• Journal of the Korean Ceramic Society
• /
• v.41 no.9
• /
• pp.709-714
• /
• 2004

The additive of low temperature sintering in Mn-doped PMN-PZT known as high piezoelectric materials was studied in this experiment. B$_2$O$_3$ was used for the additive of low temperature sintering. The effects of sintering temperature in dielectric, and piezoelectric properties were investigated with the amounts of B$_2$O$_3$. Sintered density was increased in comparison with no addition and under 2wt％ B$_2$O$_3$ and lower sintering temperature than 100$0^{\circ}C$. Therefore, in the low sintering temperature, the densification was improved by the addition of the B$_2$O$_3$. However, the sintering density was lower than that of the main composition in the case of the sintered at over 10$50^{\circ}C$. Dielectric constant with the addition of B$_2$O$_3$ was evaluated. The dielectric constant was 1000 2 wt％ of B$_2$O$_3$ and sintered at 100$0^{\circ}C$. Under 2wt％ of B$_2$O$_3$, the electromechanical coupling factor and the piezoelectric constant were not so much decreased. The electromechanical coupling factor and the piezoelectric constant were 50％ and 300(${\times}$10$^{-12}$ C/N) respectively. The mechanical quality factor was increased with B$_2$O$_3$. The mechanical quality factor was 1700 at 0.5wt％ B$_2$O$_3$ and sintered at 110$0^{\circ}C$. Dielectric loss was less than 0.5％ regardless of the amount of B$_2$O$_3$.

• Asian-Australasian Journal of Animal Sciences
• /
• v.23 no.11
• /
• pp.1427-1435
• /
• 2010

The present study was conducted to examine the effect of a stair-stepped feed intake pattern on growth, feed efficiency, and meat quality of Hanwoo steers. Twenty-seven 11-month-old Hanwoo steers were randomly divided into three groups. The control group was fed according to the Korean steer feeding program, and the other two groups were fed according to an alternated feeding schedule of 3-2-4-2 months. During the first three months of the experiment, treatment group 1 (T1) and treatment group 2 (T2) were fed 20% and 30% less than the control group, respectively. For the following two months, the T1 group was fed 20% more than the control group while the T2 group was fed 20% less than the control group. In the third step, T1 and T2 groups were fed 20% and 10% less, respectively, than the control group for four months. In the last two months, T1 and T2 groups were fed 20% more than the control group. After the stair-step feeding trial, steers were fed concentrated feed ad libitum for five months. The altered feed intake pattern did not affect daily body weight gain. However, daily feed intake tended to decrease and growth efficiency tended to increase in the two treatment groups compared to the control group. Altered feed intake also affected blood metabolite levels. The serum glucose and BUN level of the T1 group increased in the first re-fed period compared to the T2 and control groups. The serum cholesterol level of the T2 group decreased in the first restricted-re-fed growth period compared to the T1 and control groups. The serum NEFA levels of the two treatment groups increased from the first restricted period compared to the controls. The serum insulin level of the T2 group increased in the last period compared to the T1 and control groups. Regarding meat yield index, the control group was significantly higher than the T2 group (p<0.05). Regarding meat yield grade, the carcass back fat thickness of the T2 group was significantly higher than the control group (p<0.05). In marbling score, the T1 group was the highest (4.9), followed by the control group (4.1) and the T2 group (4.0). These results indicate that using a stair-stepped growth pattern (T1) can contribute to improvements in growth efficiency and muscle marbling.

• Journal of Nutrition and Health
• /
• v.51 no.4
• /
• pp.275-286
• /
• 2018

Purpose: Our previous study demonstrated that persimmon (Diospyros kaki Thumb.) at different stages of ripening provided different protective effects against high-fat/cholesterol diet (HFD)-induced dyslipidemia in rats. In this study, we compared the metabolites profile and gene expressions related to triglyceride (TG)/cholesterol metabolism in vitro and in vivo after treating with persimmon water extracts (PWE) or tannin-enriched persimmon concentrate (TEP). Methods: Primary and secondary metabolites in test materials were determined by GC-TOF/MS, UHPLC-LTQ-ESI-IT-MS/MS, and UPLC-Q-TOF-MS. The expression of genes related to TG and cholesterol metabolism were determined by RT-PCR both in HepG2 cells stimulated by oleic acid/palmitic acid and in liver tissues obtained from Wistar rats fed with HFD and PWE at 0, 150, 300, and 600 mg/d (experiment I) or TEP at 0, 7, 14, and 28 mg/d (experiment II) by oral gavage for 9 weeks. Results: PLS-DA analysis and heatmap analysis demonstrated significantly differential profiling of metabolites of PWE and TEP according to processing of persimmon powder. In vitro, TEP showed similar hypolipidemic effects as PWE, but significantly enhanced hypocholesterolemic effects compared to PWE in sterol regulatory element-binding protein 2 (SREBP2), HMG-CoA reductase (HMGCR), proprotein convertase subtilisin/kexin type 9 (PCSK9), cholesterol $7{\alpha}-hydroxylase$ (CYP7A1), and low density lipoprotein receptor (LDLR) gene expression. Consistently, TEP and PWE showed similar hypolipidemic capacity in vivo, but significantly enhanced hypocholesterolemic capacity in terms of SREBP2, HMGCR, and bile salt export pump (BSEP) gene expression. Conclusion: These results suggest that column extraction after hot water extraction may be a good strategy to enhance tannins and long-chain fatty acid amides, which might cause stimulation of hypocholesterolemic actions through downregulation of cholesterol biosynthesis gene expression and upregulation of LDL receptor gene expression.

• The Korean Journal of Physiology and Pharmacology
• /
• v.16 no.4
• /
• pp.273-279
• /
• 2012

Busulfan is an antineoplastic agent with a narrow therapeutic window. A post-hoc population pharmacokinetic analysis of a prospective randomized trial for comparison of four-times daily versus once-daily intravenous busulfan was carried out to search for predictive factors of intravenous busulfan (iBu) pharmacokinetics (PK). In this study the population PK of iBu was characterized to provide suitable dosing recommendations. Patients were randomized to receive iBu, either as 0.8 mg/kg every 6 h or 3.2 mg/kg daily over 4 days prior to hematopoietic stem cell transplantation. In total, 295 busulfan concentrations were analyzed with NONMEM. Actual body weight and sex were significant covariates affecting the PK of iBu. Sixty patients were included in the study (all Korean; 23 women, 37 men; mean [SD] age, 36.5 [10.9] years; weight, 66.5 [11.3] kg). Population estimates for a typical patient weighing 65 kg were: clearance (CL) 7.6 l/h and volume of distribution (Vd) 32.2 l for men and 29.1 L for women. Inter-individual random variabilities of CL and $V_d$ were 16% and 9%. Based on a CL estimate from the final PK model, a simple dosage scheme to achieve the target $AUC_{0-inf}$ (defined as median AUC0-inf with a once-daily dosage) of 26.18 $mg/l{\cdot}hr$, was proposed: $24.79{\cdot}ABW^{0.5}mg$ q24h, where ABW represents the actual body weight in kilograms. The dosing scheme reduced the unexplained interindividual variabilities of CL and Vd of iBu with ABW being a significant covariate affecting clearance of iBU. We propose a new simple dosing scheme for iBu based only on ABW.

• Korean Journal of Environmental Agriculture
• /
• v.41 no.4
• /
• pp.355-364
• /
• 2022

BACKGROUND: Pre-harvest interval and decline pattern of thiamethoxam were determined in kiwifruit using liquid chromatography-tandem mass spectrometry (LCMS/MS). The study was carried out to propose import tolerance using OECD maximum residue limit (MRL) calculator for the export promotion of kiwifruit to Taiwan. METHODS AND RESULTS: The thiamethoxam residue in kiwifruit was determined by using the LC-TriQ-MS/MS with the analytical process to set up the import tolerance under greenhouse conditions for Taiwan. Excellent linearity was observed for all of the analytes with a determination coefficient (R²)≥0.99. The limit of quantification was determined to be 0.01 mg/kg for both thiamethoxam and clothianidin in kiwifruit. Linearity was determined from the co-efficient of determinants (R²) obtained from the seven-point calibration curve. The standard calibration curve showed as follows; 1) Site 1 (Gimje): y = 944,406X + 1,583 (R²=0.9995), 2) Site 2 (Goheung): y = 1,356,205X + 934 (R²=0.9983), and 3) Site 3 (Jangheung): y = 1,239,937X - 3,090 (R²=0.9908). The residue of thiamethoxam in the kiwifruit for three decline trials showed the range of 0.35 to 0.56 mg/kg in site 1 (Gimje), 0.24 to 0.55 mg/kg in site 2 (Goheung), and 0.28 to 0.42 mg/kg in site 3 (Jangheung), respectively. However, clothianidin was not detected in all of the treatments. The maximum residual amounts (decline) in the samples, sprayed according to the safe-use standard for thiamethoxam 10% WG in kiwifruit (30 days before harvest, 3 sprays every 7 days) were 0.56 mg/kg in site 1, 0.55 mg/kg in site 2, and 0.42 mg/kg in site 3, respectively. CONCLUSION(S): The import tolerance (IT) of thiamethoxam for kiwifruit may be proposed to be 0.9 mg/kg by using the OECD MRL calculator.

• Nuclear Engineering and Technology
• /
• v.54 no.11
• /
• pp.4102-4110
• /
• 2022

Aiming at high-power and long-pulse operation up to 1000 s, some improvements have been made for both 2.45 GHz and 4.6 GHz lower hybrid (LH) systems during the recent 5 years. At first, the guard limiters of the LH antennas with graphite tiles were upgraded to tungsten, the most promising material for plasma facing components in nuclear fusion devices. These new guard limiters can operate at a peak power density of 12.9 MW/m². Strong hot spots were usually observed on the old graphite limiters when 4.6 GHz system operated with power >2.0 MW [B. N. Wan et al., Nucl. Fusion 57 (2017) 102019], leading to a reduction of the maximum power capability. With the new limiters, 4.6 GHz LH system, the main current drive (CD) and electron heating tool for EAST, can be operated with power >2.5 MW routinely. Long-pulse operation up to 100 s with 4.6 GHz LH power of 2.4 MW was achieved in 2021 and the maximal temperature on the guard limiters measured by an infrared (IR) camera was about 540 ℃, much below the permissible value of tungsten material (~1200 ℃). A discharge with a duration of 1056 s was achieved and the 4.6 GHz LH energy injected into the plasma was up to 1.05 GJ. Secondly, the fully-active-multijunction (FAM) launcher of 2.45 GHz system was upgraded to a passive-active-multijunction (PAM), for which the density of optimum coupling was relatively low (below the cut-off value). Good coupling with reflection coefficient ~3% has been achieved with plasma-antenna distance up to 11 cm for the new PAM. Finally, in order to eliminate the effect of ion cyclotron range of frequencies (ICRF) wave on 4.6 GHz LH wave coupling, the location of the ICRF launcher was changed to a port that is located 157.5° toroidally from the 4.6 GHz LH system and is not magnetically connected.

• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.15 no.4
• /
• pp.271-282
• /
• 1982

The browning development, mainly through the Maillard reaction, occurring in the dried fish meat products during storage causes reduction of the nutritional value due to the loss of the essential amino acid such as available lysine as well as off -flavor resulting in the deterioration of the food quality thus shortening the shelflife. In the work, the changes in the amount of available lysine, extractable nitrogenous compounds (nonprotein-N, amino-N, trimethylamine oxide, trimethylamine, and free lysine) and development of browning were measured to assess the relationship between the shelflife and the quality loss in dried filefish under the steady state conditions (35,45, and $55^{\circ}C;a_{w}'s$ of 0.44 0.52, 0.65 and 0.75 at each temperature) and fluctuating temperature condition of $35/55^{\circ}C$ will. alternating 7 day periods at each water activity. The results indicated that the amount of available lysine and extractable nitrogenous compounds except TMA decreased rapidly with increasing temperatures and water activities while the rate of available lysine and extractable nitrogenous compounds must be involved in the initial stage of brown pigment formation. The available lysine loss of the dried filefish products stored under the fluctuating temperature conditions was greater than that stored under its fixed mean temperature, $45^{\circ}C$. The activation energies for lysine loss obtained from the Arrhenius plot ranged 6.9 to 4.4 Kcal/mol and $Q_{10}$ values at $40^{\circ}C$ were 1.4 to 1.2. The values for browning were 15.7 to 14.4 Kcal/mol and 2.2 to 2.0 respectively. Shelf-life, defined as the time to reach 0.15 O. D./g solid or the limit of off-color deterioration by browning reaction, was extented longer than the halflife of Iysine loss, actually corresponding $75\%$ loss of available lysine. This suggested that the halflife of lysine loss might not be adequate to assess the shelf-life of the food system with high potential of protein, nonproteinous nitrogen compounds, and lipids.

• Journal of Animal Science and Technology
• /
• v.58 no.2
• /
• pp.6.1-6.11
• /
• 2016

Background: Dietary supplementation of unsaturated fats in ruminants, if not stabilized, can instigate oxidative stress which can have negative impact on production performance and enhance the susceptibility to various diseases. The current study examined the effect of dietary 80 % canola oil and 20 % palm oil blend (CPOB) on serum fatty acids, antioxidant profile and biochemical indices in goats. Thirty Boer bucks (4-5 months old; initial BW, $20.34{\pm}0.77kg$) were randomly assigned to diets containing 0, 4 or 8 % CPOB and fed daily for a period of 90 days. Blood was sampled from the goats on 0, 30, 60 and 90 days of the trial and the serum was analyzed for fatty acids, cholesterol, glucose, total protein, antioxidants and lipid oxidation. Results: Neither diet nor sampling time influenced serum TBARS value, catalase, glutathione peroxidase and superoxide dismutase activities, LDL cholesterol, VLDL cholesterol, triglycerides, glucose and total protein. Goats fed 4 and 8 % CPOB had higher (P < 0.05) total cholesterol and HDL cholesterol than the control goats on day 30, 60 and 90. The proportion of C15:0 decreased with increasing level of CPOB on day 30 and 60. Serum C18:1n-9 increased with increasing level of CPOB in diet on day 60. The proportion of C18:3n-3 and C22:5n-3 increased (P < 0.05), while the proportion of C18:2n-6 decreased (P < 0.05) with increase in the level of CPOB on day 60 and 90. Dietary CPOB did not affect serum total carotenoid and ${\delta}$-tocopherol but did increase (P < 0.05) ${\alpha}$ and ${\gamma}$-tocopherol. Conclusion: Dietary canola oil and palm oil blend could be supplemented in diets without instigating oxidative stress in goats.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2015.05a
• /
• pp.70-70
• /
• 2015

하천에서의 수문/수리적 특성은 주수로의 다양한 지형학적 형태로 나타난다. 특히 흐름과 수반된 유사량의 변화는 하천의 지형학적, 수리기하적 특성을 지배하며, 하도의 물리적 시스템을 변화시켜 동적 평형에 이르게 된다. 하천에서 하도 형성에 지배적인 역할을 하는 수리특성은 하도형성유량으로 지배유량이며, 보통 만제유량을 사용한다. Dunne and Leopold(1978)는 만제유량을 유사의 이송, 하천의 사행, 유선형의 변화 등 하천의 일반적인 형태를 변화시키며, 주수로의 특성을 형성하는 유량으로 정의하였다. 이와 같이 수리 지형학적 특성을 반영하는 만제유량은 하천의 특성을 나타내는 중요한 요소이다. 따라서 본 연구에서는 한강 수계 20개 하천, 27개 수위 관측소의 최소 10년 이상의 실측 자료를 기반으로 다년간의 연평균 실측유량을 산정하였으며, McCandless(2003)가 제시한 지형학적 만제지표를 이용하여 추정한 만제유량과의 상관성을 분석하였다. 추정된 만제유량은 HEC-RAS model을 이용하여 만제하폭, 만제수심, 만제 시 평균유속을 산정하였다. 27개 지점의 실측유량과 만제유량의 상관성 분석결과 만제유량은 연평균 일유량의 7.7배로 나타났다. 따라서 만제유량을 7일 평균유량(1 week mean discharge)으로 정의하였으며, 수정된 7일 유량과 만제유량의 RMSE는 13.90 m/s, MAPE는 9.94 %로 상관성이 매우 높게 나타났다. 또한 만제유량과 만제하폭, 만제수심, 평균유량, 구간경사와 상관성 분석결과 개별적으로의 상관성은 나타나지 않았으나, 만제하폭, 수심, 평균유량과 만제유량에 대한 회귀 분석을 실시한 결과 $R^2$는 0.911로 매우 높게 나타났으며, 구간경사를 추가하여 분석한 결과 $R^2$가 0.914로 증가하였다. 따라서 만제유량은 수리 기하학적 특성이 모두 반영된 하천 특성을 나타내는 복합적인 지표임을 확인하였다. 아울러 만제유량을 통해 추정된 연평균 유량($48{\cdot}Q_{bf}$)을 우리나라의 월간 유출량 분포 비율을 이용하여 일유량으로 배분/생성하였으며, 생성된 일유량을 통해 CCHE2D model을 이용하여 하상변동 모의를 수행하였다. 대상 구간은 병성천 최하류로부터 상류로 7 km 구간이며, 2013년 1월과 12월 측량 자료를 통한 1년간의 실제 하상 변동 자료와 2013년 실측 유량자료에 따른 하상변동 모의 결과 및 만제유량에 의해 배분/생성된 일유량에 따른 하상변동 모의 결과를 비교하였다. 비교 분석 결과 7일 평균 유량으로 정의된 만제유량을 통해 배분/생성된 유량의 수치모의 결과는 실제 측량자료 및 실측유량자료에 따른 하상변동 결과와 매우 일치하는 것을 확인하였다.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2015.05a
• /
• pp.580-580
• /
• 2015

하천에서의 수문/수리적 특성은 주수로의 다양한 지형학적 형태로 나타난다. 특히 흐름과 수반된 유사량의 변화는 하천의 지형학적, 수리기하적 특성을 지배하며, 하도의 물리적 시스템을 변화시켜 동적 평형에 이르게 된다. 하천에서 하도 형성에 지배적인 역할을 하는 수리특성은 하도형성 유량으로 지배유량이며, 보통 만제유량을 사용한다. Dunne and Leopold(1978)는 만제유량을 유사의 이송, 하천의 사행, 유선형의 변화 등 하천의 일반적인 형태를 변화시키며, 주수로의 특성을 형성하는 유량으로 정의하였다. 이와 같이 수리 지형학적 특성을 반영하는 만제유량은 하천의 특성을 나타내는 중요한 요소이다. 따라서 본 연구에서는 한강 수계 20개 하천, 27개 수위 관측소의 최소 10년 이상의 실측 자료를 기반으로 다년간의 연평균 실측유량을 산정하였으며, McCandless(2003)가 제시한 지형학적 만제지표를 이용하여 추정한 만제유량과의 상관성을 분석하였다. 추정된 만제유량은 HEC-RAS model을 이용하여 만제하폭, 만제수심, 만제 시 평균유속을 산정하였다. 27개 지점의 실측유량과 만제유량의 상관성 분석결과 만제유량은 연평균 일유량의 7.7배로 나타났다. 따라서 만제유량을 7일 평균유량(1 week mean discharge)으로 정의하였으며, 수정된 7일 유량과 만제유량의 RMSE는 13.90m/s, MAPE는 9.94 %로 상관성이 매우 높게 나타났다. 또한 만제유량과 만제하폭, 만제수심, 평균유량, 구간경사와 상관성 분석결과 개별적으로의 상관성은 나타나지 않았으나, 만제하폭, 수심, 평균유량과 만제유량에 대한 회귀 분석을 실시한 결과 $R^2$는 0.911로 매우 높게 나타났으며, 구간경사를 추가하여 분석한 결과 $R^2$가 0.914로 증가하였다. 따라서 만제유량은 수리 기하학적 특성이 모두 반영된 하천 특성을 나타내는 복합적인 지표임을 확인하였다. 아울러 만제유량을 통해 추정된 연평균 유량($48{\cdot}Q_{bf}$)을 우리나라의 월간 유출량 분포 비율을 이용하여 일유량으로 배분/생성하였으며, 생성된 일유량을 통해 CCHE2D model을 이용하여 하상변동 모의를 수행하였다. 대상 구간은 병성천 최하류로부터 상류로 7 km 구간이며, 2013년 1월과 12월 측량 자료를 통한 1년간의 실제 하상 변동 자료와 2013년 실측 유량자료에 따른 하상변동모의 결과 및 만제유량에 의해 배분/생성된 일유량에 따른 하상변동 모의 결과를 비교하였다. 비교 분석 결과 7일 평균 유량으로 정의된 만제유량을 통해 배분/생성된 유량의 수치모의 결과는 실제 측량자료 및 실측유량자료에 따른 하상변동 결과와 매우 일치하는 것을 확인하였다.