• Title/Summary/Keyword: D2D Coverage

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Impact of Adaptive Radiotherapy on Locally Advanced Head and Neck Cancer - A Dosimetric and Volumetric Study

  • Dewan, Abhinav;Sharma, SK;Dewan, AK.;Srivastava, Himanshu;Rawat, Sheh;Kakria, Anjali;Mishra, Maninder;Suresh, T;Mehrotra, Krati
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.3
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    • pp.985-992
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    • 2016
  • Objective of the study is to evaluate volumetric and dosimetric alterations taking place during radiotherapy for locally advanced head and neck cancer (LAHNC) and to assess benefit of replanning in them. Materials and Methods: Thirty patients with LAHNC fulfilling the inclusion and exclusion criteria were enrolled in a prospective study. Planning scans were acquired both pre-treatment and after 20 fractions (mid-course) of radiotherapy. Single plan (OPLAN) based on initial CT scan was generated and executed for entire treatment course. Beam configuration of OPLAN was applied to anatomy of interim scan and a hybrid plan (HPLAN30) was generated. Adaptive replanning (RPLAN30) for remaining fractions was done and dose distribution with and without replanning compared for remaining fractions. Results: Substantial shrinkage of target volume (TV) and parotids after 4 weeks of radiotherapy was reported (p<0.05). No significant difference between planned and delivered doses was seen for remaining fractions. Hybrid plans showed increase in delivered dose to spinal cord and parotids for remaining fractions. Interim replanning improved homogeneity of treatment plan and significantly reduced doses to cord (Dmax, D2% and D1%) and ipsilateral parotid (D33%, D50% and D66%) (p<0.05). Conclusions: Use of one or two mid-treatment CT scans and replanning provides greater normal tissue sparing along with improved TV coverage.

Comparison of terrestrial insect communities associated with the crabgrass (Digitaria ciliaris) community, Korea

  • Jeong Ho Hwang;Jong-Hak Yun
    • Journal of Ecology and Environment
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    • v.47 no.4
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    • pp.250-260
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    • 2023
  • Background: Crabgrass (Digitaria ciliaris, Poaceae) is a globally distributed weed, including in Afro-Eurasia, America, and Australia. As a highly gregarious plant, crabgrass is an important habitat for a diverse array of insects, and a potential habitat for agricultural pests. To compare the insect communities associated with the crabgrass community, insects were sampled using sweep sampling (100 sweeps per sample) at five sites, including Daejeon (Daejeon and Gap rivers), Anseong, Namhae, and Inje, with a focus on the Daejeon River. Results: A total of 5,888 individual insects belonging to eight orders, 42 families, and 115 species were collected from the five sites. Both the number of species and individuals of Hemiptera were the highest at all of the sites. In the present study, 73% of the insect population fed on D. ciliaris as a host plant. The dominant species in the D. ciliaris community was Laodelphax striatellus (Delphacidae), being ubiquitous at all the sites which showed a high abundance of rice pests in the communities and the suitability of D. ciliaris as an alternative host plant for them. The Shannon-Wiener diversity index was highest in Inje on 17 September (2.88), and the Chao1-bc diversity index was highest in the Gap River on 5 September (80). The sampling efficiency of 100 sweep samples (sample coverage) was calculated to be as high as 90%. The results of the samples taken from September to November in the Daejeon River showed that the number of species and individuals decreased gradually over time, and the number of dominant species decreased sharply between September and October. Similarity analysis indicated that sampling dates that were closer together yielded sampled assemblages with higher faunal similarity. In addition, in each sampling, the difference in the minimum temperature during the two-week period prior to sampling and faunal similarities were negatively correlated. Conclusions: This study provides foundational data that could enhance our understanding of insect diversity in D. ciliaris. The data can facilitate ecological conservation and management of Korean grasslands generally, as well as identification of potential pests that may disperse from D. ciliaris communities to nearby farmland.

Development of Indoor Repeater LHCP antenna with Dual Bands (듀얼 대역 실내 중계기용 LHCP 안테나 개발)

  • Park, Sung-Il;Kim, Sun-Il
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.13 no.5
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    • pp.221-227
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    • 2013
  • In this paper, Satellite DMB/WiBro antenna and PCS/WiBro antenna improving indoor coverage for mobile services are designed and fabricated. Satellite DMB/WiBro bands repeater antenna and PCS/WiBro bands repeater antenna are proposed as a simple radiator with loading capacitor to generate LHCP(Left Hand Circular Polarization). The proposed antenna for Satellite DMB/WiBro and PCS/WiBro bands communication are fabricated by copper plate uploader type and substrate uploader type. The designed and fabricated antenna has a bandwidth of 70MHz at 1.816GHz~1.886GHz and bandwidth of 107MHz at 2.247GHz~2.354GHz. Maximum gain of radiation pattern was up to 5dBi.

Growth Evaluation of 10 Cultivars of Creeping Bentgrass in Salt Affected Environment (염해지에서 크리핑벤트그래스 10개 품종의 생육 비교)

  • Kim, Jun-Beom;Yang, Geun-Mo;Choi, Joon-Soo
    • Asian Journal of Turfgrass Science
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    • v.22 no.2
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    • pp.149-160
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    • 2008
  • This study was carried out to examine the growth performance of 10 cultivars of creeping bentgrass under salt injury in Seo-san reclaimed area. Turfgrass performance studies included 10 creeping bentgrass cultivars (T-1, L-93, Penn A1, Pennlinks II, Seaside II, Declaration, Penn A4, Crenshaw, Dominant, and Penncross). Ten creeping bentgrass cultivars were grown on a USGA recommended research green. Plots were seeded on May 31, 2006 at the rate of $7\;g{\cdot}m^{-1}$. Electric conductivities of irrigation water (ECw) and soil (ECe) were ranged from 0.28 to $3.3\;d\;S{\cdot}m^{-1}$ and from 0.25 to $3.5\;d\;S{\cdot}m^{-1}$ respectively. Leaf color, turf quality, coverage rate, and growth rate were checked under the salty condition in reclaimed land for 2 year. Creeping bentgrass cultivars of T-1, Penn links, and Crenshaw presented dark green color and Penn A1, Declaration showed lighter green color. Penn A1, Penn A4 and L-93 exhibited the highest overall turfgrass quality. Average visual coverage was 75.3% after eleven weeks after seeding. Dominant, L-93, and Penn A1 resulted in higher visual coverage compared to the other cultivars. There was no difference in density among cultivars at 1 year after establishment. However, Declaration, Penn A1, T-1, and L-93 showed higher density compared to the other cultivars at 2 years after seeding. Creeping bentgrass showed different quality, density and color in salty soil (ECe: $0.25-3.5\;d\;S{\cdot}m^{-1}$) and from application of salty irrigation water (ECw: $0.28-3.3\;d\;S{\cdot}m^{-1}$) conditions. These results will be useful where selecting green cultivars for the golf courses in reclaimed land area.

Comparison of Three Dimensional Conformal Radiation Therapy, Intensity Modulated Radiation Therapy and Volumetric Modulated Arc Therapy for Low Radiation Exposure of Normal Tissue in Patients with Prostate Cancer

  • Cakir, Aydin;Akgun, Zuleyha;Fayda, Merdan;Agaoglu, Fulya
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.8
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    • pp.3365-3370
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    • 2015
  • Radiotherapy has an important role in the treatment of prostate cancer. Three-dimensional conformal radiation therapy (3D-CRT), intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) techniques are all applied for this purpose. However, the risk of secondary radiation-induced bladder cancer is significantly elevated in irradiated patients compared surgery-only or watchful waiting groups. There are also reports of risk of secondary cancer with low doses to normal tissues. This study was designed to compare received volumes of low doses among 3D-CRT, IMRT and VMAT techniques for prostate patients. Ten prostate cancer patients were selected retrospectively for this planning study. Treatment plans were generated using 3D-CRT, IMRT and VMAT techniques. Conformity index (CI), homogenity index (HI), receiving 5 Gy of the volume (V5%), receiving 2 Gy of the volume (V2%), receiving 1 Gy of the volume (V1%) and monitor units (MUs) were compared. This study confirms that VMAT has slightly better CI while thev olume of low doses was higher. VMAT had lower MUs than IMRT. 3D-CRT had the lowest MU, CI and HI. If target coverage and normal tissue sparing are comparable between different treatment techniques, the risk of second malignancy should be a important factor in the selection of treatment.

A Dosimetric Comparision of IMRT and VMAT in Synchronous Bilateral Breast Cancer (양측성 유방암의 세기조절방사선치료(IMRT)와 부피적조절회전방사선치료(VMAT)의 비교연구)

  • Kim, Sung-Jin;Youn, Seon-Min;Kim, Sung Kyu
    • Progress in Medical Physics
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    • v.24 no.4
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    • pp.284-289
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    • 2013
  • A study was performed comparing dosimetric characteristics of volumetric modulated arc and intensity modulated radiatio therapy on patients with bilateral breast cancer. For 5 patients, 3 plans were made for each patient; IMRT beams 8 and 12 of the beam intensity modulated radiation therapy, volumetric modulated arc therapy plan. The average PTVs volumes and $D_{98}$ for 12-IMRT were $51.04{\pm}0.57$ Gy (right), $50.80{\pm}1.07$ Gy (left), $42.94{\pm}16.16$ Gy (right), $42.56{\pm}2.09$ Gy (left). HI ($D_5{\sim}D_{95}$) and $CI_{90,95}$, even 12-IMRT has shown excellent results. In OAR, 3 plans showed excellent results. But the lowest dose of 12-IMRT. 12-IMRT achieved similar PTV coverage and sparing of organs at risk than 8-IMRT and VMAT.

Studies on Adhesion Properties between Zinc-Coated Steel Cord and Adhesion Promoter-Containing Rubber Compound (아연 코팅된 스틸코드와 접착증진제가 적용된 고무 Compound와의 접착특성 연구)

  • Ko, Sang Min;Choi, Hee Seok;Son, Woo Jung;Kang, Sin Jung
    • Journal of Adhesion and Interface
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    • v.15 no.2
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    • pp.49-56
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    • 2014
  • In this study, properties of adhesion between adhesion promoter-containing rubber compound and zinc coated steel cord was investigated. Cobalt salt, resorcinol formaldehyde resin (RF resin) and hexamethoxymethylmelamine (HMMM) were used to adhesion promoter. Since cobalt salts accelerate sulphidation rate of zinc at zinc coated steel cord surface, pullout force of rubber compound applying cobalt salts was increased compared to that of rubber compound without applying cobalt salts. Pullout force and rubber coverage of rubber compounds applying all adhesion promoters were superior because strong interlocking between rubber matrix increased modulus due to applying RF resin and HMMM and grown zinc sulfides at zinc coated steel cord surface.

Identification of Causal and/or Rare Genetic Variants for Complex Traits by Targeted Resequencing in Population-based Cohorts

  • Kim, Yun-Kyoung;Hong, Chang-Bum;Cho, Yoon-Shin
    • Genomics & Informatics
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    • v.8 no.3
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    • pp.131-137
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    • 2010
  • Genome-wide association studies (GWASs) have greatly contributed to the identification of common variants responsible for numerous complex traits. There are, however, unavoidable limitations in detecting causal and/or rare variants for traits in this approach, which depends on an LD-based tagging SNP microarray chip. In an effort to detect potential casual and/or rare variants for complex traits, such as type 2 diabetes (T2D) and triglycerides (TGs), we conducted a targeted resequencing of loci identified by the Korea Association REsource (KARE) GWAS. The target regions for resequencing comprised whole exons, exon-intron boundaries, and regulatory regions of genes that appeared within 1 Mb of the GWA signal boundary. From 124 individuals selected in population-based cohorts, a total of 0.7 Mb target regions were captured by the NimbleGen sequence capture 385K array. Subsequent sequencing, carried out by the Roche 454 Genome Sequencer FLX, generated about 110,000 sequence reads per individual. Mapping of sequence reads to the human reference genome was performed using the SSAHA2 program. An average of 62.2% of total reads was mapped to targets with an average 22X-fold coverage. A total of 5,983 SNPs (average 846 SNPs per individual) were called and annotated by GATK software, with 96.5% accuracy that was estimated by comparison with Affymetrix 5.0 genotyped data in identical individuals. About 51% of total SNPs were singletons that can be considered possible rare variants in the population. Among SNPs that appeared in exons, which occupies about 20% of total SNPs, 304 nonsynonymous singletons were tested with Polyphen to predict the protein damage caused by mutation. In total, we were able to detect 9 and 6 potentially functional rare SNPs for T2D and triglycerides, respectively, evoking a further step of replication genotyping in independent populations to prove their bona fide relevance to traits.

Difference in the Set-up Margin between 2D Conventional and 3D CT Based Planning in Patients with Early Breast Cancer (조기유방암환자의 이차원치료계획과 삼차원치료계획의 방사선조사범위의 차이)

  • Jo, Sun-Mi;Chun, Mi-Son;Kim, Mi-Hwa;Oh, Young-Taek;Kang, Seung-Hee;Noh, O-Kyu
    • Radiation Oncology Journal
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    • v.28 no.3
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    • pp.177-183
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    • 2010
  • Purpose: Simulation using computed tomography (CT) is now widely available for radiation treatment planning for breast cancer. It is an important tool to help define the tumor target and normal tissue based on anatomical features of an individual patient. In Korea, most patients have small sized breasts and the purpose of this study was to review the margin of treatment field between conventional two-dimensional (2D) planning and CT based three-dimensional (3D) planning in patients with small breasts. Materials and Methods: Twenty-five consecutive patients with early breast cancer undergoing breast conservation therapy were selected. All patients underwent 3D CT based planning with a conventional breast tangential field design. In 2D planning, the treatment field margins were determined by palpation of the breast parenchyma (In general, the superior: base of the clavicle, medial: midline, lateral: mid - axillary line, and inferior margin: 2 m below the inframammary fold). In 3D planning, the clinical target volume (CTV) ought to comprise all glandular breast tissue, and the PTV was obtained by adding a 3D margin of 1 cm around the CTV except in the skin direction. The difference in the treatment field margin and equivalent field size between 2D and 3D planning were evaluated. The association between radiation field margins and factors such as body mass index, menopause status, and bra size was determined. Lung volume and heart volume were examined on the basis of the prescribed breast radiation dose and 3D dose distribution. Results: The margins of the treatment field were smaller in the 3D planning except for two patients. The superior margin was especially variable (average, 2.5 cm; range, -2.5 to 4.5 cm; SD, 1.85). The margin of these targets did not vary equally across BMI class, menopause status, or bra size. The average irradiated lung volume was significantly lower for 3D planning. The average irradiated heart volume did not decrease significantly. Conclusion: The use of 3D CT based planning reduced the radiation field in early breast cancer patients with small breasts in relation to conventional planning. Though a coherent definition of the breast is needed, CT-based planning generated the better plan in terms of reducing the irradiation volume of normal tissue. Moreover it was possible that 3D CT based planning showed better CTV coverage including postoperative change.

Estimation of the Marginal Walking Time of Bus Users in Small-Medium Cities (중·소도시 버스이용자의 한계도보시간 추정)

  • Kim, Kyung Whan;Yoo, Hwan Hee;Lee, Sang Ho
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.28 no.4D
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    • pp.451-457
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    • 2008
  • Establishing realistic bus service coverage is needed to build optimum city bus line networks and reasonable bus service coverage areas. The purposes of this study are understanding the characteristics of the present walking time and marginal walking time of small-medium cities and constructing an ANFIS (Adaptive Neuro-Fuzzy Inference System) model to estimate the marginal walking time for certain age and income. The cities of Masan, Chongwon and Jinju are selected for study cities. The 80 percentile of present walking time of bus users of these cities are 10.2-11.1 minutes, thus the values are greater than the 5 minutes of the maximum walking time in USA and the marginal walking times of 21.1-21.8 minutes are much greater. An ANFIS model based on pulled data of the cities are constructed to estimate the marginal walking time of small-medium cities. Analyzing the relationship between marginal walking time and age/income by using the model, the marginal walking time decreases as the age increases, but is near constant from the age of 25 to 35. And the marginal walking time is inversely proportional to the income. In comparing the surveyed and the estimated values, as the statistics of coefficient of determination, MSE and MAE are 0.996, 0.163, 0.333 respectively, it may be judged that the explainability of the model is very high. The technique developed in this study can be applied to other cities.