• Title/Summary/Keyword: D314

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Synthesis and Antitumor Evaluation of 3-(2-Chloroethyl)-hydantoins from Some Amino Acids (아미노산으로부터 3-(2-Chloroethyl) hydantoin들의 합성과 그들의 항암작용 평가)

  • 김정균;윤이규;고영심;윤웅찬;박무영;문경호
    • YAKHAK HOEJI
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    • v.27 no.4
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    • pp.309-314
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    • 1983
  • Six hydantoin derivatives, 3-(2-chloroethyl) hydantoin (6a), 3-(2-chloroethyl)-5-isopropylhydantoin (6b), 3-(2-chloroethyl)-5-isobutylhydantoin (6c), 3-(2-chloroetbyl)5-(2-butyl) hydantoin (6d), 3-(2-chloroethyl)-5-benzylhydantoin (6e), 3-(2-chloroethyl)-5-(indolyl-3-methyl) hydantoin (6f), were prepared by the treatment of the corresponding salt of amino acids with 2-chloroethyl isocyanate in cold water, followed by refluxing in concentrated HCl solution. Anticancer activity of the synthesized hydantoin derivatives were examined on murine leukemia L1210 cells growing in Fischer medium. Among them, 3-(2-chloroethy)-5-isobutyl-hydantoin (6c) showed substantially low $ED_{50}$ value of $9.6{\mu}g/ml$.

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A study on the nonlinear constitutive relation in magnetostrictive materials (자왜 재료의 비선형 구조 방정식에 관한 연구)

  • Kang Kukjin;Roh Yongrae;Kim Yeon-Bo
    • Proceedings of the Acoustical Society of Korea Conference
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    • autumn
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    • pp.311-314
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    • 2000
  • 자왜 재료는 자계 포화 이하에서 비선형 특성을 갖는다고 알려져 있다. 그러나 지금까지 비선형 특성을 표현하는 자왜 재료의 구조 방정식을 유도한 사례는 전무한 실정이다. 본 연구에서는 자계 포화 이하에서 비선형 특성을 갖는 자왜 재료의 비선형 구조 방정식을 4차 텐서를 이용하여 유도하였다. 나아가 유도된 구조방정식을 이용하여 자왜 재료 내의 파동 방정식을 정식화하였다. 그리고 비선형 특성을 갖는 자왜 재료에서 평면파가 자계 방향을 따라 전파될 때 등방성 자왜 재료의 탄성파 속도를 구하였다. 이상의 결과를 검증하기 위해서 자왜 재료 중에서 가장 널리 사용되고 있는 Terfenol-D의 탄성파 속도를 측정하여 본 연구에서 유도한 자왜 재료 비선형 구조 방정식의 타당성을 일부 검증하였다. 향후에 자왜 재료의 정확한 특성을 측정하여 본 연구 결과와 비교함으로써 본 연구에서 유도한 비선형 구조 방정식의 타당성을 검증하고자 한다.

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A Design and Implementation of the Scenario-based Data Mining Tool named XM-T7D1/Miner (시나리오 기반의 데이터 마이닝 도구 XM-TDDl/Miner 설계 및 구현)

  • 이창호;이남근;이승희;이병엽;김주용
    • Proceedings of the Korea Inteligent Information System Society Conference
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    • 2000.11a
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    • pp.307-314
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    • 2000
  • 정보기술이 발달하면서 자료의 흔적들이 체계화된 데이터베이스에 저장이 되고, 더불어 데이터베이스의 규모는 점점 커지고 있다. 데이터 마이닝은 이런 방대한 자료의 분석을 통해, 그 속에 숨어있는 의미를 찾는 과점이라고 될 수 있다. 본 논문에서는 대우정보시스템(주)서 개발된 사용자지향 데이터 마이닝 도구인 XM-Tool/Miner의 개발을 대상으로 하고 있다. 개발된 XM-Tool/Miner은 문제 중심적 마이닝 도구를 목표로 하였으며, 대표적인 마이닝 알고리즘을 적용하였고, 또한 사용의 편이성에 초점을 맞추었다. 더 나아가 데이터 마이닝 기법뿐만 아니라 데이터의 샘플링과 성능향상을 통하여 방대한 데이터로부터 다양한 지식탐사가 가능해지고, 발견된 규칙 또는 지식의 유용성 측정을 통하여 업무 분야의 특성에 따라 효과적으로 반영되며 의사 결정 및 CRM마케팅, 동향분석 및 예측 등에 유용한 정보를 추출하는 도구로 사용할 수 있을 것이다.

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Strategic Action Plan for Companies to Supply Safe Products Using AHP Technology (AHP를 활용한 안전한 제품을 공급하기 위한 기업의 전략적 실행방안)

  • Seo, JunHyeok;SungMin, Bae
    • Journal of Korean Society for Quality Management
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    • v.50 no.4
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    • pp.635-646
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    • 2022
  • Purpose: In this study, the detailed implementation plan for product safety evaluation and management suggested by KS A ISO 10377 to reduce the risk of harm to consumers and users is presented so that companies can strategically implement it. Methods: In order to achieve the purpose of this study, the upper elements and detailed execution plans shown in KS A 10377 are classified into hierarchies and set as a decision hierarchy. A pairwise comparison is performed to derive it. Results: Among the top factors, 'design safety (D)' was the most important factor, with 0.314. Therefore, ensuring safety in the design stage that can prevent defects in advance is the most important action plan for companies to supply safe products. Conclusion: The results of this study, it is intended to help companies and related organizations more easily understand and continuously apply KS A ISO 10377.

Gesture Communication: Collaborative and Participatory Design in a New Type of Digital Communication (제스츄어 커뮤니케이션: 새로운 방식의 디지털 커뮤니케이션의 참여 디자인 제안)

  • Won, Ha Youn
    • Korea Science and Art Forum
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    • v.20
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    • pp.307-314
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    • 2015
  • Tele-Gesture is a tangible user interface(TUI) device that allows a user to physically point to a 3D object in real life and have their gestures play back by a robotic finger that can point to the same object, either at the same time, or at another point in time. To understand the extent of the gestures as new way of digital collaborative communication, collaboration situation and types were experimented as TUI implementations. The design prototype reveals that there is a rich non-verbal component of communication in the form of gesture-clusters and body movements that happen in an digital communication. This result of analysis can contribute to compile relevant contributions to the fields of communication, human behavior, and interaction with high technology through an interpretive social experience.

스마트 항로표지 활용·확산을 위한 법·제도 개선 방안

  • 이주영;권기원;오세웅
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • 2022.11a
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    • pp.313-314
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    • 2022
  • 항로표지법은 항로표지를 설치하고 합리적이고 효율적으로 관리하여 해상교통의 안전을 도모하고, 선박 운항의 능률을 향상시키는데 이바지하는 것을 목적하며, 항로표지의 정의와 설치·관리 및 보호, 장비·용품 등의 연구·개발 및 검사 등을 법으로 규정하고 있다. 항로표지는 해상교통의 중요한 인프라로 미래 해상환경 패러다임(MASS, AI Port, Digiral twin 등)에 대응이 가능한 스마트 항로표지로 전향하는 길목에 있다. 스마트 항로표지는 자가 고장진단 및 전원유지, 다중통신 기술 인터페이스를 제공하는 등 다목적 해양플랫폼, 전원관리시스템, 해양용다중통신 플랫폼 등을 국가 R&D를 통해 개발하고 있으며, 국내 해상 실증을 통한 글로벌 표준 제정 등의 과정을 거쳐 최종적으로는 기술이전을 통한 국내 관련 업체들의 해외진출까지를 목표로 하고 있어 기존 항로표지법을 개발될 스마트 항로표지 적용 및 활용·확산을 위한 개선 방안 마련이 필요하다.

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The Hearing Ability of Coralfish Chromis notatus to Low Frequency Sound 2. The Auditory Critical Ratio and Hearing Index (저주파음에 의한 자리돔의 청각 능력 2. 청각 임계비 및 청각능력지수)

  • 이창헌;서두옥
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.36 no.4
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    • pp.314-321
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    • 2000
  • In order to obtain the fundamental data on the auditory thresholds of fishes for catching method using low frequency sound, the auditory thresholds of coralfish Chromis notatus were measured in the presence of masking noise in the spectrum level range of 73~83dB re l$\mu$Pa/√Hz by heartbeat conditioning technique using pure tones coupled with a delayed electric shock. Critical ratios were about 23~41dB at measurement frequency, The critical ratio increased almost linearly with increasing frequency from 500Hz. The noise spectrum level at the start of masking was about 60~65dB. This suggests that hearing of coralfish is masked in the natural environment with the noise spectrum level above 60dB. The sound pressure level of which the signal sound of 300Hz is recognized by coralfish under the ambient noise is above 88dB and the critical ratio of them is above 23dB. The hearing index of coralfish with ambient noise was 81.

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Comparison of Milk Yield and Milk Composition Between Before and After Auto Milking System (AMS) Use in Dairy Cow (국내 자동착유시스템 이용농가의 설치 전·후 산유량 및 유성분 비교)

  • Ki, Kwang-Seok;Jeong, Young-Hun;Park, Sung-Jai;Kim, Sang-Bum;Lee, Wang-Shik;Lee, Hyun-June;Lim, Dong-Hyun;Kim, Hyeon Shup;Kwon, Eung-Gi;Cho, Mi-Yea;Yeo, Joon-Mo
    • Journal of Animal Environmental Science
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    • v.17 no.3
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    • pp.189-196
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    • 2011
  • The present study was conducted to investigate effects of auto milking system (AMS) on milk yield and milk composition in dairy cow using dairy herd improvement (DHI) record. DHI records for 147 cows were compared between a year before and after AMS use. AMS significantly increased daily milk yield compared with the conventional milking system (30.4kg vs 34.3 kg for CMS and AMS, respectively). There were no significant differences in the contents of milk fat (3.7% vs 3.8% for CMS and AMS) and milk protein (3.2% vs 3.2% for CMS and AMS) between CMS and AMS. But the yields of milk fat and milk protein were significantly higher for AMS than for CMS. Average somatic cell counts were 169,400/ml (1st grade) before AMS use but increased by 314,400/ml (2nd grade) after AMS use. Overall, AMS increased milk yield and the yields of milk fat and protein without affecting milk composition but also increased somatic cell count.

Confirmation of genotypic effects for the bovine APM1 gene on marbling in Hanwoo cattle

  • Kwon, Anam;Srikanth, Krishnamoorthy;Lee, Eunjin;Kim, Seonkwan;Chung, Hoyoung
    • Journal of Animal Science and Technology
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    • v.58 no.4
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    • pp.15.1-15.6
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    • 2016
  • Background: Our previous study had identified the SNP (g.81966377T > C) and indel (g.81966364D > I) located in the promoter of APM1 to have a significant effect on marbling in Hanwoo. APM1 encodes an adipocytokine called adiponectin, which plays a significant role in lipogenesis. The aim of this study was to verify and validate the effect of the SNP and indel on marbling and other carcass traits in a large, representative, countrywide population of Hanwoo cattle. The carcass traits measured were marbling (MAR), backfat thickness (BFT), loin eye area (LEA), and carcass weight (CAW). Results: Primers were designed to amplify 346 bp of the genomic segment that contained the targeted SNP (g.81966377) and the indel (g.81966364). After data curation, the genotypes of 8,378 individuals identified using direct sequencing analysis estimated frequencies for C (0.686) and T (0.314) respectively showing genotype frequencies for CC (0.470), CT (0.430) and TT (0.098). The genotypes were significantly associated with MAR, BFT and LEA. The indel had significant effect on marbling (P < .0001) with strong additive genetic effects. The allele frequencies was estimated at (DEL, 0.864) and insertion (INS, 0.136) presenting genotypes of D/D (75.63 %), D/I (21.44 %), and I/I (2.92 %). Significant departure from Hardy-Weinberg equilibrium was not detected for both the SNP and the indel. Conclusion: The SNP genotypes showed significant association with MAR, BFT and LEA with strong additive genetic effects, while the indel was significantly associated with MAR. The results confirmed that the variants can be used as a genetic marker for improving marbling in Hanwoo.

Sectorial Form UWB Antenna with a CPW-fed Uni-Planar (CPW 급전 단일 평면 부채꼴형 UWB 안테나 설계 및 제작)

  • Kim, Nam;Son, Gui-Bum;Park, Sang-Myeong
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.18 no.3 s.118
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    • pp.305-314
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    • 2007
  • In this paper, we suggested a CPW-fed UWB antenna with uni-planar sectoral structure. The area where radiation device face ground is designed to have the shape of tapered slot based on exponential function. We modified a rectangular bow-tie dipole structure antenna and thus formed a multi-resonant mode. From this, we expanded the impedance bandwidth and made a feature satisfying VSWR of less than 2 between $3.1\sim10.6GHz$. The test result showed that the return loss less than -10 dB was met in the full-band UWB system and maximum gain of $0.9\sim3.1dB$ was made with the half-power beamwidth of $40.1\sim89.9^{\circ}$ on XY plane(Theta, $Phi=90^{\circ}$) and the full band. By using CPW-fed structure with no ground on the back of the substrate, the suggested antenna is easy to design and its miniaturization is also possible.