• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.11
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• pp.2027-2031
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• 2007

Recently the diffusion of the advancement of mobile communication technique and mobile terminal increased, The users were demanded seamless services when carrying and moving. It proposed the FMIPv6(Fast Handoff for Mobile IPv6) from the IETF like this meeting this requirement. The handover procedure of the FMIPv6 causes to defecate with movement detection, new CoA configuration and binding update. But, the delay occurs from each process, when the DAD(Duplicate Address Detection) of the CoA executing, the big delay occurs. This paper proposes a scheme of delay reduction, it omits DAD process and stores in the AR(Access Router) relates in the CoA of the mobile terminal information.

• Water for future
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• v.7 no.2
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• pp.92-98
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• 1974

The DAD for Nakdong River Basin is studied on the basis of qselected storms (1916~1970) by WMO Standard method. The maximum DAD BAlue for a storm period of 24hrs assuming that the basin area is estimated as about $2,500\textrm{km}^2$ comes out to be 153mm. The investigation appears to be supporting a conclusion that the Horton's formula is also applicable to this basin.

• Korean Journal of Clinical Pharmacy
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• v.3 no.1
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• pp.79-88
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• 1993

Bioequivalence(BE) test of commercially available sustained release tablets of diltiazem hydrochloride(DTZ) was performed to give some guidelines to BE test in korea in case of which drugs with low oral bioavaiiability(BA) due to substantial first-pass hepatic loss form pharmacologically active metabolites. In such cases, the pharmacologic activity after oral administration is greater than anticipated from BA data, based on chemical assay of drug alone. Therefore, this paper explores the use and meaning of area under the plasma concentration-time(AUC) data of parent and its metabolites to access BA if sustained release tablets. Normal healthy male volunteers(n=14) were randomly divided into 2 groups, and sustained release reference$(Herbesser^{(R)})$ and test$(Herben^{(R)})$ tablets of DTZ-30mg were given orally by balanced two-period cross-over dosing schedule. The plasma concentration of DTZ and and its active metabolite, desacetyldiitiazem(DAD), were determined by high performance liquid chromatography, and, $AUC_{DTZ},\;AUC_{DAD},\;AUC_{DTZ+DAD},\;C_{max}\;and\;T_{max}$ obtained. Analysis of varlance(ANOVA) showed that $AUC_{DTZ}\;and\;C_{max}$ passed the standard $(\alpha=0.05,\;1-\beta\geq0.8,\;\Delta\leq0.2)$ of BE test of korea, but $AUC_{DAD}$ was not satisfied from the standpoint of power. On the other hand, $AUC_{DTZ\midDAD}$ may be more avaliable than $AUC_{DAD}$ from the standpoint of statistics and pharmacologic equivalence.

• Analytical Science and Technology
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• v.33 no.3
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• pp.115-124
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• 2020

Marker pens belong to school things that are controlled by the regulation system called safety confirmation under special act on the safety of products for children with the formaldehyde criteria of 20 mg/kg. With nine marker pens available commercially, formaldehyde in marker pen ink was analyzed by present test standard where marking on a fabric swatch with a pen and extracting the swatch in water and derivatization with Nash reagent followed by UV/Vis spectrophotometeric measurement (Nash-UV/Vis method), giving not detected results or a false positive result in case of a colored water extract. However, the contents of formaldehyde in ink of nine marker pens were determinded to range between 3.2 ~ 93.2 mg/kg with three results above the safety criteria of 20 mg/kg by HPLC/DAD measurements on DNPH derivatives of formaldehyde (DNPH-HPLC/DAD method) in ink dissolved directly in water using an ultrasonic bath. Therefore, the DNPH-HPLC/DAD method with the extraction of ultrasonic dissolving ink in water is proposed as a proper method for analyzing formaldehyde in ink. The proposed method has advantages of lower detection limit and accuracy with colored extracts as well as a simple and fast extraction. The accuracy and precision of this method was estimated to be 90.1 ~ 105.4 % and 0.6 ~ 3.3 %, respectively by spiking tests in the ranges of 20 mg/kg and 40 mg/kg using matrixes such as highlighter pen ink, board marker ink, chalk marker pen ink and painter marker ink.

• Journal of Life Science
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• v.21 no.7
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• pp.1046-1051
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• 2011

Diallyl disulfide (DADS), the most prevalent oil-soluble organosulfur compound in garlic, is known to have diverse biological activities, including anticarcinogenic, antiatherosclerotic, antiinflammatory, and antioxidant actions. In this study, we investigated the effect of DADS on the expression of heme oxygenase-1 (HO-1) in human liver hepatoma cell line HepG2. Treatment of HepG2 cells by DADS evoked a dose-dependent growth inhibition without significant toxicity to the cells, and also induced the expression of transcription factor Nrf2. However, DADS did not have any enhancing effect on transcription and translation of HO-1 expression in HepG2 cells. In addition, DADS efficiently blocked protein synthesis of HO-1 in HepG2 cells stimulated by CoPP or hemin. But, DADS did not decrease the content of transcripts of HO-1 gene stimulated by CoPP, with accumulation of Nrf2 and small Maf in the nucleus. Based on these results, we conclude that DADS inhibits HO-1 expression by modulation of translational level of CoPP or hemin-induced HO-1 expression in HepG2 cells.

• Korean Journal of Pharmacognosy
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• v.45 no.4
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• pp.294-299
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• 2014

The simultaneous determination of platyphylloside, aceroside and betulin was established for the quality control of Betula platyphylla bark using a high performance liquid chromatography and diode-array UV/Vis detector (HPLC-DAD). Separation and quantification were successfully achieved with a INNO C18 column ($5{\mu}m$, 4.6 mm $I.D.{\times}150mm$) by gradient elution of a mixture of methanol and water at a flow rate of 1.0 ml/min. Validation of the developed method was performed by various factor such as linearity, specificity, precision, accuracy, system suitability and stability. This method was successfully applied to the determination of contents of platyphylloside, aceroside VIII and betulin in three batches of Betula platyphylla bark extract. These results suggest that the developed HPLC method is simple, effective and could be utilized as a quality control method for Betula platyphylla bark products.

• Archives of Pharmacal Research
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• v.24 no.4
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• pp.333-337
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• 2001

The pharmacokinetic changes of diltiazem (DTZ) and its main metabolite, deacetyldiltiazem (DAD) were studied after oral administration of DTZ to normal rabbits and mild and medium folate-induced renal failure rabbits. DTZ 10 mg/kg was given to the rabbits either orally (n=6). Plasma concentrations of DTZ and DAD were determined by a high performance liquid chromatography assay. The area under the plasma concentration-time curves (AUC) and maximum plasma concentration ($C_{max}$) of DTZ were significantly increased in mild and medium folate-induced renal failure rabbits. The metabolite ratio of the DTZ to DAD were significantly decreased in mild and medium folate-induced renal failure rabbits. The volume of distribution ($V_{d}$) and total body clearance ($CL_{t}$) of DTZ were significantly decreased in mild and medium folate-induced renal failure rabbits. The elimination rate constant ($\beta$) of DTZ was significantly decreased in folate-induced renal failure rabbits, but that of DAD was significantly increased. These findings suggest that the hepatic metabolism of DTZ was inhibited and the $V_{d}$, $CL_{t}$ and $\beta$ of DTZ were significantly decreased in mild and medium folate-induced renal failure rabbits.

• Proceedings of the Korea Information Processing Society Conference
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• 2007.11a
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• pp.978-981
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• 2007

TCP(Transmission Control Protocol)는 흐름제어와 오류제어 그리고 혼잡제어 등을 통해 목적지까지 효율적으로 데이터를 전송하는 프로토콜이다. 최근 라우터 성능 및 라우팅 알고리즘 등의 발달로 인해 패킷이 비순차적으로 전송되는 패킷 재배치(packet reordering)가 빈번한 발생하여 TCP 성능 저하의 주요 원인이 되고 있다. 패킷 재배치가 TCP 로 하여금 불필요한 재전송(Spurious Retransmission) 및 혼잡제어를 수행하도록 하기 때문이다. 본 논문에서는 TCP 의 신속 재전송(Fast Retransmission)의 중복 응답 임계값(dupthresh)를 동적으로 조절함으로써, 불필요한 재전송 및 혼잡제어의 발생횟수를 효율적으로 줄이는 TCP-DAD(TCP Dynamically Adjusted Dupthresh)기법을 제안한다. 본 논문은 NS-2를 이용한 시뮬레이션을 통해 TCP-DAD 가 다른 TCP 메커니즘보다 평균적으로 약 34%의 성능 향상을 보임을 증명하였다.

• Journal of Korea Society of Industrial Information Systems
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• v.15 no.3
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• pp.11-21
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• 2010

Increase in the number of sensor nodes in sensor networks and sensor node to automatically assign addresses are needed. The method developed to address existing severe wasting, coordinators have all address information, each sensor node when addressing the shortcomings are a lot of traffic. In this paper, 6LoWPAN automatically from the sensor nodes capable of efficiently addressing Hop-Count based hierarchical address allocation algorithm is proposed. How to propose a hop-count of divided areas are separated, with no overlap and can be assigned a unique address, DAD(Duplicate Address Detection) reduced area. Perform DAD to reduce traffic, packet transmission in the IP header destination address, respectively, with a minimum 32-bit compression and packet transmission over a non-compression method to reduce the number of 11.1%.

• Proceedings of the Korea Information Processing Society Conference
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• 2009.04a
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• pp.1348-1351
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• 2009

패킷 재배치(packet reodering)는 전송한 패킷의 순서가 처음과 다르게 뒤섞여 수신지에 도착하는 현상을 의미한다. 패킷 재배치는 불필요한 재전송이나 불필요한 혼잡 제어를 수행하여 TCP의 성능을 저하시킨다. 패킷 재배치에 의한 TCP 성능 저하를 막기 위해 다양한 접근 방법이 소개되었다. TCP-DAD는 기존 TCP에서 3으로 고정된 중복 응답 임계값을 동적으로 조절하여, 잘못된 혼잡 제어를 예방하고 있다. 일반적으로 전송한 패킷의 수가 많을 때, 패킷 재배치를 경험할 확률이 높으며, 패킷 재배치에 의해 잘못된 혼잡 제어가 일어날 가능성 많다. 고속 네트워크 환경에서는 혼잡 윈도우 크기 변화의 폭이 매우 크다는 점을 고려할 때, 중복 응답 임계값을 조절하는 TCP-DAD는 한계가 있다. 본 논문에서는 고속 네트워크 환경에서의 패킷 재배치 현상으로 인한 TCP 성능저하를 완화하기 위한 새로운 알고리즘 TCP-DT를 소개한다. 이는 중복 응답 수에 의존하지 않고 타이머를 통해 혼잡 제어를 수행하는 메커니즘 이다. 본 논문은 NS-2를 사용하여 고속 네트워크 환경에서의 시뮬레이션을 통해 제안한 TCP-DT의 성능 향상을 증명하였다.