N_2$ 분리에는 적합하지 않은 결과가 나타났다.

• 한국실내디자인학회:학술대회논문집
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• 한국실내디자인학회 2004년도 춘계학술발표대회 논문집
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• pp.106-111
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• 2004

The purpose of this study is finding the spatial character for autogenous space design through the violation of Nam-dae-mun market. The violation is defined as the possession of space in excess of one's property. In Nam-dae-mun market, the violation is sanctioned by usage. Through the violation, Nam-dae-mun market naturally acquires autogenous energy and pliability. According to three steps, this research proceed. 1. To investigate the limitation of modern architecture and the meaning of the violation. 2. To research the present condition of Nam-dae-mun market and the process of spatial formation. 3. To compare 'F' building in Nam-dae-mun with Sam-ik fashion building which was redeveloped.

• 한국산학기술학회:학술대회논문집
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• 한국산학기술학회 2012년도 춘계학술논문집 2부
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• pp.769-771
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• 2012

기존의 수압측정기와 다르게 물을 좌 우로 보내고 밸브를 수평 수직으로 변환할 수 있으며 컨트롤러를 장착하여 압력을 조절할 수 있는 새로운 방식의 밸브 수압측정기를 개발하였다. 신모델 밸브 수압측정기는 CATIA를 활용하여 모델링하였다. 또한 신모델 밸브 수압측정기의 유동해석은 유한요소해석 코드인 ANSYS를 활용하여 물의 속도, 물의 흐름을 구하였다.

• 한국산학기술학회:학술대회논문집
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• 한국산학기술학회 2012년도 춘계학술논문집 2부
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• pp.765-768
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• 2012

기존의 수압측정기와 다르게 물을 좌 우로 보내고 밸브를 수평 수직으로 변환할 수 있으며 컨트롤러를 장착하여 압력을 조절할 수 있는 신모델 밸브 수압측정기를 개발하였다. 신모델 밸브 수압측정기는 CATIA를 활용하여 모델링하였다. 또한 신모델 밸브 수압측정기의 구조해석은 유한요소해석 코드인 ANSYS를 활용하여 내부압력에 따른 누수, 응력, 변형률, 변형량을 구하였다.

• Journal of Astronomy and Space Sciences
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• 제30권4호
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• pp.299-305
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• 2013

Ganui-Dae, built in the reign of King Sejong, Joseon Dynasty, is a comprehensive observatory. It has various instruments for observation and time signal such as Ganui, Gyupyo(Gnomon), water-hammering type Honui and Honsang, and so on. Studying on Ganui-Dae has been focused on its location, history, criterion, etc, so far. However, studying on its external form and construction method has been conducted insufficiently. This study suggests the model for restoration of Ganui-Dae. The model is based on the analysis about external form of Ganui-Dae in various antique maps, and its construction method in those days.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.237.2-237.2
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• 2003

DWP40458 is a novel human thrombopoietin mutein with two additional N-linked glycosylation site. The thermal stability of DWP40458 in both solution and lyophilized form was studied in the temperature range of 4-50$^{\circ}C$, compared with recombinant human TPO (rhTPO). When the aggregation or degradation pattern of DWP40458 and rhTPO solution was characterized by using SDS-PAGE, gel permeation chromatography (GPC) and reverse phase HPLC, it was found that thermostability of DWP40458 was significantly different to rhTPO in the temperature at 25, 40, 40, 50$^{\circ}C$. (omitted)

• Journal of Acupuncture Research
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• 제20권6호
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• pp.140-147
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• 2003

Objective: This study was designed to investigate the difference of treatment effect between Oriental Medicine theraphy and Oriental and Western Medicine combination theraphy on low back pain patients. Methods: We divided 40 low back pain patients into 2 groups. The Group I was treated with Oriental Medicine theraphy and the Group II was treated with Oriental and Western Medicine combination theraphy. We evaluated visual analogue scale(VAS) score before and after 3, 5, 7 days of each treatment. Results: The VAS score of Group I and Group II after 3, 5, 7 days of each treatment was significantly lower than before treatment. But there was no significant difference between two groups after 3, 5, 7 days of each treatment. Conclusions: In this study, there was no significant difference between the two groups after 3, 5, 7 days of each treatment on low back pain patients. Further studies are needed for the comparison of Oriental Medicine theraphy and Oriental and Western Medicine combination theraphy.

• Journal of Acupuncture Research
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• 제20권6호
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• pp.201-209
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• 2003

Objective : Recently, Seguele of Traffic Accident patients are increasing, especially cervical injury bring only severe sequela but also mortal damage to the patient. In treatment of the disease, the east medical treatment is another effective method. Methods : The patient resisted the west theraphy improved greatly in movement and sensation by acupuncture, moxibustion, herb medication and Physical treatment. In MRI, The treatment result is proved. Acupuncture on Stomach Meridian(足陽明胃經) referring to Naijing(內經) is thought effective. Results : Tetraplegia by Traffic Accident is considered as Wei Symptom in term of the east medicine, By means of radial and physical study of the patient treated by the east medicine, we are conviced that the east medicine is the excellent method Conclusions : Referring to the past documentary data, The only Treatment on this disease is Surgical operation, but the operation isn't the successful one because seg. of spinal cord injury is mortal. The east treatment, acupuncture, moxibustion herb medication and physical treatment isn't only effective but also satisfactory. In the future, The study on this disease by the east medicine should be made thoroughly.

• 대한한방내과학회지
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• 제36권3호
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• pp.419-426
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• 2015

Objectives This study reports three cases of pressure ulcer treated with Hwangryunhaedok-tang pharmacopuncture. Methods Three patients with pressure ulcers were treated by Hwangryunhaedok-tang pharmacopuncture and Jaungo at the Oriental Medicine Hospital of Daejeon University. Hwangryunhaedok-tang pharmacopuncture and Jaungo was administrated once a day with simple dressing. Thereafter, we observed the pressure ulcers macroscopically. Results and Conclusions After 3 weeks, wound sizes were reduced and tissue regeneration was accelerated. In conclusion, Hwangryunhaedok-tang pharmacopuncture and Jaungo are effective to treat pressure ulcers, but more studies will be required to validate its use in pressure ulcers.